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Original Article

The use of hydralazine to manipulate tumour temperatures during hyperthermia

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Pages 971-983 | Received 08 Sep 1989, Accepted 12 Feb 1990, Published online: 09 Jul 2009

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Xiaorong Sun, Ligang Xing, C. Clifton Ling & Gloria C. Li. (2010) The effect of mild temperature hyperthermia on tumour hypoxia and blood perfusion: relevance for radiotherapy, vascular targeting and imaging. International Journal of Hyperthermia 26:3, pages 224-231.
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Michael R. Horsman. (2008) Angiogenesis and vascular targeting: Relevance for hyperthermia. International Journal of Hyperthermia 24:1, pages 57-65.
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Michael R. Horsman. (2006) Tissue physiology and the response to heat. International Journal of Hyperthermia 22:3, pages 197-203.
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J. M. Poulson, Z. Vujaskovic, A. A. Gaskin, S. M. Larue, R. E. Meyer, D. M. Prescott, T. V. Samulski, D. E. Thrall & M. W. Dewhirst. (2004) Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia. International Journal of Hyperthermia 20:5, pages 477-489.
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Michael R. Horsman, Rumi Murata, Jens Overgaard. (2001) Improving Local Tumor Control by Combining Vascular Targeting Drugs, Mild Hyperthermia and Radiation. Acta Oncologica 40:4, pages 497-503.
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David M. Vail & E. Gregory Macewen. (2000) Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer. Cancer Investigation 18:8, pages 781-792.
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Z. Q. Jia, A. E. Worthington, R. P. Hill & J. W. Hunt. (1997) The effects of artery occlusion on temperature homogeneity during hyperthermia in rabbit kidneys in vivo. International Journal of Hyperthermia 13:1, pages 21-37.
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M. R. Horsman, L. E. Sampson, D. J. Chaplin & J. Overgaard. (1996) The in vivo interaction between flavone acetic acid and hyperthermia. International Journal of Hyperthermia 12:6, pages 779-789.
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G. H. Nussbaum, J. Sidi, M. Dipalma, R. Adam, M. D. Ghnassia, P. Navarro, J. W. Hand, M. Nagi, M. Rotarsky, N. P. Plaza, M. Ionescu-Goga, P. Morel, P. Alhomme, J. M. Vannetzel, H. Bismuth & C. Jasmin. (1996) Production and manipulation of elevated temperatures in pig abdomen with a three-electrode capacitive heating device. International Journal of Hyperthermia 12:3, pages 421-430.
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C.J. Lewa & J.D. de CERTAINES. (1994) Body Temperature Mapping by Magnetic Resonance Imaging. Spectroscopy Letters 27:10, pages 1369-1419.
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M. W. Dewhirst. (1994) Future directions in hyperthermia biology. International Journal of Hyperthermia 10:3, pages 339-345.
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W. Levin, M. D. Sherar, B. Cooper, R. P. Hill, J. W. Hunt & F.-F. Liu. (1994) Effect of vascular occlusion on tumour temperatures during superficial hyperthermia. International Journal of Hyperthermia 10:4, pages 495-505.
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S. McChesney Gillette, M. W. Dewhirst, E. L. Gillette, D. E. Thrall, R. L. Page, B. E. Powers, S. J. Withrow, G. Rosner, C. Wong & D. A. Sim. (1992) Response of canine soft tissue sarcomas to radiation or radiation plus hyperthermia: a randomized phase II study. International Journal of Hyperthermia 8:3, pages 309-320.
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D. T. Laskowitz, G. B. Elion, M. W. Dewhirst, O. W. Griffith, R. A. Casero, P. A. Scott, N. Bullock, D. D. Bigner & H. S. Friedman. (1992) Effects of glutathione or polyamine depletion on in vivo thermosensitization. International Journal of Hyperthermia 8:2, pages 199-208.
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Articles from other publishers (18)

Mrigendra B. Karmacharya, Laith R. Sultan, Stephen J. Hunt & Chandra M. Sehgal. (2021) Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma. Scientific Reports 11:1.
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Jeff S. Isenberg, Gema Martin-Manso, Justin B. Maxhimer & David D. Roberts. (2009) Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies. Nature Reviews Cancer 9:3, pages 182-194.
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Pierre Sonveaux. (2008) Provascular strategy: Targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment. Radiotherapy and Oncology 86:3, pages 300-313.
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David M. Vail & Douglas H. Thamm. 2004. Anticancer Drug Development Guide. Anticancer Drug Development Guide 259 284 .
Thomas G Purdie & Ting-Yim Lee. (2003) Carbon dioxide reactivity of computed tomography functional parameters in rabbit VX2 soft tissue tumour. Physics in Medicine and Biology 48:7, pages 849-860.
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Michael R Horsman & Rumi Murata. (2002) Combination of vascular targeting agents with thermal or radiation therapy. International Journal of Radiation Oncology*Biology*Physics 54:5, pages 1518-1523.
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Bruce M Fenton. (2001) Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models. International Journal of Radiation Oncology*Biology*Physics 49:3, pages 799-808.
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H. J. Feldmann, M. Molls & P. Vaupel. 2000. Blood Perfusion and Microenvironment of Human Tumors. Blood Perfusion and Microenvironment of Human Tumors 47 62 .
David M. Vail & E. Gregory MacEwen. 1997. Anticancer Drug Development Guide. Anticancer Drug Development Guide 197 213 .
Bård Kronen Krossnes, Olav Mella & Ingvald Tyssebotn. (1996) Effect of sodium nitroprusside-induced hypotension on the blood flow in subcutaneous and intramuscular BT4An tumors and normal tissues in rats. International Journal of Radiation Oncology*Biology*Physics 36:2, pages 393-401.
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Bård Kronen Krossnes, Olav Mella & Olav Dahl. (1996) Use of the vasodilator sodium nitroprusside during local hyperthermia: Effects on tumor temperature and tumor response in a rat tumor model. International Journal of Radiation Oncology*Biology*Physics 36:2, pages 403-415.
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M. Heinrich Seegenschmiedt, Peter Fessenden & Clare C. VernonM. Heinrich Seegenschmiedt & Horst J. Feldmann. 1996. Thermoradiotherapy and Thermochemotherapy. Thermoradiotherapy and Thermochemotherapy 3 23 .
Beverly A. Teicher. (1995) Physiologic Mechanisms of Therapeutic Resistance: Blood Flow and Hypoxia. Hematology/Oncology Clinics of North America 9:2, pages 475-506.
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D. M. Prescott. 1995. Thermoradiotherapy and Thermochemotherapy. Thermoradiotherapy and Thermochemotherapy 177 189 .
Heidi Lyng, Odd R. Monge, Eli M. Sager & Einar K. Rofstad. (1993) Prediction of treatment temperatures in clinical hyperthermia of locally advanced breast carcinoma: The use of contrast enhanced computed tomography. International Journal of Radiation Oncology*Biology*Physics 26:3, pages 451-457.
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Beverly A Teicher, Sylvia A Holden, David Northey, Mark W Dewhirst & Terence S Herman. (1993) Therapeutic effect of infused fluosol-da/carbogen with ephedrine, flunarizine, or nitroprusside. International Journal of Radiation Oncology*Biology*Physics 26:1, pages 103-109.
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Mark W. Dewhirst, David Madwed, Robert E. Meyer, Edgardo T. Ong, Bruce Klitzman, Gary L. Rosner & Richard Dodge. (2007) Reduction in tumor blood flow in skin flap tumor after hydralazine is not due to a vascular steal phenomenon. Radiation Oncology Investigations 1:5, pages 270-278.
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D.M. Prescott, T.V. Samulski, M.W. Dewhirst, R.L. Page, D.E. Thrall, R.K. Dodge & J.R. Oleson. (1992) Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs. International Journal of Radiation Oncology*Biology*Physics 23:2, pages 377-385.
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