Advanced search
Publication Cover
International Journal of Hyperthermia Volume 13, 1997 - Issue 3
Submit an article Journal homepage
152
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Mammalian cells adapted to growth at pH 67 have elevated HSP27 levels and are resistant to cisplatin

P. R. Wachsberger Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
J. Landry Centre de recherche en cancérologie de l'Université Laval, l'Hotel-Dieu de Québec, Québec, Canada, G1R 2J6
,
C. Storck Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
K. Davis Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
M. D. O'Hara Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
C. S. Owen Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
D. B. Leeper Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Kimmel Cancer Institute, Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA
&
R. A. Coss Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Kimmel Cancer Institute, Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA
 show all
Pages 251-255 | Received 25 Jun 1996, Accepted 03 Dec 1996, Published online: 09 Jul 2009

Citations (26)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Shicang Yu, Guijun Huang, Guisheng Qian, Yuying Li, Guoming Wu & Ruiling Guo. (2007) Efficacy of Chemotherapeutic Agents Under Hypoxic Conditions in Pulmonary Adenocarcinoma Multidrug Resistant Cell Line. Journal of Chemotherapy 19:2, pages 203-211.
Read now

Articles from other publishers (25)

Yamin Yang, Sijia Liu, Chunxiao Chen, Haipeng Huang, Ling Tao, Zhiyu Qian & Weitao Li. (2020) Microfluidic-enabled self-organized tumor model for in vitro cytotoxicity assessment of doxorubicin. Biomedical Microdevices 22:4.
Crossref
Suchisnigdha Datta, Priyanka Saha, Subhabrata Dey & Dona Sinha. 2020. Pharmacotherapeutic Botanicals for Cancer Chemoprevention. Pharmacotherapeutic Botanicals for Cancer Chemoprevention 67 119 .
Viviane Palmeira da Silva, Carulina Bueno Mesquita, Júlia Silveira Nunes, Bianca de Bem Prunes, Pantelis Varvaki Rados & Fernanda Visioli. (2018) Effects of extracellular acidity on resistance to chemotherapy treatment: a systematic review. Medical Oncology 35:12.
Crossref
Ruben Lacroix, Elisa A. Rozeman, Marina Kreutz, Kathrin Renner & Christian U. Blank. (2018) Targeting tumor-associated acidity in cancer immunotherapy. Cancer Immunology, Immunotherapy 67:9, pages 1331-1348.
Crossref
Ran HongSong Iy Han. (2018) Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells . The Korean Journal of Physiology & Pharmacology 22:5, pages 513.
Crossref
Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Claudiu Supuran & Stefano Fais. (2017) Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy. Metabolites 8:1, pages 2.
Crossref
Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Anna Laurenzana, Francesca Margheri, Gabriella Fibbi, Mario Del Rosso, Francesca Bianchini & Lido Calorini. (2017) The acidic microenvironment as a possible niche of dormant tumor cells. Cellular and Molecular Life Sciences 74:15, pages 2761-2771.
Crossref
Enrico Pierluigi Spugnini, Pierre Sonveaux, Christian Stock, Mario Perez-Sayans, Angelo De Milito, Sofia Avnet, Abel Garcìa Garcìa, Salvador Harguindey & Stefano Fais. (2015) Proton channels and exchangers in cancer. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:10, pages 2715-2726.
Crossref
Maymona Al-Husari, Craig Murdoch & Steven D. Webb. (2013) A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth. Journal of Mathematical Biology 69:4, pages 839-873.
Crossref
Maymona Al-Husari & Steven D. Webb. (2013) Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours. PLoS ONE 8:8, pages e72020.
Crossref
Maymona Al-Husari & Steven D. Webb. (2013) Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate. Journal of Theoretical Biology 322, pages 58-71.
Crossref
David J. Adams, William R. Waud, Mansukh C. Wani, Govindarajan Manikumar, James L. Flowers, Timothy A. Driscoll & Lee Roy Morgan. (2010) BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. Cancer Chemotherapy and Pharmacology 67:4, pages 855-865.
Crossref
S. Fais. (2010) Proton pump inhibitor‐induced tumour cell death by inhibition of a detoxification mechanism. Journal of Internal Medicine 267:5, pages 515-525.
Crossref
C. Knorr, J. O. Pelz, J. Göhl, W. Hohenberger & T. Meyer. (2010) Expression of Chemoresistance-Related Genes and Heat Shock Protein 72 in Hyperthermic Isolated Limb Perfusion of Malignant Melanoma: An Experimental Study. Journal of Oncology 2010, pages 1-7.
Crossref
José Rivera, Diego Megias & Jerónimo Bravo. (2007) Proteomics-Based Strategy To Delineate the Molecular Mechanisms of the Metastasis Suppressor Gene BRMS1. Journal of Proteome Research 6:10, pages 4006-4018.
Crossref
Yong Zhang & Xun Shen. (2007) Heat Shock Protein 27 Protects L929 Cells from Cisplatin-Induced Apoptosis by Enhancing Akt Activation and Abating Suppression of Thioredoxin Reductase Activity. Clinical Cancer Research 13:10, pages 2855-2864.
Crossref
David J. Adams, Miriam L. Wahl, James L. Flowers, Banalata Sen, Michael Colvin, Mark W. Dewhirst, Govindarajan Manikumar & Mansukh C. Wani. (2005) Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient. Cancer Chemotherapy and Pharmacology 57:2, pages 145-154.
Crossref
Arnaud ParcellierElise SchmittMathilde BrunetArlette HammannEric SolaryCarmen Garrido. (2005) Small Heat Shock Proteins HSP27 and αB-Crystallin: Cytoprotective and Oncogenic Functions. Antioxidants & Redox Signaling 7:3-4, pages 404-413.
Crossref
Marie H. Hanigan, Mei Deng, Lei Zhang, Peyton T. TaylorJr.Jr. & Maia G. Lapus. (2005) Stress response inhibits the nephrotoxicity of cisplatin. American Journal of Physiology-Renal Physiology 288:1, pages F125-F132.
Crossref
Weng-Lang Yang, Grace Yang-Biggs, Yin Wu, Xuemei Ye, George Gallos, Randall P Owen & T.S Ravikumar. (2003) Development of cross-resistance between heat and cisplatin or hydroxyurea treatments in fadu squamous carcinoma cells. Journal of Surgical Research 111:1, pages 143-151.
Crossref
Cheng E. Ng, S. Qutob, M. Pavliv, P. Lamarche, J.P. Mao & G. Peter Raaphorst. (2002) Hsp 27 is better associated with the expression of inducible thermotolerance in human pancreatic tumor cell lines than hsp 70, p53 or p21/waf1/cip1. Journal of Thermal Biology 27:1, pages 47-54.
Crossref
Daniel R. Ciocca & Laura M. Vargas-Roig. 2002. Small Stress Proteins. Small Stress Proteins 205 218 .
S. Takeno, T. Noguchi, Y. Takahashi, R. Kikuchi, Y. Uchida & S. Yokoyama. (2001) Immunohistochemical and clinicopathologic analysis of response to neoadjuvant therapy for esophageal squamous cell carcinoma. Diseases of the Esophagus 14:2, pages 149-154.
Crossref
Shinobu Okada, Kanako Ono, Nobuyuki Hamada, Tetsuo Inada & Nobuo Kubota. (2001) A low-pH culture condition enhances the radiosensitizing effect of wortmannin. International Journal of Radiation Oncology*Biology*Physics 49:4, pages 1149-1156.
Crossref
Natarajan Raghunand & Robert J Gillies. (2000) pH and drug resistance in tumors. Drug Resistance Updates 3:1, pages 39-47.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.