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International Journal of Hyperthermia Volume 13, 1997 - Issue 3
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Original Article

Mammalian cells adapted to growth at pH 67 have elevated HSP27 levels and are resistant to cisplatin

P. R. Wachsberger Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
J. Landry Centre de recherche en cancérologie de l'Université Laval, l'Hotel-Dieu de Québec, Québec, Canada, G1R 2J6
,
C. Storck Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
K. Davis Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
M. D. O'Hara Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
C. S. Owen Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
D. B. Leeper Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Kimmel Cancer Institute, Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA
&
R. A. Coss Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Kimmel Cancer Institute, Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA
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Pages 251-255 | Received 25 Jun 1996, Accepted 03 Dec 1996, Published online: 09 Jul 2009

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Shicang Yu, Guijun Huang, Guisheng Qian, Yuying Li, Guoming Wu & Ruiling Guo. (2007) Efficacy of Chemotherapeutic Agents Under Hypoxic Conditions in Pulmonary Adenocarcinoma Multidrug Resistant Cell Line. Journal of Chemotherapy 19:2, pages 203-211.
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Viviane Palmeira da Silva, Carulina Bueno Mesquita, Júlia Silveira Nunes, Bianca de Bem Prunes, Pantelis Varvaki Rados & Fernanda Visioli. (2018) Effects of extracellular acidity on resistance to chemotherapy treatment: a systematic review. Medical Oncology 35:12.
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Ruben Lacroix, Elisa A. Rozeman, Marina Kreutz, Kathrin Renner & Christian U. Blank. (2018) Targeting tumor-associated acidity in cancer immunotherapy. Cancer Immunology, Immunotherapy 67:9, pages 1331-1348.
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Maymona Al-Husari & Steven D. Webb. (2013) Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate. Journal of Theoretical Biology 322, pages 58-71.
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David J. Adams, William R. Waud, Mansukh C. Wani, Govindarajan Manikumar, James L. Flowers, Timothy A. Driscoll & Lee Roy Morgan. (2010) BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. Cancer Chemotherapy and Pharmacology 67:4, pages 855-865.
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S. Fais. (2010) Proton pump inhibitor‐induced tumour cell death by inhibition of a detoxification mechanism. Journal of Internal Medicine 267:5, pages 515-525.
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C. Knorr, J. O. Pelz, J. Göhl, W. Hohenberger & T. Meyer. (2010) Expression of Chemoresistance-Related Genes and Heat Shock Protein 72 in Hyperthermic Isolated Limb Perfusion of Malignant Melanoma: An Experimental Study. Journal of Oncology 2010, pages 1-7.
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José Rivera, Diego Megias & Jerónimo Bravo. (2007) Proteomics-Based Strategy To Delineate the Molecular Mechanisms of the Metastasis Suppressor Gene BRMS1. Journal of Proteome Research 6:10, pages 4006-4018.
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Yong Zhang & Xun Shen. (2007) Heat Shock Protein 27 Protects L929 Cells from Cisplatin-Induced Apoptosis by Enhancing Akt Activation and Abating Suppression of Thioredoxin Reductase Activity. Clinical Cancer Research 13:10, pages 2855-2864.
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David J. Adams, Miriam L. Wahl, James L. Flowers, Banalata Sen, Michael Colvin, Mark W. Dewhirst, Govindarajan Manikumar & Mansukh C. Wani. (2005) Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient. Cancer Chemotherapy and Pharmacology 57:2, pages 145-154.
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Arnaud ParcellierElise SchmittMathilde BrunetArlette HammannEric SolaryCarmen Garrido. (2005) Small Heat Shock Proteins HSP27 and αB-Crystallin: Cytoprotective and Oncogenic Functions. Antioxidants & Redox Signaling 7:3-4, pages 404-413.
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Marie H. Hanigan, Mei Deng, Lei Zhang, Peyton T. TaylorJr.Jr. & Maia G. Lapus. (2005) Stress response inhibits the nephrotoxicity of cisplatin. American Journal of Physiology-Renal Physiology 288:1, pages F125-F132.
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Weng-Lang Yang, Grace Yang-Biggs, Yin Wu, Xuemei Ye, George Gallos, Randall P Owen & T.S Ravikumar. (2003) Development of cross-resistance between heat and cisplatin or hydroxyurea treatments in fadu squamous carcinoma cells. Journal of Surgical Research 111:1, pages 143-151.
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Cheng E. Ng, S. Qutob, M. Pavliv, P. Lamarche, J.P. Mao & G. Peter Raaphorst. (2002) Hsp 27 is better associated with the expression of inducible thermotolerance in human pancreatic tumor cell lines than hsp 70, p53 or p21/waf1/cip1. Journal of Thermal Biology 27:1, pages 47-54.
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Daniel R. Ciocca & Laura M. Vargas-Roig. 2002. Small Stress Proteins. Small Stress Proteins 205 218 .
S. Takeno, T. Noguchi, Y. Takahashi, R. Kikuchi, Y. Uchida & S. Yokoyama. (2001) Immunohistochemical and clinicopathologic analysis of response to neoadjuvant therapy for esophageal squamous cell carcinoma. Diseases of the Esophagus 14:2, pages 149-154.
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Shinobu Okada, Kanako Ono, Nobuyuki Hamada, Tetsuo Inada & Nobuo Kubota. (2001) A low-pH culture condition enhances the radiosensitizing effect of wortmannin. International Journal of Radiation Oncology*Biology*Physics 49:4, pages 1149-1156.
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Natarajan Raghunand & Robert J Gillies. (2000) pH and drug resistance in tumors. Drug Resistance Updates 3:1, pages 39-47.
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