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Original Article

Melatonin and selenium reduce plasma cytokine and brain oxidative stress levels in diabetic rats

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Pages 1490-1496 | Received 06 Jan 2015, Accepted 04 May 2015, Published online: 05 Aug 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Yong Li, Senbo Zhu, Junchao Luo, Yu Tong, Yixuan Zheng, Lichen Ji, Zeju He, Qiangan Jing, Jiaqing Huang, Yinjun Zhang & Qing Bi. (2023) The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies. Drug Design, Development and Therapy 17, pages 1515-1529.
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Rana Shahabi, Ali Anissian, Seyed Ali Javadmoosavi & Farinaz Nasirinezhad. (2021) Protective and anti-inflammatory effect of selenium nano-particles against bleomycin-induced pulmonary injury in male rats. Drug and Chemical Toxicology 44:1, pages 92-100.
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Guoying Deng, Chenyun Dai, Jinyuan Chen, Anqi Ji, Jingpeng Zhao, Yue Zhai, Yingjie Kang, Xijian Liu, Yin Wang & Qiugen Wang. (2018) Porous Se@SiO2 nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis. International Journal of Nanomedicine 13, pages 1809-1818.
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Khalaf F. Alsharif, Ehab Kotb Elmahallawy, Mohamed A. Alblihd, Asmaa A. Hamad, Nani Nasreldin, Walaa Alsanie, Ahmad Majed Aljoudi, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Alaa Jameel A. Albarakati, Maha S. Lokman, Ashraf Albrakati & Fatma Abo Zakaib Ali. (2023) Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats. Frontiers in Veterinary Science 10.
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Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Fatma Abo Zakaib Ali, Malik A. Altayar, Mohammed M. Jalal, Rayan Salem M. Albalawi, Abdulwahab Ali Abuderman, Khalaf F. Alsharif, Waseem AlZamzami, Ashraf Albrakati & Ehab Kotb Elmahallawy. (2022) Melatonin ameliorates the adrenal and pancreatic alterations in streptozotocin-induced diabetic rats: Clinical, biochemical, and descriptive histopathological studies. Frontiers in Veterinary Science 9.
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Ayesha Rehman, Peter John & Attya Bhatti. (2021) Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications. Nanomaterials 11:8, pages 2005.
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Chongyang She, Fu Shang, Min Cui, Xiufen Yang & Ningpu Liu. (2020) Association between dietary antioxidants and risk for diabetic retinopathy in a Chinese population. Eye 35:7, pages 1977-1984.
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Afshin Rahbarghazi, Marefat Siahkouhian, Reza Rahbarghazi, Mahdi Ahmadi, Lotfali Bolboli, Mahdi Mahdipour, Leila Haghighi, Mehdi Hassanpour, Fatemeh Sokouti Nasimi & Rana Keyhanmanesh. (2021) Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue. Tissue and Cell 69, pages 101486.
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Mohammad Hossein Pourhanifeh, Azam Hosseinzadeh, Ehsan Dehdashtian, Karim Hemati & Saeed Mehrzadi. (2020) Melatonin: new insights on its therapeutic properties in diabetic complications. Diabetology & Metabolic Syndrome 12:1.
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Fareha Wajid, Raju Poolacherla, Fatiha Kabir Mim, Amna Bangash & Ian H. Rutkofsky. (2020) Therapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus. Journal of Diabetes & Metabolic Disorders 19:2, pages 1797-1825.
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Yuanyuan Tu, Manhui Zhu, Zhenzhen Wang, Kun Wang, Lili Chen, Wangrui Liu, Qin Shi, Qingliang Zhao, Yake Sun, Xiaoyu Wang, E. Song & Xiaojuan Liu. (2020) Melatonin inhibits Müller cell activation and pro‐inflammatory cytokine production via upregulating the MEG3/miR‐204/Sirt1 axis in experimental diabetic retinopathy. Journal of Cellular Physiology 235:11, pages 8724-8735.
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Ercan Baş & Mustafa Nazıroğlu. (2019) Treatment with melatonin and selenium attenuates docetaxel‐induced apoptosis and oxidative injury in kidney and testes of mice. Andrologia 51:8.
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Zeki Serdar Ataizi, Kemal Ertilav & Mustafa Nazıroğlu. (2019) Mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, Ca2+ influx and inflammatory cytokine molecular pathways in the docetaxel-treated mice by melatonin and selenium treatments. Metabolic Brain Disease 34:4, pages 1077-1089.
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Moosa Javdani, Atefeh Habibi, Sadegh Shirian, Gholam Ali Kojouri & Farzaneh Hosseini. (2018) Effect of Selenium Nanoparticle Supplementation on Tissue Inflammation, Blood Cell Count, and IGF-1 Levels in Spinal Cord Injury-Induced Rats. Biological Trace Element Research 187:1, pages 202-211.
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Begum Gurel-Gokmen, Hazal Ipekci, Sehkar Oktay, Burcın Alev, Unsal Velı Ustundag, Esın Ak, Dılek Akakın, Goksel Sener, Ebru Emekli-Alturfan, Aysen Yarat & Tugba Tunali-Akbay. (2018) Melatonin improves hyperglycemia induced damages in rat brain. Diabetes/Metabolism Research and Reviews 34:8, pages e3060.
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Kumari Anupam, Jyotsana Kaushal, Nirmal Prabhakar & Archana Bhatnagar. (2018) Effect of redox status of peripheral blood on immune signature of circulating regulatory and cytotoxic T cells in streptozotocin induced rodent model of type I diabetes. Immunobiology 223:10, pages 586-597.
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Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Robabeh Mohammadbeigi, Maryam Rahimi & Zatollah Asemi. (2017) Effects of Selenium Supplementation on Gene Expression Levels of Inflammatory Cytokines and Vascular Endothelial Growth Factor in Patients with Gestational Diabetes. Biological Trace Element Research 181:2, pages 199-206.
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Orhan Akpınar, Mustafa Nazıroğlu & Hatice Akpınar. (2017) Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats. Brain Research Bulletin 130, pages 1-9.
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Mehmet Cemal Kahya, Mustafa Nazıroğlu & İshak Suat Övey. (2016) Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of Diabetic Rats by Melatonin and Selenium. Molecular Neurobiology 54:3, pages 2345-2360.
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Kadir Demirci, Mustafa Nazıroğlu, İshak Suat Övey & Hasan Balaban. (2016) Selenium attenuates apoptosis, inflammation and oxidative stress in the blood and brain of aged rats with scopolamine-induced dementia. Metabolic Brain Disease 32:2, pages 321-329.
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Guoying Deng, Kerun Niu, Feng Zhou, Buxiao Li, Yingjie Kang, Xijian Liu, Junqing Hu, Bo Li, Qiugen Wang, Chengqing Yi & Qian Wang. (2017) Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species. Scientific Reports 7:1.
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M.A. El-GhazalyN. FadelE. RashedA. El-BatalS.A. Kenawy. (2017) Anti-inflammatory effect of selenium nanoparticles on the inflammation induced in irradiated rats. Canadian Journal of Physiology and Pharmacology 95:2, pages 101-110.
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Ning Wang, Hor-Yue Tan, Sha Li, Yu Xu, Wei Guo & Yibin Feng. (2017) Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant. Oxidative Medicine and Cellular Longevity 2017, pages 1-13.
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Sanket N. Patel & Cesar A. Lau-Cam. 2017. Taurine 10. Taurine 10 337 351 .
Fan Peng, Xin Guo, Zhihong Li, Changzheng Li, Changdong Wang, Weiran Lv, Junjie Wang, Fangxiang Xiao, Mohammad Kamal & Chengfu Yuan. (2016) Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver. Molecules 21:12, pages 1731.
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Arif Demirdaş, Mustafa Nazıroğlu & Gülin Özdamar Ünal. (2016) Agomelatine reduces brain, kidney and liver oxidative stress but increases plasma cytokine production in the rats with chronic mild stress-induced depression. Metabolic Brain Disease 31:6, pages 1445-1453.
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Betül Yazğan, Yener Yazğan, İshak Suat Övey & Mustafa Nazıroğlu. (2016) Raloxifene and Tamoxifen Reduce PARP Activity, Cytokine and Oxidative Stress Levels in the Brain and Blood of Ovariectomized Rats. Journal of Molecular Neuroscience 60:2, pages 214-222.
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