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Brain Injury Volume 30, 2016 - Issue 1
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Original Article

Genetic and pharmacological intervention of the p75NTR pathway alters morphological and behavioural recovery following traumatic brain injury in mice

Janet AlderRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Wendy FujiokaRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Anna GiarratanaRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Jenna WissockiRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Keya ThakkarRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Phung VuongRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Bijal PatelRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Trisha ChakrabortyRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Rami ElsabehRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Ankit ParikhRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
Hartaj S. GirnRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
,
David CrockettRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA
&
Smita Thakker-VariaRutgers Robert Wood Johnson Medical School, Piscataway, NJ, USACorrespondence[email protected]
 show all
Pages 48-65 | Received 14 Feb 2015, Accepted 26 Aug 2015, Published online: 18 Nov 2015

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Shavonne Teng, Alicia Palmieri, Isabella Maita, Cynthia Zheng, Gitanjali Das, Juyeon Park, Renping Zhou, Janet Alder & Smita Thakker-Varia. (2019) Inhibition of EphA/Ephrin-A signaling using genetic and pharmacologic approaches improves recovery following traumatic brain injury in mice. Brain Injury 33:10, pages 1385-1401.
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Articles from other publishers (25)

Gang Liu, Meijun He, Chaoran Wu, Pin Lv, Hao Sun, Heng Wang, Xiaoyan Xin & Hong Liao. (2024) Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI. Experimental Neurology 372, pages 114618.
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Golnoush Mirzahosseini, Justin Mark Adam, Sanaz Nasoohi, Azza B. El-Remessy & Tauheed Ishrat. (2022) Lost in Translation: Neurotrophins Biology and Function in the Neurovascular Unit. The Neuroscientist 29:6, pages 694-714.
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Srestha Dasgupta, Laura E. Montroull, Mansi A. Pandya, Juan P. Zanin, Wei Wang, Zhuhao Wu & Wilma J. Friedman. (2023) Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR. eneuro 10:8, pages ENEURO.0067-23.2023.
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Qing Liu, Shuai Zhou, Xiao Wang, Chengxu Gu, Qixuan Guo, Xikai Li, Chunlei Zhang, Naili Zhang, Luping Zhang & Fei Huang. (2022) Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats. Journal of Neuroinflammation 19:1.
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Yehong Tian, Xiaowei Qiu, Xuewei Qi, Zhenzhen Dong, Jianxin Zhao, Jinchang Huang & Xin Jiang. (2022) Electroacupuncture promotes apoptosis and inhibits axonogenesis by activating p75 neurotrophin receptor for triple-negative breast xenograft in mice. Journal of Chemical Neuroanatomy 124, pages 102133.
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Mingming Chen, Linlu Guo, Jie Hao, Jie Ni, Qunyu Lv, Xiaoyan Xin & Hong Liao. (2020) p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound. Cellular and Molecular Neurobiology 42:4, pages 1153-1166.
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Sahithi Reddi, Smita Thakker-Varia, Janet Alder & AnnaO Giarratana. (2022) Status of precision medicine approaches to traumatic brain injury. Neural Regeneration Research 17:10, pages 2166.
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Myung Chul Yoo, Jinmann Chon, Junyang Jung, Sung Su Kim, Seonhwan Bae, Sang Hoon Kim & Seung Geun Yeo. (2021) Potential Therapeutic Strategies and Substances for Facial Nerve Regeneration Based on Preclinical Studies. International Journal of Molecular Sciences 22:9, pages 4926.
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David Gustafsson, Andrea Klang, Sebastian Thams & Elham Rostami. (2021) The Role of BDNF in Experimental and Clinical Traumatic Brain Injury. International Journal of Molecular Sciences 22:7, pages 3582.
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Ecem Sevim Longur, Özgür Yiğit, Çiğdem Kalaycık Ertugay, Ela Araz Server, Turgut Adatepe, Dilek Akakın, Oya Orun & Ayça Karagöz Köroğlu. (2020) Effect of Bumetanide on Facial Nerve Regeneration in Rat Model. Otolaryngology–Head and Neck Surgery 164:1, pages 117-123.
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Anna O. Giarratana, Cynthia Zheng, Sahithi Reddi, Shavonne L. Teng, David Berger, Derek Adler, Patrick Sullivan, Smita Thakker-Varia & Janet Alder. (2020) APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes. Scientific Reports 10:1.
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Laura E. Montroull, Deborah E. Rothbard, Hur D. Kanal, Veera D’Mello, Vincent Dodson, Carol M. Troy, Juan P. Zanin, Steven W. Levison & Wilma J. Friedman. (2020) Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice. ASN Neuro 12, pages 175909142093086.
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Anna O. Giarratana, Shavonne Teng, Sahithi Reddi, Cynthia Zheng, Derek Adler, Smita Thakker-Varia & Janet Alder. (2019) BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes. Frontiers in Neurology 10.
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Khalil Saadipour, Alexia Tiberi, Sylvia Lombardo, Elena Grajales, Laura Montroull, Noralyn B. Mañucat-Tan, John LaFrancois, Michael Cammer, Paul M. Mathews, Helen E. Scharfman, Francesca-Fang Liao, Wilma J. Friedman, Xin-Fu Zhou, Giueseppina Tesco & Moses V. Chao. (2019) Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor. Molecular and Cellular Neuroscience 99, pages 103395.
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Dongxia Tao, Fangxi Liu, Xiaoyu Sun, Huiling Qu, Shanshan Zhao, Zhike Zhou, Ting Xiao, Chuansheng Zhao & Mei Zhao. (2019) Bumetanide: A review of its neuroplasticity and behavioral effects after stroke. Restorative Neurology and Neuroscience 37:4, pages 397-407.
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Laura Ester Montroull, Víctor Danelon, Andrea Beatriz Cragnolini & Daniel Hugo Mascó. (2019) Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death. Frontiers in Cellular Neuroscience 13.
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Zhen Xu, Wei-Hua Shi, Long-Biao Xu, Min-Feng Shao, Zu-Peng Chen, Guo-Chong Zhu & Qun Hou. (2018) Resident Microglia Activate before Peripheral Monocyte Infiltration and p75NTR Blockade Reduces Microglial Activation and Early Brain Injury after Subarachnoid Hemorrhage. ACS Chemical Neuroscience 10:1, pages 412-423.
Crossref
Fredrik Clausen, Lars Hillered & Niklas Marklund. 2019. Animal Models of Neurotrauma. Animal Models of Neurotrauma 3 18 .
Carla Lucini, Livia D’Angelo, Pietro Cacialli, Antonio Palladino & Paolo de Girolamo. (2018) BDNF, Brain, and Regeneration: Insights from Zebrafish. International Journal of Molecular Sciences 19:10, pages 3155.
Crossref
Pietro Cacialli, Livia D'angelo, Olivier Kah, Pascal Coumailleau, Marie-Madeleine Gueguen, Elisabeth Pellegrini & Carla Lucini. (2018) Neuronal expression of brain derived neurotrophic factor in the injured telencephalon of adult zebrafish. Journal of Comparative Neurology 526:4, pages 569-582.
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Pietro Cacialli, Antonio Palladino & Carla Lucini. (2018) Role of brain-derived neurotrophic factor during the regenerative response after traumatic brain injury in adult zebrafish. Neural Regeneration Research 13:6, pages 941.
Crossref
Lindolfo Da Silva Meirelles, Daniel Simon & Andrea Regner. (2017) Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain. International Journal of Molecular Sciences 18:5, pages 1082.
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Stephen W. ScheffMubeen A. Ansari. (2017) Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals. Journal of Neurotrauma 34:8, pages 1491-1510.
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Stephen W. Scheff & Kelly N. Roberts. (2016) Cognitive assessment of pycnogenol therapy following traumatic brain injury. Neuroscience Letters 634, pages 126-131.
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Wei Yu, Randika Parakramaweera, Shavonne Teng, Manasa Gowda, Yashsavi Sharad, Smita Thakker-Varia, Janet Alder & Federico Sesti. (2016) Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury. The Journal of Neuroscience 36:43, pages 11084-11096.
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