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Original Article

N of 1 study: amantadine for the amotivational syndrome in a patient with traumatic brain injury

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Pages 49-54 | Published online: 03 Jul 2009

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Peggy Spauwen, Bert Ter Mors, Peter van Harten, Anne-Fleur Domensino, Rudolf Ponds & Caroline van Heugten. (2022) Efficacy and safety of amantadine as a treatment for apathy after brain injury: Two single-case experimental design studies. Neuropsychological Rehabilitation 32:6, pages 872-896.
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Heather M. Ma & Ross D. Zafonte. (2020) Amantadine and memantine: a comprehensive review for acquired brain injury. Brain Injury 34:3, pages 299-315.
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B.J. Ter Mors, A.P.M. Backx, P. Spauwen, R.W.H.M. Ponds, P.N. Van Harten & C.M. Van Heugten. (2019) Efficacy of amantadine on behavioural problems due to acquired brain injury: A systematic review. Brain Injury 33:9, pages 1137-1150.
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A. T. Lane-Brown & R. L. Tate. (2009) Apathy after acquired brain impairment: A systematic review of non-pharmacological interventions. Neuropsychological Rehabilitation 19:4, pages 481-516.
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David B Arciniegas, C Alan Anderson, Jeannie Topkoff & Thomas W McAllister. (2005) Mild traumatic brain injury: a neuropsychiatric approach to diagnosis, evaluation, and treatment. Neuropsychiatric Disease and Treatment 1:4, pages 311-327.
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Gil Newburn & Deborah Newburn. (2005) Selegiline in the management of apathy following traumatic brain injury. Brain Injury 19:2, pages 149-154.
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Shari Hughes, Angela Colantonio, P. Lina Santaguida & Thomas Paton. (2005) Amantadine to enhance readiness for rehabilitation following severe traumatic brain injury. Brain Injury 19:14, pages 1197-1206.
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Hochang B. Lee, Constantine G. Lyketsos & Vani Rao. (2003) Pharmacological management of the psychiatric aspects of traumatic brain injury. International Review of Psychiatry 15:4, pages 359-370.
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Articles from other publishers (68)

Laiba Azhar, Raphael W. Kusumo, Giovanni Marotta, Krista L. Lanctôt & Nathan Herrmann. (2022) Pharmacological Management of Apathy in Dementia. CNS Drugs 36:2, pages 143-165.
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Bas C. Stunnenberg, Joost BerendsRobert C. Griggs, Jeffrey Statland, Gea Drost, Jane Nikles, Hans GroenewoudBaziel G.M. van EngelenGert Jan van der WiltJoost Raaphorst. (2022) N-of-1 Trials in Neurology. Neurology 98:2.
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Davi Jorge Fontoura Solla & Wellingson Silva Paiva. 2021. Traumatic Brain Injury. Traumatic Brain Injury 179 185 .
Monique A. Pimontel, Dora Kanellopoulos & Faith M. Gunning. (2019) Neuroanatomical Abnormalities in Older Depressed Adults With Apathy: A Systematic Review. Journal of Geriatric Psychiatry and Neurology 33:5, pages 289-303.
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Hye-Geum Kim, Bon-Hoon Koo, Seung Woo Lee & Eun-Jin Cheon. (2019) Apathy syndrome in a patient previously treated with selective serotonin reuptake inhibitors for depression. Yeungnam University Journal of Medicine 36:3, pages 249-253.
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Thida Thant & Joel Yager. (2019) Updating Apathy: Using Research Domain Criteria to Inform Clinical Assessment and Diagnosis of Disorders of Motivation. Journal of Nervous & Mental Disease 207:9, pages 707-714.
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Ginger Polich, Mary Alexis Iaccarino & Ross Zafonte. 2019. Psychopharmacology of Neurologic Disease. Psychopharmacology of Neurologic Disease 253 267 .
Angela Scicutella. 2019. Acquired Brain Injury. Acquired Brain Injury 227 301 .
Roberta W. Scherer, Lea Drye, Jacobo Mintzer, Krista Lanctôt, Paul Rosenberg, Nathan Herrmann, Prasad Padala, Olga Brawman-Mintzer, William Burke, Suzanne Craft, Alan J. Lerner, Allan Levey, Anton Porsteinsson & Christopher H. van Dyck. (2018) The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial. Trials 19:1.
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Santiago Perez-Lloret & Olivier Rascol. (2018) Efficacy and safety of amantadine for the treatment of l-DOPA-induced dyskinesia. Journal of Neural Transmission 125:8, pages 1237-1250.
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Justin R. Davanzo & Shelly D. Timmons. 2018. Controversies in Severe Traumatic Brain Injury Management. Controversies in Severe Traumatic Brain Injury Management 179 190 .
Laura L. Frakey. 2018. Encyclopedia of Clinical Neuropsychology. Encyclopedia of Clinical Neuropsychology 293 302 .
Rapson Gomez, Clive Skilbeck, Matt Thomas & Mark Slatyer. (2017) Growth Mixture Modeling of Depression Symptoms Following Traumatic Brain Injury. Frontiers in Psychology 8.
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José R. Maldonado. (2017) Acute Brain Failure. Critical Care Clinics 33:3, pages 461-519.
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Laura L. Frakey. 2017. Encyclopedia of Clinical Neuropsychology. Encyclopedia of Clinical Neuropsychology 1 10 .
Timothy Rittman, Ian TS Coyle-Gilchrist & James B Rowe. (2016) Managing cognition in progressive supranuclear palsy. Neurodegenerative Disease Management 6:6, pages 499-508.
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Larissa Shamseer, Margaret Sampson, Cecilia Bukutu, Christopher H. Schmid, Jane Nikles, Robyn Tate, Bradley C. Johnston, Deborah Zucker, William R. Shadish, Richard Kravitz, Gordon Guyatt, Douglas G. Altman, David Moher, Sunita Vohra, Douglas G. Altman, Cecilia Bukutu, Jocalyn Clark, Elise Cogo, Nicole B. Gabler, Gordon Guyatt, Richard Kravitz, Janine Janosky, Bradley C. Johnston, Bob Li, Jeff Mahon, Robin Marles, David Moher, Jane Nikles, Margaret Sampson, Christopher H. Schmid, William R. Shadish, Larissa Shamseer, Robyn Tate, Sunita Vohra & Deborah Zucker. (2016) CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. Journal of Clinical Epidemiology 76, pages 18-46.
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Biba R Stanton & Alan Carson. (2016) Apathy: a practical guide for neurologists. Practical Neurology 16:1, pages 42-47.
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D. Plantier & J. Luauté. (2016) Drugs for behavior disorders after traumatic brain injury: Systematic review and expert consensus leading to French recommendations for good practice. Annals of Physical and Rehabilitation Medicine 59:1, pages 42-57.
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M. V. Chelyapina, E. V. Sharova & O. S. Zaytsev. (2016) The cholinergic deficiency syndrome in patients with depressed consciousness after severe brain injury. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 116:7, pages 17.
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T.T.-J. Chong & M. Husain. 2016. Motivation - Theory, Neurobiology and Applications. Motivation - Theory, Neurobiology and Applications 389 426 .
Dennis J. ZgaljardicGary S. SealeLynn A. SchaeferRichard O. TempleJack ForemanTimothy R. Elliott. (2015) Psychiatric Disease and Post-Acute Traumatic Brain Injury. Journal of Neurotrauma 32:23, pages 1911-1925.
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Elizabeth R. Skidmore, Ellen M. Whyte, Meryl A. Butters, Lauren Terhorst & Charles F. ReynoldsIIIIII. (2015) Strategy Training During Inpatient Rehabilitation May Prevent Apathy Symptoms After Acute Stroke. PM&R 7:6, pages 562-570.
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David Moore. 2015. Psychiatry. Psychiatry 1647 1705 .
Joseph H. Friedman. (2014) Withdrawing amantadine in dyskinetic patients with Parkinson disease: The AMANDYSK trial. Neurology 83:11, pages 1035-1036.
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Flora M. Hammond, Allison K. Bickett, James H. Norton & Rashmi Pershad. (2014) Effectiveness of Amantadine Hydrochloride in the Reduction of Chronic Traumatic Brain Injury Irritability and Aggression. Journal of Head Trauma Rehabilitation 29:5, pages 391-399.
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Gary R. Turner & Mark D'Esposito. 2014. Textbook of Neural Repair and Rehabilitation. Textbook of Neural Repair and Rehabilitation 489 499 .
. 2014. Textbook of Neural Repair and Rehabilitation. Textbook of Neural Repair and Rehabilitation 437 508 .
Sergio E. Starkstein & Jaime Pahissa. (2014) Apathy Following Traumatic Brain Injury. Psychiatric Clinics of North America 37:1, pages 103-112.
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Fabienne Ory-MagneJean-Christophe CorvolJean-Philippe AzulayAnne-Marie BonnetChristine Brefel-CourbonPhilippe DamierEstelle DellapinaAlain DestéeFranck DurifMonique GalitzkyThibaud LebouvierWassilios MeissnerClaire ThalamasFrançois TisonAlexandrine SalisAgnès SommetFrançois VialletMarie VidailhetOlivier Rascol. (2014) Withdrawing amantadine in dyskinetic patients with Parkinson disease. Neurology 82:4, pages 300-307.
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Lea T. Drye, Roberta W. Scherer, Krista L. Lanctôt, Paul B. Rosenberg, Nathan Herrmann, David Bachman & Jacobo E. Mintzer. (2013) Designing a Trial to Evaluate Potential Treatments for Apathy in Dementia: The Apathy in Dementia Methylphenidate Trial (ADMET). The American Journal of Geriatric Psychiatry 21:6, pages 549-559.
Crossref
Sergio E. Starkstein & Daniel Tranel. 2012. Neurobiology of Psychiatric Disorders. Neurobiology of Psychiatric Disorders 53 74 .
Robert A. Mitchell, Nathan Herrmann & Krista L. Lanctôt. (2011) The Role of Dopamine in Symptoms and Treatment of Apathy in Alzheimer's Disease. CNS Neuroscience & Therapeutics 17:5, pages 411-427.
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Ashok Krishnamoorthy & David Craufurd. (2011) Treatment of Apathy in Huntington’s Disease and Other Movement Disorders. Current Treatment Options in Neurology 13:5, pages 508-519.
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Amanda T. Lane-Brown & Robyn L. Tate. (2012) Apathy After Traumatic Brain Injury: An Overview of the Current State of Play. Brain Impairment 12:1, pages 43-53.
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V. F. J. Newcombe, J. G. Outtrim, D. A. Chatfield, A. Manktelow, P. J. Hutchinson, J. P. Coles, G. B. Williams, B. J. Sahakian & D. K. Menon. (2011) Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury. Brain 134:3, pages 759-768.
Crossref
Laura L. Frakey. 2011. Encyclopedia of Clinical Neuropsychology. Encyclopedia of Clinical Neuropsychology 210 217 .
Ricardo E Jorge, Sergio E Starkstein & Robert G Robinson. (2010) Apathy following Stroke. The Canadian Journal of Psychiatry 55:6, pages 350-354.
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Peter Frommelt & Hubert LössleinJonathan J. Evans. 2010. NeuroRehabilitation. NeuroRehabilitation 135 144 .
Shinya Ishii, Nancy Weintraub & James R. Mervis. (2009) Apathy: A Common Psychiatric Syndrome in the Elderly. Journal of the American Medical Directors Association 10:6, pages 381-393.
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Amanda Lane-Brown & Robyn Tate. (2009) Interventions for apathy after traumatic brain injury. Cochrane Database of Systematic Reviews.
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José R. Maldonado. (2008) Pathoetiological Model of Delirium: a Comprehensive Understanding of the Neurobiology of Delirium and an Evidence-Based Approach to Prevention and Treatment. Critical Care Clinics 24:4, pages 789-856.
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Brian Levine, Gary R. Turner & Donald T. Stuss. 2015. Cognitive Neurorehabilitation. Cognitive Neurorehabilitation 464 486 .
Nathan Herrmann, Lana S. Rothenburg, Sandra E. Black, Michelle Ryan, Barbara A. Liu, Usoa E. Busto & Krista L. Lanctôt. (2008) Methylphenidate for the Treatment of Apathy in Alzheimer Disease. Journal of Clinical Psychopharmacology 28:3, pages 296-301.
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Robert M. Roth, Laura A. Flashman & Thomas W. McAllister. (2008) Apathy and its treatment. Current Treatment Options in Neurology 9:5, pages 363-370.
Crossref
Robert M. Roth, Laura A. Flashman & Thomas W. McAllister. (2007) Apathy and its treatment. Current Treatment Options in Neurology 9:5, pages 363-370.
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Chiadi U. Onyike, Jeannie-Marie E. Sheppard, JoAnn T. Tschanz, Maria C. Norton, Robert C. Green, Martin Steinberg, Kathleen A. Welsh-Bohmer, John C. Breitner & Constantine G. Lyketsos. (2007) Epidemiology of Apathy in Older Adults: The Cache County Study. The American Journal of Geriatric Psychiatry 15:5, pages 365-375.
Crossref
Carolyn L Villareal. (2016) Amantadine Therapy in Traumatic Brain Injury Patients. Journal of Pharmacy Technology 23:2, pages 95-103.
Crossref
ANGELA SCICUTELLA. 2007. Acquired Brain Injury. Acquired Brain Injury 81 121 .
Shawn J. Kile. (2006) DIAGNOSIS AND TREATMENT OF POSTCONCUSSIVE NEUROBEHAVIORAL SYMPTOMS. CONTINUUM: Lifelong Learning in Neurology 12, pages 60-71.
Crossref
Sue R. Beers, Anna Skold, Clifton Edward Dixon & Philip David Adelson. (2005) Neurobehavioral Effects of Amantadine After Pediatric Traumatic Brain Injury. Journal of Head Trauma Rehabilitation 20:5, pages 450-463.
Crossref
Ryan C.W. Hall, Richard C.W. Hall & Marcia J. Chapman. (2005) Definition, Diagnosis, and Forensic Implications of Postconcussional Syndrome. Psychosomatics 46:3, pages 195-202.
Crossref
Ryan DeMarchi, Vikas Bansal, Anthony Hung, Karol Wroblewski, Hemi Dua, Sanjeev Sockalingam & Shree Bhalerao. (2014) Review of Awakening Agents. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 32:1, pages 4-17.
Crossref
Liza B. Green, Joseph E. Hornyak & Edward A. Hurvitz. (2004) Amantadine in Pediatric Patients with Traumatic Brain Injury. American Journal of Physical Medicine & Rehabilitation 83:12, pages 893-897.
Crossref
Denise Feil, Jill Razani, Kyle Boone & Ira Lesser. (2003) Apathy and cognitive performance in older adults with depression. International Journal of Geriatric Psychiatry 18:6, pages 479-485.
Crossref
Vani Rao & Constantine G Lyketsos. (2002) Psychiatric aspects of traumatic brain injury. Psychiatric Clinics of North America 25:1, pages 43-69.
Crossref
David B. Arciniegas, Kerri Held & Peter Wagner. (2002) Cognitive impairment following traumatic brain injury. Current Treatment Options in Neurology 4:1, pages 43-57.
Crossref
M.L.C. Labi. (2002) Tratamiento neurofarmacológico tras un traumatismo craneoencefálico. Rehabilitación 36:6, pages 364-372.
Crossref
R. Terré, A. Pérez, T. Roig, M. Bernabéu & S. Ramón. (2002) Tratamiento farmacológico con amantadina en pacientes con lesión cerebral. Rehabilitación 36:1, pages 13-17.
Crossref
Tilman WetterlingTilman Wetterling. 2002. Organische psychische Störungen. Organische psychische Störungen 457 483 .
Tilman WetterlingTilman Wetterling. 2002. Organische psychische Störungen. Organische psychische Störungen 281 456 .
Lilian Thorpe & Bernard Groulx. (2014) Depressive Syndromes in Dementia. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 28:S1, pages S83-S95.
Crossref
Thé‐Phung To, Joan T Tierney & Malcolm J Hopwood. (2000) Serotonergic and Dopaminergic Agents Facilitate Rehabilitation Following Hypoxic Brain Injury. The Australian Journal of Hospital Pharmacy 30:5, pages 202-205.
Crossref
S. Al-Adawi, G.S. Dawe & A.A. Al-Hussaini. (2000) Aboulia: neurobehavioural dysfunction of dopaminergic system?. Medical Hypotheses 54:4, pages 523-530.
Crossref
Vani Rao & Constantine Lyketsos. (2000) Neuropsychiatric Sequelae of Traumatic Brain Injury. Psychosomatics 41:2, pages 95-103.
Crossref
Steven R. Flanagan. (2014) Psychostimulant Treatment of Stroke and Brain Injury. CNS Spectrums 5:3, pages 59-69.
Crossref
Ross Beckley & Barbara Fisher. 1998. Attention Deficit Disorder. Attention Deficit Disorder.
W.Jerry Mysiw & M.Elizabeth Sandel. (1997) The agitated brain injured patient. Part 2: Pathophysiology and treatment. Archives of Physical Medicine and Rehabilitation 78:2, pages 213-220.
Crossref

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