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Current Eye Research Volume 35, 2010 - Issue 9
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Original Article

Confirmation of Changes in Human Meibum Lipid Infrared Spectra with Age Using Principal Component Analysis

Douglas BorchmanDepartment of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
,
Gary N. FoulksDepartment of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USACorrespondence[email protected]
&
Marta C. YappertDepartment of Chemistry, University of Louisville, Louisville, Kentucky, USA
Pages 778-786 | Received 15 Feb 2010, Accepted 29 Apr 2010, Published online: 26 Aug 2010

Citations (22)

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Read on this site (1)

Zara Ashraf, Uzma Pasha, Victoria Greenstone, Janeeta Akbar, Edwin Apenbrinck, Gary N Foulks & Douglas Borchman. (2011) Quantification of Human Sebum on Skin and Human Meibum on the Eye Lid Margin Using Sebutape®, Spectroscopy and Chemical Analysis. Current Eye Research 36:6, pages 553-562.
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Articles from other publishers (21)

Isabel Moreno, Sudhir Verma, Tarsis Ferreira Gesteira & Vivien J. Coulson- Thomas. (2023) Recent advances in age-related meibomian gland dysfunction (ARMGD). The Ocular Surface 30, pages 298-306.
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Saumya Nagar, Layla Ajouz, Kelly K. Nichols, Sandeep Kumar, Cathy Zhao, Kugen K. Naidoo, Michael R. Robinson & Douglas Borchman. (2023) Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis. Investigative Opthalmology & Visual Science 64:10, pages 22.
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Yuchen Cai, Siyi Zhang, Liangbo Chen & Yao Fu. (2023) Integrated multi-omics and machine learning approach reveals lipid metabolic biomarkers and signaling in age-related meibomian gland dysfunction. Computational and Structural Biotechnology Journal 21, pages 4215-4227.
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Tomo Suzuki, Koji Kitazawa, Yuko Cho, Masataka Yoshida, Takashi Okumura, Atsushi Sato & Shigeru Kinoshita. (2022) Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction. The Ocular Surface 26, pages 310-317.
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Igor A. Butovich & Tomo Suzuki. (2021) Effects of Aging on Human Meibum. Investigative Opthalmology & Visual Science 62:12, pages 23.
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Douglas Borchman. (2021) Lipid conformational order and the etiology of cataract and dry eye. Journal of Lipid Research 62, pages 100039.
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Douglas Borchman, Varun Ramakrishnan, Collin Henry & Aparna Ramasubramanian. (2019) Differences in Meibum and Tear Lipid Composition and Conformation. Cornea 39:1, pages 122-128.
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Aparna Ramasubramanian, Ryan BlackburnHeegook YeoSamiyyah M. SledgeZahara N. GullySharika SinghSanya MehtaAakash MehtaMarta C. YappertDouglas Borchman. (2019) Structural Differences in Meibum From Donors After Hematopoietic Stem Cell Transplantations. Cornea 38:9, pages 1169-1174.
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Georgi As. Georgiev, Douglas Borchman, Petar Eftimov & Norihiko Yokoi. (2019) Lipid Saturation and the Rheology of Human Tear Lipids. International Journal of Molecular Sciences 20:14, pages 3431.
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Douglas Borchman, Aparna Ramasubramanian & Gary N. Foulks. (2019) Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction. Investigative Opthalmology & Visual Science 60:6, pages 2286.
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Douglas Borchman. (2019) The optimum temperature for the heat therapy for meibomian gland dysfunction. The Ocular Surface 17:2, pages 360-364.
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Poonam Mudgil, Douglas Borchman & Aparna Ramasubramanian. (2018) Insights into Tear Film Stability from Babies and Young Adults: A Study of Human Meibum Lipid Conformation and Rheology. International Journal of Molecular Sciences 19:11, pages 3502.
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Samiyyah Sledge, Collin Henry, Douglas Borchman, Marta Yappert, Rahul Bhola, Aparna Ramasubramanian, Ryan Blackburn, Jonathan Austin, Kayla Massey, Shanzeh Sayied, Aliza Williams, Georgi Georgiev & Kenneth Schikler. (2017) Human Meibum Age, Lipid–Lipid Interactions and Lipid Saturation in Meibum from Infants. International Journal of Molecular Sciences 18:9, pages 1862.
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Simon H.J. Brown, Carolina M.E. Kunnen, Eric B. Papas, Percy Lazon de la Jara, Mark D.P. Willcox, Stephen J. Blanksby & Todd W. Mitchell. (2016) Intersubject and Interday Variability in Human Tear and Meibum Lipidomes: A Pilot Study. The Ocular Surface 14:1, pages 43-48.
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Sin Man Lam, Louis Tong, Bastien Reux, Xinrui Duan, Andrea Petznick, Siew Sian Yong, Cynthia Boo Shiao Khee, Martin J. Lear, Markus R. Wenk & Guanghou Shui. (2014) Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. Journal of Lipid Research 55:2, pages 299-306.
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Poonam Mudgil, Douglas Borchman, Marta C. Yappert, Diana Duran, Gregory W. Cox, Ryan J. Smith, Rahul Bhola, Gary R. Dennis & John S. Whitehall. (2013) Lipid order, saturation and surface property relationships: A study of human meibum saturation. Experimental Eye Research 116, pages 79-85.
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Douglas Borchman, Marta C. Yappert, Sarah E. Milliner, Diana Duran, Gregory W. Cox, Ryan J. Smith & Rahul Bhola. (2013) 13C and 1H NMR ester region resonance assignments and the composition of human infant and child meibum. Experimental Eye Research 112, pages 151-159.
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Gary N. Foulks, Douglas Borchman, Marta Yappert & Shelley Kakar. (2013) Topical Azithromycin and Oral Doxycycline Therapy of Meibomian Gland Dysfunction. Cornea 32:1, pages 44-53.
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Andrew D. Pucker & Jason J. Nichols. (2012) Analysis of Meibum and Tear Lipids. The Ocular Surface 10:4, pages 230-250.
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Samad Faheem, Sung-Hye Kim, Jonathan Nguyen, Shantanu Neravetla, Matthew Ball, Gary N. Foulks, Marta C. Yappert & Douglas Borchman. (2012) Wax-tear and meibum protein, wax–β-carotene interactions in vitro using infrared spectroscopy. Experimental Eye Research 100, pages 32-39.
Crossref
Igor A. Butovich. (2011) Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids. Progress in Lipid Research 50:3, pages 278-301.
Crossref

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