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Current Eye Research Volume 37, 2012 - Issue 10
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Original Article

Association Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin-II (UTS2) Gene, Diabetes Mellitus, and Diabetic Retinopathy

Seydi OkumusDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, Gaziantep, TurkeyCorrespondence[email protected]
,
Yusuf Ziya IgciDepartment of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Tugba TaskinDepartment of Chemistry, Faculty of Arts and Sciences, University of Gaziantep, Gaziantep, Turkey
,
Serdar OztuzcuDepartment of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Bulent GurlerDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Zeynep EslikDepartment of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Bulent GogebakanDepartment of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Erol CoskunDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Ibrahim ErbagciDepartment of Ophthalmology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Seniz DemiryurekDepartment of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
,
Beyhan CengizDepartment of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
&
Abdullah T. DemiryurekDepartment of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
 show all
Pages 921-929 | Received 16 Dec 2011, Accepted 21 Apr 2012, Published online: 15 May 2012

Citations (16)

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Asmaa Kamal, Fatema T Elgengehy, Zahraa Elawady, Nahla A. Fawzy & Ola El Sisi. (2022) Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behçet’s Disease. Immunological Investigations 51:4, pages 899-908.
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Articles from other publishers (15)

Hamza Malik OKUYAN, Menderes Yusuf TERZİ, Gülay DURAN & Aydıner KALACI. (2021) UROTENSİN II’NİN İNSAN OSTEOBLAST HÜCRELERİNDE ENFLAMASYONLA İLİŞKİLİ ROLÜThe Role of Urotensin II Associated with Inflammation in Human Osteoblast Cells. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi 9:1, pages 353-361.
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Vikas Kumar, Jaswinder Singh, Kiran Bala & Jasbir Singh. (2020) Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population. Molecular Biology Reports 47:12, pages 9489-9497.
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Asmaa Kamal, Ahmed Mohsen, Amr Kamal & Ibrahem Siam. (2020) Study of the association between Urotensin 2 (p.T21M and p.S89N) variants and breast cancer in Egyptian patients. Gene Reports 20, pages 100789.
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João Pereira-Castro, Carmen Brás-Silva & Ana Patrícia Fontes-Sousa. (2019) Novel insights into the role of urotensin II in cardiovascular disease. Drug Discovery Today 24:11, pages 2170-2180.
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Mehmet Calan, Tugba Arkan, Tuncay Kume & Fırat Bayraktar. (2018) The relationship between urotensin II and insulin resistance in women with gestational diabetes mellitus. Hormones 18:1, pages 91-97.
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Yawei Zhao, Shuhua Fang, Kerong Que, Guangli Xu, Heng Zhang, Cong Qi & Nian Yang. (2018) Urotensin-II gene rs228648 polymorphism associated with the risk of diabetes mellitus. Bioscience Reports 38:6.
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Suzanne Broadgate, Christine Kiire, Stephanie Halford & Victor Chong. (2018) Diabetic macular oedema: under-represented in the genetic analysis of diabetic retinopathy. Acta Ophthalmologica 96, pages 1-51.
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Jing Zhao, Jie Jiang, Jie Wang, Lin Liu, Xiao-Ning Han, Song-Yun Chu, Lin Xue & Wen-Hui Ding. (2017) Genetic polymorphisms of UTS2 rs2890565 Ser89Asn in cardiac hypertrophy in Chinese Han population . Postgraduate Medical Journal 93:1101, pages 406-413.
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Asmaa Kamal, Fatema T Elgengehy & AL Hussein M. EL Dakrony. (2017) Study of urotensin-2 (T21M and S89N) gene polymorphisms in systemic sclerosis. Meta Gene 12, pages 125-129.
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Onder Yumrutas, Serdar Oztuzcu, Hakan Büyükhatipoglu, Ibrahim Bozgeyik, Esra Bozgeyik, Yusuf Ziya Igci, Haydar Bagis, M. Ozgur Cevik, M. Emin Kalender, Zeynep Eslik & Ahmet Arslan. (2015) The role of the UTS2 gene polymorphisms and plasma Urotensin-II levels in breast cancer. Tumor Biology 36:6, pages 4427-4432.
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Hubert Vaudry, Jérôme Leprince, David Chatenet, Alain Fournier, David G. Lambert, Jean-Claude Le Mével, Eliot H. Ohlstein, Adel Schwertani, Hervé Tostivint & David Vaudry. (2014) International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function. Pharmacological Reviews 67:1, pages 214-258.
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Marcelo Chen, Wun-Rong Lin, Chieh-Hsiang Lu, Ching-Chu Chen, Yu-Chuen Huang, Wen-Ling Liao & Fuu-Jen Tsai. (2014) Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients. Journal of Diabetes and its Complications 28:4, pages 460-463.
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Hamood Al Kindi, Anouar Hafiane, Zhipeng You, Isabella Albanese, Louise Pilote, Jacques Genest & Adel Schwertani. (2014) Circulating levels of the vasoactive peptide urotensin II in patients with acute coronary syndrome and stable coronary artery disease. Peptides 55, pages 151-157.
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Bülent Gögebakan, Vedat Uruc, Raif Ozden, Ibrahim Gokhan Duman, Abdullah Erman Yagiz, Hamza Malik Okuyan, Ozgur Aldemir, Yunus Dogramaci & Aydiner Kalaci. (2014) Urotensin II (U-II), a novel cyclic peptide, possibly associated with the pathophysiology of osteoarthritis. Peptides 54, pages 159-161.
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Serdar Oztuzcu, Mustafa Ulasli, Yavuz Pehlivan, Muhammer Özgür Çevik, Beyhan Cengiz, Bulent Gogebakan, Yusuf Ziya Igci, Seydi Okumuş, Ahmet Arslan & Ahmet Mesut Onat. (2013) Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD). Peptides 42, pages 97-100.
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