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Current Eye Research Volume 4, 1985 - Issue 10
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Original Article

The efficacy of retinoic acid ointment for treatment of xerophthalmia and corneal epithelial wounds

John L. Ubels Departments of Physiology and Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, 53226
,
Henry F. Edelhauser Departments of Physiology and Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, 53226
,
Kevin M. Foley Alcon Laboratories, Inc, Fort Worth, TX, USA
,
John C. Liao Alcon Laboratories, Inc, Fort Worth, TX, USA
&
Philip Gressel Alcon Laboratories, Inc, Fort Worth, TX, USA
Pages 1049-1057 | Received 08 Jul 1985, Accepted 30 Aug 1985, Published online: 02 Jul 2009

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Elias Chelala, Ali Dirani, Ali Fadlallah & Sharbel Fahd. (2013) The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study. Clinical Ophthalmology 7, pages 1913-1918.
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Akito Odaka, Hiroshi Toshida, Toshihiko Ohta, Nobuhito Tabuchi, Daisuke Koike, Chikako Suto & Akira Murakami. (2012) Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resection. Clinical Ophthalmology 6, pages 1585-1593.
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Hiroshi Toshida, Akito Odaka, Daisuke Koike & Akira Murakami. (2008) Effect of Retinol Palmitate Eye Drops on Experimental Keratoconjunctival Epithelial Damage Induced byn-Heptanol in Rabbit. Current Eye Research 33:1, pages 13-18.
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Nicole M. Bossenbroek, Timothy H. Sulahian & John L. Ubels. (1998) Expression of nuclear retinoic acid receptor and retinoid X receptor mRNA in the cornea and conjunctiva. Current Eye Research 17:5, pages 462-469.
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John L. Ubels, Megan H. Dennis, Joanne H. Mitchell, Lee A. Wiley & Robert W. Curley. (1995) Biological activity of N-(4-hydroxyphenyl) retinamide-O-glucuronide in corneal and conjunctival cells of rabbits and humans. Current Eye Research 14:12, pages 1115-1124.
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John L. Ubels, Vivian Rismondo & Henry F. Edelhauser. (1987) Treatment of corneal xerophthalmia in rabbits with micromolar doses of topical retinoic acid. Current Eye Research 6:5, pages 735-737.
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Articles from other publishers (23)

Joon Young Hyon & Sang Beom Han. (2022) Dry Eye Disease and Vitamins: A Narrative Literature Review. Applied Sciences 12:9, pages 4567.
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Ailin Song, Hazem M. Mousa, Matias Soifer & Victor L. Perez. (2022) Recognizing vitamin A deficiency: special considerations in low-prevalence areas. Current Opinion in Pediatrics 34:2, pages 241-247.
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Paolo Fogagnolo, Stefano De Cilla’, Micol Alkabes, Pierfilippo Sabella & Luca Rossetti. (2021) A Review of Topical and Systemic Vitamin Supplementation in Ocular Surface Diseases. Nutrients 13:6, pages 1998.
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Yu-Kai Kuo, I-Chan Lin, Li-Nien Chien, Tzu-Yu Lin, Ying-Ting How, Ko-Hua Chen, Gregory J. Dusting & Ching-Li Tseng. (2019) Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits. Journal of Clinical Medicine 8:8, pages 1227.
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Yunes Panahi, Seyyed Mahdi Rajaee & Amirhossein Sahebkar. (2017) Ocular Effects of Sulfur Mustard and Therapeutic Approaches. Journal of Cellular Biochemistry 118:11, pages 3549-3560.
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Sandeep Kumar, Pascal Dollé, Norbert B. Ghyselinck & Gregg Duester. (2017) Endogenous retinoic acid signaling is required for maintenance and regeneration of cornea. Experimental Eye Research 154, pages 190-195.
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Aurélie Comptour, Marion Rouzaire, Corinne Belville, Nicolas Bonnin, Estelle Daniel, Frédéric Chiambaretta, Loïc Blanchon & Vincent Sapin. (2016) Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing. Scientific Reports 6:1.
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Chameen Samarawickrama, Sky Chew & Stephanie Watson. (2015) Retinoic acid and the ocular surface. Survey of Ophthalmology 60:3, pages 183-195.
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Masako Hattori, Kazuhiro Shimizu, Kozo Katsumura, Hidehiro Oku, Yoichiro Sano, Kayo Matsumoto, Yoko Yamaguchi & Tsunehiko Ikeda. (2011) Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing. Graefe's Archive for Clinical and Experimental Ophthalmology 250:4, pages 557-563.
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John L. Ubels. (2005) A retrospective on topical retinoids occasioned by observation of unexpected interactions of retinoic acid with androgens and glucocorticoids in immortalized lacrimal acinar cells. Experimental Eye Research 80:2, pages 281-284.
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John L. Ubels, John T. Wertz, Kyle E. Ingersoll, Roger S. Jackson II & Mark D. Aupperlee. (2002) Down-regulation of Androgen Receptor Expression and Inhibition of Lacrimal Gland Cell Proliferation by Retinoic Acid. Experimental Eye Research 75:5, pages 561-571.
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Luo Lu, Peter S. Reinach & Winston W.-Y. Kao. (2016) Corneal Epithelial Wound Healing. Experimental Biology and Medicine 226:7, pages 653-664.
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Murat Dogru, Chikako Katakami & Masanori Inoue. (2001) Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology 108:3, pages 586-592.
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H. Selek, N. Ünlü, M. Orhan & M. Irkeç. (2018) Evaluation of Retinoic Acid Ophthalmic Emulsion in Dry Eye. European Journal of Ophthalmology 10:2, pages 121-127.
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Vincent Baeyens, Olivia Felt, Robert Gurny, Francine F. Behar-Cohen, Christine Percicot & Alain Régnier. 2000. Controlled Release Veterinary Drug Delivery. Controlled Release Veterinary Drug Delivery 115 171 .
Murat Dogru, Chikako Katakami, Naoyuki Nakagawa, Kazuaki Tetsumoto & Misao Yamamoto. (1998) Impression cytology in atopic dermatitis11The authors have no proprietary interest in any of the products or equipment mentioned in this article.. Ophthalmology 105:8, pages 1478-1484.
Crossref
Vincent Baeyens, Christine Percicot, Monia Zignani, Arati A Deshpande, Vassilios Kaltsatos & Robert Gurny. (1997) Ocular drug delivery in veterinary medicine. Advanced Drug Delivery Reviews 28:3, pages 335-361.
Crossref
Sudi Patel, Colin Ferrier & Jeff Plaskow. 1994. Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 285 287 .
John L. Ubels, Antonino Iorfino & William J. O'Brien. (1991) Retinoic acid decreases the number of EGF receptors in corneal epithelium and Chang conjunctival cells. Experimental Eye Research 52:6, pages 763-765.
Crossref
Elaine R. BermanElaine R. Berman. 1991. Biochemistry of the Eye. Biochemistry of the Eye 89 150 .
Jeffrey E. Schultz. (1990) Treating giant papillary conjunctivitis while wearing contact lenses. International Contact Lens Clinic 17:5-6, pages 139-143.
Crossref
Jonathan A. Gold, Jerome L. Shupack & Mary Alice Nemec. (2007) Ocular Side Effects of the Retinoids. International Journal of Dermatology 28:4, pages 218-225.
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Karl G. Stonecipher, Harold G. Jensen, J. James Rowsey & Robert E. Nordquist. (1988) Topical application of all-trans-retinoic acid. Graefe's Archive for Clinical and Experimental Ophthalmology 226:4, pages 371-376.
Crossref

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