9
Views
62
CrossRef citations to date
0
Altmetric
Original Article

S-antigen: identification of the MAbA9-C6 monoclonal antibody binding site and the uveitopathogenic sites

, , , , , , & show all
Pages 995-1004 | Received 17 Oct 1986, Accepted 07 Nov 1986, Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (27)

Scott W. McPherson, Josh P. Roberts & Dale S. Gregerson. (2005) Peripheral Expression of Rod Photoreceptor Arrestin Induces an Epitope-Specific, Protective Response Against Experimental Autoimmune Uveoretinitis. Current Eye Research 30:6, pages 491-502.
Read now
DALE S. GREGERSON. (2002) PERIPHERAL EXPRESSION OF OCULAR ANTIGENS IN REGULATION AND THERAPY OF OCULAR AUTOIMMUNITY. International Reviews of Immunology 21:2-3, pages 101-121.
Read now
Michael Abrams, Harminder S. Dua, Joseph Herbert & Larry A. Donoso. (1994) S-antigen immunoreactivity in tumors of the choroid plexus. Ocular Immunology and Inflammation 2:1, pages 23-27.
Read now
Yoichi Sasamoto, Satoshi Kotake, Koji Yoshikawa, Barbara Wiggert, Igal Gery & Hidehiko Matsuda. (1994) Interphotoreceptor retinoid-binding protein derived peptide can induce experimental autoimmune uveoretinitis in various rat strains. Current Eye Research 13:11, pages 845-849.
Read now
Tamara R. Vrabec, Dale S. Gregerson, H. S. Dua & Larry A. Donoso. (1992) Inhibition of Experimental Autoimmune Uveoretinitis by Oral Administration of S-Antigen and Synthetic Peptides. Autoimmunity 12:3, pages 175-184.
Read now
Rainer H. Stiemer, Uwe Westenfelder, Yvonne de Kozak, Heinrich Gausepohl, Massoud Mirshahi, Rainer W. Frank, Jean-Pierre Faure & Daniela N. Männel. (1992) Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha. Current Eye Research 11:sup1, pages 197-202.
Read now
Dale S. Gregerson, Steven P. Fling, Larry A. Donoso & Dan P. Gold. (1992) Unresponsiveness to self-peptides of S-antigen in EAU: an overview of recent results. Current Eye Research 11:sup1, pages 67-74.
Read now
S. Suleyman, E. Kasp, B. Ellis, J. P. Banga & D. C. Dumonde. (1991) Idiotypic Characterisation of Monoclonal Antibodies with Restricted Epitope Specificity for Retinal S-Antigen. Autoimmunity 9:2, pages 91-97.
Read now
H. S. Dua, P. Hossain, P. A. J. Brown, A. McKinnon, J. V. Forrester, D. S. Gregerson & L. A. Donoso. (1991) Structure-Function Studies of S-Antigen: Use of Proteases to Reveal a Dominant Uveitogenic Site. Autoimmunity 10:2, pages 153-163.
Read now
J. Clifford Waldrep & Larry A. Donoso. (1990) Auxiliary production of antibodies to ocular antigens in experimental autoimmune uveoretinitis. Current Eye Research 9:3, pages 241-248.
Read now
Larry A. Donoso, Dale S. Gregerson, Steven P. Fling, Carmen F. Merryman & Theodore W. Sery. (1990) The use of synthetic peptides in the study of experimental autoimmune uveitis. Current Eye Research 9:sup1, pages 155-161.
Read now
Dale S. Gregerson, Steven P. Fling, Wesley F. Obritsch, Carmen F. Merryman & Larry A. Donoso. (1990) A new perspective of S-antigen from immunochemical analysis. Current Eye Research 9:sup1, pages 145-153.
Read now
Steven P. Fling, Dale S. Gregerson, Wesley F. Obritsch, Michael Boyce-Jacino, Carmen F. Merryman & Larry A. Donoso. (1990) Multiple, spatially distinct T cell epitopes within a pathogenic 123 residue cyanogen bromide peptide of bovine retinal S-antigen. Current Eye Research 9:sup1, pages 111-117.
Read now
J. V. Forrester, J. Liversidge, H. S. Dua, H. Towler & P. G. McMenamin. (1990) Comparison of clinical and experimental uveitis. Current Eye Research 9:sup1, pages 75-84.
Read now
Larry A. Donoso, Carol L. Shields & Eva Y-Hp Lee. (1989) Immunohistochemistry of retinoblastoma: A review. Ophthalmic Paediatrics and Genetics 10:1, pages 3-32.
Read now
Vijay K. Singh, Larry A. Donoso, Kunihiko Yamaki & Toshimichi Shinohara. (1989) Uveitopathogenic Sites in Bovine S-Antigen. Autoimmunity 3:3, pages 177-187.
Read now
Vijay K. Singh, Kunihiko Yamaki, Larry A. Donoso & Toshimichi Shinohara. (1988) S-antigen: experimental autoimmune uveitis induced in guinea pigs with two synthetic peptides. Current Eye Research 7:1, pages 87-92.
Read now
Shigeto Hirose, Takao Tanaka, Robert B. Nussenblatt, Alan G. Palestine, Barbara Wiggert, T. Michael Redmond, Gerald J. Chader & Igal Gery. (1988) Lymphocyte responses to retinal-specific antigens in uveitis patients and healthy subjects. Current Eye Research 7:4, pages 393-402.
Read now
T. Michael Redmond, Hiroki Sanui, John M. Nickerson, Diane E. Borst, Barbara Wiggert, Toichiro Kuwabara & Igal Gery. (1988) Cyanogen bromide fragments of bovine interphotoreceptor retinoid-binding protein induce experimental autoimmune uveoretinitis in Lewis rats. Current Eye Research 7:4, pages 375-385.
Read now
Volker Knospe, Larry A Donoso, J. Paul Banga, Song Yue, Eva Kasp & Dale S. Gregerson. (1988) Epitope mapping of bovine retinal S-antigen with monoclonal antibodies. Current Eye Research 7:11, pages 1137-1147.
Read now
Larry A. Donoso, Kunihiko Yamaki, Carmen F Merryman, Tochimichi Shinohara, Song Yue & Theodore W. Sery. (1988) Human S-antigen: Characterization of uveitopathogenic sites. Current Eye Research 7:11, pages 1077-1085.
Read now
Steven P. Fling, Volker Knospe & Dale S. Gregerson. (1988) Preparation of overlapping peptides of bovine retinal S-antigen and their localization by immunoblotting with peptide-specific antibodies. Current Eye Research 7:2, pages 191-199.
Read now
Volker Knospe, Steven P. Fling & Dale S. Gregerson. (1988) Assignment of several epitopes to cyanogen bromide peptides of bovine retinal S-antigen by immunoblotting with peptide-specific antibodies. Current Eye Research 7:2, pages 181-189.
Read now
Larry A. Donoso, Carmen F. Merryman, Theodore W. Sery, Toshimichi Shinohara, Bernard Dietzschold, Anthony Smith & Carolyn M. Kalsow. (1987) S-antigen: Characterization of a pathogenic epitope which mediates experimental autoimmune uveitis and pinealitis in Lewis rats. Current Eye Research 6:9, pages 1151-1159.
Read now
G. Doekes, R. van der Gaag, A. Rothova, Y. van Kooyk, L. Broersma, M. J. M. Zaal, G. Dijkman, M. E. Fortuin, G. S. Baarsma & A. Kijlstra. (1987) Humoral and cellular immune responsiveness to human S-antigen in uveitis. Current Eye Research 6:7, pages 909-919.
Read now

Articles from other publishers (35)

Mary J. Mattapallil, Phyllis B. Silver, Joseph J. Mattapallil, Reiko Horai, Zaruhi Karabekian, J. Hugh McDowell, Chi-Chao Chan, Eddie A. James, William W. Kwok, H. Nida Sen, Robert B. Nussenblatt, Chella S. David & Rachel R. Caspi. (2011) Uveitis-Associated Epitopes of Retinal Antigens Are Pathogenic in the Humanized Mouse Model of Uveitis and Identify Autoaggressive T Cells. The Journal of Immunology 187:4, pages 1977-1985.
Crossref
Kevin R. Rupprecht, Rad K. Nair, Larissa C. Harwick, Jonathan Grote, Gangamani S. Beligere, Sushil D. Rege, Yon-Yih Chen, Zhen Lin & Jeffrey R. Fishpaugh. (2010) Development of a dot-blot assay for screening monoclonal antibodies to low-molecular-mass drugs. Analytical Biochemistry 407:2, pages 160-164.
Crossref
Robert B. Nussenblatt. 2010. Uveitis. Uveitis 1 36 .
Hideo Kohno, Tsutomu Sakai, Saburo Saito, Kiichiro Okano & Kenji Kitahara. (2007) Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin. Experimental Eye Research 84:3, pages 569-576.
Crossref
Scott W. McPherson, Josh P. Roberts & Dale S. Gregerson. (1999) Systemic Expression of Rat Soluble Retinal Antigen Induces Resistance to Experimental Autoimmune Uveoretinitis. The Journal of Immunology 163:8, pages 4269-4276.
Crossref
D. Gupta, V. K. Singh, J. Rajasingh, T. Shinohara, R. Misra & S. S. Agarwal. (1996) Cellular immune responses of patients with juvenile chronic arthritis to retinal antigens and their synthetic peptides. Immunologic Research 15:1, pages 74-83.
Crossref
J H Yamamoto, M Minami, G Inaba, K Masuda & M Mochizuki. (1993) Cellular autoimmunity to retinal specific antigens in patients with Behcet's disease.. British Journal of Ophthalmology 77:9, pages 584-589.
Crossref
G. Parruti, F. Peracchia, M. Sallese, G. Ambrosini, M. Masini, D. Rotilio & A. De Blasi. (1993) Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing. Journal of Biological Chemistry 268:13, pages 9753-9761.
Crossref
H S Dua, M S Abrams, J A Barrett & L A Donoso. (1992) The effect of retinal autoantigens and their peptides on the inhibition of experimental autoimmune uveitis. Eye 6:5, pages 447-452.
Crossref
Steven P. Fling, Daniel P. Gold & Dale S. Gregerson. (1992) Multiple, autoreactive TCR Vβ genes utilized in response to a small pathogenic peptide of an autoantigen in EAU. Cellular Immunology 142:2, pages 275-286.
Crossref
Rainer H. Stiemer, Heinrich Gausepohl, Massoud Mirshahi, Yvonne de Kozak, Margot Kraft, Jean-Pierre Faure & Rainer W. Frank. (1992) Immunological characterization of an immunomodulatory epitope in S-antigen/arrestin with a sequence motif common to tumor necrosis factor α. Immunology Letters 32:3, pages 233-240.
Crossref
Joyce H. Yamamoto, Osamu Okajima, Manabu Mochizuki, Toshimichi Shinohara, Barbara Wiggert, Gerald J. Chader, Igal Gery & Robert B. Nussenblatt. (1992) Cellular immune responses to retinal antigens in retinitis pigmentosa. Graefe's Archive for Clinical and Experimental Ophthalmology 230:2, pages 119-123.
Crossref
Rainer H. Stiemer, Uwe Westenfelder, Heinrich Gausepohl, Massoud Mirshahi, Anita Gundt, Rainer W. Frank & Daniela N. Männel. (1992) A common epitope on human tumor necrosis factor alpha and the autoantigen ‘S-antigen/arrestin’ induces TNF-α production. Journal of Autoimmunity 5:1, pages 15-26.
Crossref
M.L. Breitman, M. Tsuda, J. Usukura, T. Kikuchi, A. Zucconi, W. Khoo & T. Shinohara. (1991) Expression of S-antigen in retina, pineal gland, lens, and brain is directed by 5'-flanking sequences. Journal of Biological Chemistry 266:23, pages 15505-15510.
Crossref
Wolfgang E. Lieb, Laura Smith-Lang, Harminder Singh Dua, Alan C. Christensen & Larry A. Donoso. (1991) Identification of an S-antigen-like molecule in Drosophila melanogaster: An immunohistochemical study. Experimental Eye Research 53:2, pages 171-178.
Crossref
Izhak Nir & Neeraj Agarwal. (1991) Arrestin mRNA expression, biosynthesis, and localization in degenerating photoreceptors of mutantrds mice retinas. The Journal of Comparative Neurology 308:1, pages 1-10.
Crossref
Elaine R. BermanElaine R. Berman. 1991. Biochemistry of the Eye. Biochemistry of the Eye 309 467 .
Cheryl M. Craft, Donald H. Whitmore & Larry A. Donoso. (1990) Differential Expression of mRNA and Protein Encoding Retinal and Pineal S-Antigen During the Light/Dark Cycle. Journal of Neurochemistry 55:5, pages 1461-1473.
Crossref
Robert B. Nussenblatt. (1990) The natural history of uveitis. International Ophthalmology 14:5-6, pages 303-308.
Crossref
Marc D. de Smet, Joyce H. Yamamoto, Manabu Mochizuki, Igal Gery, Vijay K. Singh, Tochimichi Shinohara, Barbara Wiggert, Gerald J. Chader & Robert B. Nussenblatt. (1990) Cellular Immune Responses of Patients with Uveitis to Retinal Antigens and Their Fragments. American Journal of Ophthalmology 110:2, pages 135-142.
Crossref
Toshimichi Shinohara, Vijay K. Singh, Masahiko Tsuda, Kunihiko Yamaki, Tohru Abe & Shuji Suzuki. (1990) S-antigen: From gene to autoimmune uveitis. Experimental Eye Research 50:6, pages 751-757.
Crossref
Dale S. Gregerson, Carmen F. Merryman, Wesley F. Obritsch & Larry A. Donoso. (1990) Identification of a potent new pathogenic site in human retinal S-antigen which induces experimental autoimmune uveoretinitis in LEW rats. Cellular Immunology 128:1, pages 209-219.
Crossref
Y. De Kozak & M. Mirshahi. (1990) Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression. International Ophthalmology 14:1, pages 43-56.
Crossref
R. B. Nussenblatt. (1990) Immunoregulation of uveitis. International Ophthalmology 14:1, pages 13-18.
Crossref
Dale S. Gregerson, Steven P. Fling, Wesley F. Obritsch, Carmen F. Merryman & Larry A. Donoso. 1990. The Molecular Biology of Autoimmune Disease. The Molecular Biology of Autoimmune Disease 209 219 .
Dale S. Gregerson, Volker Knospe & Larry A. Donoso. (1989) Selection of antibody epitopes in an immunopathogenic neural autoantigen. Journal of Neuroimmunology 24:3, pages 191-206.
Crossref
Dale S. Gregerson, Steven P. Fling, Wesley F. Obritsch, Carmen F. Merryman & Larry A. Donoso. (1989) Identification of T cell recognition sites in S-antigen: Dissociation of proliferative and pathogenic sites. Cellular Immunology 123:2, pages 427-440.
Crossref
Susumu Tsunasawa & Hitoshi Shichi. (1989) The amino acid sequence of S-antigen: N-terminus and uveitogenic peptides. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 994:2, pages 191-193.
Crossref
R. R. Caspi. 1989. Immunology of Eye Diseases. Immunology of Eye Diseases 61 86 .
John V. Forrester, Janet Liversidge & Hamish M. Towler. 1989. Cyclosporin. Cyclosporin 159 180 .
M. Tsuda, M. Syed, K. Bugra, J.P. Whelan, J.F. McGinnis & T. Shinohara. (1988) Structural analysis of mouse S-antigen. Gene 73:1, pages 11-20.
Crossref
Vijay K. Singh, Robert B. Nussenblatt, Larry A. Donoso, Kunihiko Yamaki, Chi-Chao Chan & Toshimichi Shinohara. (1988) Identification of a uveitopathogenic and lymphocyte proliferation site in bovine S-antigen. Cellular Immunology 115:2, pages 413-419.
Crossref
Kunihiko Yamaki, Masahiko Tsuda & Toshimichi Shinohara. (1988) The sequence of human retinal S-antigen reveals similarities with α-transducin. FEBS Letters 234:1, pages 39-43.
Crossref
Carolyn M. Kalsow & Waldon B. Wacker. (1988) Effect of denaturization on the immunogenicity and uveitogenicity of retinal S-antigen. Experimental Eye Research 47:1, pages 113-121.
Crossref
T. Shinohara, L. Donoso, M. Tsuda, K. Yamaki & V.K. Singh. (1988) S-antigen: Structure, function and experimental autoimmune uveitis (EAU). Progress in Retinal Research 8, pages 51-66.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.