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Original Article

Bruch's membrane age-related changes vary by region

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Pages 1211-1221 | Received 09 Jun 1987, Accepted 12 Aug 1987, Published online: 02 Jul 2009

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Karen M. Gehrs, Don H. Anderson, Lincoln V. Johnson & Gregory S. Hageman. (2006) Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts. Annals of Medicine 38:7, pages 450-471.
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David A. DiLoreto$suffix/text()$suffix/text(), Caesar Luo, David J. Calkins & Manuel del Cerro. (2006) An Ultrastructural Study of the Pathology of the Retinal Pigment Epithelium, Bruch's Membrane, and the Choriocapillaris in the Aged Fischer 344 Rat. Current Eye Research 31:9, pages 749-763.
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Jan M. Provis, Philip L. Penfold, Elisa E. Cornish, Trent M. Sandercoe & Michele C. Madigan. (2005) Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration. Clinical and Experimental Optometry 88:5, pages 269-281.
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Zhen Wang, David C. Paik, Lucian V. Del Priore, Robert L. Burch III Scholar & Elizabeth R. Gaillard. (2005) Nitrite-Modified Extracellular Matrix Proteins Deleteriously Affect Retinal Pigment Epithelial Cell Function and Viability: A Comparison Study with Nonenzymatic Glycation Mechanisms. Current Eye Research 30:8, pages 691-702.
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Michael V. Miceli, David A. Newsome, David J. Tate & T.G. Sarphie. (2000) Pathologic changes in the retinal pigment epithelium and Bruch’s membrane of fat-fed atherogenic mice. Current Eye Research 20:1, pages 8-16.
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Wen-Lang Lin. (1989) Immunogold localization of extracellular matrix molecules in Bruch's membrane of the rat. Current Eye Research 8:11, pages 1171-1178.
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Sara Risseeuw, Matthew G. Pilgrim, Sergio Bertazzo, Connor N. Brown, Lajos Csincsik, Sarah Fearn, Richard B. Thompson, Arthur A. Bergen, Jacoline B. ten Brink, Elod Kortvely, Wilko Spiering, Jeannette Ossewaarde – van Norel, Redmer van Leeuwen & Imre Lengyel. (2023) Bruch´s membrane calcification in pseudoxanthoma elasticum: comparing histopathology and clinical imaging. Ophthalmology Science, pages 100416.
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Emilee Rickabaugh, Dillon Weatherston, Thomas I. Harris, Justin A. Jones & Elizabeth Vargis. (2023) Engineering a Biomimetic In Vitro Model of Bruch’s Membrane Using Hagfish Slime Intermediate Filament Proteins . ACS Biomaterials Science & Engineering 9:8, pages 5051-5061.
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Sarah Hammadi, Nikolaos Tzoumas, Mariantonia Ferrara, Ingrid Porpino Meschede, Katharina Lo, Claire Harris, Majlinda Lako & David H. Steel. (2023) Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration. Journal of Clinical Medicine 12:8, pages 2870.
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Teodora Piskova, Aleksandra N. Kozyrina & Jacopo Di Russo. (2023) Mechanobiological implications of age-related remodelling in the outer retina. Biomaterials Advances 147, pages 213343.
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C. Platzl, A. Kaser-Eichberger, A. Benavente-Perez & F. Schroedl. (2022) The choroid-sclera interface: An ultrastructural study. Heliyon 8:5, pages e09408.
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Sara Risseeuw, Redmer van Leeuwen, Saskia M. Imhof, Wilko Spiering & Jeannette Ossewaarde-van Norel. (2021) The Natural History of Bruch’s Membrane Calcification in Pseudoxanthoma Elasticum. Ophthalmology Science 1:1, pages 100001.
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Nikolaos Tzoumas, Dean Hallam, Claire L. Harris, Majlinda Lako, David Kavanagh & David H.W. Steel. (2021) Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants. Survey of Ophthalmology 66:2, pages 378-401.
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Mark A. Fields, Lucian V. Del Priore, Ron A. Adelman & Lawrence J. Rizzolo. (2020) Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier. Progress in Retinal and Eye Research 76, pages 100803.
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Karina Hadrian, Harutyun Melkonyan, Stefan Schlatt, Joachim Wistuba, Susanne Wasmuth, Arnd Heiligenhaus, Solon Thanos & Michael R.R. Böhm. (2019) Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. Experimental Eye Research 185, pages 107676.
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Christine A. Curcio. (2018) Antecedents of Soft Drusen, the Specific Deposits of Age-Related Macular Degeneration, in the Biology of Human Macula. Investigative Opthalmology & Visual Science 59:4, pages AMD182.
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Christine A. Curcio. (2018) Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies. Investigative Opthalmology & Visual Science 59:4, pages AMD160.
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Cynthia Owsley. (2016) Vision and Aging. Annual Review of Vision Science 2:1, pages 255-271.
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Joel Kaluzny, Patryk Purta, Zach Poskin, Jeremy D. Rogers & Amani A. Fawzi. (2016) Ex Vivo Confocal Spectroscopy of Autofluorescence in Age-Related Macular Degeneration. PLOS ONE 11:9, pages e0162869.
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Stefanie Volland, Julian Esteve-Rudd, Juyea Hoo, Claudine Yee & David S. Williams. (2015) A Comparison of Some Organizational Characteristics of the Mouse Central Retina and the Human Macula. PLOS ONE 10:4, pages e0125631.
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Jost B. Jonas, Leonard Holbach & Songhomitra Panda-Jonas. (2014) Bruch′s membrane thickness in high myopia. Acta Ophthalmologica 92:6, pages e470-e474.
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Anni Sorkio, Heidi Hongisto, Kai Kaarniranta, Hannu Uusitalo, Kati Juuti-Uusitalo & Heli Skottman. (2014) Structure and Barrier Properties of Human Embryonic Stem Cell–Derived Retinal Pigment Epithelial Cells Are Affected by Extracellular Matrix Protein Coating. Tissue Engineering Part A, pages 140120073644000.
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Tuomas Paimela, Juha M.T. Hyttinen, Johanna Viiri, Tuomas Ryhänen, Reijo O. Karjalainen, Antero Salminen & Kai Kaarniranta. (2011) Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells. Pharmacological Research 64:5, pages 501-508.
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Cynthia Owsley. (2011) Aging and vision. Vision Research 51:13, pages 1610-1622.
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L.S. Murdaugh, Z. Wang, L.V. Del Priore, J. Dillon & E.R. Gaillard. (2010) Age-related accumulation of 3-nitrotyrosine and nitro-A2E in human Bruch's membrane. Experimental Eye Research 90:5, pages 564-571.
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Heping Xu, Mei Chen & John V. Forrester. (2009) Para-inflammation in the aging retina. Progress in Retinal and Eye Research 28:5, pages 348-368.
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L.S. Murdaugh, J. Dillon & E.R. Gaillard. (2009) Modifications to the basement membrane protein laminin using glycolaldehyde and A2E: A model for aging in Bruch's membrane. Experimental Eye Research 89:2, pages 187-192.
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K. Kaarniranta & A. Salminen. (2008) Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors. Journal of Molecular Medicine 87:2, pages 117-123.
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N.H. Victor Chong, Jason Keonin, Phil J. Luthert, Christina I. Frennesson, David M. Weingeist, Rachel L. Wolf, Robert F. Mullins & Gregory S. Hageman. (2005) Decreased Thickness and Integrity of the Macular Elastic Layer of Bruch's Membrane Correspond to the Distribution of Lesions Associated with Age-Related Macular Degeneration. The American Journal of Pathology 166:1, pages 241-251.
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Ronald Klein, Barbara E.K Klein, Sandra C Tomany & Karen J Cruickshanks. (2003) The association of cardiovascular disease with the long-term incidence of age-related maculopathy. Ophthalmology 110:6, pages 1273-1280.
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Ali A. Hussain, Lisa Rowe & John Marshall. (2002) Age-related alterations in the diffusional transport of amino acids across the human Bruch’s-choroid complex. Journal of the Optical Society of America A 19:1, pages 166.
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Carlo Knupp, N.H.Victor Chong, Peter M.G. Munro, Philip J. Luthert & John M. Squire. (2002) Analysis of the Collagen VI Assemblies Associated with Sorsby's Fundus Dystrophy. Journal of Structural Biology 137:1-2, pages 31-40.
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Tracey A. Bailey, Robert A. Alexander, Sander R. Dubovy, Philip J. Luthert & N.H. Victor Chong. (2001) Measurement of TIMP-3 Expression and Bruch's Membrane Thickness in Human Macula. Experimental Eye Research 73:6, pages 851-858.
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Robert F. Mullins, Stephen R. Russell, Don H. Anderson & Gregory S. Hageman. (2000) Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. The FASEB Journal 14:7, pages 835-846.
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Christine A Curcio, Phillip L Saunders, Perry W Younger & Goldis Malek. (2000) Peripapillary chorioretinal atrophy. Ophthalmology 107:2, pages 334-343.
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Christoph W Spraul, Gabriele E Lang, Hans E Grossniklaus & Gerhard K Lang. (1999) Histologic and Morphometric Analysis of the Choroid, Bruch's Membrane, and Retinal Pigment Epithelium in Postmortem Eyes With Age-Related Macular Degeneration and Histologic Examination of Surgically Excised Choroidal Neovascular Membranes. Survey of Ophthalmology 44, pages S10-S32.
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R. Guymer, P. Luthert & A. Bird. (1999) Changes in Bruch’s membrane and related structures with age. Progress in Retinal and Eye Research 18:1, pages 59-90.
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