65
Views
75
CrossRef citations to date
0
Altmetric
Original Article

Photoreceptor rescue in the RCS rat without pigment epithelium transplantation

&
Pages 183-191 | Received 25 Sep 1989, Accepted 11 Jan 1990, Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Baishijiao Bian, Congjian Zhao, Xiangyu He, Yu Gong, Chunge Ren, Lingling Ge, Yuxiao Zeng, Qiyou Li, Min Chen, Chuanhuang Weng, Juncai He, Yajie Fang, Haiwei Xu & Zheng Qin Yin. (2020) Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia. Journal of Extracellular Vesicles 9:1.
Read now
Henry Klassen. (2016) Stem cells in clinical trials for treatment of retinal degeneration. Expert Opinion on Biological Therapy 16:1, pages 7-14.
Read now
Magdalene J. Seiler & Robert B. Aramant. (2005) Transplantation of Neuroblastic Progenitor Cells as a Sheet Preserves and Restores Retinal Function. Seminars in Ophthalmology 20:1, pages 31-42.
Read now
Neville N. Osborne, Glyn Chidlow, John P.M. Wood, Karl-Georg Schmidt, Robert Casson & José Melena. (2001) Expectations in the treatment of retinal diseases: Neuroprotection. Current Eye Research 22:5, pages 321-332.
Read now
Pascal Dureau, Sébastien Bonnel, Maurice Menasche, Jean-Louis Dufier & Marc Abitbol. (2001) Quantitative analysis of intravitreal injections in the rat. Current Eye Research 22:1, pages 74-77.
Read now
Magdalene J. Seiler, Robert B. Aramant & Anders Bergström. (1995) Co-transplantation of embryonic retina and retinal pigment epithelial cells to rabbit retina. Current Eye Research 14:3, pages 199-207.
Read now
M. F. Humphrey, C. Parker, Y. Chu & I. J. Constable. (1993) Transient preservation of photoreceptors on the flanks of argon laser lesions in the RCS rat. Current Eye Research 12:4, pages 367-372.
Read now
B. Ehinger, C. Zucker, A. Bergström, M. Seiler, R. Aramant & A. Adolph. (1992) Electron microscopy of human first trimester and rat mid-term retinal cell transplants with long development time. Neuro-Ophthalmology 12:2, pages 103-114.
Read now
Linxi Li, Harold J. Sheedlo, Vinod Gaur & James E. Turner. (1991) Effects of macrophage and retinal pigment epithelial cell transplants on photoreceptor cell rescue in RCS rats. Current Eye Research 10:10, pages 947-958.
Read now

Articles from other publishers (66)

Grant W. Marquart, Jonathan Stoddard, Karen Kinnison, Felicia Zhou, Richard Hugo, Renee Ryals, Scott Shubert, Trevor J. McGill & Marilyn R. Mackiewicz. (2022) Increasing the Efficacy of Gold Nanorod Uptake in Stem Cell-Derived Therapeutic Cells: Implications for Stem Cell Labeling and Optical Coherence Tomography Imaging. ACS Applied Nano Materials 5:5, pages 6995-7008.
Crossref
Carson C. Petrash, Alan G. Palestine & M. Valeria Canto-Soler. (2021) Immunologic Rejection of Transplanted Retinal Pigmented Epithelium: Mechanisms and Strategies for Prevention. Frontiers in Immunology 12.
Crossref
TongalpH Tezel & Adam Ruff. (2021) Retinal cell transplantation in retinitis pigmentosa. Taiwan Journal of Ophthalmology 11:4, pages 336.
Crossref
Sarah Naguib, Alexandra Bernardo-Colón & Tonia S. Rex. (2021) Intravitreal injection worsens outcomes in a mouse model of indirect traumatic optic neuropathy from closed globe injury. Experimental Eye Research 202, pages 108369.
Crossref
Ruchi SharmaDevika BoseArvydas Maminishkis & Kapil Bharti. (2020) Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?. Annual Review of Pharmacology and Toxicology 60:1, pages 553-572.
Crossref
Daniel S. Narayan, Glyn Chidlow, John P. M. Wood & Robert J. Casson. (2019) Investigations Into Bioenergetic Neuroprotection of Cone Photoreceptors: Relevance to Retinitis Pigmentosa. Frontiers in Neuroscience 13.
Crossref
Brian Fury, Henry Klassen & Gerhard Bauer. 2019. Cell-Based Therapy for Degenerative Retinal Disease. Cell-Based Therapy for Degenerative Retinal Disease 81 95 .
Karl A. Z. Hudspith, Gibert Xue & Mandeep S. Singh. 2019. Cell-Based Therapy for Degenerative Retinal Disease. Cell-Based Therapy for Degenerative Retinal Disease 11 28 .
H. Lorach, S. Kang, R. Dalal, M. B. Bhuckory, Y. Quan & D. Palanker. (2018) Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation. Scientific Reports 8:1.
Crossref
Deepti Singh, Shao-Bin Wang, Tina Xia, Laurel Tainsh, Maryam Ghiassi-Nejad, Tao Xu, Shaomin Peng, Ron A. Adelman & Lawrence J. Rizzolo. (2018) A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Biomaterials 154, pages 158-168.
Crossref
Kevin P. Kennelly, Toby M. Holmes, Deborah M. Wallace, Cliona O'farrelly & David J. Keegan. (2017) Early Subretinal Allograft Rejection is Characterized by Innate Immune Activity. Cell Transplantation 26:6, pages 983-1000.
Crossref
Sujatha A. Jayakody, Anai Gonzalez-Cordero, Robin R. Ali & Rachael A. Pearson. (2015) Cellular strategies for retinal repair by photoreceptor replacement. Progress in Retinal and Eye Research 46, pages 31-66.
Crossref
Andreas Reichenbach & Andreas Bringmann. (2015) Retinal Glia. Colloquium Series on Neuroglia in Biology and Medicine: from Physiology to Disease 2:1, pages 1-644.
Crossref
Steven D Schwartz, Carl D Regillo, Byron L Lam, Dean Eliott, Philip J Rosenfeld, Ninel Z Gregori, Jean-Pierre Hubschman, Janet L Davis, Gad Heilwell, Marc Spirn, Joseph Maguire, Roger Gay, Jane Bateman, Rosaleen M Ostrick, Debra Morris, Matthew Vincent, Eddy Anglade, Lucian V Del Priore & Robert Lanza. (2015) Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. The Lancet 385:9967, pages 509-516.
Crossref
Anton M. Kolomeyer & Marco A. Zarbin. (2014) Trophic factors in the pathogenesis and therapy for retinal degenerative diseases. Survey of Ophthalmology 59:2, pages 134-165.
Crossref
Vamsi K. Gullapalli, Mohamad A. Khodair, Hao Wang, Ilene K. Sugino, Steven Madreperla & Marco A. Zarbin. 2013. Retina. Retina 2058 2077 .
Mark A. Fields, John Hwang, Jie Gong, Hui Cai & Lucian V. Del Priore. 2013. Stem Cell Biology and Regenerative Medicine in Ophthalmology. Stem Cell Biology and Regenerative Medicine in Ophthalmology 1 29 .
Yao Li, Yi-Ting Tsai, Chun-Wei Hsu, Deniz Erol, Jin Yang, Wen-Hsuan Wu, Richard J. Davis, Dieter Egli & Stephen H. Tsang. (2012) Long-term Safety and Efficacy of Human-Induced Pluripotent Stem Cell (iPS) Grafts in a Preclinical Model of Retinitis Pigmentosa. Molecular Medicine 18:9, pages 1312-1319.
Crossref
E Touchard, P Heiduschka, M Berdugo, L Kowalczuk, P Bigey, S Chahory, C Gandolphe, J-C Jeanny & F Behar-Cohen. (2011) Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose. Gene Therapy 19:9, pages 886-898.
Crossref
Andreas Bringmann, Ianors Iandiev, Thomas Pannicke, Antje Wurm, Margrit Hollborn, Peter Wiedemann, Neville N. Osborne & Andreas Reichenbach. (2009) Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects. Progress in Retinal and Eye Research 28:6, pages 423-451.
Crossref
Carla B. Mellough, David H.W. Steel & Majlinda Lako. (2009) Genetic Basis of Inherited Macular Dystrophies and Implications for Stem Cell Therapy. Stem Cells 27:11, pages 2833-2845.
Crossref
Norman D. Radtke, Robert B. Aramant, Heywood M. Petry, Parke T. Green, Diane J. Pidwell & Magdalene J. Seiler. (2008) Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium. American Journal of Ophthalmology 146:2, pages 172-182.e1.
Crossref
GERALD J. CHADER. 2008. Ocular Therapeutics. Ocular Therapeutics 443 472 .
Lyndon da Cruz, Fred K. Chen, Ahmad Ahmado, John Greenwood & Pete Coffey. (2007) RPE transplantation and its role in retinal disease. Progress in Retinal and Eye Research 26:6, pages 598-635.
Crossref
Ravindra Kumar & Kamla Dutt. (2006) Enhanced Neurotrophin Synthesis and Molecular Differentiation in Non-Transformed Human Retinal Progenitor Cells Cultured in a Rotating Bioreactor. Tissue Engineering 0:0, pages 060118075515001.
Crossref
Ravindra KumarKamla Dutt. (2006) Enhanced Neurotrophin Synthesis and Molecular Differentiation in Non-Transformed Human Retinal Progenitor Cells Cultured in a Rotating Bioreactor. Tissue Engineering 12:1, pages 141-158.
Crossref
Vamsi K. Gullapalli, Mohamad A. Khodair, Hao Wang, Ilene K. Sugino, Steven Madreperla & Marco A. Zarbin. 2006. Retina. Retina 2597 2613 .
O.V. Kubay, D.G. Charteris, H.S. Newland & G.L. Raymond. (2005) Retinal Detachment Neuropathology and Potential Strategies for Neuroprotection. Survey of Ophthalmology 50:5, pages 463-475.
Crossref
Y Sauvé, S.V Girman, S Wang, D.J Keegan & R.D Lund. (2002) Preservation of visual responsiveness in the superior colliculus of RCS rats after retinal pigment epithelium cell transplantation. Neuroscience 114:2, pages 389-401.
Crossref
Toshimichi Shinohara, Dhirendra P. Singh & Nigar Fatma. (2002) LEDGF, a survival factor, activates stress-related genes. Progress in Retinal and Eye Research 21:3, pages 341-358.
Crossref
Robert B Aramant & Magdalene J Seiler. (2002) Retinal transplantation—advantages of intact fetal sheets. Progress in Retinal and Eye Research 21:1, pages 57-73.
Crossref
Ulrich Schraermeyer, Gabriele Thumann, Thomas Luther, Norbert Kociok, Stefan Arnhold, Klaus Kruttwig, Christian Andressen, Klaus Addicks & Karl Ulrich Bartz-Schmidt. (2017) Subretinally Transplanted Embryonic Stem Cells Rescue Photoreceptor Cells from Degeneration in the RCS Rats. Cell Transplantation 10:8, pages 673-680.
Crossref
B Lu, R.D Lund & P.J Coffey. (2001) Basal increase in c-Fos-like expression in superior colliculus of Royal College of Surgeons dystrophic rats can be abolished by intraocular injection of tetrodotoxin. Neuroscience 107:1, pages 109-115.
Crossref
Karl J Wahlin, Ruben Adler, Donald J Zack & Peter A Campochiaro. (2001) Neurotrophic Signaling in Normal and Degenerating Rodent Retinas. Experimental Eye Research 73:5, pages 693-701.
Crossref
Henry Klassen, Simon J.O. Whiteley, Michael J. Young & Raymond D. Lund. (2001) Graft Location Affects Functional Rescue Following RPE Cell Transplantation in the RCS Rat. Experimental Neurology 169:1, pages 114-121.
Crossref
Wei Cao, Feng Li, Roy H Steinberg & Matthew M Lavail. (2001) Development of Normal and Injury-induced Gene Expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the Rat Retina. Experimental Eye Research 72:5, pages 591-604.
Crossref
Gabriele Thumann. (2001) Development and Cellular Functions of the Iris Pigment Epithelium. Survey of Ophthalmology 45:4, pages 345-354.
Crossref
Michael J. Young, Jasodhara Ray, Simon J.O. Whiteley, Henry Klassen & Fred H. Gage. (2000) Neuronal Differentiation and Morphological Integration of Hippocampal Progenitor Cells Transplanted to the Retina of Immature and Mature Dystrophic Rats. Molecular and Cellular Neuroscience 16:3, pages 197-205.
Crossref
Toshifuml Konobu, Francis Sessler, Lai-Yi Luo & John Lehmann. (2017) The hNT Human Neuronal Cell Line Survives and Migrates into Rat Retina. Cell Transplantation 7:6, pages 549-558.
Crossref
Saddek Mohand-Said, Alain Deudon-Combe, David Hicks, Manuel Simonutti, Valérie Forster, Anne-Claire Fintz, Thierry Léveillard, Henri Dreyfus & José-Alain Sahel. (1998) Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proceedings of the National Academy of Sciences 95:14, pages 8357-8362.
Crossref
Philip J Luthert & N H Victor Chong. (1998) Photoreceptor rescue. Eye 12:3, pages 591-596.
Crossref
Yi Chu, Martin F Humphrey, Valerie V Alder & Ian J Constable FRACS. (2009) Immunocytochemical localization of basic fibroblast growth factor and glial fibrillary acidic protein after laser photocoagulation in the Royal College of Surgeons rat. Australian and New Zealand Journal of Ophthalmology 26:1, pages 87-96.
Crossref
M.B.A. Djamgoz, M.W. Hankins, J. Hirano & S.N. Archer. (1997) Neurobiology of retinal dopamine in relation to degenerative states of the tissue. Vision Research 37:24, pages 3509-3529.
Crossref
Rajesh K. Sharma & Berndt Ehinger. (2009) Retinal cell transplants: How close to clinical application?. Acta Ophthalmologica Scandinavica 75:4, pages 355-363.
Crossref
WEI CAO, RONG WEN, FENG LI, MATTHEW M LAVAIL & ROY H STEINBERG. (1997) Mechanical Injury Increases bFGF and CNTF mRNA Expression in the Mouse Retina. Experimental Eye Research 65:2, pages 241-248.
Crossref
Bienvenido V. CastilloJr.Jr., Manuel del Cerro, Rodger M. White, Christopher Cox, Jeffrey Wyatt, Gana Nadiga & Coca del Cerro. (1997) Efficacy of Nonfetal Human RPE for Photoreceptor Rescue: A Study in Dystrophic RCS Rats. Experimental Neurology 146:1, pages 1-9.
Crossref
Manuel del Cerro, Eliot S. Lazar & David Diloreto, Jr.. (1997) The first decade of continuous progress in retinal transplantation. Microscopy Research and Technique 36:2, pages 130-141.
Crossref
Erica L. Fletcher & Michael Kalloniatis. (1996) Neurochemical architecture of the normal and degenerating rat retina. The Journal of Comparative Neurology 376:3, pages 343-360.
Crossref
Solon Thanos, Stephen Moore & Yeon-mi Hong. (1996) Retinal microglia. Progress in Retinal and Eye Research 15:2, pages 331-361.
Crossref
Robert B. Aramant & Magdalene J. Seiler. 1996. Yearbook of Cell and Tissue Transplantation 1996–1997. Yearbook of Cell and Tissue Transplantation 1996–1997 193 201 .
Joshua L. Dunaief, Robert C. Kwun, Nikhil Bhardwaj, Robert Lopez, Peter Gouras & Stephen P. Goff. (1995) Retroviral Gene Transfer into Retinal Pigment Epithelial Cells Followed by Transplantation into Rat Retina. Human Gene Therapy 6:9, pages 1225-1229.
Crossref
R.K. Sharma, A. Bergström & B. Ehinger. (1995) Retinal cell transplants. Progress in Retinal and Eye Research 15:1, pages 197-230.
Crossref
Martin F. Humphrey, Yi Chu, Claudia Sharp, Krishna Mann & Piroska Rakoczy. 1995. Degenerative Diseases of the Retina. Degenerative Diseases of the Retina 209 216 .
Roy H. Steinberg. (1994) Survival factors in retinal degenerations. Current Opinion in Neurobiology 4:4, pages 515-524.
Crossref
Ann H. Milam. (1993) Strategies for rescue of retinal photoreceptor cells. Current Opinion in Neurobiology 3:5, pages 797-804.
Crossref
Solon Thanos & Waltraud Richter. (1993) The migratory potential of vitally labelled microglial cells within the retina of rats with hereditary photoreceptor dystrophy. International Journal of Developmental Neuroscience 11:5, pages 671-680.
Crossref
Martin F Humphrey, Yi Chu, Carol Parker & Ian J Constable. 1993. Retinal Degeneration. Retinal Degeneration 299 308 .
Matthew M. Lavail, Linxi Li, James E. Turner & Douglas Yasumura. (1992) Retinal pigment epithelial cell transplantation in RCS rats: Normal metabolism in rescued photoreceptors. Experimental Eye Research 55:4, pages 555-562.
Crossref
Solon Thanos. (1992) Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy. Brain Research 588:1, pages 21-28.
Crossref
R. Banerjee & R. D. Lund. (1992) A role for microglia in the maintenance of photoreceptors in retinal transplants lacking pigment epithelium. Journal of Neurocytology 21:4, pages 235-243.
Crossref
Harold John Sheedlo, Linxi Li, Vinod P. Gaur, Richard W. Young, Anthony D. Seaton, S.V. Stovall, C.D. Jaynes & James E. Turner. 1992. 1 49 .
V. Gaur, N. Agarwal, L. Li & J.E. Turner. (1992) Maintenance of opsin and S-antigen gene expression in RCS dystrophic rats following RPE transplantation. Experimental Eye Research 54:1, pages 91-101.
Crossref
Harold J. Sheedlo, Vinod Gaur, Linxi Li, Anthony D. Seaton & James E. Turner. (1991) Transplantation to the diseased and damaged retina. Trends in Neurosciences 14:8, pages 347-350.
Crossref
Linxi Li & James E. Turner. (1991) Optimal conditions for long-term photoreceptor cell rescue in RCS rats: The necessity for healthy RPE transplants. Experimental Eye Research 52:6, pages 669-679.
Crossref
Michael O. Hall & Toshka A. Abrams. (1991) RPE cells from normal rats do not secrete a factor which enhances the phagocytosis of ROS by dystrophic rat RPE cells. Experimental Eye Research 52:4, pages 461-464.
Crossref
Ella G. Faktorovich, Roy H. Steinberg, Douglas Yasumura, Michael T. Matthes & Matthew M. LaVail. (1990) Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347:6288, pages 83-86.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.