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Original Article

Topical fluoroquinolones: Antimicrobial activity and in vitro corneal epithelial toxicity

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Pages 557-563 | Received 07 Jan 1991, Accepted 24 Apr 1991, Published online: 02 Jul 2009

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Read on this site (8)

Michael Mimouni, Noa Geffen, Eli Rosen & Fani Segev. (2016) The effect of gatifloxacin 0.3% or moxifloxacin 0.5% on corneal healing, ocular tolerability and toxicity following pterygium surgery. Cutaneous and Ocular Toxicology 35:1, pages 8-12.
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Kendall E. Donaldson, Fabiana B. Marangon, Lauren Schatz, Anna S. Venkatraman & Eduardo C. Alfonso. (2006) The effect of moxifloxacin on the normal human cornea. Current Medical Research and Opinion 22:10, pages 2073-2078.
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Judy M. Moreau, Linda C. Green, Lee S. Engel, James M. Hill & Richard J. O'Callaghan. (1998) Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model. Current Eye Research 17:8, pages 808-812.
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A.G. Akkan, I. Mutlu, S. Ozyazgan, A. Gok, U. Yigit, Z. Ozuner, V. Senses & H. Pekel. (1997) Penetration of Topically Applied Ciprofloxacin, Norfloxacin and Ofloxacin into the Aqueous Humor of the Uninflamed Human Eye. Journal of Chemotherapy 9:4, pages 257-262.
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Dan Stevens & John R. Samples. (1994) Fluoroquinolones for the Treatment of Microbial Infections. Journal of Toxicology: Cutaneous and Ocular Toxicology 13:4, pages 275-277.
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Tsutomu Fujihara, Tsutomu Nakano & Mitsushi Hikida. (1993) Effect of Ofloxacin Eye Drops and Eye Ointment on Corneal Re-Epithelialization. Journal of Toxicology: Cutaneous and Ocular Toxicology 12:1, pages 67-73.
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Thomas F. Mauger, Jeffrey F. McAdoo & Tamara Fackler. (1993) Aerobic Responses of the Cornea to Aminoglycoside Antibiotics. Journal of Toxicology: Cutaneous and Ocular Toxicology 12:3, pages 221-226.
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Paul E. Cutarelli, Hillard M. Lazarus, Michael R. Jacobs & Jonathan H. Lass. (1993) Antimicrobial activity and in vitro corneal epithelial toxicity of antimicrobial agents for Gram-positive corneal pathogens. Current Eye Research 12:7, pages 603-608.
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Articles from other publishers (35)

Camille André, Mohammad Mirazul Islam, Eleftherios Paschalis & Paulo J. M. Bispo. (2023) Comparative In Vitro Activity of New Lipoglycopeptides and Vancomycin Against Ocular Staphylococci and Their Toxicity on the Human Corneal Epithelium. Cornea 42:5, pages 615-623.
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Fakhria A. Al-Joufi, Mounir M. Salem-Bekhit, Ehab I. Taha, Mohamed A. Ibrahim, Magdy M. Muharram, Sultan Alshehri, Mohammed M. Ghoneim & Faiyaz Shakeel. (2022) Enhancing Ocular Bioavailability of Ciprofloxacin Using Colloidal Lipid-Based Carrier for the Management of Post-Surgical Infection. Molecules 27:3, pages 733.
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Ting Yang, Ting-Jun Fan & Bin Xu. (2020) Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells. Toxicology in Vitro 66, pages 104868.
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Sanjeev Kumar Paikra, Janmejaya Bag & Monalisa Mishra. 2020. Nanoformulations in Human Health. Nanoformulations in Human Health 259 283 .
Matthew J. Annear & Simon M. Petersen-Jones. 2019. Equine Surgery. Equine Surgery 956 981 .
Hitendra S. Mahajan & Sachin R. Deshmukh. (2015) Development and evaluation of gel-forming ocular films based on xyloglucan. Carbohydrate Polymers 122, pages 243-247.
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Olga Igorevna Aleksandrova, Igor Nikolaevich Okolov, Yuri Victorovich Takhtaev, Juliya Igorevna Khorolskaya, Tamara Slavikovna Hintuba & Miralda Ivanovna Blinova. (2015) A comparative evaluation of antimicrobial eye drops cytotoxicity. Ophthalmology Reports 8:1, pages 89-97.
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Enrique O. Graue-Hernández, Alejandro Navas & Arturo Ramírez-Miranda. 2013. Ocular Surface Disease: Cornea, Conjunctiva and Tear Film. Ocular Surface Disease: Cornea, Conjunctiva and Tear Film 189 193 .
Pravin Pawar, Rajesh Katara & Dipak Majumdar. (2012) Design and evaluation of moxifloxacin hydrochloride ocular inserts. Acta Pharmaceutica 62:1, pages 93-104.
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Rita Mencucci, Iacopo Paladini, Domenico E. Pellegrini-Giampietro, Ugo Menchini & Tania Scartabelli. (2011) In vitro comparison of the cytotoxic effects of clinically available ophthalmic solutions of fluoroquinolones on human keratocytes. Canadian Journal of Ophthalmology 46:6, pages 513-520.
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Charles D. Reilly & Mark J. Mannis. 2011. Cornea. Cornea 613 621 .
Claudia Hartley. (2010) Treatment of Corneal Ulcers: What are the Medical Options?. Journal of Feline Medicine and Surgery 12:5, pages 384-397.
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Anne Danion, Isabelle Arsenault & Patrick Vermette. (2007) Antibacterial Activity of Contact Lenses Bearing Surface-Immobilized Layers of Intact Liposomes Loaded With Levofloxacin. Journal of Pharmaceutical Sciences 96:9, pages 2350-2363.
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Andrew M Thompson. (2007) Ocular toxicity of fluoroquinolones. Clinical & Experimental Ophthalmology 35:6, pages 566-577.
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Steven Matsumoto, William Way, Kirk Tarlo & Brian Short. (2006) Comparative Toxicity of Fluoroquinolone Antibiotics on Corneal Cells In Vitro. Cornea 25:9, pages S1-S7.
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Andrea Leonardi, Vincenzo Papa, Iva Fregona, Pietro Russo, Giuseppe De Franchis & Giovanni Milazzo. (2006) In Vitro Effects of Fluoroquinolone and Aminoglycoside Antibiotics on Human Keratocytes. Cornea 25:1, pages 85-90.
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David H. McGee, William F. Holt, Philip R. Kastner & Rebecca L. Rice. (2005) Safety of Moxifloxacin as Shown in Animal and In Vitro Studies. Survey of Ophthalmology 50:6, pages S46-S54.
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Clara Marino, Grazia Maria Paladino, Anna Claudia Scuderi, Francesco Trombetta, Kennet Mugridge & Vincenzo Enea. (2005) In Vivo Toxicity of Netilmicin and Ofloxacin on Intact and Mechanically Damaged Eyes of Rabbit. Cornea 24:6, pages 710-716.
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Audrey W. Yu-Speight, Thomas J. Kern & Hollis N. Erb. (2005) Ciprofloxacin and ofloxacin aqueous humor concentrations after topical administration in dogs undergoing cataract surgery. Veterinary Ophthalmology 8:3, pages 181-187.
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Emilia Ghelardi, Arianna Tavanti, Paola Davini, Francesco Celandroni, Sara Salvetti, Eva Parisio, Enrico Boldrini, Sonia Senesi & Mario Campa. (2004) A Mucoadhesive Polymer Extracted from Tamarind Seed Improves the Intraocular Penetration and Efficacy of Rufloxacin in Topical Treatment of Experimental Bacterial Keratitis. Antimicrobial Agents and Chemotherapy 48:9, pages 3396-3401.
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Timmy A. Kovoor, Andrea S. Kim, James P. McCulley, H. Dwight Cavanagh, James V. Jester, Abhijit C. Bugde & W. Matthew Petroll. (2004) Evaluation of the Corneal Effects of Topical Ophthalmic Fluoroquinolones Using In Vivo Confocal Microscopy. Eye & Contact Lens: Science & Clinical Practice 30:2, pages 90-94.
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Victor E Reviglio, Melinda A Hakim, Jae K Song & Terrence P O'Brien. (2003) Effect of topical fluoroquinolones on the expression of matrix metalloproteinases in the cornea. BMC Ophthalmology 3:1.
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Ming-Cheng Tai, Da-Wen Lu & Chiao-Hsi Chiang. (2003) Corneal and Scleral Permeability of Quinolones—A Pharmacokinetics Study. Journal of Ocular Pharmacology and Therapeutics 19:6, pages 547-554.
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Vincenzo Papa, Andrea Leonardi, Claudia Getuli, Vanessa Pacelli, Pietro Russo & Giovanni Milazzo. (2003) Effect of Ofloxacin and Netilmicin on Human Corneal and Conjunctival Cells In Vitro . Journal of Ocular Pharmacology and Therapeutics 19:6, pages 535-545.
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Anna Claudia Scuderi, Grazia Maria Paladino, Clara Marino & Francesco Trombetta. (2003) In Vitro Toxicity of Netilmicin and Ofloxacin on Corneal Epithelial Cells. Cornea 22:5, pages 468-472.
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G. Sárközy. (2001) Quinolones: a class of antimicrobial agents. Veterinární medicína 46:9-10, pages 257-274.
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Jules Baum & Michael Barza. (2000) The Evolution of Antibiotic Therapy for Bacterial Conjunctivitis and Keratitis: 1970–2000. Cornea 19:5, pages 659-672.
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Osman Çekiç, Coşar Batman, Ümit Yasar, Nursabah E. Başci, Atilla Bozkurt & S Oguz Kayaalp. (1999) Human aqueous and vitreous humour levels of ciprofloxacin following oral and topical administration. Eye 13:4, pages 555-558.
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Carlos Pavesio, Nigel Morlet, Bruce Allan, Hosam El Kassaby, Romain DeCock, Jeremy Butcher, Roger Baer, David Broadway, Stephen J. Charles, Graham Duguid, Peter Heyworth, Chris Jenkins, Genevieve Larkin, Ian C. Lloyd, Andrew McNaught, John Dart, Andrew Tullo, Linda Ficker, Darwin Minassian, Melville Matheson & Alan P. Johnson. (1997) Ofloxacin Monotherapy for the Primary Treatment of Microbial Keratitis. Ophthalmology 104:11, pages 1902-1909.
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Luciane B. Moreira, Ray F. Lee, Clarissa de Oliveira, Laurie LaBree & Peter J. McDonnell. (1997) Effect of topical fluoroquinolones on corneal re-epithelialization after excimer laser keratectomy. Journal of Cataract and Refractive Surgery 23:6, pages 845-848.
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S. A. BROWN. (2008) Fluoroquinolones in animal health. Journal of Veterinary Pharmacology and Therapeutics 19:1, pages 1-14.
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J P Diamond, L White, J P Leeming, H Bing Hoh & D L Easty. (1995) Topical 0.3% ciprofloxacin, norfloxacin, and ofloxacin in treatment of bacterial keratitis: a new method for comparative evaluation of ocular drug penetration.. British Journal of Ophthalmology 79:6, pages 606-609.
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Joel Mindel, Michael B. Starr & Joseph M. Lally. (1995) Antimicrobial prophylaxis for ophthalmic surgery. Survey of Ophthalmology 39:6, pages 485-501.
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Steven S. Matsumoto, Michael E. Stern, Roger M. Oda, Corine R. Ghosn, Josephine W. Cheng, Tammy A. Gelber, Yili Wang, Austin M. Zoutis & Claude B. Anger. (2012) Effect of Ofloxacin on Corneal Epithelial Wound Healing Evaluated by In Vitro and In Vivo Methods. Drug Investigation 6:2, pages 96-103.
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A. Gwon. (1992) Topical ofloxacin compared with gentamicin in the treatment of external ocular infection. Ofloxacin Study Group.. British Journal of Ophthalmology 76:12, pages 714-718.
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