Advanced search
Publication Cover
Current Eye Research Volume 12, 1993 - Issue 9
Submit an article Journal homepage
98
Views
71
CrossRef citations to date
0
Altmetric
Original Article

Dexamethasone induced ultrastructural changes in cultured human trabecular meshwork cells

Karen Wilson Alcon Laboratories, Inc., 6201 South Freeway, Fort Worth, TX, 76134-2099, USA
,
Mitchell D. McCartney Alcon Laboratories, Inc., 6201 South Freeway, Fort Worth, TX, 76134-2099, USA
,
Sharon T. Miggans Alcon Laboratories, Inc., 6201 South Freeway, Fort Worth, TX, 76134-2099, USA
&
Abbot F. Clark Alcon Laboratories, Inc., 6201 South Freeway, Fort Worth, TX, 76134-2099, USA
Pages 783-793 | Received 06 Jan 1993, Accepted 24 Aug 1993, Published online: 02 Jul 2009

Citations (71)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Sneha Shrestha, Madhu Thapa & Dev Narayan Shah. (2014) Pattern of Intraocular Pressure Fluctuation in Uveitic Eyes Treated with Corticosteroids. Ocular Immunology and Inflammation 22:2, pages 110-115.
Read now
Oscar Buchacra, Susana Duch, Elena Milla & Oana Stirbu. (2011) One-year analysis of the iStent trabecular microbypass in secondary glaucoma. Clinical Ophthalmology 5, pages 321-326.
Read now

Articles from other publishers (69)

Michael Peng, Naga Pradeep Rayana, Jiannong Dai, Chenna Kesavulu Sugali, Hasna Baidouri, Ayush Suresh, Vijay Krishna Raghunathan & Weiming Mao. (2022) Cross-linked actin networks (CLANs) affect stiffness and/or actin dynamics in transgenic transformed and primary human trabecular meshwork cells. Experimental Eye Research 220, pages 109097.
Crossref
Maryam Abtahi, Chris J. Rudnisky, Samir Nazarali & Karim F. Damji. (2022) Incidence of steroid response in microinvasive glaucoma surgery with trabecular microbypass stent and ab interno trabeculectomy. Canadian Journal of Ophthalmology 57:3, pages 167-174.
Crossref
KAZUHIKO TANABE, ITARU KIMURA, HARU OKAMOTO, ZAI-LONG CHI, MASAKAZU AKAHORI, NOBUHIRO SHIMOZAWA, NOBUYUKI EBIHARA, AKIRA MURAKAMI & TAKESHI IWATA. (2022) The Expression of Rab8, Ezrin, Radixin and Moesin in the Ciliary Body of Cynomolgus Monkeys. Juntendo Medical Journal 68:4, pages 339-351.
Crossref
Ji Liu & Claudia A. Arrigg. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 2541 2560 .
Amy O'Regan, Colm J. O'Brien & Sarah B. Eivers. (2021) The lysophosphatidic acid axis in fibrosis: Implications for glaucoma. Wound Repair and Regeneration 29:4, pages 613-626.
Crossref
Felix Yemanyi, Hasna Baidouri, Alan R. Burns & VijayKrishna Raghunathan. (2020) Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells. Investigative Opthalmology & Visual Science 61:13, pages 16.
Crossref
Kyung Tae Kim, Hwanho Lee, Jin Young Kim, Ju Byung Chae, Sungmin Hyung & Dong Yoon Kim. (2020) Association between Early Anatomic Response and Intraocular Pressure Change after Intravitreal Dexamethasone Implant: An Optical Coherence Tomography Study. Journal of Clinical Medicine 9:9, pages 2692.
Crossref
Gloria Roberti, Francesco Oddone, Luca Agnifili, Andreas Katsanos, Manuele Michelessi, Leonardo Mastropasqua, Luciano Quaranta, Ivano Riva, Lucia Tanga & Gianluca Manni. (2020) Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management. Survey of Ophthalmology 65:4, pages 458-472.
Crossref
Tanuj Dada, Priyanka Ramesh & Jyoti Shakrawal. (2020) Meditation: A Polypill for Comprehensive Management of Glaucoma Patients. Journal of Glaucoma 29:2, pages 133-140.
Crossref
Brittany B. MartabanoMichala de Linde HenriksenJenny A. ColussiJulia L. SharpZeke WangMichael R. Lappin. (2020) Effect of topical administration of 0.1% diclofenac sodium ophthalmic solution at four frequencies on intraocular pressure in healthy Beagles. American Journal of Veterinary Research 81:1, pages 41-46.
Crossref
Kenneth W Price, Thomas A Albini & Steven Yeh. (2020) Suprachoroidal Injection of Triamcinolone—Review of a Novel Treatment for Macular Edema Caused by Noninfectious Uveitis. US Ophthalmic Review 13:2, pages 76.
Crossref
Ji Liu & Claudia A. Arrigg. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 20 .
Shane Griffin, Timothy Boyce, Beth Edmunds, William Hills, Marjorie Grafe & Shandiz Tehrani. (2019) Endogenous hypercortisolism inducing reversible ocular hypertension. American Journal of Ophthalmology Case Reports 16, pages 100573.
Crossref
Thania Bogarin, Sindhu Saraswathy, Goichi Akiyama, Xiaobin Xie, Robert N. Weinreb, Jie Zheng & Alex S. Huang. (2019) Cellular and cytoskeletal alterations of scleral fibroblasts in response to glucocorticoid steroids. Experimental Eye Research 187, pages 107774.
Crossref
Ayesha Mohd Zain, Umi K. Md Noh, Salina Hussein, Jemaima Che Hamzah, Safinaz Mohd Khialdin & Norshamsiah Md Din. (2019) The Relationship Between Long-term Use of Intranasal Corticosteroid and Intraocular Pressure. Journal of Glaucoma 28:4, pages 321-324.
Crossref
Xavier Gasull, Marta Castany, Aida Castellanos, Mikel Rezola, Alba Andrés-Bilbé, Maria Isabel Canut, Raúl Estévez, Teresa Borrás & Núria Comes. (2019) The LRRC8-mediated volume-regulated anion channel is altered in glaucoma. Scientific Reports 9:1.
Crossref
Kevin Taliaferro, Alexander Crawford, Justin Jabara, Jonathan Lynch, Edward Jung, Raimonds Zvirbulis & Trevor Banka. (2018) Intraocular Pressure Increases After Intraarticular Knee Injection With Triamcinolone but Not Hyaluronic Acid. Clinical Orthopaedics & Related Research 476:7, pages 1420-1425.
Crossref
Saeed Shokoohi-Rad, Ramin Daneshvar, Mahsa Jafarian-Shahri & Parisa Rajaee. (2018) Comparison between Betamethasone, Fluorometholone and Loteprednol Etabonate on intraocular pressure in patients after keratorefractive surgery. Journal of Current Ophthalmology 30:2, pages 130-135.
Crossref
Sze Wan Shan, Chi Wai Do, Thomas Chuen Lam, Ricky Pak Wing Kong, King Kit Li, Ka Man Chun, William Daniel Stamer & Chi Ho To. (2017) New Insight of Common Regulatory Pathways in Human Trabecular Meshwork Cells in Response to Dexamethasone and Prednisolone Using an Integrated Quantitative Proteomics: SWATH and MRM-HR Mass Spectrometry. Journal of Proteome Research 16:10, pages 3753-3765.
Crossref
Sarah D. Ahadome, Chi Zhang, Elizabeth Tannous, James Shen & Jie J. Zheng. (2017) Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells. Experimental Cell Research 357:1, pages 116-123.
Crossref
Jaclyn Y. Bermudez, Michela Montecchi-Palmer, Weiming Mao & Abbot F. Clark. (2017) Cross-linked actin networks (CLANs) in glaucoma. Experimental Eye Research 159, pages 16-22.
Crossref
Ilya Rybkin, Rosana Gerometta, Gabrielle Fridman, Oscar Candia & John Danias. (2017) Model systems for the study of steroid-induced IOP elevation. Experimental Eye Research 158, pages 51-58.
Crossref
W. Daniel Stamer & Abbot F. Clark. (2017) The many faces of the trabecular meshwork cell. Experimental Eye Research 158, pages 112-123.
Crossref
Brenda Nuyen, Robert N. Weinreb & Shira L. Robbins. (2017) Steroid-induced glaucoma in the pediatric population. Journal of American Association for Pediatric Ophthalmology and Strabismus 21:1, pages 1-6.
Crossref
Priyadarshini Mishra, AlokPratap Singh, Vikas Kanaujia, Rachna Agarwal, Prabhaker Mishra, Ashwani Guleria & Alka Tripathi. (2017) Intraocular pressure and its correlation with midnight plasma cortisol level in Cushing's disease and other endogenous Cushing's syndrome. Indian Journal of Ophthalmology 65:9, pages 826.
Crossref
A. Sethi & A.F. Clark. 2017. Reference Module in Neuroscience and Biobehavioral Psychology. Reference Module in Neuroscience and Biobehavioral Psychology.
Allyson A. Gosling, Julie A. Kiland, Lauren E. Rutkowski, Adam Hoefs, Norman Matthew Ellinwood & Gillian J. McLellan. (2016) Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats. Veterinary Ophthalmology 19, pages 69-76.
Crossref
Deborah M. Wallace & Colm J. O'Brien. (2016) The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma. Experimental Eye Research 142, pages 102-109.
Crossref
Darryl R. Overby & Abbot F. Clark. (2015) Animal models of glucocorticoid-induced glaucoma. Experimental Eye Research 141, pages 15-22.
Crossref
Deborah M. WallaceOlya PokrovskayaColm J. O'Brien. (2015) The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma. Journal of Ocular Pharmacology and Therapeutics 31:7, pages 386-395.
Crossref
Norhafiza Razali, Renu Agarwal, Puneet Agarwal, Marina Y Kapitonova, Methil Kannan Kutty, Alexey Smirnov, Nor Salmah Bakar & Nafeeza M. Ismail. (2015) Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs. European Journal of Pharmacology 749, pages 73-80.
Crossref
Mohamed S. Sayed & Richard K. Lee. (2015) Current Management Approaches for Uveitic Glaucoma. International Ophthalmology Clinics 55:3, pages 141-160.
Crossref
Vincenzo Maurino & Francesco Aiello. 2015. New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System, Part B. New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System, Part B 271 295 .
Chelvin C.A. Sng, Marcus Ang & Keith Barton. 2015. New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System, Part B. New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System, Part B 243 269 .
Deborah M. Wallace, Joanne E. Murphy-Ullrich, J. Crawford Downs & Colm J. O'Brien. (2014) The role of matricellular proteins in glaucoma. Matrix Biology 37, pages 174-182.
Crossref
You Ra KimWan Seok KangEui Yong KweonNam Chun ChoDong Wook Lee. (2014) Steroid-Induced Ocular Hypertension Model in the Mice. Journal of the Korean Ophthalmological Society 55:8, pages 1202.
Crossref
Jung Bin HanKyung Hoon SeoSeung-Young Yu. (2014) The Effect of Prophylactic IOP-Lowering Medication after Intravitreal Dexamethasone Implantation. Journal of the Korean Ophthalmological Society 55:12, pages 1828.
Crossref
Nikolaos Kopsachilis, Konstantinos T. Tsaousis, Ioannis T. Tsinopoulos, Friedrich E. Kruse & Ulrich Welge-Lüssen. (2012) Human anterior lens capsule serving as a substrate for human trabecular meshwork cells cultivation. Cell and Tissue Banking 14:3, pages 407-412.
Crossref
Sandeep Kumar, Shaily Shah, Hai Michael Tang, Matthew Smith, Teresa Borrás & John Danias. (2013) Tissue Plasminogen Activator in Trabecular Meshwork Attenuates Steroid Induced Outflow Resistance in Mice. PLoS ONE 8:8, pages e72447.
Crossref
Konstantinos T Tsaousis, Nikolaos Kopsachilis, Ioannis T Tsinopoulos, Stavros A Dimitrakos, Friedrich E Kruse & Ulrich Welge-Luessen. (2013) Time-dependent morphological alterations and viability of cultured human trabecular cells after exposure to Trypan blue. Clinical & Experimental Ophthalmology 41:5, pages 484-490.
Crossref
Weerawat Kiddee, Graham E. Trope, Lisa Sheng, Laura Beltran-Agullo, Michael Smith, M. Hermina Strungaru, Jasrajbir Baath & Yvonne M. Buys. (2013) Intraocular Pressure Monitoring Post Intravitreal Steroids: A Systematic Review. Survey of Ophthalmology 58:4, pages 291-310.
Crossref
Yisheng Zhong, Jing Wang & Xunda Luo. (2013) Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma. BioMed Research International 2013, pages 1-8.
Crossref
Theofilos Tourtas, Marco T. Birke, Friedrich E. Kruse, Ulrich-Christoph Welge-Lüssen & Kerstin Birke. (2012) Preventive Effects of Omega-3 and Omega-6 Fatty Acids on Peroxide Mediated Oxidative Stress Responses in Primary Human Trabecular Meshwork Cells. PLoS ONE 7:2, pages e31340.
Crossref
Haeng Ku KangHee Seung Chin. (2012) Complications after Intravitreal Triamcinolone Acetonide Injection: Incidence and Risk Factors. Journal of the Korean Ophthalmological Society 53:1, pages 76.
Crossref
Christian Albrecht May. (2012) Could Mineralocorticoids Play a Role in the Pathophysiology of Open Angle Glaucoma?. Journal of Ophthalmology 2012, pages 1-5.
Crossref
Eranga N. Vithana, Tin Aung, Chiea Chuen Khor, Belinda K. Cornes, Wan-Ting Tay, Xueling Sim, Raghavan Lavanya, Renyi Wu, Yingfeng Zheng, Martin L. Hibberd, Kee Seng Chia, Mark Seielstad, Liang Kee Goh, Seang-Mei Saw, E. Shyong Tai & Tien Y. Wong. (2011) Collagen-related genes influence the glaucoma risk factor, central corneal thickness. Human Molecular Genetics 20:4, pages 649-658.
Crossref
Sarojini Vijayasekaran, Ian L. McAllister, William H. Morgan, Kanishka R. Mendis, Paul G. McMenamin, Stephen J. Cringle & Dao-Yi Yu. (2010) Intravitreal triamcinolone acetonide induced changes in the anterior segment in a pig model of branch retinal vein occlusion. Graefe's Archive for Clinical and Experimental Ophthalmology 249:2, pages 215-222.
Crossref
B'Ann True Gabelt & Paul L. Kaufman. 2011. Adler's Physiology of the Eye. Adler's Physiology of the Eye 274 307 .
Abbot F Clark, Xinyu Zhang & Thomas Yorio. 2010. Ocular Disease. Ocular Disease 146 152 .
Amy Lewis Hennessy & Alan L. Robin. 2010. The Glaucoma Book. The Glaucoma Book 989 993 .
N.C. Wade, I. Grierson, S. O'Reilly, M.J. Hoare, K.P.B. Cracknell, L.I. Paraoan, D. Brotchie & A.F. Clark. (2009) Cross-linked actin networks (CLANs) in bovine trabecular meshwork cells. Experimental Eye Research 89:5, pages 648-659.
Crossref
Ahmed Sallam, Hiten G. Sheth, Zohar Habot-Wilner & Susan Lightman. (2009) Outcome of Raised Intraocular Pressure in Uveitic Eyes with and without a Corticosteroid-Induced Hypertensive Response. American Journal of Ophthalmology 148:2, pages 207-213.e1.
Crossref
Abbot F. Clark & Robert J. Wordinger. (2009) The role of steroids in outflow resistance. Experimental Eye Research 88:4, pages 752-759.
Crossref
Adel M. Malek, Chang Xu, Edward S. Kim & Seth L. Alper. (2007) Hypertonicity triggers RhoA-dependent assembly of myosin-containing striated polygonal actin networks in endothelial cells. American Journal of Physiology-Cell Physiology 292:5, pages C1645-C1659.
Crossref
Mitchell D. McCartney, David Cantu-Crouch & Abbot F. Clark. (2006) Freeze-fracture examination of cultured human trabecular meshwork cells: Effect of dexamethasone. Experimental Eye Research 82:6, pages 994-1001.
Crossref
J P Kersey & D C Broadway. (2005) Corticosteroid-induced glaucoma: a review of the literature. Eye 20:4, pages 407-416.
Crossref
Abbot F. Clark, Daniel Brotchie, A. Thomas Read, Peggy Hellberg, Sherry English‐Wright, Iok‐Hou Pang, C. Ross Ethier & Ian Grierson. (2004) Dexamethasone alters F‐actin architecture and promotes cross‐linked actin network formation in human trabecular meshwork tissue. Cell Motility 60:2, pages 83-95.
Crossref
Velota C.T. Sung & Keith Barton. (2004) Management of inflammatory glaucomas. Current Opinion in Ophthalmology 15:2, pages 136-140.
Crossref
Xinyu Zhang, Raghu R Krishnamoorthy, Ganesh Prasanna, Santosh Narayan, Abbot Clark & Thomas Yorio. (2003) Dexamethasone regulates endothelin-1 and endothelin receptors in human non-pigmented ciliary epithelial (HNPE) cells. Experimental Eye Research 76:3, pages 261-272.
Crossref
Ramesh C Tripathi, Brenda J Tripathi & Chris Haggerty. (2003) Drug-Induced Glaucomas. Drug Safety 26:11, pages 749-767.
Crossref
John H Fingert, Edwin M Stone, Val C Sheffield & Wallace L.M Alward. (2002) Myocilin Glaucoma. Survey of Ophthalmology 47:6, pages 547-561.
Crossref
Todd Shearer & Craig E Crosson. (2001) Activation of Extracellular Signal-regulated Kinase in Trabecular Meshwork Cells. Experimental Eye Research 73:1, pages 25-35.
Crossref
H.THOMAS STEELY Jr, SHERRY L. ENGLISH-WRIGHT & ABBOT F. CLARK. (2000) The Similarity of Protein Expression in Trabecular Meshwork and Lamina Cribrosa: Implications for Glaucoma. Experimental Eye Research 70:1, pages 17-30.
Crossref
Johnnie L. Underwood, Collin G. Murphy, Janet Chen, Linda Franse-Carman, Irmgard Wood, David L. Epstein & Jorge A. Alvarado. (1999) Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. American Journal of Physiology-Cell Physiology 277:2, pages C330-C342.
Crossref
Robert J Wordinger & Abbot F Clark. (1999) Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma. Progress in Retinal and Eye Research 18:5, pages 629-667.
Crossref
Elke Lütjen-Drecoll. (1999) Functional morphology of the trabecular meshwork in primate eyes. Progress in Retinal and Eye Research 18:1, pages 91-119.
Crossref
JAIME E. DICKERSON, JR, H.THOMAS STEELY, JR, SHERRY L. ENGLISH-WRIGHT & ABBOT F. CLARK. (1998) The Effect of Dexamethasone on Integrin and Laminin Expression in Cultured Human Trabecular Meshwork Cells. Experimental Eye Research 66:6, pages 731-738.
Crossref
E.TIMOTHY O'BRIEN, MICHAEL KINCH, TIMOTHY W. HARDING & DAVID L. EPSTEIN. (1997) A Mechanism for Trabecular Meshwork Cell Retraction: Ethacrynic Acid Initiates the Dephosphorylation of Focal Adhesion Proteins. Experimental Eye Research 65:4, pages 471-483.
Crossref
W R Lee. (1995) The pathology of the outflow system in primary and secondary glaucoma. Eye 9:1, pages 1-23.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.