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Original Article

DNA single strand breaks in human lens epithelial cells from patients with cataract

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Pages 423-431 | Received 14 Sep 1992, Accepted 07 Apr 1993, Published online: 02 Jul 2009

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Lukasz Laskowski, David Williams, Colin Seymour & Carmel Mothersill. (2022) Environmental and industrial developments in radiation cataractogenesis. International Journal of Radiation Biology 98:6, pages 1074-1082.
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S. G. R. Barnard, J. Moquet, S. Lloyd, M. Ellender, E. A. Ainsbury & R. A. Quinlan. (2018) Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage. International Journal of Radiation Biology 94:12, pages 1116-1124.
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Özlem Erol Tinaztepe, Mustafa Ay & Eray Eser. (2017) Nuclear and Mitochondrial DNA of Age-Related Cataract Patients Are Susceptible to Oxidative Damage. Current Eye Research 42:4, pages 583-588.
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Usha P. Andley, Zheng Song & David L. Mitchell. (1999) DNA repair and survival in human lens epithelial cells with extended lifespan. Current Eye Research 18:3, pages 224-230.
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Articles from other publishers (49)

Risa Yamaoka, Fumito Kanada, Masaya Nagaya, Masaru Takashima, Yoshihiro Takamura, Masaru Inatani & Masaya Oki. (2022) Analysis of cataract-regulated genes using chemical DNA damage induction in a rat ex vivo model. PLOS ONE 17:12, pages e0273456.
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Claudia Hartley & Rui Pedro Rodrigues Oliveira. 2022. Wild and Exotic Animal Ophthalmology. Wild and Exotic Animal Ophthalmology 215 268 .
Gabriel E. Matos-Rodrigues & Rodrigo A. P. Martins. (2021) An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo. Frontiers in Cell and Developmental Biology 9.
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Elizabeth A. Ainsbury & Stephen G.R. Barnard. (2021) Sensitivity and latency of ionising radiation-induced cataract. Experimental Eye Research 212, pages 108772.
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Xiao-Dong Gong, Yan Wang, Xue-Bin Hu, Shu-Yu Zheng, Jia-Ling Fu, Qian Nie, Ling Wang, Min Hou, Jia-Wen Xiang, Yuan Xiao, Qian Gao, Yue-Yue Bai, Yi-Zhi Liu & David Wan-Cheng Li. (2021) Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance. Aging 13:13, pages 17568-17591.
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Hongqiu Zhang, Manmohan Singh, Achuth Nair, Kirill V. Larin & Salavat R. Aglyamov. (2021) Elasticity Changes in the Crystalline Lens during Oxidative Damage and the Antioxidant Effect of Alpha-Lipoic Acid Measured by Optical Coherence Elastography. Photonics 8:6, pages 207.
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S. G. R. Barnard, R. McCarron, M. Mancuso, I. De Stefano, S. Pazzaglia, D. Pawliczek, C. Dalke & E. A. Ainsbury. (2021) Radiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/–) and Ercc2(+/–) Mutated Mice. Radiation Research 197:1.
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Fang‐Yuan Liu, Jia‐Ling Fu, Ling Wang, Qian Nie, Zhongwen Luo, Min Hou, Yuan Yang, Xiao‐Dong Gong, Yan Wang, Yuan Xiao, Jiawen Xiang, Xuebin Hu, Lan Zhang, Mingxing Wu, Weirong Chen, Bing Cheng, Lixia Luo, Xinyu Zhang, Xialin Liu, Danying Zheng, Shengsong Huang, Yizhi Liu & David Wan‐Cheng Li. (2020) Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses. Aging Cell 19:10.
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Martin Kreuzer, Tanja Dučić, Marko Hawlina & Sofija Andjelic. (2020) Synchrotron-based FTIR microspectroscopy of protein aggregation and lipids peroxidation changes in human cataractous lens epithelial cells. Scientific Reports 10:1.
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Belal I. Hanafy, Gareth W. V. Cave, Yvonne Barnett & Barbara Pierscionek. (2020) Treatment of Human Lens Epithelium with High Levels of Nanoceria Leads to Reactive Oxygen Species Mediated Apoptosis. Molecules 25:3, pages 441.
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Lihua Kang, Xi Zou, Guowei Zhang, Jing Xiang, Yong Wang, Mei Yang, Xiang Chen, Jian Wu & And Huaijin Guan. (2019) A variant in a microRNA binding site in NEIL2 3′UTR confers susceptibility to age‐related cataracts. The FASEB Journal 33:9, pages 10469-10476.
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Stephen G. R. Barnard, Roisin McCarron, Jayne Moquet, Roy Quinlan & Elizabeth Ainsbury. (2019) Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens. Scientific Reports 9:1.
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Qian Nie, Ling Wang, Xiaodong Gong, Jia-Wen Xiang, Yuan Xiao, Jie Xie, Lan Yang, Huimin Chen, Yuwen Gan, Zhigang Chen & David Wan-Cheng Li. (2019) Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis. Current Molecular Medicine 18:8, pages 542-549.
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Hesham M. Elmazar, Ibrahim Elmadbouh, Sameh S. Mandour, Gehad M. Al Ariny & Asmaa M. Ibrahim. (2018) Association between cataract progression and ischemia-modified albumin in relation to oxidant–antioxidant profiles in the serum, aqueous humor, and lens. Journal of Cataract and Refractive Surgery 44:2, pages 134-139.
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Caroline S. Cencer, Shravan K. Chintala, Tenira J. Townsend, Daniel P. Feldmann, Mirna A. Awrow, Nahrain A. Putris, Mason E. Geno, Maria G. Donovan & Frank J. Giblin. (2018) PARP-1/PAR Activity in Cultured Human Lens Epithelial Cells Exposed to Two Levels of UVB Light. Photochemistry and Photobiology 94:1, pages 126-138.
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Yong Wang, Junfang Zhang, Jian Wu & Huaijin Guan. (2017) Expression of DNA repair genes in lens cortex of age-related cortical cataract. Experimental and Molecular Pathology 102:2, pages 219-223.
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Mark L. Wang, C. Edward Hoffler, Asif M. Ilyas, William H. Kirkpatrick, Pedro K. Beredjiklian & Charles F. Leinberry. (2016) Hand Surgery and Fluoroscopic Eye Radiation Dosage. HAND 12:1, pages 21-25.
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Wenjuan Zhao, Wenqing Zhao, Jun Zhao, Dong Wang & Jinghai Li. (2015) Screening of potential target genes for cataract by analyzing mRNA expression profile of mouse Hsf4-null lens. BMC Ophthalmology 15:1.
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Shakila Tobwala, Humeyra Karacal & Nuran Ercal. 2015. Studies on the Cornea and Lens. Studies on the Cornea and Lens 327 359 .
Shakila Tobwala, Eylem Y. Pinarci, Yasaswi Maddirala & Nuran Ercal. (2014) N-acetylcysteine amide protects against dexamethasone-induced cataract related changes in cultured rat lenses. Advances in Biological Chemistry 04:01, pages 26-34.
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Shengqun Jiang, Nan Hu, Jing Zhou, Junfang Zhang, Ruifang Gao, Jianyan Hu & Huaijin Guan. (2013) Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population. AGE 35:6, pages 2435-2444.
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Øyvind Osnes-Ringen, Amaia O. Azqueta, Morten C. Moe, Charlotta Zetterström, Magnus Røger, Bjørn Nicolaissen & Andrew R. Collins. (2013) DNA damage in lens epithelium of cataract patients in vivo and ex vivo . Acta Ophthalmologica 91:7, pages 652-656.
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Dong Chang, Xuefei Zhang, Shengzhong Rong, Qian Sha, Peipei Liu, Tao Han & Hongzhi Pan. (2013) Serum Antioxidative Enzymes Levels and Oxidative Stress Products in Age-Related Cataract Patients. Oxidative Medicine and Cellular Longevity 2013, pages 1-7.
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N.J. Kleiman. (2012) Radiation cataract. Annals of the ICRP 41:3-4, pages 80-97.
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Yi Jia, Yi Li, Shaoqing Du & Kaixun Huang. (2012) Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-induced apoptosis in human lens epithelial cells. Experimental Eye Research 100, pages 7-16.
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Mark A. Babizhayev. (2011) Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open‐angle glaucoma: challenges of dual combination therapy with N ‐acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine . Fundamental & Clinical Pharmacology 26:1, pages 86-117.
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F.A. Stewart, A.V. Akleyev, M. Hauer-Jensen, J.H. Hendry, N.J. Kleiman, T.J. MacVittie, B.M. Aleman, A.B. Edgar, K. Mabuchi, C.R. Muirhead, R.E. Shore & W.H. Wallace. (2012) ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context. Annals of the ICRP 41:1-2, pages 1-322.
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R. Michael & A. J. Bron. (2011) The ageing lens and cataract: a model of normal and pathological ageing. Philosophical Transactions of the Royal Society B: Biological Sciences 366:1568, pages 1278-1292.
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Mark A. Babizhayev, Khava S. Vishnyakova & Yegor E. Yegorov. (2011) Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous. Fundamental & Clinical Pharmacology 25:2, pages 139-162.
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Orhan Ates, Hakan Hamit Alp, Ibrahim Kocer, Orhan Baykal & İlknur A. Salman. (2010) Oxidative DNA damage in patients with cataract. Acta Ophthalmologica 88:8, pages 891-895.
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Yun-Gui Yang, Pierre-Olivier Frappart, Lucien Frappart, Zhao-Qi Wang & Wei-Min Tong. (2006) A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis. DNA Repair 5:8, pages 885-893.
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