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Original Article

Expression of wound healing and stress-related proteins in keratoconus corneas

, , , &
Pages 1124-1131 | Received 15 Mar 1996, Accepted 11 Jul 1996, Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

I-Ping Loh & Trevor Sherwin. (2022) Is Keratoconus an Inflammatory Disease? The Implication of Inflammatory Pathways. Ocular Immunology and Inflammation 30:1, pages 246-255.
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Karim Mahmoud Nabil, Ghada Mohamed Elhady & Heba Morsy. (2019) The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population. Clinical Ophthalmology 13, pages 2217-2223.
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Isabella M Y Cheung, Charles N J Mcghee & Trevor Sherwin. (2014) Beneficial effect of the antioxidant riboflavin on gene expression of extracellular matrix elements, antioxidants and oxidases in keratoconic stromal cells. Clinical and Experimental Optometry 97:4, pages 349-355.
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Isabella My Cheung, Charles Nj Mcghee & Trevor Sherwin. (2014) Deficient repair regulatory response to injury in keratoconic stromal cells. Clinical and Experimental Optometry 97:3, pages 234-239.
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Isabella My Cheung, Charles Nj Mcghee & Trevor Sherwin. (2013) A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species‐associated processes. Clinical and Experimental Optometry 96:2, pages 188-196.
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Sivaraman A. Balasubramanian, David C. Pye & Mark D. P. Willcox. (2010) Are Proteinases the Reason for Keratoconus?. Current Eye Research 35:3, pages 185-191.
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K. Maurer James, Ronald D. Parker & J. CARR GREGORY. (2000) Differences in Corneal Cytokine Levels with Surfactant-Induced Ocular Irritation in Rats. Journal of Toxicology: Cutaneous and Ocular Toxicology 19:1, pages 3-20.
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Michelle Kurpakus Wheater, Karen A. Kernacki & Linda D. Hazlett. (1999) Corneal cell proteins and ocular surface pathology. Biotechnic & Histochemistry 74:3, pages 146-159.
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Articles from other publishers (48)

Rohit Shetty, Pooja Khamar, Gairik Kundu, Arkasubhra Ghosh & Swaminathan Sethu. 2023. Keratoconus. Keratoconus 159 168 .
K Sooraj, Swati Shukla, Ranjeet Kaur, Jeewan Singh Titiyal & Jasbir Kaur. (2022) The protective role of HSP27 in ocular diseases. Molecular Biology Reports 49:6, pages 5107-5115.
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Maite López-López, Uxía Regueiro, Susana Belén Bravo, María del Pilar Chantada-Vázquez, Carmen Pena, Elío Díez-Feijoo, Pablo Hervella & Isabel Lema. (2022) Shotgun Proteomics for the Identification and Profiling of the Tear Proteome of Keratoconus Patients. Investigative Opthalmology & Visual Science 63:5, pages 12.
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Paulina Escandon, Angela Liu, Sarah E. Nicholas, Asher Khan, Kamran M. Riaz & Dimitrios Karamichos. (2022) Unravelling Novel Roles of Salivary Exosomes in the Regulation of Human Corneal Stromal Cell Migration and Wound Healing. International Journal of Molecular Sciences 23:8, pages 4330.
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Xiao-Dan Hao, Hua Gao, Wen-Hua Xu, Chan Shan, Ying Liu, Zhi-Xia Zhou, Kun Wang & Pei-Feng Li. (2022) Systematically Displaying the Pathogenesis of Keratoconus via Multi-Level Related Gene Enrichment-Based Review. Frontiers in Medicine 8.
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Somasheila I. Murthy, Dilip K. Mishra & Varsha M. Rathi. 2022. Keratoconus. Keratoconus 31 43 .
Huan Zhang, Xiupeng Cao, Ying Liu, Peihong Wang & Xuan Li. (2021) Tear Levels of Inflammatory Cytokines in Keratoconus: A Meta-Analysis of Case-Control and Cross-Sectional Studies. BioMed Research International 2021, pages 1-17.
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Г.В. Ситник. (2021) Pathogenesis and Tear Cytokine Expression in Keratoconus. Review of Literature. Офтальмология. Восточная Европа:4, pages 532-543.
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César Carriazo & María José Cosentino. 2021. New Frontiers for the Treatment of Keratoconus. New Frontiers for the Treatment of Keratoconus 123 137 .
Rohit Shetty, Sharon D'Souza, Pooja Khamar, Arkasubhra Ghosh, Rudy M.M.A. NuijtsSwaminathan Sethu. (2020) Biochemical Markers and Alterations in Keratoconus. Asia-Pacific Journal of Ophthalmology 9:6, pages 533-540.
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Hossein Aghamollaei, Shahram Parvin & Alireza Shahriary. (2020) Review of proteomics approach to eye diseases affecting the anterior segment. Journal of Proteomics 225, pages 103881.
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Eleftherios Loukovitis, Nikolaos Kozeis, Zisis Gatzioufas, Athina Kozei, Eleni Tsotridou, Maria Stoila, Spyros Koronis, Konstantinos Sfakianakis, Paris Tranos, Miltiadis Balidis, Zacharias Zachariadis, Dimitrios G. Mikropoulos, George Anogeianakis, Andreas Katsanos & Anastasios G. Konstas. (2019) The Proteins of Keratoconus: a Literature Review Exploring Their Contribution to the Pathophysiology of the Disease. Advances in Therapy 36:9, pages 2205-2222.
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Cezmi Dogan, Samira Hagverdiyeva, Burak Mergen & Guzin İskeleli. (2018) Effect of the Rigid Gas-Permeable Contact Lens Use on the Endothelial Cells in Patients With Keratoconus. Eye & Contact Lens: Science & Clinical Practice 44:2, pages S314-S317.
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Neeru A. Vallabh, Vito Romano & Colin E. Willoughby. (2017) Mitochondrial dysfunction and oxidative stress in corneal disease. Mitochondrion 36, pages 103-113.
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E. César Carriazo & María José Cosentino. (2017) Corneal Lifting New Approach in the Treatment of Corneal Ectasia. Highlights of Ophthalmology 45:3ENG, pages 10-17.
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Trevor Sherwin, Salim Ismail, I-Ping Loh & Jennifer Jane McGhee. 2017. Keratoconus. Keratoconus 25 41 .
Peng Song, Shuting Wang, Peicheng Zhang, Wenjie Sui, Yangyang Zhang, Ting Liu & Hua Gao. (2016) The Superficial Stromal Scar Formation Mechanism in Keratoconus: A Study Using Laser Scanning In Vivo Confocal Microscopy. BioMed Research International 2016, pages 1-10.
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Robert P.L. Wisse, Jonas J.W. Kuiper, Renze Gans, Saskia Imhof, Timothy R.D.J. Radstake & Allegonda Van der Lelij. (2015) Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review. The Ocular Surface 13:4, pages 272-283.
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Rana Sorkhabi, Amir Ghorbanihaghjo, Nazli Taheri & Mohammad Hosein Ahoor. (2014) Tear film inflammatory mediators in patients with keratoconus. International Ophthalmology 35:4, pages 467-472.
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V Galvis, T Sherwin, A Tello, J Merayo, R Barrera & A Acera. (2015) Keratoconus: an inflammatory disorder?. Eye 29:7, pages 843-859.
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Jingjing You, Li Wen, Athena Roufas, Chris Hodge, Gerard Sutton & Michele C. Madigan. (2015) Expression of HGF and c-Met Proteins in Human Keratoconus Corneas. Journal of Ophthalmology 2015, pages 1-8.
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Ozgur Bulent Timucin, Mehmet Fatih Karadag, Adnan Cinal, Muntecep Asker, Selvi Asker & Damla Timucin. (2013) Assessment of corneal endothelial cell density in patients with keratoconus not using contact lenses. Contact Lens and Anterior Eye 36:2, pages 80-85.
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Dimitrios Karamichos, Ramin Zareian, Xiaoqing Guo, Audrey Hutcheon, Jeffrey Ruberti & James Zieske. (2012) Novel in Vitro Model for Keratoconus Disease. Journal of Functional Biomaterials 3:4, pages 760-775.
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Amit Jinabhai, Clare O’Donnell, Hema Radhakrishnan & Vincent Nourrit. (2012) Forward light scatter and contrast sensitivity in keratoconic patients. Contact Lens and Anterior Eye 35:1, pages 22-27.
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Bariah Mohd-Ali, Mustafa Abdu, Choong Yean Yaw & Norhani Mohidin. (2012) Clinical characteristics of keratoconus patients in Malaysia: a review from a cornea specialist centre. Journal of Optometry 5:1, pages 38-42.
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Ozgur Bulent Timucin, Mehmet Fatih Karadag & Adnan Cinal. (2011) Assessment of Keratocyte Density in Patients With Keratoconus Not Using Contact Lenses. Cornea 30:5, pages 576-579.
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M Cristina Kenney & Ronald N Gaster. 2010. Ocular Disease. Ocular Disease 42 48 .
Isabel Lema, Juan A Durán, Consuelo Ruiz, Elío Díez-Feijoo, Arantxa Acera & Jesús Merayo. (2008) Inflammatory Response to Contact Lenses in Patients With Keratoconus Compared With Myopic Subjects. Cornea 27:7, pages 758-763.
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Anders Behndig. 2008. Free Radicals in Ophthalmic Disorders. Free Radicals in Ophthalmic Disorders 55 70 .
Raja Narayanan, Ronald N Gaster & M Cristina Kenney. (2006) Pseudophakic Corneal Edema. Cornea 25:9, pages 993-1004.
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Biao Shi, Bin Han, Ivan R Schwab & R Rivkah Isseroff. (2006) UVB Irradiation-Induced Changes in the 27-kd Heat Shock Protein (HSP27) in Human Corneal Epithelial Cells. Cornea 25:8, pages 948-955.
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Marko Määttä, Timo Väisänen, Marja-Riitta Väisänen, Taina Pihlajaniemi & Timo Tervo. (2006) Altered Expression of Type XIII Collagen in Keratoconus and Scarred Human Cornea. Cornea 25:4, pages 448-453.
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Marko Määttä, Ritva Heljasvaara, Raija Sormunen, Taina Pihlajaniemi, Helena Autio-Harmainen & Timo Tervo. (2006) Differential Expression of Collagen Types XVIII/Endostatin and XV in Normal, Keratoconus, and Scarred Human Corneas. Cornea 25:3, pages 341-349.
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Biao Shi & R. Rivkah Isseroff. (2006) Arsenite pre-conditioning reduces UVB-induced apoptosis in corneal epithelial cells through the anti-apoptotic activity of 27 kDa heat shock protein (HSP27). Journal of Cellular Physiology 206:2, pages 301-308.
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Fu Shang & Allen Taylor. (2004) Function of the ubiquitin proteolytic pathway in the eye. Experimental Eye Research 78:1, pages 1-14.
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M.Cristina Kenney, Nadia Zorapapel, Shari Atilano, Marilyn Chwa, Alexander Ljubimov & Donald Brown. (2003) Insulin-like growth factor-I (IGF-I) and transforming growth factor-β (TGF-β) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. Experimental Eye Research 77:5, pages 537-546.
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M Cristina Kenney & Donald J Brown. (2003) The Cascade Hypothesis of Keratoconus. Contact Lens and Anterior Eye 26:3, pages 139-146.
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Uwe Pleyer & Christian Hartmann. (2003) Postoperative wound dehiscence. Ophthalmology 110:9, pages 1864-1865.
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Jay C Erie, Sanjay V Patel, Jay W McLaren, Cherie B Nau, David O Hodge & William M Bourne. (2002) Keratocyte density in keratoconus. A confocal microscopy studyaaInternetAdvance publication at ajo.com Sept 17, 2002.. American Journal of Ophthalmology 134:5, pages 689-695.
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Rajeev Buddi, Brian Lin, Shari R. Atilano, Nadia C. Zorapapel, M. Cristina Kenney & Donald J. Brown. (2016) Evidence of Oxidative Stress in Human Corneal Diseases. Journal of Histochemistry & Cytochemistry 50:3, pages 341-351.
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Susanne Pitz & Roland Moll. (2002) Intermediate-filament expression in ocular tissue. Progress in Retinal and Eye Research 21:2, pages 241-262.
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Alexander V. Ljubimov, Mehrnoosh Saghizadeh, Robert Pytela, Dean Sheppard & M. Cristina Kenney. (2016) Increased Expression of Tenascin-C-binding Epithelial Integrins in Human Bullous Keratopathy Corneas. Journal of Histochemistry & Cytochemistry 49:11, pages 1341-1350.
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M. Saghizadeh, M. Chwa, A. Aoki, B. Lin, A. Pirouzmanesh, D.J. Brown, A.V. Ljubimov & M.C. Kenney. (2001) Altered Expression of Growth Factors and Cytokines in Keratoconus, Bullous Keratopathy and Diabetic Human Corneas. Experimental Eye Research 73:2, pages 179-189.
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Kelly Wentz-Hunter, E. Lillian Cheng, Jun Ueda, Joel Sugar & Beatrice Y. J. T. Yue. (2001) Keratocan Expression Is Increased in the Stroma of Keratoconus Corneas. Molecular Medicine 7:7, pages 470-477.
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M. Christina Kenney, Marilyn Chwa, Brian Lin, Gang-Hua Huang, Alexander V. Ljubimov & Donald J. Brown. (2001) Identification of Cell Types in Human Diseased Corneas. Cornea 20:3, pages 309-316.
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ALEXANDER V. LJUBIMOV, SAUL A. ALBA, ROBERT E. BURGESON, YOSHIFUMI NINOMIYA, YOSHIKAZU SADO, TUNG-TIEN SUN, ANTHONY B. NESBURN, M.CRISTINA KENNEY & EZRA MAGUEN. (1998) Extracellular Matrix Changes in Human Corneas After Radial Keratotomy. Experimental Eye Research 67:3, pages 265-272.
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Tero Kivelä & Marita Uusitalo. (1998) Structure, development and function of cytoskeletal elements in non-neuronal cells of the Human Eye. Progress in Retinal and Eye Research 17:3, pages 385-428.
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R.Brent Whitelock, Yuhong Li, Lili Zhou, Joel Sugar & Beatrice Y.J.T. Yue. (1997) Expression of Transcription Factors in Keratoconus, a Cornea-Thinning Disease. Biochemical and Biophysical Research Communications 235:1, pages 253-258.
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