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Review

Th9: A New Player in Asthma Pathogenesis?

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Pages 115-125 | Published online: 07 Feb 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Peng Xiong, Tonglin Liu, Hao Huang, Yi Yuan, Wendi Zhang, Lina Fu & Yu Chen. (2022) IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance. Immunopharmacology and Immunotoxicology 44:5, pages 712-718.
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Qing Zhou, Yu Fu, Liangan Hu, Qian Li, Meng Jin & E. Jiang. (2018) Relationship of circulating chemerin and omentin levels with Th17 and Th9 cell immune responses in patients with asthma. Journal of Asthma 55:6, pages 579-587.
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Bessey Geevarghese & Adriana Weinberg. (2014) Cell-mediated immune responses to respiratory syncytial virus infection. Human Vaccines & Immunotherapeutics 10:4, pages 1047-1056.
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David Gibeon & Andrew N Menzies-Gow. (2012) Targeting interleukins to treat severe asthma. Expert Review of Respiratory Medicine 6:4, pages 423-439.
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Agnes Hamzaoui, Haïfa Maalmi, Anissa Berraïes, Hanadi Abid, Jamel Ammar & Kamel Hamzaoui. (2011) Transcriptional characteristics of CD4+ T cells in young asthmatic children: RORC and FOXP3 axis. Journal of Inflammation Research 4, pages 139-146.
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Shigeru Saito, Akitoshi Nakashima, Mika Ito & Tomoko Shima. (2011) Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology. Expert Review of Clinical Immunology 7:5, pages 649-657.
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Articles from other publishers (30)

He Zhao, Zhaowei Gu, Yunxiu Wang, Meng Wang, Yue Zhan, Xin Zhao & Zhiwei Cao. (2022) IL-9 neutralizing antibody suppresses allergic inflammation in ovalbumin-induced allergic rhinitis mouse model. Frontiers in Pharmacology 13.
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Nasser Al Busaidi, Adnan Alweqayyan, Ashraf Al Zaabi, Bassam Mahboub, Fatma Al-Huraish, Mansoor Hameed, Mona Al-Ahmad, Mousa Khadadah, Nabil Al Lawati, Nasser Behbehani, Omar Al Jabri, Reyad Salman, Saif Al Mubaihsi & Shadha Al Raisi. (2022) Gulf Asthma Diagnosis and Management in Adults: Expert Review and Recommendations. The Open Respiratory Medicine Journal 16:1.
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Haiyan Chen, Fangyuan Gao, Yi Bao, Jiaoyang Zheng, Liangliang Sun, Wei Tang, Junjie Zou & Yongquan Shi. (2021) Blimp-1 inhibits Th9 cell differentiation and attenuates diabetic coronary heart disease. International Immunopharmacology 95, pages 107510.
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Xinqi Wu, Wei Jiang, Xiaoli Wang, Chi Zhang, Jinlong Cai, Shuilian Yu, Jianhong Sun & Zhiliang Tian. (2020) SGK1 enhances Th9 cell differentiation and airway inflammation through NF-κB signaling pathway in asthma. Cell and Tissue Research 382:3, pages 563-574.
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Lucas Moreira Maia, Marcela Carvalho Espaladori, Julia Maria Braga Diniz, Warley Luciano Faria Tavares, Luciana Carla Neves de Brito, Leda Quércia Vieira & Antônio Paulino Ribeiro Sobrinho. (2020) Clinical endodontic procedures modulate periapical cytokine and chemokine gene expressions. Clinical Oral Investigations 24:10, pages 3691-3697.
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Kaustav Chowdhury, Uma Kumar, Soumabha Das, Jaydeep Chaudhuri, Prabin Kumar, Maumita Kanjilal, Parashar Ghosh, Geetabali Sircar, Ravi Kiran Basyal, Uma Kanga, Santu Bandyopadhaya & Dipendra Kumar Mitra. (2018) Synovial IL-9 facilitates neutrophil survival, function and differentiation of Th17 cells in rheumatoid arthritis. Arthritis Research & Therapy 20:1.
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Ashraf M. Hamza, Salma S. Omar, Reham A. H. Abo El-Wafa & Marwa J. Elatrash. (2017) Expression levels of transcription factor PU.1 and interleukin-9 in atopic dermatitis and their relation to disease severity and eruption types. International Journal of Dermatology 56:5, pages 534-539.
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Takashi Ito, Koichi Hirose, Ayako Norimoto, Tomohiro Tamachi, Masaya Yokota, Aiko Saku, Hiroaki Takatori, Shinobu Saijo, Yoichiro Iwakura & Hiroshi Nakajima. (2017) Dectin-1 Plays an Important Role in House Dust Mite–Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells. The Journal of Immunology 198:1, pages 61-70.
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Girolamo Pelaia, Alessandro Vatrella & Rosario MaselliGirolamo Pelaia, Alessandro Vatrella & Rosario Maselli. 2017. Asthma: Targeted Biological Therapies. Asthma: Targeted Biological Therapies 93 96 .
Wilmer Gerardo Rojas-Zuleta & Elizabeth Sanchez. 2017. Th9 Cells. Th9 Cells 21 35 .
Tatyana Gavrilova, Saritha Kartan, Lauren S. Sherman, Oleta A. Sandiford & Pranela Rameshwar. 2016. The Biology and Therapeutic Application of Mesenchymal Cells. The Biology and Therapeutic Application of Mesenchymal Cells 573 580 .
Chaoqian Li, Xiaohong Jiang, Mingjie Luo, Guangyi Feng, Qixiang Sun & Yiping Chen. (2016) Mycobacterium vaccae Nebulization Can Protect against Asthma in Balb/c Mice by Regulating Th9 Expression. PLOS ONE 11:8, pages e0161164.
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Wilmer Gerardo Rojas-Zuleta & Gloria Vásquez. (2016) Th9 lymphocytes: A recent history from IL-9 to its potential role in rheumatic diseases. Autoimmunity Reviews 15:7, pages 649-655.
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Vivekanandhan Aravindhan & Haridoss Madhumitha. (2016) Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses. Journal of Diabetes Research 2016, pages 1-10.
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Patrick D. Mitchell, Amani I. El-Gammal & Paul M. O’Byrne. 2017. Pharmacology and Therapeutics of Asthma and COPD. Pharmacology and Therapeutics of Asthma and COPD 131 152 .
PD Mitchell, AI El-Gammal & PM O'Byrne. (2016) Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma. Clinical Pharmacology & Therapeutics 99:1, pages 38-48.
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Fei Huang, Hong-mei Qiao, Jia-ning Yin, Yang Gao, Yang-hua Ju & Ya-nan Li. (2015) Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLOS ONE 10:11, pages e0141717.
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Tali Czarnowicki, Juana Gonzalez, Avner Shemer, Dana Malajian, Hui Xu, Xiuzhong Zheng, Saakshi Khattri, Patricia Gilleaudeau, Mary Sullivan-Whalen, Mayte Suárez-Fariñas, James G. Krueger & Emma Guttman-Yassky. (2015) Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population. Journal of Allergy and Clinical Immunology 136:1, pages 104-115.e7.
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Nora SILVA, Loreto ABUSLEME, Denisse BRAVO, Nicolás DUTZAN, Jocelyn GARCIA-SESNICH, Rolando VERNAL, Marcela HERNÁNDEZ & Jorge GAMONAL. (2015) Host response mechanisms in periodontal diseases. Journal of Applied Oral Science 23:3, pages 329-355.
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L Ma, H-B Xue, X-H Guan, C-M Shu, J-H Zhang & J Yu. (2014) Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis. Clinical and Experimental Immunology 175:1, pages 25-31.
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Rajamanickam Anuradha, Parakkal Jovvian George, Luke E. Hanna, Vedachalam Chandrasekaran, Paul Kumaran, Thomas B. Nutman & Subash Babu. (2013) IL-4–, TGF-β–, and IL-1–Dependent Expansion of Parasite Antigen-Specific Th9 Cells Is Associated with Clinical Pathology in Human Lymphatic Filariasis. The Journal of Immunology 191:5, pages 2466-2473.
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Jeremy C. Parker, Surendran Thavagnanam, Grzegorz Skibinski, Jeremy Lyons, Jennifer Bell, Liam G. Heaney & Michael D. Shields. (2013) Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model. PLoS ONE 8:5, pages e61023.
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Hong Li, Matthew L. Edin, J. Alyce Bradbury, Joan P. Graves, Laura M. DeGraff, Artiom Gruzdev, Jennifer Cheng, Ryan T. Dackor, Ping Ming Wang, Carl D. Bortner, Stavros Garantziotis, Anton M. Jetten & Darryl C. Zeldin. (2013) Cyclooxygenase-2 Inhibits T Helper Cell Type 9 Differentiation during Allergic Lung Inflammation via Down-regulation of IL-17RB. American Journal of Respiratory and Critical Care Medicine 187:8, pages 812-822.
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Stephanie M. Coomes, Victoria S. Pelly & Mark S. Wilson. (2013) Plasticity within the αβ + CD4 + T-cell lineage: when, how and what for? . Open Biology 3:1, pages 120157.
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Andreza Maria Fabio Aranha, Carlos Eduardo Repeke, Thiago Pompermaier Garlet, Andreia Espindola Vieira, Ana Paula Campanelli, Ana Paula Favaro Trombone, Ariadne Letra, Renato Menezes Silva & Gustavo Pompermaier Garlet. (2013) Evidence Supporting a Protective Role for Th9 and Th22 Cytokines in Human and Experimental Periapical Lesions. Journal of Endodontics 39:1, pages 83-87.
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Koa Hosoki, Akiko Nakamura, Mizuho Nagao, Yukiko Hiraguchi, Hisashi Tanida, Reiko Tokuda, Hideo Wada, Tsutomu Nobori, Shigeru Suga & Takao Fujisawa. (2012) Staphylococcus aureus directly activates eosinophils via platelet-activating factor receptor . Journal of Leukocyte Biology 92:2, pages 333-341.
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Akitoshi Nakashima, Tomoko Shima, Kumiko Inada, Mika Ito & Shigeru Saito. (2012) The Balance of the Immune System between T Cells and NK Cells in Miscarriage. American Journal of Reproductive Immunology 67:4, pages 304-310.
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Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma & Bing Xia. (2012) CD4 + T Cells: Differentiation and Functions . Clinical and Developmental Immunology 2012, pages 1-12.
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Peter J. Barnes. (2012) Severe asthma: Advances in current management and future therapy. Journal of Allergy and Clinical Immunology 129:1, pages 48-59.
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Matthew C. Catley, Julie Coote, Mohamed Bari & Kate L. Tomlinson. (2011) Monoclonal antibodies for the treatment of asthma. Pharmacology & Therapeutics 132:3, pages 333-351.
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