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Research Article

YKL-40 Protein is a Marker of Asthma

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Pages 767-772 | Published online: 08 Sep 2011

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Ilaria Campo, Michele Zorzetto & Francesco Bonella. (2015) Facts and promises on lung biomarkers in interstitial lung diseases. Expert Review of Respiratory Medicine 9:4, pages 437-457.
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João Rufo, Luís Taborda-Barata & Olga Lourenço. (2013) Serum biomarkers in elderly asthma. Journal of Asthma 50:10, pages 1011-1019.
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Ruilin Pan, Qingqing Li, Xuming Zhu, Ying Zhou, Ling Ding & Yubao Cui. (2021) Diagnostic value of YKL-40 for patients with asthma: A meta-analysis. Allergy and Asthma Proceedings 42:6, pages e167-e173.
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Emine Vezir, Ersoy Civelek, Emine Dibek Misirlioglu, Muge Toyran, Murat Capanoglu, Esra Karakus, Tamer Kahraman, Meltem Ozguner, Fatma Demirel, Ihsan Gursel & Can Naci Kocabas. (2021) Effects of Obesity on Airway and Systemic Inflammation in Asthmatic Children. International Archives of Allergy and Immunology 182:8, pages 679-689.
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Raj Rani & Varsha Singh. (2020) Overexpression of YKL-40 (CHI3L1 gene) in patient fluids may be a potential predictive marker for early detection of comorbidity in non-communicable disease. Medical Hypotheses 143, pages 110076.
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R GuanR LinR Jin, L Lu, X Liu, S Hu & L Sun. (2019) Chitinase-like protein YKL-40 regulates human bronchial epithelial cells proliferation, apoptosis, and migration through TGF-β1/Smads pathway. Human & Experimental Toxicology 39:4, pages 451-463.
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Chun-Wen Su, Mu-Kuan Chen, Wei-Chen Hung, Shun-Fa Yang, Chun-Yi Chuang & Chiao-Wen Lin. (2018) Functional variant of CHI3L1 gene is associated with neck metastasis in oral cancer. Clinical Oral Investigations 23:6, pages 2685-2694.
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Levi B. Richards, Anne H. Neerincx, Job J.M.H. van Bragt, Peter J. Sterk, Elisabeth H.D. Bel & Anke H. Maitland-van der Zee. (2018) Biomarkers and asthma management: analysis and potential applications. Current Opinion in Allergy & Clinical Immunology 18:2, pages 96-108.
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Wenjing Li & Mark C. Glaum. 2018. Severe Asthma. Severe Asthma 59 88 .
Bradley E. Chipps, Neil G. Parikh & Sheena K. Maharaj. (2017) Severe Asthma in Children. Current Allergy and Asthma Reports 17:4.
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Sarla Naglot, Praveen Aggarwal, Sharmistha Dey & Krishna Dalal. (2017) Estimation of Serum YKL-40 by Real-Time Surface Plasmon Resonance Technology in North-Indian Asthma Patients. Journal of Clinical Laboratory Analysis 31:2, pages e22028.
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I. D. Pavord, S. Afzalnia, A. Menzies-Gow & L. G. Heaney. (2017) The current and future role of biomarkers in type 2 cytokine-mediated asthma management. Clinical & Experimental Allergy 47:2, pages 148-160.
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Anna James & Gunilla Hedlin. (2016) Biomarkers for the Phenotyping and Monitoring of Asthma in Children. Current Treatment Options in Allergy 3:4, pages 439-452.
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XiaoYan Long, Hui Hu, Shuyu Li, Mingna Chen, Jizhang Cai & Bingxin Song. (2016) Hippocampal YKL-40 expression in rats after status epilepticus. Epilepsy Research 125, pages 52-57.
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Cong-Lin LiuHolger WemmelundYi WangMengyang LiaoJes S. LindholtSøren P. JohnsenHenrik VestergaardCleverson FernandesGalina K. SukhovaXiang ChengJin-Ying ZhangChongzhe YangXiaozhu HuangAlan DaughertyBruce D. LevyPeter LibbyGuo-Ping Shi. (2016) Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture. Arteriosclerosis, Thrombosis, and Vascular Biology 36:3, pages 570-578.
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Anna J. James, Lovisa E. Reinius, Marri Verhoek, Anna Gomes, Maciej Kupczyk, Ulf Hammar, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Elisabeth Bel, Juha Kere, Cilla Söderhäll, Barbro Dahlén, Rolf G. Boot & Sven-Erik Dahlén. (2016) Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine 193:2, pages 131-142.
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Ines Mack, Andreas Hector, Marlene Ballbach, Julius Kohlhäufl, Katharina J Fuchs, Alexander Weber, Marcus A Mall & Dominik Hartl. (2015) The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. Molecular and Cellular Pediatrics 2:1.
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Tianwen Lai, Min Chen, Zaichun Deng, Yingying Lǚ, Dong Wu, Dongming Li & Bin Wu. (2015) YKL-40 is correlated with FEV1 and the asthma control test (ACT) in asthmatic patients: influence of treatment. BMC Pulmonary Medicine 15:1.
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Sarla Naglot, Krishna Dalal, Praveen Aggarwal & Rima Dada. (2015) Association of CG Genotype at rs4950928 Promoter in CHI3L1 Gene with YKL-40 Levels and Asthma Susceptibility in North Indian Asthma Patients. Indian Journal of Clinical Biochemistry 30:4, pages 403-411.
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Sarah M. McCormick & Nicola M. Heller. (2015) Commentary: IL-4 and IL-13 receptors and signaling. Cytokine 75:1, pages 38-50.
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Stephania Libreros, Ramon Garcia-Areas, Patricia Keating, Nathalia Gazaniga, Philip Robinson, Alison Humbles & Vijaya L Iragavarapu-Charyulu. (2015) Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1. Journal of Leukocyte Biology 97:5, pages 929-940.
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Krzysztof Specjalski, Marta Chełmińska & Ewa Jassem. (2015) YKL-40 Protein Correlates with the Phenotype of Asthma. Lung 193:2, pages 189-194.
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Ismail Kocyigit, Ozkan Gungor, Ender Dogan, Serhat Karadavut, Cigdem Karakukcu, Eray Eroglu, Ozcan Orscelik, Aydin Unal, Ali Dogan, Murat Hayri Sipahioglu, Bulent Tokgoz & Oktay Oymak. (2015) The Serum YKL-40 Level is Associated with Vascular Injury and Predicts Proteinuria in Nephrotic Syndrome Patients. Journal of Atherosclerosis and Thrombosis 22:3, pages 257-264.
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Mads Emil Bjørn, Christen Lykkegaard Andersen, Morten Krogh Jensen & Hans C. Hasselbalch. (2014) Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state. European Journal of Haematology 93:3, pages 224-228.
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Farnaz Fatemi, Esmaeil Sadroddiny, Azam Gheibi, Taiebeh Mohammadi Farsani & Gholam Ali Kardar. (2014) Biomolecular markers in assessment and treatment of asthma. Respirology 19:4, pages 514-523.
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Su-qin Ben, Ya-li Qiu, Juan Zhou, Xiao-yu Zhou, Shan Zhang, Yi Wu, Shao-qing Ju & Song-shi Ni. (2013) Ovalbumin enhances YKL-40, IL-5, GM-CSF, and eotaxin expression simultaneously in primarily cultured mouse tracheal epithelial cells. In Vitro Cellular & Developmental Biology - Animal 50:3, pages 243-250.
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Stefano Guerra, Marilyn Halonen, Duane L. Sherrill, Claire Venker, Amber Spangenberg, Anne-elie Carsin, Lluïsa Tarès, Iris Lavi, Esther Barreiro, Jesús Martínez-Moratalla, Isabel Urrutia, Jordi Sunyer, Josep M. Antó & Fernando D. Martinez. (2013) The relation of circulating YKL-40 to levels and decline of lung function in adult life. Respiratory Medicine 107:12, pages 1923-1930.
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Aditi Sahu, Krishna Dalal, Sarla Naglot, Parveen Aggarwal & C. Murali Krishna. (2013) Serum Based Diagnosis of Asthma Using Raman Spectroscopy: An Early Phase Pilot Study. PLoS ONE 8:11, pages e78921.
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Chunyi Liu, Qi Li, Xiangdong Zhou, Victor P. Kolosov & Juliy M. Perelman. (2013) The chitinase-like protein YKL-40 increases mucin5AC production in human bronchial epithelial cells. Experimental Cell Research 319:18, pages 2866-2873.
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Michelino Di Rosa, Giulia Malaguarnera, Corinne De Gregorio, Filippo Drago & Lucia Malaguarnera. (2012) Evaluation of CHI3L-1 and CHIT-1 Expression in Differentiated and Polarized Macrophages. Inflammation 36:2, pages 482-492.
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N. D. Mygind, K. Iversen, L. Køber, J. P. Goetze, H. Nielsen, S. Boesgaard, M. Bay, J. S. Johansen, O. W. Nielsen, V. Kirk & J. Kastrup. (2012) The inflammatory biomarker YKL ‐40 at admission is a strong predictor of overall mortality . Journal of Internal Medicine 273:2, pages 205-216.
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