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Pharmacotherapy

Fluticasone/Formoterol Combination Therapy versus Budesonide/Formoterol for the Treatment of Asthma: A Randomized, Controlled, Non-Inferiority Trial of Efficacy and Safety

, M.D., , M.D., , M.D., , & , M.D.
Pages 1060-1070 | Published online: 26 Oct 2012

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Read on this site (9)

Rajesh Venkitakrishnan, MD, dnb, Prasanna Kumar Thomas, MD, Ankit Bansal, MD, dnb, Indranath Ghosh, MD, Jolsana Augustine, dtcd, dnb, R. Divya, md & Melcy Cleetus, dtcd, dnb. (2022) Fluticasone/formoterol compared with other ICS/LABAs in asthma: a systematic review. Journal of Asthma 59:6, pages 1221-1230.
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Satish Chandra Kilaru, Avya Gopal Bansal, Vaishali Sandeep Naik, Meena Lopez & Jaideep Ashok Gogtay. (2022) A review of the efficacy and safety of fluticasone propionate/formoterol fixed-dose combination. Expert Review of Respiratory Medicine 16:5, pages 529-540.
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Sebastien Boisseau, Murtaza Qasuri, Weng Tong Ho, Wrik Ghosh & Yacine Hadjiat. (2020) Perspective on the Budgetary Impact of FP/FORM pMDI on Treatment and Management of Exacerbation in Moderate-to-Severe Asthma Patients in Singapore. ClinicoEconomics and Outcomes Research 12, pages 567-577.
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A Papi, D Dokic, W Tzimas, I Mészáros, A Olech-Cudzik, Z Koroknai, K McAulay, S Mersmann, PS Dalvi & T Overend. (2017) Fluticasone propionate/formoterol for COPD management: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1961-1971.
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Hiroshi Chantaphakul & Kiat Ruxrungtham. (2016) Fixed-Dose combination of the inhaled corticosteroid and long-acting beta2-agonist therapy in adults with persistent asthma. Expert Opinion on Pharmacotherapy 17:5, pages 631-642.
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Theresa R Prosser & Suzanne G Bollmeier. (2015) Fluticasone-formoterol: a systematic review of its potential role in the treatment of asthma. Therapeutics and Clinical Risk Management 11, pages 889-899.
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Ricardo Antonio Tan & Jonathan Corren. (2014) Clinical utility and development of the fluticasone/formoterol combination formulation (Flutiform®) for the treatment of asthma. Drug Design, Development and Therapy 8, pages 1555-1561.
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David Price & Elizabeth V Hillyer. (2014) Fluticasone propionate/formoterol fumarate in fixed-dose combination for the treatment of asthma. Expert Review of Respiratory Medicine 8:3, pages 275-291.
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Articles from other publishers (34)

Yuji Oba, Sumayya Anwer, Tarang Patel, Tinashe Maduke & Sofia Dias. (2023) Addition of long-acting beta2 agonists or long-acting muscarinic antagonists versus doubling the dose of inhaled corticosteroids (ICS) in adolescents and adults with uncontrolled asthma with medium dose ICS: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2023:8.
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Sanjeeva Dissanayake, Gill MundinJo WoodwardMark LomaxPrashant Dalvi. (2023) Pharmacokinetic and Pharmacodynamic Comparison of Fluticasone Propionate/Formoterol Fumarate Administered via a Pressurized Metered-Dose Inhaler and a Novel Breath-Actuated Inhaler in Healthy Volunteers. Journal of Aerosol Medicine and Pulmonary Drug Delivery 36:2, pages 65-75.
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Yuji Oba, Sumayya Anwer, Tinashe Maduke, Tarang Patel & Sofia Dias. (2022) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying doses of inhaled corticosteroids in adolescents and adults with asthma: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2022:12.
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Ralph Brattsand & Olof Selroos. (2022) May a different kinetic mode explain the high efficacy/safety profile of inhaled budesonide?. Pulmonary Pharmacology & Therapeutics 77, pages 102167.
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Kittipong Maneechotesuwan, Dave Singh, Leandro G. Fritscher, Nese Dursunoglu, Abhijith P.G.Abhay Phansalkar, Bhumika Aggarwal, Emilio Pizzichini, Justyna Chorazy & Heather Burnett. (2022) Impact of inhaled fluticasone propionate/salmeterol on health-related quality of life in asthma: A network meta-analysis. Respiratory Medicine 203, pages 106993.
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Ashraf Elsayed Sileem, Ahmed Ali, Hanan Elnahas & Ahmed M. Gouda. (2021) Comparing the Asthma Control and Anti-inflammatory Effects of Different Fixed Combinations of Inhaled Corticosteroids Plus Long-acting Beta 2 Agonist; A Randomized Clinical Trial. Open Access Macedonian Journal of Medical Sciences 9:B, pages 771-778.
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Yee Vern Yong, Siti Hajar Mahamad Dom, Nurulmaya Ahmad Sa’ad, Rosliza Lajis, Faridah Aryani Md. Yusof & Jamalul Azizi Abdul Rahaman. (2021) Development and Practical Application of a Multiple-Criteria Decision Analysis Framework on Respiratory Inhalers: Is It Always Useful in the MOH Malaysia Medicines Formulary Listing Context?. MDM Policy & Practice 6:1, pages 238146832199406.
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V. Rajesh, Jolsana Augustine, R. Divya & Melcy Cleetus. (2020) Inhaled Formoterol-Fluticasone Single Inhaler Therapy in Asthma: Real-World Efficacy, Budget Impact, and Potential to Improve Adherence. Canadian Respiratory Journal 2020, pages 1-8.
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Renzheng Guan, Yanli Liu, Dunqiang Ren, Jinfeng Li, Tao Xu & Haiyan Hu. (2019) The efficacy and safety of fluticasone propionate/formoterol compared with fluticasone propionate/salmeterol in treating pediatric asthma: a systematic review and meta-analysis. Journal of International Medical Research 48:3, pages 030006051988944.
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Seong-Dae Woo, Young-Min Ye, Youngsoo Lee, So-Hee Lee, Yoo Seob Shin, Joo Hun ParkHyunna ChoiHyun-Young LeeHyun-Jung ShinHae-Sim Park. (2020) Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial. Allergy, Asthma & Immunology Research 12:3, pages 454.
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David B. Price, Victoria Carter, Jessica Martin, Elizabeth A. Gardener, Derek Skinner, Sen Yang, Matthias Hoffman, Jenna C. Willis & Andrew J. Cooper. (2019) Comparative Safety Profile of the Fixed-Dose Combination Corticosteroid and Long-acting β2-Agonist Fluticasone Propionate/Formoterol Fumarate: A 36-Month Longitudinal Cohort Study in UK Primary Care. Drugs 80:1, pages 47-60.
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Dominik Kappeler, Knut Sommerer, Claudius Kietzig, Bärbel Huber, Jo Woodward, Mark Lomax & Prashant Dalvi. (2018) Pulmonary deposition of fluticasone propionate/formoterol in healthy volunteers, asthmatics and COPD patients with a novel breath-triggered inhaler. Respiratory Medicine 138, pages 107-114.
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Akash Balki, S. Balamurugan, Suhas Bardapurkar, Sonia Dalal, Ajeet Singh, B.P. Singh, Abhijit Vaidya & Jaideep A. Gogtay. (2018) Comparison of fluticasone/formoterol with budesonide/formoterol pMDI in adults with moderate to severe persistent asthma: Results from a 12-week randomized controlled trial. Pulmonary Pharmacology & Therapeutics 48, pages 28-36.
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Vibeke Backer, Adam Ellery, Sylvia Borzova, Stephen Lane, Magda Kleiberova, Peter Bengtsson, Tadeusz Tomala, Dominique Basset-Stheme, Carla Bennett, Dirk Lindner, Arthur Meiners & Tim Overend. (2018) Non-interventional study of the safety and effectiveness of fluticasone propionate/formoterol fumarate in real-world asthma management. Therapeutic Advances in Respiratory Disease 12, pages 175346661879698.
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Anna Płoszczuk, Miroslava Bosheva, Kay Spooner, Tammy McIver & Sanjeeva Dissanayake. (2018) Efficacy and safety of fluticasone propionate/formoterol fumarate in pediatric asthma patients: a randomized controlled trial. Therapeutic Advances in Respiratory Disease 12, pages 175346661877792.
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David BellLucielle MansfieldMark Lomax. (2017) A Randomized, Crossover Trial Evaluating Patient Handling, Preference, and Ease of Use of the Fluticasone Propionate/Formoterol Breath-Triggered Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery 30:6, pages 425-434.
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O. Schmidt, W. Petro, G. Hoheisel, F. Kanniess, P. Oepen & B. Langer-Brauburger. (2017) Real-life effectiveness of asthma treatment with a fixed-dose fluticasone/formoterol pressurised metered-dose inhaler – Results from a non-interventional study. Respiratory Medicine 131, pages 166-174.
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Fabio Arpinelli, Mauro Carone, Gioacchino Riccardo & Giorgio Bertolotti. (2016) Health-related quality of life measurement in asthma and chronic obstructive pulmonary disease: review of the 2009-2014 literature. Multidisciplinary Respiratory Medicine 11:1.
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Eva Martínez Moragón, Julio Delgado, Pedro Ojeda, Luis Pérez del Llano, Juan Manuel Collar, Cristina Antón-Rodriguez & Carlos Martín-Saborido. (2016) Economic Evaluation of Fluticasone Propionate/Formoterol (Flutiform®) vs. Fluticasone/Salmeterol and Budesonide/Formoterol in Spain. Pulmonary Therapy 2:2, pages 199-213.
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Andrzej Emeryk, Rabih Klink, Tammy McIver & Prashant Dalvi. (2016) A 12-week open-label, randomized, controlled trial and 24-week extension to assess the efficacy and safety of fluticasone propionate/formoterol in children with asthma. Therapeutic Advances in Respiratory Disease 10:4, pages 324-337.
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Alberto PapiAdel H. MansurTetyana PertsevaKirsten KaiserTammy McIverBirgit GrotheSanjeeva Dissanayake. (2016) Long-Term Fluticasone Propionate/Formoterol Fumarate Combination Therapy Is Associated with a Low Incidence of Severe Asthma Exacerbations. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:4, pages 346-361.
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René Aalbers, Claus Vogelmeier & Piotr Kuna. (2016) Achieving asthma control with ICS/LABA: A review of strategies for asthma management and prevention. Respiratory Medicine 111, pages 1-7.
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J.A. Quintano Jiménez, L. Ginel Mendoza, L.M. Entrenas Costa & J. Polo García. (2016) Combinación a dosis fija de fluticasona propionato/formoterol fumarato para el tratamiento del asma: una revisión de la farmacología, eficacia y tolerabilidad. SEMERGEN - Medicina de Familia 42, pages 2-9.
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M. Latorre, P. Paggiaro, W. Canonica, M.P. Foschino & A. Papi. (2015) A valid option for asthma control: Clinical evidence on efficacy and safety of fluticasone propionate/formoterol combination in a single inhaler. Pulmonary Pharmacology & Therapeutics 34, pages 31-36.
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William C. AndersonIIIIII & Stanley J. Szefler. (2015) New and future strategies to improve asthma control in children. Journal of Allergy and Clinical Immunology 136:4, pages 848-859.
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Mitesh Patel & Dominick Shaw. (2015) A review of standard pharmacological therapy for adult asthma – Steps 1 to 5. Chronic Respiratory Disease 12:2, pages 165-176.
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Alberto Papi, David Price, Joaquin Sastre, Kirsten Kaiser, Mark Lomax, Tammy McIver & Sanjeeva Dissanayake. (2015) Efficacy of fluticasone propionate/formoterol fumarate in the treatment of asthma: A pooled analysis. Respiratory Medicine 109:2, pages 208-217.
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P. Devillier, H. Salvator, S. Grassin-Delyle, E. Naline, C. Advenier & N. Roche. (2014) Une nouvelle association fixe de fluticasone/formotérol dans un aérosol-doseur pressurisé pour le traitement de l’asthme. Revue des Maladies Respiratoires 31:8, pages 700-713.
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A. Papi, F. Blasi, G.W. Canonica, M. Cazzola, S. Centanni, M.P. Foschino Barbaro, A.S. Melani, P. Paggiaro, F. Ricciardolo, A. Rossi & N. Scichilone. (2014) Fluticasone propionate/formoterol: A fixed-combination therapy with flexible dosage. European Journal of Internal Medicine 25:8, pages 695-700.
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Baljinder Johal, Markus Howald, Manfred Fischer, Jonathan Marshall & Geraldine Venthoye. (2013) Fine Particle Profile of Fluticasone Propionate/Formoterol Fumarate Versus Other Combination Products: the DIFFUSE Study. Combination Products in Therapy 3:1-2, pages 39-51.
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Gillian M. Keating & Kate McKeage. (2013) Fluticasone propionate/formoterol fumarate: a guide to its use in persistent asthma. Drugs & Therapy Perspectives 29:11, pages 342-347.
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A. Cukier, C.M.A. Jacob, N.A. Rosario Filho, J. Fiterman, E.O. Vianna, J.L. Hetzel, M.A. Neis, E. Fiss, F.F.M. Castro, A.L.G. Fernandes, R. Stirbulov & E. Pizzichini. (2013) Fluticasone/formoterol dry powder versus budesonide/formoterol in adults and adolescents with uncontrolled or partly controlled asthma. Respiratory Medicine 107:9, pages 1330-1338.
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Sukhbir K Shahid. (2013) Newer glucocorticosteroids and corticosteroid resistance reversal in asthma. Pharmaceutical Patent Analyst 2:3, pages 373-385.
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Sanjeeva Dissanayake, Birgit Grothe & Kirsten Kaiser. (2012) Fluticasone/formoterol: a new single-aerosol combination therapy for patients with asthma. Respiratory Medicine 106, pages S20-S28.
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