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Original Article

Delivery of Inhaled Medication to Children

Pages 443-467 | Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Gregor Anderson, Neil Johnson, Aruni Mulgirigama & Bhumika Aggarwal. (2018) Use of spacers for patients treated with pressurized metered dose inhalers: focus on the VENTOLIN™ Mini Spacer. Expert Opinion on Drug Delivery 15:4, pages 419-430.
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Priyanka Agrawal, Sandeep Soni, Gaurav Mittal & Aseem Bhatnagar. (2015) Preclinical safety evaluation of submicronized sildenafil citrate nebulization solution in small experimental animals. Experimental Lung Research 41:8, pages 450-458.
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BethL. Laube, Gail Sharpless, Charles Shermer, Vincent Sullivan & Kenneth Powell. (2012) Deposition of Dry Powder Generated by Solovent in Sophia Anatomical Infant Nose-Throat (SAINT) Model. Aerosol Science and Technology 46:5, pages 514-520.
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Federico Lavorini & Giovanni A Fontana. (2009) Targeting drugs to the airways: the role of spacer devices. Expert Opinion on Drug Delivery 6:1, pages 91-102.
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J. Christian Virchow. (2005) What plays a role in the choice of inhaler device for asthma therapy?. Current Medical Research and Opinion 21:sup4, pages S19-S25.
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Herman A Cohen, Zeev Cohen, Avi Shalom Pomeranz, Brigita Czitron & Ernesto Kahan. (2005) Bacterial Contamination of Spacer Devices Used by Asthmatic Children. Journal of Asthma 42:3, pages 169-172.
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Carine LW Janssen, A Suzan Spoelstra & Mark M. Brueren. (2003) Asthmatic children's inhalation techniques in general practice. European Journal of General Practice 9:4, pages 143-145.
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Donald N. R. Payne & Ian M. Balfour-Lynn. (2001) Children with Difficult Asthma: A Practical Approach. Journal of Asthma 38:3, pages 189-203.
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Cynthia H. Cole. (2000) Inhaled Glucocorticoid Therapy in Infants at Risk for Neonatal Chronic Lung Disease. Journal of Asthma 37:7, pages 533-543.
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Cynthia H Cole. (2000) Postnatal glucocorticosteroid therapy for treatment and prevention of neonatal chronic lung disease. Expert Opinion on Investigational Drugs 9:1, pages 53-67.
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Articles from other publishers (61)

Felix C. Wiegandt, Ulrich P. Froriep, Fabian Müller, Theodor Doll, Andreas Dietzel & Gerhard Pohlmann. (2021) Breath-Triggered Drug Release System for Preterm Neonates. Pharmaceutics 13:5, pages 657.
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Mohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. MadneyMohamed E. A. Abdelrahim, Haitham Saeed, Hadeer S. Harb & Yasmin M. Madney. 2021. Essentials of Aerosol Therapy in Critically ill Patients. Essentials of Aerosol Therapy in Critically ill Patients 115 135 .
Ian Mitchell & Gaynor GoviasIan Mitchell & Gaynor Govias. 2021. Asthma Education. Asthma Education 223 253 .
Fatih ÇİÇEK. (2020) Pediatri uzmanı ve asistanlarının astım tedavisinde kullanılan ilaçlar hakkındaki bilgi düzeylerinin değerlendirilmesi.To evaluate the level of knowledge of the pediatricians about the drugs used in the treatment of asthma.. Zeynep Kamil Tıp Bülteni 51:1, pages 14-18.
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Kai Berkenfeld, Alf Lamprecht & Jason T. McConville. (2015) Devices for Dry Powder Drug Delivery to the Lung. AAPS PharmSciTech 16:3, pages 479-490.
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David V Tuxen & Matthew T Naughton. 2014. Oh's Intensive Care Manual. Oh's Intensive Care Manual 401 413.e5 .
Klaus Bønnelykke, Bo L. K. Chawes, Signe Vindfeld, Alison C. Moore & Hans Bisgaard. (2013) Aerosol Particle Size Does Not Predict Pharmacokinetic Determined Lung Dose in Children . The Journal of Clinical Pharmacology 53:5, pages 517-522.
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Alessandra Scaparrotta, Sabrina Di Pillo, Marina Attanasi, Daniele Rapino, Anna Cingolani, Nicola Pietro Consilvio, Marcello Verini & Francesco Chiarelli. (2012) Montelukast versus inhaled corticosteroids in the management of pediatric mild persistent asthma. Multidisciplinary Respiratory Medicine 7:1.
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Neal J. Thomas & Frank A. Maffei. 2012. Pediatric Critical Care Study Guide. Pediatric Critical Care Study Guide 480 498 .
Kathleen M. Ventre & John H. Arnold. 2011. Textbook of Critical Care. Textbook of Critical Care 504 515 .
Marie D. Frazier & Ira M. Cheifetz. (2010) The Role of Heliox in Paediatric Respiratory Disease. Paediatric Respiratory Reviews 11:1, pages 46-53.
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Klaus Bønnelykke, Jacob J. Jespersen & Hans Bisgaard. (2008) Early bioavailability of inhaled salbutamol reflects lung dose in children. British Journal of Clinical Pharmacology 66:4, pages 562-563.
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Joseph D. Spahn & Stanley J. Szefler. 2008. Pediatric Respiratory Medicine. Pediatric Respiratory Medicine 219 233 .
H. William Kelly. (2007) Rationale for the major changes in the pharmacotherapy section of the National Asthma Education and Prevention Program guidelines. Journal of Allergy and Clinical Immunology 120:5, pages 989-994.
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M.C. Rizzo, D. Solé & C.K. Naspitz. (2007) Corticosteroids (inhaled and/or intranasal) in the treatment of respiratory allergy in children: safety vs. efficacy. Allergologia et Immunopathologia 35:5, pages 197-208.
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Rebekah Mannix & Richard Bachur. (2007) Status asthmaticus in children. Current Opinion in Pediatrics 19:3, pages 281-287.
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David I. Bernstein & David B. Allen. (2007) Evaluation of tests of hypothalamic-pituitary-adrenal axis function used to measure effects of inhaled corticosteroids. Annals of Allergy, Asthma & Immunology 98:2, pages 118-127.
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Paul Y. Qaqundah, Robert W. Sugerman, Elaina Ceruti, Jorge Fernando Maspero, Joseph F. Kleha, Catherine A. Scott, Wei Wu, Rashmi Mehta & Courtney Crim. (2006) Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in pre–school-age children with asthma: A randomized, double-blind, placebo-controlled study. The Journal of Pediatrics 149:5, pages 663-670.e1.
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David OstAli Nadroo, Nitin Ron & Pramod Narula. 2006. Respiratory Emergencies. Respiratory Emergencies 533 561 .
YUHEI HAMASAKI. (2006) . Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunollogy 20:5, pages 469-475.
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Olof Selroos, Lars Borgstr??m & Jarl Ingelf. (2006) Performance of Turbuhaler?? in Patients with Acute Airway Obstruction and COPD, and in Children with Asthma. Treatments in Respiratory Medicine 5:5, pages 305-315.
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Paul L.-P. Brand. (2005) Quels sont les principaux problèmes du traitement inhalé chez les enfants ?. Revue de Pneumologie Clinique 61, pages 25-28.
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Alexander G. ChuchalinAhmed I. ManjraNadezhda N. RozinovaOlga SkopkováGiovanni Della CioppaDenise TillGuenther KaiserTaiwo FasholaJohn Kottakis. (2005) Formoterol Delivered via a New Multi-Dose Dry Powder Inhaler (Certihaler ™ ) Is as Effective and Well Tolerated as the Formoterol Dry Powder Inhaler (Aerolizer ® ) in Children with Persistent Asthma . Journal of Aerosol Medicine 18:1, pages 63-73.
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Brian J O’Connor. (2004) The ideal inhaler: design and characteristics to improve outcomes. Respiratory Medicine 98, pages S10-S16.
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Andrea von Berg, Prakash M. Jeena, Peter A. Soemantri, André Vertruyen, Peter Schmidt, Fronke Gerken & Hassan Razzouk. (2004) Efficacy and safety of ipratropium bromide plus fenoterol inhaled via Respimat® Soft Mist™ Inhaler vs. a conventional metered dose inhaler plus spacer in children with asthma. Pediatric Pulmonology 37:3, pages 264-272.
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&NA;. (2003) Metered-dose inhalers with spacer devices are the system of choice for delivering short-acting ??2-agonists to children with asthma. Drugs & Therapy Perspectives 19:10, pages 23-26.
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Mariëlle E.A.C. Broeders, Johan Molema, Wim C.J. Hop & Hans T.M. Folgering. (2003) Inhalation Profiles in Asthmatics and COPD Patients: Reproducibility and Effect of Instruction. Journal of Aerosol Medicine 16:2, pages 131-141.
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Paul L.P. Brand & Ruurd Jan Roorda. (2003) Drug Delivery in Pediatric Patients with Asthma. American Journal of Drug Delivery 1:1, pages 61-70.
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Athena Economides & Martha V. White. 2003. Current Review of Asthma. Current Review of Asthma 107 116 .
Brian J. Lipworth, Daniel K. C. Lee, Jacob Anhøj & Hans Bisgaard. (2002) Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children. British Journal of Clinical Pharmacology 54:5, pages 544-547.
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John C. Carl & Carolyn M. Kercsmar. (2002) Management of acute pediatric asthma. Current Allergy and Asthma Reports 2:6, pages 468-476.
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M.V. MIDDLE, J. TERBLANCHÉ, V.L. PERRIN & M.G.L. HERTOG. (2002) Bronchodilating effects of salbutamol from a novel inhaler AirmaxTM. Respiratory Medicine 96:7, pages 493-498.
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X.-M ZENG, D O'LEARY, M PHELAN, S JONES & J COLLEDGE. (2002) Delivery of salbutamol and of budesonide from a novel multi-dose inhaler AirmaxTM. Respiratory Medicine 96:6, pages 404-411.
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H. William Kelly & Hengameh Heidarian- Raissy. (2002) The use of inhaled corticosteroids in children with asthma. Current Allergy and Asthma Reports 2:2, pages 133-143.
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Gillian M. Keating & Diana Faulds. (2002) Airmax???*. Drugs 62:13, pages 1887-1895.
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Eduardo Schnitzler & Pablo Minces. (2002) Is helium a better vehicle for aerosol therapy?. Pediatric Critical Care Medicine 3:1, pages 86-87.
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Jacob Anhøj & Johannes H.Wildhaber. 2001. Drug Delivery to the Lung. Drug Delivery to the Lung 389 420 .
Claudio Terzano. (2001) Pressurized Metered Dose Inhalers and Add-on Devices. Pulmonary Pharmacology & Therapeutics 14:5, pages 351-366.
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Barbara KnorrLuis M. FranchiHans BisgaardJan Hendrik VermeulenPeter LeSouef, Nancy SantanelloTheresa M. MicheleTheodore F. ReissHa H. NguyenDonna L. Bratton. (2001) Montelukast, a Leukotriene Receptor Antagonist, for the Treatment of Persistent Asthma in Children Aged 2 to 5 Years. Pediatrics 108:3, pages e48-e48.
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Tina Penick Brock & Dennis M. Williams. (2016) Clinical Considerations in the Use of Inhalation Delivery Devices. Journal of Pharmacy Practice 14:4, pages 277-295.
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Antonio Vignola, Pascal Chanez & Jean Bousquet. 2001. Severe Asthma. Severe Asthma 575 596 .
KIM G. NIELSEN & HANS BISGAARD. (2001) Bronchodilation and Bronchoprotection in Asthmatic Preschool Children from Formoterol Administered by Mechanically Actuated Dry-powder Inhaler and Spacer. American Journal of Respiratory and Critical Care Medicine 164:2, pages 256-259.
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Heinrich A. Werner. (2001) Status Asthmaticus in Children. Chest 119:6, pages 1913-1929.
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H. William Kelly & Shirley Murphy. (2001) Helping Children Adhere to Asthma Treatment Regimens. Pediatric Asthma, Allergy & Immunology 15:1, pages 25-30.
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Martin Duerden & David Price. (2001) Training Issues in the Use of Inhalers. Disease Management and Health Outcomes 9:2, pages 75-87.
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Warren H. Finlay. 2001. The Mechanics of Inhaled Pharmaceutical Aerosols. The Mechanics of Inhaled Pharmaceutical Aerosols 277 293 .
Clive Wilson, Neena Washington & Clive Washington. 2000. Physiological Pharmaceutics. Physiological Pharmaceutics.
Karen M. Hvizdos & Blair Jarvis. (2000) Budesonide Inhalation Suspension. Drugs 60:5, pages 1141-1178.
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Hans Bisgaard. (2000) Long-acting ?2-agonists in management of childhood asthma: A critical review of the literature. Pediatric Pulmonology 29:3, pages 221-234.
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H. William Kelly. (1999) PHARMACOLOGY OF INHALED GLUCOCORTICOIDS. Immunology and Allergy Clinics of North America 19:4, pages 725-738.
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Joseph D. Spahn. (1999) GLUCOCORTICOID PHARMACOKINETICS. Immunology and Allergy Clinics of North America 19:4, pages 709-723.
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Kurt Nikander & H. Bisgaard. (1999) Impact of constant and breath-synchronized nebulization on inhaled mass of nebulized budesonide in infants and children. Pediatric Pulmonology 28:3, pages 187-193.
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HANS BISGAARD, JOHN GILLIES, MARCELLE GROENEWALD & CLAIRE MADEN. (1999) The Effect of Inhaled Fluticasone Propionate in the Treatment of Young Asthmatic Children. American Journal of Respiratory and Critical Care Medicine 160:1, pages 126-131.
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H. Bisgaard. (1999) Future options for aerosol delivery to children. Allergy 54:s49, pages 97-103.
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Jacob Anhøj, Hans Bisgaard & Brian J. Lipworth. (2001) Effect of electrostatic charge in plastic spacers on the lung delivery of HFA‐salbutamol in children. British Journal of Clinical Pharmacology 47:3, pages 333-336.
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Hans Bisgaard. (1999) Reply to Drs Seale and Donnelly. Respiratory Medicine 93:2, pages 144-145.
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Hans Bisgaard. (1999) Towards improved aerosol devices for the young child. Pediatric Pulmonology 27:S18, pages 78-78.
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H.William Kelly. (1998) Establishing a therapeutic index for the inhaled corticosteroids: Part I. Journal of Allergy and Clinical Immunology 102:4, pages S36-S51.
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H. Bisgaard. (1998) Targeting drugs to the respiratory tract. Research in Immunology 149:3, pages 229-231.
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HANS BISGAARD. (1998) Automatic Actuation of a Dry Powder Inhaler into a Nonelectrostatic Spacer. American Journal of Respiratory and Critical Care Medicine 157:2, pages 518-521.
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H. Bisgaard. (1997) What dose fraction represents the respirable dose?. Respiratory Medicine 91, pages 20-21.
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