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Original Article

Anti-interleukin-4 Inhibits Immunoglobulin E Production in a Murine Model of Atopic Asthma

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Pages 195-201 | Published online: 02 Jul 2009

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Michael Wegmann. (2009) Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. Expert Review of Molecular Diagnostics 9:1, pages 85-100.
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Loren W. Hunt. (2001) How to manage difficult asthma cases. Postgraduate Medicine 109:5, pages 61-68.
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I. Caroline Crocker, Kirtibala Gupta, Robert G. Townley & Manzoor M. Khan. (1998) The Profile of the Cytokines Secreted During the Generation of T-Helper Cells from Atopic Asthmatic Subjects. Journal of Asthma 35:2, pages 187-201.
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Madhur D. Shastri, Wai Chin Chong, Kamal Dua, Gregory M. Peterson, Rahul P. Patel, Malik Q. Mahmood, Murtaza Tambuwala, Dinesh K. Chellappan, Nicole G. Hansbro, Shakti D. Shukla & Philip M. Hansbro. (2020) Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators. Inflammopharmacology 29:1, pages 15-33.
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Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Takachika Hiroi, Akio Mori & Osamu Kaminuma. (2019) Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness. International Journal of Molecular Sciences 20:12, pages 2980.
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I. P. Shilovskiy, D. V. Eroshkina, A. A. Babakhin & M. R. Khaitov. (2017) Anticytokine therapy of allergic asthma. Molecular Biology 51:1, pages 1-13.
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Suqin Zhang, Yuqin Li & Yufeng Liu. (2014) Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis. Inflammation 38:3, pages 1207-1212.
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Noriko Shimura & Shuji Kojima. (2014) Effects of Low-Dose-Gamma Rays on the Immune System of Different Animal Models of Disease. Dose-Response 12:3, pages dose-response.1.
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Girolamo Pelaia, Alessandro Vatrella & Rosario Maselli. (2012) The potential of biologics for the treatment of asthma. Nature Reviews Drug Discovery 11:12, pages 958-972.
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Tania Maes, Guy F. Joos & Guy G. Brusselle. (2012) Targeting Interleukin-4 in Asthma: Lost in Translation?. American Journal of Respiratory Cell and Molecular Biology 47:3, pages 261-270.
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T. Morioka, K. Yamanaka, H. Mori, Y. Omoto, K. Tokime, M. Kakeda, I. Kurokawa, E.C. Gabazza, A. Tsubura, Y. Yasutomi & H. Mizutani. (2009) IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis. British Journal of Dermatology 160:6, pages 1172-1179.
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Markus Koch, Martin Witzenrath, Christine Reuter, Marion Herma, Hartwig Schütte, Norbert Suttorp, Helen Collins & Stefan H. E. Kaufmann. (2006) Role of Local Pulmonary IFN-γ Expression in Murine Allergic Airway Inflammation. American Journal of Respiratory Cell and Molecular Biology 35:2, pages 211-219.
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K Nishikubo, Y Murata, S Tamaki, K Sugama, K Imanaka-Yoshida, N Yuda, M Kai, S Takamura, W Sebald, Y Adachi & Y Yasutomi. (2003) A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma. Gene Therapy 10:26, pages 2119-2125.
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Stephen T. Holgate & David Broide. (2003) New targets for allergic rhinitis — a disease of civilization. Nature Reviews Drug Discovery 2:11, pages 903-915.
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T K HART, M N BLACKBURN, M BRIGHAM-BURKE, K DEDE, N AL-MAHDI, P ZIA-AMIRHOSSEINI & R M COOK. (2002) Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clinical and Experimental Immunology 130:1, pages 93-100.
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Azzeddine Dakhama & Erwin Gelfand. 2002. Biotherapeutic Approaches to Asthma. Biotherapeutic Approaches to Asthma 247 291 .
R. E. BEADLE, D. W. HOROHOV & S. D. GAUNT. (2010) Interleukin-4 and interferon-gamma gene expression in summer pasture-associated obstructive pulmonary disease affected horses. Equine Veterinary Journal 34:4, pages 389-394.
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Kian Fan Chung. (2002) Current and potential improvements in the treatment of asthma from increased understanding of airway pathophysiology. Allergology International 51:3, pages 153-166.
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Shelby P. Umland, Robert P. Schleimer & Sebastian L. Johnston. (2002) Review of the Molecular and Cellular Mechanisms of Action of Glucocorticoids for Use in Asthma. Pulmonary Pharmacology & Therapeutics 15:1, pages 35-50.
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Annette M. Colavita, Alan J. Reinach & Stephen P. Peters. (2000) CONTRIBUTING FACTORS TO THE PATHOBIOLOGY OF ASTHMA. Clinics in Chest Medicine 21:2, pages 263-277.
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Shau-Ku Huang. (1998) Molecular modulation of allergic responses. Journal of Allergy and Clinical Immunology 102:6, pages 887-892.
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Wang & Forsyth. (1998) Asthma and respiratory syncytial virus infection in infancy: is there a link?. Clinical & Experimental Allergy 28:8, pages 927-935.
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I Caroline Crocker, Martin K Church, Sean Newton & Robert G Townley. (1998) Glucocorticoids Inhibit Proliferation and Interleukin-4 and Interleukin-5 Secretion by Aeroallergen-Specific T-Helper Type 2 Cell Lines. Annals of Allergy, Asthma & Immunology 80:6, pages 509-516.
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