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Acta Oncologica Volume 31, 1992 - Issue 2
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Original Article

Biological and Clinical Significance of Cathepsin D in Breast Cancer

Henri Rochefort
Pages 125-130 | Received 25 Jun 1991, Accepted 19 Sep 1991, Published online: 08 Jul 2009

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Sally S. Twining. (1994) Regulation of Proteolytic Activity in Tissues. Critical Reviews in Biochemistry and Molecular Biology 29:5, pages 315-383.
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Martin Fusek, Michael Mares & Vaclav Vetvicka. 2013. Handbook of Proteolytic Enzymes. Handbook of Proteolytic Enzymes 54 63 .
Yao-Tseng Wen, Yu-Chen Chang, Lung-Cheng Lin & Pao-Chi Liao. (2011) Collection of in vivo-like liver cell secretome with alternative sample enrichment method using a hollow fiber bioreactor culture system combined with tangential flow filtration for secretomics analysis. Analytica Chimica Acta 684:1-2, pages 81-88.
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Vitalia Sagulenko, Daniel Muth, Evgeny Sagulenko, Tobias Paffhausen, Manfred Schwab & Frank Westermann. (2008) Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death. Carcinogenesis 29:10, pages 1869-1877.
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Liang Hu, Jennifer M. Roth, Peter Brooks, Joanna Luty & Simon Karpatkin. (2008) Thrombin Up-regulates Cathepsin D which Enhances Angiogenesis, Growth, and Metastasis. Cancer Research 68:12, pages 4666-4673.
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W G Jiang, M C A Puntis & M B Hallett. (1994) Molecular and cellular basis of cancer invasion and metastasis: Implications for treatment. British Journal of Surgery 81:11, pages 1576-1590.
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Martin Fusek & Václav Větvička. (2005) DUAL ROLE OF CATHEPSIN D: LIGAND AND PROTEASE. Biomedical Papers 149:1, pages 43-50.
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D. Nikolić-Vukosavljević, M. Markićević, G. Grujić-Adanja, A. Petrović, K. Kanjer & Z. Nešković-Konstantinović. (2005) Cathepsin D-related Disease-free Interval in pT1 Primary Breast Carcinomas: A Pilot Study. Clinical & Experimental Metastasis 22:4, pages 363-368.
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Hiroshi ISHINO, Toshiaki KUNIMURA, Kenji IWAKU, Kyoko MATSUKAWA, Yuko DATE, Syun SATO, Atsushi ISHINO, Yukihiro WADA, Kazuma MORI, Hisashi HOSAKA, Takeyoshi KITAYAMA & Toshio MOROHOSHI. (2005) The Expression of Cathepsin D in Uterine Cervical Intraepithelial Neoplasia Correlates with the Nuclear Expression of Ki-67 and p53. The Showa University Journal of Medical Sciences 17:4, pages 177-184.
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A. Vashishta, M. Fusek & V. Větvička. (2005) Possible role of procathepsin D in human cancer. Folia Microbiologica 50:1, pages 71-76.
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M HAUSMANN, F OBERMEIER, K SCHREITER, T SPOTTL, W FALK, J SCHÖLMERICH, H HERFARTH, P SAFTIG & G ROGLER. (2004) Cathepsin D is up-regulated in inflammatory bowel disease macrophages. Clinical and Experimental Immunology 136:1, pages 157-167.
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Šumski Šimaga, Damir Babić, Maja Osmak, Marina Šprem & Marija Abramić. (2003) Tumor cytosol dipeptidyl peptidase III activity is increased with histological aggressiveness of ovarian primary carcinomas. Gynecologic Oncology 91:1, pages 194-200.
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E. Ioachim, E. Kitsiou, K. Charalabopoulos, A. Mitselou, N. Zagorianakou, G. Makrydimas, S. Tzioras & M. Salmas. (2003) Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices. International Journal of Gynecological Cancer 13:3, pages 344-351.
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M.L Berthe, M Esslimani Sahla, P Roger, M Gleizes, G.J Lemamy, J.P Brouillet & H Rochefort. (2003) Mannose-6-phosphate/insulin-like growth factor-II receptor expression levels during the progression from normal human mammary tissue to invasive breast carcinomas. European Journal of Cancer 39:5, pages 635-642.
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E Ioachim, A Charchanti, E Briasoulis, V Karavasilis, H Tsanou, D.L Arvanitis, N.J Agnantis & N Pavlidis. (2002) Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. European Journal of Cancer 38:18, pages 2362-2370.
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Vaclav Vetvicka, Petr Benes & Martin Fusek. (2002) Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors. Cancer Gene Therapy 9:10, pages 854-863.
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Ugur Saygili, Meral Koyuncuoglu, Sabahattin Altunyurt, Serkan Guclu, Turhan Uslu & Oktay Erten. (2001) May Cathepsin D Immunoreactivity Be Used as a Prognostic Factor in Endometrial Carcinomas? A Comparative Immunohistochemical Study. Gynecologic Oncology 83:1, pages 20-24.
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Koshi MORI, Yasuhiro KON, Akihiro KONNO & Toshihiko IWANAGA. (2001) Cellular Distribution of Napsin (Kidney-Derived Aspartic Protease-like Protein, KAP) mRNA in the Kidney, Lung and Lymphatic Organs of Adult and Developing Mice.. Archives of Histology and Cytology 64:3, pages 319-327.
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S Greco, S Marsigliante, G Leo & C Storelli. (2000) Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas. Cancer Letters 160:1, pages 13-19.
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Gérard Rossé, Erich Kueng, Malcolm G. P. Page, Vesna Schauer-Vukasinovic, Thomas Giller, Hans-Werner Lahm, Peter Hunziker & Daniel Schlatter. (2000) Rapid Identification of Substrates for Novel Proteases Using a Combinatorial Peptide Library. Journal of Combinatorial Chemistry 2:5, pages 461-466.
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Susan Yeyeodu, Kyujeong Ahn, Victoria Madden, Richard Chapman, Linhua Song & Ann H. Erickson. (2000) Procathepsin L Self-Association as a Mechanism for Selective Secretion. Traffic 1:9, pages 724-737.
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Vaclav Vetvicka, Jana Vetvickova & Martin Fusek. (2000) Role of procathepsin D activation peptide in prostate cancer growth. The Prostate 44:1, pages 1-7.
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Vesna Schauer-Vukasinovic, Matthew B. Wright, Volker Breu & Thomas Giller. (2000) Cloning, expression and functional characterization of rat napsin. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1492:1, pages 207-210.
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Vesna Schauer‐Vukasinovic, Daniel Bur, Eric Kitas, Daniel Schlatter, Gerard Rossé, Hans‐Werner Lahm & Thomas Giller. (2001) Purification and characterization of active recombinant human napsin A. European Journal of Biochemistry 267:9, pages 2573-2580.
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Jean-Marc Rey, Charles Theillet, Jean-Paul Brouillet & Henri Rochefort. (2000) Stable amino-acid sequence of the Mannose-6-phosphate/insulin-like growth-factor-II receptor in ovarian carcinomas with loss of heterozygosity and in breast-cancer cell lines. International Journal of Cancer 85:4, pages 466-473.
Crossref
A. Ruibal, J. Schneider, M.a C. del Río, J. Arias, M.I. Núñez & A. Tejerina. (2000) La expresión de la molécula de adhesión CD44v6 en carcinomas ductales infiltrantes de mama se asocia con la hormonodependencia. Nuestra experiencia con 168 casos. Revista Española de Medicina Nuclear 19:5, pages 350-355.
Crossref
A Scorilas, T Trangas, J Yotis, C Pateras & M Talieri. (1999) Determination of c-myc amplification and overexpression in breast cancer patients: evaluation of its prognostic value against c-erbB-2, cathepsin-D and clinicopathological characteristics using univariate and multivariate analysis. British Journal of Cancer 81:8, pages 1385-1391.
Crossref
Vesna Schauer-Vukasinovic, Daniel Bur, Dorothee Kling, Fiona Grüninger & Thomas Giller. (1999) Human napsin A: expression, immunochemical detection, and tissue localization. FEBS Letters 462:1-2, pages 135-139.
Crossref
José M Martínez, Isabel Prieto, María J Ramírez, Cristobal Cueva, Francisco Alba & Manuel Ramírez. (1999) Aminopeptidase Activities in Breast Cancer Tissue. Clinical Chemistry 45:10, pages 1797-1802.
Crossref
P Pujol, J-P Daurès, J-P Brouillet, T Maudelonde, H Rochefort & J Grenier. (1999) Time at surgery during menstrual cycle and menopause affects pS2 but not cathepsin D levels in breast cancer. British Journal of Cancer 79:5-6, pages 909-914.
Crossref
Sheldon R. Gordon & James DeMoss. (1999) Exposure to Lysosomotropic Amines and Protease Inhibitors Retard Corneal Endothelial Cell Migration along the Natural Basement Membrane during Wound Repair. Experimental Cell Research 246:1, pages 233-242.
Crossref
P. P. Athanassiadou, P. H. Athanassiades, P. Davaris, E. I. Petrakakou, CH. I. Zerva & K. A. Kyrkou. (2004) Expression of Cathepsin D and pS2 in imprint smears of breast carcinoma. Cytopathology 9:4, pages 240-247.
Crossref
Vaclav Vetvicka, Jana Vetvickova & Martin Fusek. (1998) Effect of procathepsin D and its activation peptide on prostate cancer cells. Cancer Letters 129:1, pages 55-59.
Crossref
E-F. Solomayer, I.J. Diel, G.C. Meyberg, Ch. Gollan, S. Bode, D. Wallwiener & G. Bastert. (1998) Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer. Breast Cancer Research and Treatment 49:2, pages 145-154.
Crossref
Š Šimaga, D Babić, M Osmak, J Ilić-Forko, Lj Vitale, D Miličić & M Abramić. (1998) Dipeptidyl peptidase III in malignant and non-malignant gynaecological tissue. European Journal of Cancer 34:3, pages 399-405.
Crossref
Vaclav Vetvicka, Jana Vetvickova, Ivan Hilgert, Zdenek Voburka & Martin Fusek. (1997) Analysis of the interaction of procathepsin D activation peptide with breast cancer cells. International Journal of Cancer 73:3, pages 403-409.
Crossref
E. Hähnel, J. Harvey & R. Hähnel. (1997) Comparison of total cathepsin D in breast tissue of patients with benign and malignant breast disease. The Breast 6:5, pages 291-292.
Crossref
G. HERNANDEZ‐VIDAL, L. B. JEFFCOTT & M. E. DAVIES. (2010) Cellular heterogeneity in cathepsin D distribution in equine articular cartilage. Equine Veterinary Journal 29:4, pages 267-273.
Crossref
Philip H Fortgens, Clive Dennison & Edith Elliott. (1997) Anti-cathepsin D chicken IgY antibodies: characterisation, cross-species reactivity and application in immunogold labelling of human splenic neutrophils and fibroblasts. Immunopharmacology 36:2-3, pages 305-311.
Crossref
Patricia Glikman, Amelia Rogozinski, Julian Mosto, Angelica Pollina, Carlos Garbovesky & Carlos Levy. (2018) Relationship between Cathepsin-D and Other Prognostic Factors in Human Breast Cancer. Tumori Journal 83:3, pages 685-688.
Crossref
Celia A. Whitesitt, Richard L. Simon, Jon K. Reel, Sandra K. Sigmund, Michael L. Phillips, J. Kevin Shadle, Lawrence J. Heinz, Gary A. Koppel, David C. Hunden, Sherryl L. Lifer, Dennis Berry, Judy Ray, Sheila P Little, Xiadong Liu, Winston S. Marshall & Jill A. Panetta. (1996) Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D. Bioorganic & Medicinal Chemistry Letters 6:18, pages 2157-2162.
Crossref
Gaetano Leto, Francesca Maria Tumminello, Giuseppe Pizzolanti, Giuseppe Montalto, Maurizio Soresi, Irene Ruggeri & Nicola Gebbia. (1996) Cathepsin D Serum Mass Concentrations in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis. Clinical Chemistry and Laboratory Medicine 34:7.
Crossref
Per E. Lønning & Ernst A. Lien. (1995) Mechanisms of action of endocrine treatment in breast cancer. Critical Reviews in Oncology/Hematology 21:1-3, pages 158-193.
Crossref
G. Scambia, P.Benedetti Panici, G. Ferrandina, M. Distefano, M.E. Romanini, G. Sica & S. Mancuso. (1995) Significance of Cathepsin-D expression in uterine tumours. European Journal of Cancer 31:9, pages 1449-1454.
Crossref
Lisa D. Laury-Kleintop, Elizabeth C. Coronel, Marianne K. Lange, Thomas Tachovsky, Santo Longo, Sandra Tucker & Jack A. Alhadeff. (1995) Western blotting and isoform analysis of cathepsin D from normal and malignant human breast cell lines. Breast Cancer Research and Treatment 35:2, pages 211-220.
Crossref
Ajay kumar Khanna, Yutaka Tokuda, Makoto Shibuya, Makiko Tanaka, Tadashi Sekine, Tomoo Tajima, R Yoshiyuki Osamura & Toshio Mitomi. (1995) Clinical and histological prognostic factors in axillary node-negative breast cancer: Univariate and multivariate analysis with relation to 5 year recurrence. Breast Cancer 2:1, pages 51-58.
Crossref
O Chinot, S Romain & PM Martin. (1995) Apport de la biologie à la décision thérapeutique: le cancer du sein en 1995. Bulletin du Cancer/Radiothérapie 82:2, pages 225-237.
Crossref
Gerald Koelsch, Peter Metcalf, Vaclav Vetvicka & Martin Fusek. 1995. Aspartic Proteinases. Aspartic Proteinases 273 278 .
Robert D. Cardiff. (1994) Cathepsin D and breast cancer: Useful?. Human Pathology 25:9, pages 847-848.
Crossref
Václav Větvička, Jana Věktvičková & Martin Fusek. (1994) Effect of human procathepsin D on proliferation of human cell lines. Cancer Letters 79:2, pages 131-135.
Crossref
I. J. Diel, S. D. Costa, M. Kaufmann & G. Bastert. 1994. Metastatic Bone Disease. Metastatic Bone Disease 31 45 .

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