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Original Article

Efficacy of a New 5-Fluorouracil Derivative, Bof-A2, in Advanced Non-Small Cell Lung Cancer a Multi-Center Phase Ii Study

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Pages 523-526 | Received 28 Sep 1993, Accepted 15 Feb 1994, Published online: 08 Jul 2009

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Takukazu Nagakawa, Masato Kayahara, Tetsuo Ohta, Hirohisa Kitagawa, Kiyohiro Mikami, Takashi Kurata & Shun Otsuji. (2000) Dihydropyrimidine Dehydrogenase Activity in Human Pancreatic Tumor Tissues. Cancer Investigation 18:6, pages 516-520.
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Godefridus J Peters & Stephen P Ackland. (1996) Leading Article: Oncologic, Endocrine & Metabolic: New antimetabolites in preclinical and clinical development. Expert Opinion on Investigational Drugs 5:6, pages 637-679.
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Himanshu Verma, Gera Narendra, Baddipadige Raju, Pankaj Kumar Singh & Om Silakari. (2022) Dihydropyrimidine Dehydrogenase-Mediated Resistance to 5-Fluorouracil: Mechanistic Investigation and Solution. ACS Pharmacology & Translational Science 5:11, pages 1017-1033.
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Dmitriy M. Volochnyuk, Oleksandr O. Grygorenko & Alina O. Gorlova. 2014. Fluorine in Heterocyclic Chemistry Volume 2. Fluorine in Heterocyclic Chemistry Volume 2 577 672 .
Tyvin A. RichRobert C. ShepardStephen T. Mosley. (2004) Four Decades of Continuing Innovation With Fluorouracil: Current and Future Approaches to Fluorouracil Chemoradiation Therapy. Journal of Clinical Oncology 22:11, pages 2214-2232.
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M Kawahara, K Furuse, Y Segawa, K Yoshimori, K Matsui, S Kudoh, K Hasegawa & H Niitani. (2001) Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer. British Journal of Cancer 85:7, pages 939-943.
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J. NemunaitisR. EagerT. TwaddellA. CoreyK. SekarK. TkaczukJ. ThompsonP.M. HoffR. Pazdur. (2000) Phase I Assessment of the Pharmacokinetics, Metabolism, and Safety of Emitefur in Patients With Refractory Solid Tumors. Journal of Clinical Oncology 18:19, pages 3423-3434.
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D. Bissett, F. Ahmed, H. McLeod & J. Cassidy. (2000) Oral Fluoropyrimidines in the Treatment of Colorectal Cancer. Clinical Oncology 12:4, pages 240-245.
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John S. Macdonald. (1999) Oral Fluoropyrimidines. American Journal of Clinical Oncology: Cancer Clinical Trials 22:5, pages 475.
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Shun Miyauchi, Takeshi Imaoka, Tadashi Okada, Masaaki Motoyama, Teruhisa Kawaguchi, Hitoshi Akiyama & Masaaki Odomi. (1996) Leukopenia-Inducing Effect of a Combination of a New 5-Fluorouracil (5-FU)-Derived Drug, BOF-A2 (Emitefur), with Other 5-FU-Derived Drugs or BV-araU (Sorivudine) in Rats. Japanese Journal of Pharmacology 70:2, pages 139-148.
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