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Acta Oncologica Volume 35, 1996 - Issue 1
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Original Article

Relationship Between Intestinal Fibrosis and Histopathologic and Morphometric Changes in Consequential and Late Radiation Enteropathy

Carl W. Langberg Department of Oncology, Ullevål Hospital, Oslo
,
Torill Sauer Department of Pathology, Ullevål Hospital, Oslo
,
Jon B. Reitan Department of Radiation Medicine, Norwegian Radiation Protection Authority, østerås
&
Martin Hauer-Jensen Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Pages 81-87 | Received 07 Nov 1994, Accepted 12 Jun 1995, Published online: 08 Jul 2009

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Prabath G. Biju, Igor Gubrij, Sarita Garg, Prem K. Gupta, Martin Hauer-Jensen & Alexander F. Burnett. (2014) Radiation lethality potentiation in total body irradiated mice by a commonly prescribed proton pump inhibitor, Pantoprazole sodium. International Journal of Radiation Biology 90:7, pages 554-559.
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I. M. Westra, B. T. Pham, G. M. M. Groothuis & P. Olinga. (2013) Evaluation of fibrosis in precision-cut tissue slices. Xenobiotica 43:1, pages 98-112.
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Articles from other publishers (62)

Sarita Garg, Tarun K. Garg, Isabelle R. Miousse, Stephen Y. Wise, Oluseyi O. Fatanmi, Alena V. Savenka, Alexei G. Basnakian, Vijay K. Singh & Martin Hauer-Jensen. (2022) Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model. Antioxidants 11:10, pages 1895.
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Sarita Garg, Tarun K. Garg, Stephen Y. Wise, Oluseyi O. Fatanmi, Isabelle R. Miousse, Alena V. Savenka, Alexei G. Basnakian, Vijay K. Singh & Martin Hauer-Jensen. (2022) Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate. International Journal of Molecular Sciences 23:9, pages 4643.
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Daisuke Watanabe & Nobuhiko Kamada. (2022) Contribution of the Gut Microbiota to Intestinal Fibrosis in Crohn's Disease. Frontiers in Medicine 9.
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Adam Corken, Sanchita P. Ghosh, Ruofei Du, Marjan Boerma, Jerry Ware & Rupak Pathak. (2022) Platelet glycoprotein Ibα provides radiation protection. Radiotherapy and Oncology 167, pages 143-148.
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Heba A. Mohamed & Riham S. Said. (2021) Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways. International Immunopharmacology 92, pages 107347.
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Isabelle R. Miousse, Laura E. Ewing, Charles M. Skinner, Rupak Pathak, Sarita Garg, Kristy R. Kutanzi, Stepan Melnyk, Martin Hauer-Jensen & Igor Koturbash. (2020) Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. American Journal of Physiology-Gastrointestinal and Liver Physiology 318:3, pages G439-G450.
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Brett I. Bell, Sravya Koduri, Carlo Salas Salinas, James Monslow, Ellen Puré, Edgar Ben-Josef, Constantinos Koumenis & Ioannis I. Verginadis. (2019) Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation. International Journal of Radiation Oncology*Biology*Physics 103:3, pages 719-727.
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Sei Hwan You, Mee Yon Cho, Joon Hyung Sohn & Chang Geol Lee. (2018) Pancreatic radiation effect in apoptosis-related rectal radiation toxicity. Journal of Radiation Research 59:5, pages 529-540.
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Dominik Bettenworth. 2018. Fibrostenotic Inflammatory Bowel Disease. Fibrostenotic Inflammatory Bowel Disease 127 145 .
Isabelle R. Miousse, Rupak Pathak, Sarita Garg, Charles M. Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D. Landes, Annie Lumen, Alan J. Tackett, Nicolaas E.P. Deutz, Martin Hauer-Jensen & Igor Koturbash. (2017) Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes & Nutrition 12:1.
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Junru Wang, Rupak Pathak, Sarita Garg & Martin Hauer-Jensen. (2017) Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy. World Journal of Gastroenterology 23:26, pages 4701.
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Rupak Pathak, Junru Wang, Sarita Garg, Nukhet Aykin-Burns, Karl-Uwe Petersen & Martin Hauer-Jensen. (2016) Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiation Research 186:2, pages 112-120.
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Catherine Booth, Gregory L. Tudor, Barry P. Katz & Thomas J. MacVittie. (2015) The Delayed Effects of Acute Radiation Syndrome. Health Physics 109:5, pages 399-413.
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P-Y Chang, Y-Q Qu, J Wang & L-H Dong. (2015) The potential of mesenchymal stem cells in the management of radiation enteropathy. Cell Death & Disease 6:8, pages e1840-e1840.
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Liu-gen Jin, Jian-Jun Chu, Qing-feng Pang, Fu-zheng Zhang, Gang Wu, Le-Yuan Zhou, Xiao-jun Zhang & Chun-gen Xing. (2015) Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats. Environmental Toxicology and Pharmacology 40:1, pages 156-163.
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Junru Wang, Junying Zheng, Ashwini Kulkarni, Wen Wang, Sarita Garg, Paul L. Prather & Martin Hauer-Jensen. (2014) Palmitoylethanolamide Regulates Development of Intestinal Radiation Injury in a Mast Cell-Dependent Manner. Digestive Diseases and Sciences 59:11, pages 2693-2703.
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Sarita Garg, Wenze Wang, Biju G Prabath, Marjan Boerma, Junru Wang, Daohong Zhou & Martin Hauer-Jensen. (2014) Bone Marrow Transplantation Helps Restore the Intestinal Mucosal Barrier after Total Body Irradiation in Mice. Radiation Research 181:3, pages 229.
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Alexander F. Burnett, Prabath G. Biju, Huanli Lui & Martin Hauer-Jensen. (2013) Oral Interleukin 11 as a Countermeasure to Lethal Total-Body Irradiation in a Murine Model. Radiation Research 180:6, pages 595-602.
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Marjan Boerma, Junru Wang, Vijayalakshmi Sridharan, Jean-Marc Herbert & Martin Hauer-Jensen. (2013) Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart. PLoS ONE 8:7, pages e70479.
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P Chang, Y Qu, Y Liu, S Cui, D Zhu, H Wang & X Jin. (2013) Multi-therapeutic effects of human adipose-derived mesenchymal stem cells on radiation-induced intestinal injury. Cell Death & Disease 4:6, pages e685-e685.
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Junru Wang, Ashwini Kulkarni, Madhu Chintala, Louis M. Fink & Martin Hauer-Jensen. (2013) Inhibition of Protease-activated Receptor 1 Ameliorates Intestinal Radiation Mucositis in a Preclinical Rat Model. International Journal of Radiation Oncology*Biology*Physics 85:1, pages 208-214.
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Gregory Lyng, Richard Logan & Maria Mancini. 2013. Pathobiology of Cancer Regimen-Related Toxicities. Pathobiology of Cancer Regimen-Related Toxicities 75 95 .
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Catherine Booth, Gregory Tudor, Nicola Tonge, Terez Shea-Donohue & Thomas J. MacVittie. (2012) Evidence of Delayed Gastrointestinal Syndrome in High-dose Irradiated Mice. Health Physics 103:4, pages 400-410.
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Maaike Berbée, Qiang Fu, Sarita Garg, Shilpa Kulkarni, K. Sree Kumar & Martin Hauer-Jensen. (2011) Pentoxifylline Enhances the Radioprotective Properties of γ-Tocotrienol: Differential Effects on the Hematopoietic, Gastrointestinal and Vascular Systems. Radiation Research 175:3, pages 297-306.
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Junru Wang, Marjan Boerma, Ashwini Kulkarni, Morley D. Hollenberg & Martin Hauer-Jensen. (2010) Activation of Protease Activated Receptor 2 by Exogenous Agonist Exacerbates Early Radiation Injury in Rat Intestine. International Journal of Radiation Oncology*Biology*Physics 77:4, pages 1206-1212.
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Zvi Symon, Yifat Goldshmidt, Orit Picard, Miri Yavzori, Shomron Ben-Horin, Dror Alezra, Iris Barshack & Yehuda Chowers. (2010) A Murine Model for the Study of Molecular Pathogenesis of Radiation Proctitis. International Journal of Radiation Oncology*Biology*Physics 76:1, pages 242-250.
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Vesta ValuckaiteOlga ZaborinaJason LongMartin Hauer-Jensen, Junru Wang, Christopher HolbrookAlexander ZaborinKenneth Drabik, Mukta Katdare, Helena Mauceri, Ralph Weichselbaum, Millicent A. FirestoneKa Yee LeeEugene B. Chang, Jeffrey MatthewsJohn C. Alverdy. (2009) Oral PEG 15–20 protects the intestine against radiation: role of lipid rafts. American Journal of Physiology-Gastrointestinal and Liver Physiology 297:6, pages G1041-G1052.
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Qiang Fu, Maaike Berbée, Marjan Boerma, Junru Wang, Herbert A. Schmid & Martin Hauer-Jensen. (2009) The Somatostatin Analog SOM230 (Pasireotide) Ameliorates Injury of the Intestinal Mucosa and Increases Survival after Total-Body Irradiation by Inhibiting Exocrine Pancreatic Secretion. Radiation Research 171:6, pages 698-707.
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Nicolas Jullien, Karl Blirando, Fabien Milliat, Jean-Christophe Sabourin, Marc Benderitter & Agnès François. (2009) Up-Regulation of Endothelin Type A Receptor in Human and Rat Radiation Proctitis: Preclinical Therapeutic Approach With Endothelin Receptor Blockade. International Journal of Radiation Oncology*Biology*Physics 74:2, pages 528-538.
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Maaike Berbée, Qiang Fu, Marjan Boerma, Junru Wang, K. Sree Kumar & Martin Hauer-Jensen. (2009) γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism. Radiation Research 171:5, pages 596-605.
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Marjan Boerma, Junru Wang, Alexander F. Burnett, Alessandro D. Santin, Juan J. Roman & Martin Hauer-Jensen. (2007) Local Administration of Interleukin-11 Ameliorates Intestinal Radiation Injury in Rats. Cancer Research 67:19, pages 9501-9506.
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Junru Wang, Marjan Boerma, Qiang Fu, Ashwini Kulkarni, Louis M. Fink & Martin Hauer-Jensen. (2007) Simvastatin Ameliorates Radiation Enteropathy Development After Localized, Fractionated Irradiation by a Protein C-Independent Mechanism. International Journal of Radiation Oncology*Biology*Physics 68:5, pages 1483-1490.
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Ryo-ichi Yoshimura, Masaru Iwata, Hitoshi Shibuya, Yasuyuki Sakai & Kazunori Kihara. (2006) Acute and late genitourinary toxicity of conformal radiotherapy for prostate cancer. Radiation Medicine 24:8, pages 553-559.
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Junru Wang, Xiaohua Qiu, Ashwini Kulkarni & Martin Hauer-Jensen. (2006) Calcitonin Gene-Related Peptide and Substance P Regulate the Intestinal Radiation Response. Clinical Cancer Research 12:13, pages 4112-4118.
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Junru Wang, Huaien Zheng, Ashwini Kulkarni, Xuemei Ou & Martin Hauer-Jensen. (2006) Regulation of early and delayed radiation responses in rat small intestine by capsaicin-sensitive nerves. International Journal of Radiation Oncology*Biology*Physics 64:5, pages 1528-1536.
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Sulochana Devi, Richard H. Kennedy, Lija Joseph, Nawal S. Shekhawat, Russell B. Melchert & Jacob Joseph. (2006) Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats. Cardiovascular Pathology 15:2, pages 75-82.
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Jacob Joseph, Richard H. Kennedy, Sulochana Devi, Junru Wang, Lija Joseph & Martin Hauer-Jensen. (2005) Protective role of mast cells in homocysteine-induced cardiac remodeling. American Journal of Physiology-Heart and Circulatory Physiology 288:5, pages H2541-H2545.
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J. Wang, H. Zheng, X. Ou, C.M. Albertson, L.M. Fink, J‐M. Herbert & M. Hauer‐Jensen. (2004) Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side‐effects after radiation therapy and as countermeasure against radiation exposure. Journal of Thrombosis and Haemostasis 2:11, pages 2027-2035.
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Jacob Joseph, Lija Joseph, Nawal S. Shekhawat, Sulochana Devi, Junru Wang, Russell B. Melchert, Martin Hauer-Jensen & Richard H. Kennedy. (2003) Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats. American Journal of Physiology-Heart and Circulatory Physiology 285:2, pages H679-H686.
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Junru Wang, Huaien Zheng, Ching-Ching Sung, Konrad K. Richter & Martin Hauer-Jensen. (1998) Cellular Sources of Transforming Growth Factor-β Isoforms in Early and Chronic Radiation Enteropathy. The American Journal of Pathology 153:5, pages 1531-1540.
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Konrad K. Richter, Louis M. Fink, Bradley M. Hughes, Ching-Ching Sung & Martin Hauer-Jensen. (1997) Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?. Radiotherapy and Oncology 44:1, pages 65-71.
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