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Review Article

Cancer stem cells in osteosarcoma: Recent progress and perspective

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Pages 1142-1150 | Received 23 Dec 2010, Accepted 21 Apr 2011, Published online: 01 Jul 2011

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Giulia Bernardini, Marcella Laschi, Michela Geminiani & Annalisa Santucci. (2014) Proteomics of osteosarcoma. Expert Review of Proteomics 11:3, pages 331-343.
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Ruby A. Vincent, Ginevra Passeri, Joshua Northcote‐Smith, Kuldip Singh & Kogularamanan Suntharalingam. (2022) The Osteosarcoma Stem Cell Activity of a Gallium(III)‐Phenanthroline Complex Appended to Salicylate. ChemBioChem 23:24.
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Zhixing Chen, Hui Yang, Qianlu Zhang, Qiongying Hu & Ziyi Zhao. (2022) Chelerythrine Inhibits Stemness of Cancer Stem-Like Cells of Osteosarcoma and PI3K/AKT/mTOR Signal. Journal of Oncology 2022, pages 1-11.
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Weifei Zhang, Liangchen Wei, Jian Weng, Fei Yu, Haotian Qin, Deli Wang & Hui Zeng. (2022) Advances in the research of osteosarcoma stem cells and its related genes. Cell Biology International 46:3, pages 336-343.
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Jiachen He, Chichi Chen, Liang Chen, Ruoyu Cheng, Jie Sun, Xingzhi Liu, Lin Wang, Can Zhu, Sihan Hu, Yuan Xue, Jian Lu, Huiling Yang, Wenguo Cui & Qin Shi. (2022) Honeycomb-Like Hydrogel Microspheres for 3D Bulk Construction of Tumor Models. Research 2022.
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Letizia Polito, Giulia Calafato, Massimo Bortolotti, Cecilia Chiarelli Olivari, Stefania Maiello & Andrea Bolognesi. (2021) Antibody Conjugates for Sarcoma Therapy: How Far along Are We?. Biomedicines 9:8, pages 978.
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Louise Marchandet, Morgane Lallier, Céline Charrier, Marc Baud’huin, Benjamin Ory & François Lamoureux. (2021) Mechanisms of Resistance to Conventional Therapies for Osteosarcoma. Cancers 13:4, pages 683.
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Anita K. Luu & Alicia M. Viloria-Petit. (2020) Targeting Mechanotransduction in Osteosarcoma: A Comparative Oncology Perspective. International Journal of Molecular Sciences 21:20, pages 7595.
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Li Wang, Xiaojia Huang, Xinru You, Tianqi Yi, Bing Lu, Jiali Liu, Guohao Lu, Minglin Ma, Changye Zou, Jun Wu & Wei Zhao. (2020) Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma. Signal Transduction and Targeted Therapy 5:1.
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Ingrid Lilienthal & Nikolas Herold. (2020) Targeting Molecular Mechanisms Underlying Treatment Efficacy and Resistance in Osteosarcoma: A Review of Current and Future Strategies. International Journal of Molecular Sciences 21:18, pages 6885.
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Deng Xiang, Yugang Li & Yanshui Lin. (2020) Circular RNA circCCDC66 Contributes to Malignant Phenotype of Osteosarcoma by Sponging miR-338-3p to Upregulate the Expression of PTP1B. BioMed Research International 2020, pages 1-9.
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Sukru Ozturk, Cansu Gorgun, Sevtap Gokalp, Seda Vatansever & Aylin Sendemir. (2020) Development and characterization of cancer stem cell‐based tumoroids as an osteosarcoma model. Biotechnology and Bioengineering 117:8, pages 2527-2539.
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Lara Šošić, Pål Kristian Selbo, Zuzanna K. Kotkowska, Thomas M. Kündig, Anders Høgset & Pål Johansen. (2020) Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines. Cancers 12:1, pages 165.
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Chao He, Jian Sun, Chao Liu, Yuhang Jiang & Yongqiang Hao. (2019) Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin. Clinical Epigenetics 11:1.
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Elizabeth Ann Roundhill, Sara Jabri & Susan Ann Burchill. (2019) ABCG1 and Pgp identify drug resistant, self-renewing osteosarcoma cells. Cancer Letters 453, pages 142-157.
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Achmad Fauzi Kamal, Deded Yudha Pranatha, Waluyo Sugito, Faisal Rahman, Eka Susanto, Silmi Mariya & Wei Ming Chen. (2018) Isolation, Culture and Characterization of Cancer Stem Cells from Primary Osteosarcoma. The Open Stem Cell Journal 5:1, pages 1-13.
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Hao Li, Xiaodong Fu, Yingjian Gao, Xiaomiao Li, Yi Shen & Weili Wang. (2018) Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells. Journal of Bone Oncology 11, pages 17-22.
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Monica Gatti, Agnese Solari, Alessandra Pattarozzi, Chiara Campanella, Stefano Thellung, Lorella Maniscalco, Raffaella De Maria, Roberto Würth, Alessandro Corsaro, Adriana Bajetto, Alessandra Ratto, Angelo Ferrari, Antonio Daga, Federica Barbieri & Tullio Florio. (2018) In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity. Experimental Cell Research 363:1, pages 48-64.
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Guang-Ning Yan, Xue-Feng Tang, Xian-Chao Zhang, Ting He, Yu-Sheng Huang, Xi Zhang, Gang Meng, De-Yu Guo, Yang-Fan Lv & Qiao-Nan Guo. (2017) TSSC3 represses self-renewal of osteosarcoma stem cells and Nanog expression by inhibiting the Src/Akt pathway. Oncotarget 8:49, pages 85628-85641.
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Yangling Li, Miao Xian, Bo Yang, Meidan Ying & Qiaojun He. (2017) Inhibition of KLF4 by Statins Reverses Adriamycin-Induced Metastasis and Cancer Stemness in Osteosarcoma Cells. Stem Cell Reports 8:6, pages 1617-1629.
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Yutaka Nezu, Kosuke Matsuo, Akira Kawai, Tomoyuki Saito & Takahiro Ochiya. 2017. Osteosarcoma - Biology, Behavior and Mechanisms. Osteosarcoma - Biology, Behavior and Mechanisms.
Swathi V. Iyer, Atul Ranjan, Harold K. Elias, Alejandro Parrales, Hiromi Sasaki, Badal C. Roy, Shahid Umar, Ossama W. Tawfik & Tomoo Iwakuma. (2016) Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression. Nature Communications 7:1.
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Jianxun Yang & Ning Wang. (2016) Analysis of the molecular mechanism of osteosarcoma using a bioinformatics approach. Oncology Letters 12:5, pages 3075-3080.
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Maricel C. Gozo, Dongyu Jia, Paul-Joseph Aspuria, Dong-Joo Cheon, Naoyuki Miura, Ann E. Walts, Beth Y. Karlan & Sandra Orsulic. (2016) FOXC2 augments tumor propagation and metastasis in osteosarcoma. Oncotarget 7:42, pages 68792-68802.
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Ranran Sun, Jacson Shen, Yan Gao, Yubing Zhou, Zujiang Yu, Francis Hornicek, Quancheng Kan & Zhenfeng Duan. (2016) Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential. Oncotarget 7:25, pages 38333-38346.
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Ander Abarrategi, Juan Tornin, Lucia Martinez-Cruzado, Ashley Hamilton, Enrique Martinez-Campos, Juan P. Rodrigo, M. Victoria González, Nicola Baldini, Javier Garcia-Castro & Rene Rodriguez. (2016) Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies. Stem Cells International 2016, pages 1-13.
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Guang-Ning Yan, Yang-Fan Lv & Qiao-Nan Guo. (2016) Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets. Cancer Letters 370:2, pages 268-274.
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Pierre J. Marie, Olivia Fromigué & Dominique Modrowski. 2015. Bone Cancer. Bone Cancer 39 54 .
Markus Rimann, Sandra Laternser, Ana Gvozdenovic, Roman Muff, Bruno Fuchs, Jens M. Kelm & Ursula Graf-Hausner. (2014) An in vitro osteosarcoma 3D microtissue model for drug development. Journal of Biotechnology 189, pages 129-135.
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Francesco Sabbatino, Yangyang Wang, Xinhui Wang, Joseph H. Schwab, Soldano Ferrone & Cristina R. Ferrone. (2014) Novel Tumor Antigen-Specific Monoclonal Antibody-Based Immunotherapy to Eradicate Both Differentiated Cancer Cells and Cancer-Initiating Cells in Solid Tumors. Seminars in Oncology 41:5, pages 685-699.
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HONGTAO HE, JIANGDONG NI & JUN HUANG. (2014) Molecular mechanisms of chemoresistance in osteosarcoma (Review). Oncology Letters 7:5, pages 1352-1362.
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Mojdeh Safari. (2014) An overview of the role of cancer stem cells in spine tumors with a special focus on chordoma. World Journal of Stem Cells 6:1, pages 53.
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Madonna M. McManus, Kurt R. Weiss & Dennis P. M. Hughes. 2014. Current Advances in Osteosarcoma. Current Advances in Osteosarcoma 67 92 .
Marica Gemei, Claudia Corbo, Francesca D'Alessio, Rosa Di Noto, Renza Vento & Luigi Del Vecchio. (2013) Surface proteomic analysis of differentiated versus stem-like osteosarcoma human cells. PROTEOMICS 13:22, pages 3293-3297.
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Eva Wessel Stratford, Monica Bostad, Russell Castro, Ellen Skarpen, Kristian Berg, Anders Høgset, Ola Myklebost & Pål Kristian Selbo. (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:8, pages 4235-4243.
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AINA HE, WEIXIANG QI, YUJING HUANG, TAO FENG, JIE CHEN, YUANJUE SUN, ZAN SHEN & YANG YAO. (2012) CD133 expression predicts lung metastasis and poor prognosis in osteosarcoma patients: A clinical and experimental study. Experimental and Therapeutic Medicine 4:3, pages 435-441.
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Chen Gong, Hui Liao, Jiang Wang, Yang Lin, Jun Qi, Liang Qin, Lin-Qiang Tian & Feng-Jing Guo. (2012) LY294002 Induces G0/G1 Cell Cycle Arrest and Apoptosis of Cancer Stem-like Cells from Human Osteosarcoma Via Down-regulation of PI3K Activity. Asian Pacific Journal of Cancer Prevention 13:7, pages 3103-3107.
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