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Original Articles

Comparable cell survival between high dose rate flattening filter free and conventional dose rate irradiation

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Pages 652-657 | Received 13 Aug 2012, Accepted 28 Sep 2012, Published online: 06 Nov 2012

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Serhat Aras, İ̇hsan Oğuz Tanzer, Seyhan Karaçavuş, Neslihan Sayir, Esra Erdem, Fatih Hacımustafaoğlu, Ceren Ezgi Erdoğan, Tansel Sapmaz, Türkan İkizceli, Halime Hanım Pençe, Kürşad Nuri Baydili & Tolga Katmer. (2023) Effect of melatonin on low and high dose radiotherapy induced thyroid injury. Biotechnic & Histochemistry 98:5, pages 346-352.
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Serhat Aras, Ihsan Oguz Tanzer, Seyhan Karacavus, Neslihan Sayir, Esra Erdem, Fatih Hacimustafaoglu, Ceren Ezgi Erdogan, Tansel Sapmaz, Turkan Ikizceli, Halime Hanim Pence, Kursad Nuri Baydili & Tolga Katmer. (2021) Radioprotective effect of melatonin against flattening filter-free irradiation-induced rat parotid gland damage. Radiation Effects and Defects in Solids 176:7-8, pages 621-637.
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Serhat Aras, Mustafa Efendioğlu, Aini Wulamujiang, Sidika Seyma Ozkanli, Mevlüt Sait Keleş & İhsan Oğuz Tanzer. (2021) Radioprotective effect of melatonin against radiotherapy-induced cerebral cortex and cerebellum damage in rat. International Journal of Radiation Biology 97:3, pages 348-355.
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Serhat Aras, İhsan Oğuz Tanzer, Neslihan Sayir, Mevlüt Sait Keleş & Fatma Betül Özgeriş. (2021) Radiobiological comparison of flattening filter (FF) and flattening filter-free (FFF) beam in rat laryngeal tissue. International Journal of Radiation Biology 97:2, pages 249-255.
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Ludwig Dubois, Rianne Biemans, Brigitte Reniers, Geert Bosmans, Daniela Trani, Mark Podesta, Robert Kollaard, Kasper ma Rouschop, Jan Theys, Marc Vooijs, Martin Pruschy, Frank Verhaegen & Philippe Lambin. (2015) High dose rate and flattening filter free irradiation can be safely implemented in clinical practice. International Journal of Radiation Biology 91:10, pages 778-785.
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Articles from other publishers (22)

Serhat Aras, Seyma Ozkanli, Esra Erdem, Sevtap Gokalp & Ceren Ezgi Erdogan. (2023) Investigation of low and high dose rate X-ray effects on histopathological changes and prognostic importance of Ki-67 in laryngeal cancer radiotherapy. Applied Radiation and Isotopes 197, pages 110823.
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Valentina Dini, Giuseppe Esposito, Andrea Sacconi, Marco D’Andrea, Maria Antonella Tabocchini, Pasquale Anello, Lucia Ricci-Vitiani, Mariachiara Buccarelli, Roberto Pallini & Lidia Strigari. (2023) Effectiveness of Flattening-Filter-Free versus Flattened Beams in V79 and Glioblastoma Patient-Derived Stem-like Cells. International Journal of Molecular Sciences 24:2, pages 1107.
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Chao Ge, Huidong Wang, Kunzhi Chen, Wuji Sun, Huicheng Li & Yinghua Shi. (2022) Effect of plan complexity on the dosimetry, delivery accuracy, and interplay effect in lung VMAT SBRT with 6 MV FFF beam. Strahlentherapie und Onkologie 198:8, pages 744-751.
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Ana Marques, Ana Belchior, Francisco Silva, Fernanda Marques, Maria Paula Cabral Campello, Teresa Pinheiro, Pedro Santos, Luis Santos, António P. A. Matos & António Paulo. (2022) Dose Rate Effects on the Selective Radiosensitization of Prostate Cells by GRPR-Targeted Gold Nanoparticles. International Journal of Molecular Sciences 23:9, pages 5279.
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Serhat Aras, İhsan Oğuz Tanzer, Ünal Can, Hikmettin Demir, Engin Sümer, Kürşad Nuri Baydili & Rahime Orak. (2022) Radioprotective effects of melatonin against varying dose rates on radiotherapy-induced salivary gland damage scintigraphy findings. Radiation Physics and Chemistry 193, pages 109953.
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Serhat Aras. (2021) Effect of Flattening Filter and Flattening Filter Free beams on radiotherapy-induced peripheral blood cell damage. Radiation Physics and Chemistry 182, pages 109383.
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Serhat Aras, İhsan Oğuz Tanzer, Ünal Can, Engin Sümer & Kürşad Nuri Baydili. (2021) The role of melatonin on acute thyroid damage induced by high dose rate X-ray in head and neck radiotherapy. Radiation Physics and Chemistry 179, pages 109206.
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M. Ben Kacem, M. A. Benadjaoud, M. Dos Santos, F. Soysouvanh,  V. Buard, G. Tarlet, B. Le Guen, A. François, O. Guipaud, F. Milliat &  V. Paget. (2020) Variation of 4 MV X-ray dose rate strongly impacts biological response both in vitro and in vivo. Scientific Reports 10:1.
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Gyöngyi Farkas, Zsuzsa S Kocsis, Gábor Székely, Dalma Mihály, Csilla Pesznyák, Tamás Pócza, Tibor Major, Csaba Polgár & Zsolt Jurányi. (2020) Quantifying biological effects of radiation from high-energy linear accelerators on lymphocytes. Journal of Radiation Research 61:1, pages 73-81.
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Keren Tazat, Oleg Reshetnyak, Natan Shtraus, Ifat Sayag, Nicola J. Mabjeesh & Sharon Amir. (2020) Delivery of Radiation at the Lowest Dose Rate by a Modern Linear Accelerator is Most Effective in Inhibiting Prostate Cancer Growth. Technology in Cancer Research & Treatment 19, pages 153303382093552.
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Jing Hao, Andrew Godley, Jocelyn D. Shoemake, Zheyi Han, Anthony Magnelli & Jennifer S. Yu. (2018) The effects of extra high dose rate irradiation on glioma stem-like cells. PLOS ONE 13:8, pages e0202533.
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Hisashi Nakano, Kazumasa Minami, Masashi Yagi, Hiromasa Imaizumi, Yuki Otani, Shinichi Inoue, Masaaki Takashina, Yuji Seo, Yutaka Takahashi, Iori Sumida, Kazuhiko Ogawa & Masahiko Koizumi. (2018) Radiobiological effects of flattening filter–free photon beams on A549 non-small-cell lung cancer cells. Journal of Radiation Research 59:4, pages 442-445.
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Katharina Bell, Jochen Fleckenstein, Frank Nuesken, Norbert Licht, Christian Rübe & Yvonne Dzierma. (2016) mARC Treatment of Hypopharynx Carcinoma with Flat and Flattening-Filter-Free Beam Energies – A Planning Study. PLOS ONE 11:10, pages e0164616.
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Judit Boda-Heggemann, Antje-Christin Knopf, Anna Simeonova-Chergou, Hansjörg Wertz, Florian Stieler, Anika Jahnke, Lennart Jahnke, Jens Fleckenstein, Lena Vogel, Anna Arns, Manuel Blessing, Frederik Wenz & Frank Lohr. (2016) Deep Inspiration Breath Hold—Based Radiation Therapy: A Clinical Review. International Journal of Radiation Oncology*Biology*Physics 94:3, pages 478-492.
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Anna Simeonova-Chergou, Anika Jahnke, Kerstin Siebenlist, Florian Stieler, Sabine Mai, Judit Boda-Heggemann, Frederik Wenz, Frank Lohr & Lennart Jahnke. (2016) Automatically gated image-guided breath-hold IMRT is a fast, precise, and dosimetrically robust treatment for lung cancer patientsAutomatisch gesteuerte, bildgestützte IMRT im Atemanhalt als schnelle, präzise und dosimetrisch stabile Therapie für Patienten mit Bronchialkarzinom. Strahlentherapie und Onkologie 192:3, pages 166-173.
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Sonja Stieb, Stephanie Lang, Claudia Linsenmeier, Shaun Graydon & Oliver Riesterer. (2015) Safety of high-dose-rate stereotactic body radiotherapy. Radiation Oncology 10:1.
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Mi-Hyoung Kim, Seung-Youn Jung, Jiyeon Ahn, Sang-Gu Hwang, Hee-Jong Woo, Sungkwan An, Seon Young Nam, Dae-Seog Lim & Jie-Young Song. (2015) Quantitative proteomic analysis of single or fractionated radiation-induced proteins in human breast cancer MDA-MB-231 cells. Cell & Bioscience 5:1.
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Caroline Steenken, Jens Fleckenstein, Stefan Kegel, Lennart Jahnke, Anna Simeonova, Linda Hartmann, Jens Kübler, Marlon R. Veldwijk, Frederik Wenz, Carsten Herskind & Frank Anton Giordano. (2015) Impact of flattening-filter-free radiation on the clonogenic survival of astrocytic cell linesEinfluss von Flattening-Filter-freier Bestrahlung auf das klonogene Überleben von Astrozytomzelllinien. Strahlentherapie und Onkologie 191:7, pages 590-596.
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Jan Hrbacek, Stephanie Lang, Shaun N. Graydon, Stephan Klöck & Oliver Riesterer. (2014) Dosimetric comparison of flattened and unflattened beams for stereotactic ablative radiotherapy of stage I non-small cell lung cancer. Medical Physics 41:3, pages 031709.
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Florian Stieler, Jens Fleckenstein, Anna Simeonova, Frederik Wenz & Frank Lohr. (2013) Intensity modulated radiosurgery of brain metastases with flattening filter-free beams. Radiotherapy and Oncology 109:3, pages 448-451.
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Judit Boda-Heggemann, Sabine Mai, Jens Fleckenstein, Kerstin Siebenlist, Anna Simeonova, Michael Ehmann, Volker Steil, Frederik Wenz, Frank Lohr & Florian Stieler. (2013) Flattening-filter-free intensity modulated breath-hold image-guided SABR (Stereotactic ABlative Radiotherapy) can be applied in a 15-min treatment slot. Radiotherapy and Oncology 109:3, pages 505-509.
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Nicolas Peguret, Max Dahele, Johan P. Cuijpers, Ben J. Slotman & Wilko F.A.R. Verbakel. (2013) Frameless high dose rate stereotactic lung radiotherapy: Intrafraction tumor position and delivery time. Radiotherapy and Oncology 107:3, pages 419-422.
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