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Acta Oncologica Volume 53, 2014 - Issue 3
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ORIGINAL ARTICLES

Can dogs smell lung cancer? First study using exhaled breath and urine screening in unselected patients with suspected lung cancer

Tore AmundsenDepartment of Thoracic Medicine, St. Olavs Hospital HF, Trondheim, Norway;Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayCorrespondence[email protected]
,
Stein SundstrømDepartment of Oncology, St. Olavs Hospital HF, Trondheim, Norway
,
Turid BuvikTrondheim School of Dog Behaviour, Trondheim, Norway
,
Odrun Arna GederaasDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
&
Rune HaaverstadDepartment of Cardiothoracic Surgery, Haukeland University Hospital, Bergen, Norway;Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway
Pages 307-315 | Received 19 Mar 2013, Accepted 10 Jun 2013, Published online: 19 Aug 2013

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Spencer W. Brooks, Daniel R. Moore, Evan B. Marzouk, Frasier R. Glenn & Robert M. Hallock. (2015) Canine Olfaction and Electronic Nose Detection of Volatile Organic Compounds in the Detection of Cancer: A Review. Cancer Investigation 33:9, pages 411-419.
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Articles from other publishers (43)

Tien Le & Ronny Priefer. (2023) Detection technologies of volatile organic compounds in the breath for cancer diagnoses. Talanta 265, pages 124767.
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Shih-Feng Liu, Hung-I Lu, Wei-Lien Chi, Guan-Heng Liu & Ho-Chang Kuo. (2023) Sniffer Dogs Diagnose Lung Cancer by Recognition of Exhaled Gases: Using Breathing Target Samples to Train Dogs Has a Higher Diagnostic Rate Than Using Lung Cancer Tissue Samples or Urine Samples. Cancers 15:4, pages 1234.
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Micah OxnerAllyson TrangJhalak MehtaChristopher ForsythBarbara SwansonAli KeshavarzianAbhinav Bhushan. (2023) The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases. BME Frontiers 4.
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Flora Gouzerh, Guila Ganem, Anaïs Pichevin, Laurent Dormont & Frédéric Thomas. (2023) Ability of animals to detect cancer odors. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:1, pages 188850.
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Astrid Concha. 2023. Olfactory Research in Dogs. Olfactory Research in Dogs 291 331 .
Tadeusz Jezierski & Michał Dzięcioł. 2023. Chemical Signals in Vertebrates 15. Chemical Signals in Vertebrates 15 453 487 .
Margaret A. Crawford, John A. Perrone, Clare M. Browne, Catherina L. Chang, Sandra Hopping & Timothy L. Edwards. (2022) Transitioning from training to testing with scent detection animals: Application to lung cancer detection dogs. Journal of Veterinary Behavior 55-56, pages 23-34.
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Aiden E. Juge, Margaret F. Foster & Courtney L. Daigle. (2022) Canine olfaction as a disease detection technology: A systematic review. Applied Animal Behaviour Science 253, pages 105664.
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Petra Riedlova, Spiros Tavandzis, Josef Kana, Miroslava Tobiasova, Iva Jasickova & Jaromir Roubec. (2022) Olfactometric diagnosis of lung cancer by canine scent – A double-blinded study. Complementary Therapies in Medicine 64, pages 102800.
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Pierre Bauër, Michelle Leemans, Etienne Audureau, Caroline Gilbert, Carole Armal & Isabelle Fromantin. (2022) Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review. Integrative Cancer Therapies 21, pages 153473542211405.
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Charlotte Feil, Frank Staib, Martin R. Berger, Thorsten Stein, Irene Schmidtmann, Andreas Forster & Carl C. Schimanski. (2021) Sniffer dogs can identify lung cancer patients from breath and urine samples. BMC Cancer 21:1.
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Agata Kokocińska-Kusiak, Martyna Woszczyło, Mikołaj Zybala, Julia Maciocha, Katarzyna Barłowska & Michał Dzięcioł. (2021) Canine Olfaction: Physiology, Behavior, and Possibilities for Practical Applications. Animals 11:8, pages 2463.
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Paula Jendrny, Friederike Twele, Sebastian Meller, Albertus Dominicus Marcellinus Eras Osterhaus, Esther Schalke & Holger Andreas Volk. (2021) Canine olfactory detection and its relevance to medical detection. BMC Infectious Diseases 21:1.
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Shoko Kure, Shinya Iida, Marina Yamada, Hiroyuki Takei, Naoyuki Yamashita, Yuji Sato & Masao Miyashita. (2021) Breast Cancer Detection from a Urine Sample by Dog Sniffing: A Preliminary Study for the Development of a New Screening Device, and a Literature Review. Biology 10:6, pages 517.
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Roberto Gasparri, Giulia Sedda, Valentina Caminiti, Patrick Maisonneuve, Elena Prisciandaro & Lorenzo Spaggiari. (2021) Urinary Biomarkers for Early Diagnosis of Lung Cancer. Journal of Clinical Medicine 10:8, pages 1723.
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Srikar S Muppidi, Rishi Katragadda, Julia Lega, Taqiyya Alford, Carolyn B Aidman & Charles Moore. (2021) A review of the efficacy of a low-cost cancer screening test using cancer sniffing canines. Journal of Breath Research 15:2, pages 024001.
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Roland Becker. (2020) Non-invasive cancer detection using volatile biomarkers: Is urine superior to breath?. Medical Hypotheses 143, pages 110060.
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Agata Kokocinska-Kusiak, Joanna Matalińska, Mariusz Sacharczuk, Magdalena Sobczyńska, Katarzyna Góral-Radziszewska, Beata Wileńska, Aleksandra Misicka & Tadeusz Jezierski. (2020) Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear?. Journal of Veterinary Behavior 39, pages 64-76.
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Claire M. Guest, Rob Harris, Iqbal Anjum, Astrid R. Concha & Nicola J. Rooney. (2020) A Lesson in Standardization – Subtle Aspects of the Processing of Samples Can Greatly Affect Dogs' Learning. Frontiers in Veterinary Science 7.
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Kai Yang, Jingzhou Ma, Xiaokang Qiao, Yawei Cui, Lichao Jia & Hongqiang Wang. (2020) Hierarchical porous LaFeO3 nanostructure for efficient trace detection of formaldehyde. Sensors and Actuators B: Chemical 313, pages 128022.
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Jennifer L. Essler, Clara Wilson, Alexander C. Verta, Rebecca Feuer & Cynthia M. Otto. (2020) Differences in the Search Behavior of Cancer Detection Dogs Trained to Have Either a Sit or Stand-Stare Final Response. Frontiers in Veterinary Science 7.
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Silvia Michela Mazzola, Federica Pirrone, Giulia Sedda, Roberto Gasparri, Rosalia Romano, Lorenzo Spaggiari & Albertini Mariangela. (2020) Two-step investigation of lung cancer detection by sniffer dogs. Journal of Breath Research 14:2, pages 026011.
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Roger Giese & Klaus Hackner. 2020. Breathborne Biomarkers and the Human Volatilome. Breathborne Biomarkers and the Human Volatilome 551 581 .
Heather Junqueira, Thomas A. Quinn, Roger Biringer, Mohamed Hussein, Courtney Smeriglio, Luisa Barrueto, Jordan Finizio & Xi Ying “Michelle” Huang. (2019) Accuracy of Canine Scent Detection of Non–Small Cell Lung Cancer in Blood Serum. The Journal of the American Osteopathic Association 119:7, pages 413-418.
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Annamaria Catino, Gianluigi de Gennaro, Alessia Di Gilio, Laura Facchini, Domenico Galetta, Jolanda Palmisani, Francesca Porcelli & Niccolò Varesano. (2019) Breath Analysis: A Systematic Review of Volatile Organic Compounds (VOCs) in Diagnostic and Therapeutic Management of Pleural Mesothelioma. Cancers 11:6, pages 831.
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Mary Jean Amon & Luis H. Favela. (2019) Distributed cognition criteria: Defined, operationalized, and applied to human-dog systems. Behavioural Processes 162, pages 167-176.
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Anni Koskinen, Adel Bachour, Jenni Vaarno, Heli Koskinen, Sari Rantanen, Leif Bäck & Tuomas Klockars. (2018) A detection dog for obstructive sleep apnea. Sleep and Breathing 23:1, pages 281-285.
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Chris Newman & Christina D. Buesching. 2019. Chemical Signals in Vertebrates 14. Chemical Signals in Vertebrates 14 238 250 .
Catherine Reeve, Peter Wentzell, Bjorn Wielens, Cortney Jones, Kim Stehouwer & Simon Gadbois. (2018) Assessing individual performance and maintaining breath sample integrity in biomedical detection dogs. Behavioural Processes 155, pages 8-18.
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Emanuele Brai & Lavinia Alberi. 2018. Sensory Nervous System. Sensory Nervous System.
Carola Fischer-Tenhagen, Dorothea Johnen, Irene Nehls & Roland Becker. (2018) A Proof of Concept: Are Detection Dogs a Useful Tool to Verify Potential Biomarkers for Lung Cancer?. Frontiers in Veterinary Science 5.
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Jim Shields & Lana M. Austin. 2018. Using Detection Dogs to Monitor Aquatic Ecosystem Health and Protect Aquatic Resources. Using Detection Dogs to Monitor Aquatic Ecosystem Health and Protect Aquatic Resources 71 117 .
Alex D Rygg, Blaire Van Valkenburgh & Brent A Craven. (2017) The Influence of Sniffing on Airflow and Odorant Deposition in the Canine Nasal Cavity. Chemical Senses 42:8, pages 683-698.
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Timothy L. Edwards, Clare M. Browne, Adee Schoon, Christophe Cox & Alan Poling. (2017) Animal olfactory detection of human diseases: Guidelines and systematic review. Journal of Veterinary Behavior 20, pages 59-73.
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Carola Fischer-Tenhagen, Dorothea Johnen, Wolfgang Heuwieser, Roland Becker, Kristin Schallschmidt & Irene Nehls. (2017) Odor Perception by Dogs: Evaluating Two Training Approaches for Odor Learning of Sniffer Dogs. Chemical Senses 42:5, pages 435-441.
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Federica Pirrone & Mariangela Albertini. (2017) Olfactory detection of cancer by trained sniffer dogs: A systematic review of the literature. Journal of Veterinary Behavior 19, pages 105-117.
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Klaus Hackner & Joachim Pleil. (2017) Canine olfaction as an alternative to analytical instruments for disease diagnosis: understanding ‘dog personality’ to achieve reproducible results. Journal of Breath Research 11:1, pages 012001.
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Mark E. LasburyMark E. Lasbury. 2017. The Realization of Star Trek Technologies. The Realization of Star Trek Technologies 279 312 .
Klaus Hackner, Peter Errhalt, Michael Rolf Mueller, Manulea Speiser, Beatrice A Marzluf, Andrea Schulheim, Peter Schenk, Johannes Bilek & Theodor Doll. (2016) Canine scent detection for the diagnosis of lung cancer in a screening-like situation. Journal of Breath Research 10:4, pages 046003.
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. 2016. Canine Olfaction Science and Law. Canine Olfaction Science and Law 409 461 .
Tadeusz Jezierski, Marta Walczak, Tomasz Ligor, Joanna Rudnicka & Bogusław Buszewski. (2015) Study of the art: canine olfaction used for cancer detection on the basis of breath odour. Perspectives and limitations. Journal of Breath Research 9:2, pages 027001.
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Kristin Schallschmidt, Roland Becker, Hanna Zwaka, Randolf Menzel, Dorothea Johnen, Carola Fischer-Tenhagen, Jana Rolff & Irene Nehls. (2015) In vitro cultured lung cancer cells are not suitable for animal-based breath biomarker detection . Journal of Breath Research 9:2, pages 027103.
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Sala Horowitz. (2014) The Olfactory Sense and Its Clinical Applications. Alternative and Complementary Therapies 20:3, pages 130-135.
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