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Acta Oncologica Volume 53, 2014 - Issue 3
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LETTERS TO THE EDITOR

Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

Peter NygrenDepartment of Radiology, Oncology and Radiation Science, Section of Oncology, Uppsala University, Uppsala, SwedenCorrespondence[email protected]
&
Rolf LarssonDepartment of Medical Sciences, Section of Clinical Pharmacology, Uppsala University, Uppsala, Sweden
Pages 427-428 | Received 07 Sep 2013, Accepted 09 Sep 2013, Published online: 28 Oct 2013

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Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, David Solow-Cordero, Kwang-Min Kim, Aneesh V Samineni, Mansi B Parekh, Lobat Tayebi & Jayakumar Rajadas. (2016) Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. Drug Design, Development and Therapy 10, pages 1307-1322.
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Crossref
V Walf-Vorderwülbecke, K Pearce, T Brooks, M Hubank, M M van den Heuvel-Eibrink, C M Zwaan, S Adams, D Edwards, J Bartram, S Samarasinghe, P Ancliff, A Khwaja, N Goulden, G Williams, J de Boer & O Williams. (2017) Targeting acute myeloid leukemia by drug-induced c-MYB degradation. Leukemia 32:4, pages 882-889.
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Crossref
Tesshi Yamada & Mari Masuda. (2017) Emergence of TNIK inhibitors in cancer therapeutics . Cancer Science 108:5, pages 818-823.
Crossref
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Crossref
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Crossref
Tara Williamson, Ren-Yuan Bai, Verena Staedtke, David Huso & Gregory J. Riggins. (2016) Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model. Oncotarget 7:42, pages 68571-68584.
Crossref
Giridhar Mudduluru, Wolfgang Walther, Dennis Kobelt, Mathias Dahlmann, Christoph Treese, Yehuda G. Assaraf & Ulrike Stein. (2016) Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets. Drug Resistance Updates 26, pages 10-27.
Crossref
Věra Králová, Veronika Hanušová, Emil Rudolf, Kristýna Čáňová & Lenka Skálová. (2016) Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro . Journal of Pharmacy and Pharmacology 68:2, pages 208-218.
Crossref
J. Jesús Naveja, Alfonso Dueñas-González & José L. Medina-Franco. 2016. Epi-Informatics. Epi-Informatics 327 357 .
Francesco Bertolini, Vikas P. Sukhatme & Gauthier Bouche. (2015) Drug repurposing in oncology—patient and health systems opportunities. Nature Reviews Clinical Oncology 12:12, pages 732-742.
Crossref
Christina T.K. Wales, Frederick R. Taylor, Allan T. Higa, Harvey A. McAllister & Aaron T. Jacobs. (2015) ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells. Anti-Cancer Drugs 26:6, pages 657-666.
Crossref
Jeffrey Skolnick, Mu Gao, Ambrish Roy, Bharath Srinivasan & Hongyi Zhou. (2015) Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function. Bioorganic & Medicinal Chemistry Letters 25:6, pages 1163-1170.
Crossref
Martin Michaelis, Bishr Agha, Florian Rothweiler, Nadine Löschmann, Yvonne Voges, Michel Mittelbronn, Tatjana Starzetz, Patrick N. Harter, Behnaz A. Abhari, Simone Fulda, Frank Westermann, Kristoffer Riecken, Silvia Spek, Klaus Langer, Michael Wiese, Wilhelm G. Dirks, Richard Zehner, Jaroslav Cinatl, Mark N. Wass & Jindrich Cinatljr.jr.. (2015) Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen. Scientific Reports 5:1.
Crossref
Andrew R. Larsen, Ren-Yuan Bai, Jon H. Chung, Alexandra Borodovsky, Charles M. Rudin, Gregory J. Riggins & Fred Bunz. (2015) Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor. Molecular Cancer Therapeutics 14:1, pages 3-13.
Crossref
Bhavneet Bhinder, Jeni P. Mahida, Glorymar Ibáñez, Kathryn Champ, Christophe Antczak & Hakim Djaballah. 2015. Recent Advances in Retinoblastoma Treatment. Recent Advances in Retinoblastoma Treatment 73 84 .
. (2014) Mebendazole/oxaliplatin. Reactions Weekly 1497:1, pages 26-26.
Crossref

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