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Research Article

RANKL Inhibition Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta

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Pages 123-131 | Received 02 Apr 2009, Accepted 10 Jun 2009, Published online: 06 Jan 2010

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Read on this site (3)

Tanya A Enderli, Stephanie R Burtch, Jara N Templet & Alessandra Carriero. (2016) Animal models of osteogenesis imperfecta: applications in clinical research. Orthopedic Research and Reviews 8, pages 41-55.
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Roberta Besio & Antonella Forlino. (2015) Treatment options for osteogenesis imperfecta. Expert Opinion on Orphan Drugs 3:2, pages 165-181.
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Roberta Besio & Antonella Forlino. (2015) New frontiers for dominant osteogenesis imperfecta treatment: gene/cellular therapy approaches. Advances in Regenerative Biology 2:1.
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Articles from other publishers (30)

Grégoire André, Antoine Chretien, Antoine Demoulin, Mélanie Beersaerts, Pierre-Louis Docquier & Catherine Behets. (2023) Col1A-2 Mutation in Osteogenesis Imperfecta Mice Contributes to Long Bone Fragility by Modifying Cell-Matrix Organization. International Journal of Molecular Sciences 24:23, pages 17010.
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Long Bai, Yanpeng Liu, Xiaohui Zhang, Peiru Chen, Ruiqiang Hang, Yin Xiao, Jing Wang & Changsheng Liu. (2023) Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy. Biomaterials 297, pages 122125.
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Natividad Alcorta-Sevillano, Arantza Infante, Iratxe Macías & Clara I. Rodríguez. (2022) Murine Animal Models in Osteogenesis Imperfecta: The Quest for Improving the Quality of Life. International Journal of Molecular Sciences 24:1, pages 184.
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Fang Lv, Xiaoling Cai & Linong Ji. (2022) An Update on Animal Models of Osteogenesis Imperfecta. Calcified Tissue International 111:4, pages 345-366.
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No’ad Shanas, William Querido, Jack Oswald, Karl Jepsen, Erin Carter, Cathleen Raggio & Nancy Pleshko. (2021) Infrared Spectroscopy-Determined Bone Compositional Changes Associated with Anti-Resorptive Treatment of the oim/oim Mouse Model of Osteogenesis Imperfecta . Applied Spectroscopy 76:4, pages 416-427.
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Julia Etich, Mirko Rehberg, Beate Eckes, Gerhard Sengle, Oliver Semler & Frank Zaucke. (2020) Signaling pathways affected by mutations causing osteogenesis imperfecta. Cellular Signalling 76, pages 109789.
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Mickaël Cardinal, Alicia Dessain, Thomas Roels, Sébastien Lafont, Michael S. Ominsky, Jean-Pierre Devogelaer, Daniel Chappard, Guillaume Mabilleau, Patrick Ammann, Catherine Nyssen-Behets & Daniel H. Manicourt. (2020) Sclerostin-Antibody Treatment Decreases Fracture Rates in Axial Skeleton and Improves the Skeletal Phenotype in Growing oim/oim Mice. Calcified Tissue International 106:5, pages 494-508.
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Y. Ko, G. Lee, B. Kim, M. Park, Y. Jang & W. Lim. (2019) Modification of the RANKL-RANK-binding site for the immunotherapeutic treatment of osteoporosis. Osteoporosis International 31:5, pages 983-993.
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Peter Varga, Bettina M. Willie, Chris Stephan, Kenneth M. Kozloff & Philippe K. Zysset. (2020) Finite element analysis of bone strength in osteogenesis imperfecta. Bone 133, pages 115250.
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Junho Ahn, Erin Carter, Cathleen L. Raggio & Daniel W. Green. (2019) Acetabular Protrusio in Patients With Osteogenesis Imperfecta: Risk Factors and Progression. Journal of Pediatric Orthopaedics 39:10, pages e750-e754.
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Izaskun Mitxitorena, Arantza Infante, Blanca Gener & Clara I Rodríguez. (2019) Suitability and limitations of mesenchymal stem cells to elucidate human bone illness. World Journal of Stem Cells 11:9, pages 578-593.
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Mickaël Cardinal, Janne Tys, Thomas Roels, Sébastien Lafont, Michael S. Ominsky, Jean-Pierre Devogelaer, Daniel Chappard, Guillaume Mabilleau, Patrick Ammann, Catherine Nyssen-Behets & Daniel H. Manicourt. (2019) Sclerostin antibody reduces long bone fractures in the oim/oim model of osteogenesis imperfecta. Bone 124, pages 137-147.
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Giacomina Brunetti, Gabriele D’Amato, Mariangela Chiarito, Apollonia Tullo, Graziana Colaianni, Silvia Colucci, Maria Grano & Maria Felicia Faienza. (2018) An update on the role of RANKL–RANK/osteoprotegerin and WNT-ß-catenin signaling pathways in pediatric diseases. World Journal of Pediatrics 15:1, pages 4-11.
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Roy Morello. (2018) Osteogenesis imperfecta and therapeutics. Matrix Biology 71-72, pages 294-312.
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Stacey L. Fossey, John L. Vahle & Joel R. Leininger. 2018. Boorman's Pathology of the Rat. Boorman's Pathology of the Rat 299 319 .
Gwangchul Lee, Youngjong Ko, Mineon Park, Bora Kim, Hoon Hyun & Wonbong Lim. (2018) Recombinant DNA cloning of the active region of the receptor activator of NF-κB ligand (RANKL) gene and its role in osteoclastogenesis. Biotechnology and Bioprocess Engineering 22:6, pages 686-692.
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Ronit Marom, Yi-Chien Lee, Ingo Grafe & Brendan Lee. (2016) Pharmacological and biological therapeutic strategies for osteogenesis imperfecta. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 172:4, pages 367-383.
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Cathleen L Raggio, Nancy Pleshko & Adele L Boskey. (2016) The Effect of Stontium Ranelate on Fracture Reduction in Osteogenesis Imperfecta is Comparable to Recent Bisphosphonate Data. Journal of Bone and Mineral Research 31:11, pages 2065-2065.
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Shinya Takigawa, Brian Frondorf, Shengzhi Liu, Yang Liu, Baiyan Li, Akihiro Sudo, Joseph M. Wallace, Hiroki Yokota & Kazunori Hamamura. (2016) Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice. Journal of Pharmacological Sciences 132:2, pages 154-161.
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G. Brunetti, F. Papadia, A. Tummolo, R. Fischetto, F. Nicastro, L. Piacente, A. Ventura, G. Mori, A. Oranger, I. Gigante, S. Colucci, M. Ciccarelli, M. Grano, L. Cavallo, M. Delvecchio & M. F. Faienza. (2016) Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-?. Osteoporosis International 27:7, pages 2355-2365.
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Stacey Fossey, John Vahle, Philip Long, Scott Schelling, Heinrich Ernst, Rogely Waite Boyce, Jacquelin Jolette, Brad Bolon, Alison Bendele, Matthias Rinke, Laura Healy, Wanda High, Daniel Robert Roth, Michael Boyle & Joel Leininger. (2016) Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth). Journal of Toxicologic Pathology 29:3_Suppl, pages 49S-103S.
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Adele L. Boskey, Josephine Marino, Lyudmila Spevak, Nancy Pleshko, Stephen Doty, Erin M. Carter & Cathleen L. Raggio. (2015) Are Changes in Composition in Response to Treatment of a Mouse Model of Osteogenesis Imperfecta Sex-dependent?. Clinical Orthopaedics and Related Research? 473:8, pages 2587-2598.
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Robert O. Ritchie. (2014) In pursuit of damage tolerance in engineering and biological materials. MRS Bulletin 39:10, pages 880-890.
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Alessandra Carriero, Elizabeth A Zimmermann, Adriana Paluszny, Simon Y Tang, Hrishikesh Bale, Bjorn Busse, Tamara Alliston, Galateia Kazakia, Robert O Ritchie & Sandra J Shefelbine. (2014) How Tough Is Brittle Bone? Investigating Osteogenesis Imperfecta in Mouse Bone. Journal of Bone and Mineral Research 29:6, pages 1392-1401.
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Eric S. Orwoll & Elizabeth Martin. 2014. Osteogenesis Imperfecta. Osteogenesis Imperfecta 519 525 .
Charlotte L. Phillips, Stephanie M. Carleton & Bettina A. Gentry. 2014. Osteogenesis Imperfecta. Osteogenesis Imperfecta 197 207 .
Xiaomei Yao, Stephanie M. Carleton, Arin D. Kettle, Jennifer Melander, Charlotte L. Phillips & Yong Wang. (2013) Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model. Annals of Biomedical Engineering 41:6, pages 1139-1149.
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Marianne Rohrbach & Cecilia Giunta. (2012) Recessive osteogenesis imperfecta: Clinical, radiological, and molecular findings. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 160C:3, pages 175-189.
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R. Bargman, R. Posham, A. L. Boskey, E. DiCarlo, C. Raggio & N. Pleshko. (2011) Comparable outcomes in fracture reduction and bone properties with RANKL inhibition and alendronate treatment in a mouse model of osteogenesis imperfecta. Osteoporosis International 23:3, pages 1141-1150.
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Antonella Forlino, Wayne A. Cabral, Aileen M. Barnes & Joan C. Marini. (2011) New perspectives on osteogenesis imperfecta. Nature Reviews Endocrinology 7:9, pages 540-557.
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