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Research Article

The MEK5/ERK5 pathway mediates fluid shear stress promoted osteoblast differentiation

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Pages 96-102 | Received 07 May 2013, Accepted 07 Oct 2013, Published online: 10 Jan 2014

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Xingwen Wang, Bin Geng, Hong Wang, shenghong Wang, Dacheng Zhao, Jinwen He, Fan Lu, Jiangdong An, Cuifang Wang & Yayi Xia. (2022) Fluid shear stress-induced down-regulation of microRNA-140-5p promotes osteoblast proliferation by targeting VEGFA via the ERK5 pathway. Connective Tissue Research 63:2, pages 156-168.
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Bo Zhang, Liping An, Bin Geng, Ning Ding, Elam Coalson, Lang Wan, Liang Yan, Fawaz H. A. Mohammed, Chongwen Ma, Rui Li, Xinxin Yang, Xiaohui Zhang, Cuifang Wang, Jinglin Ma & Yayi Xia. (2021) ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress. Connective Tissue Research 62:2, pages 194-205.
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Zhang Bo, Geng Bin, Wang Jing, Wang Cuifang, An Liping, Ma Jinglin, Jiang Jin, Tan Xiaoyi, Chen Cong, Ding Ning & Xia Yayi. (2016) Fluid shear stress promotes osteoblast proliferation via the Gαq–ERK5 signaling pathway. Connective Tissue Research 57:4, pages 299-306.
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Articles from other publishers (18)

Yunxian Jia, Zarnaz Khan, Mili Ji, Wenjin Zhong, Xuehao Wang, Airong Qian & Lifang Hu. 2024. Bone Cell Biomechanics, Mechanobiology and Bone Diseases. Bone Cell Biomechanics, Mechanobiology and Bone Diseases 125 149 .
Fahima Munmun, Omair A. Mohiuddin, Van T. Hoang, Matthew E. Burow, Bruce A. Bunnell, Veronica M. Sola, Agata R. Carpentieri & Paula A. Witt‐Enderby. (2022) The role of MEK1/2 and MEK5 in melatonin‐mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation. Journal of Pineal Research 73:2.
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Feng Shi, Dongqin Xiao, Chengdong Zhang, Wei Zhi, Yumei Liu & Jie Weng. (2021) The effect of macropore size of hydroxyapatite scaffold on the osteogenic differentiation of bone mesenchymal stem cells under perfusion culture. Regenerative Biomaterials 8:6.
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Rupesh Paudel, Lorenza Fusi & Marc Schmidt. (2021) The MEK5/ERK5 Pathway in Health and Disease. International Journal of Molecular Sciences 22:14, pages 7594.
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Yue Sun, Yuzhen Liang, Zhengming Li & Ning Xia. (2020) Liraglutide Promotes Osteoblastic Differentiation in MC3T3-E1 Cells by ERK5 Pathway. International Journal of Endocrinology 2020, pages 1-11.
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Valentin Jossen, Dieter Eibl & Regine Eibl. 2021. Digital Twins. Digital Twins 185 228 .
Tuan-Mao Guo, Yan-Li Xing, Hai-Yun Zhu, Lan Yang, Guo-Xiong Liu & Xi-Min Qiao. (2019) Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats. Bioscience Reports 39:9.
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Paul Campsie, Peter G. Childs, Shaun N. Robertson, Kenny Cameron, James Hough, Manuel Salmeron-Sanchez, Penelope M. Tsimbouri, Parag Vichare, Matthew J. Dalby & Stuart Reid. (2019) Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis. Scientific Reports 9:1.
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Nhat-Tu Le, Nguyet Minh Hoang, Keigi Fujiwara & Jun-ichi Abe. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 3052 3074 .
Liyin Yu, Xingfeng Ma, Junqin Sun, Jie Tong, Liang Shi, Lijun Sun & Jianbao Zhang. (2017) Fluid shear stress induces osteoblast differentiation and arrests the cell cycle at the G0 phase via the ERK1/2 pathway. Molecular Medicine Reports 16:6, pages 8699-8708.
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Carolyn J. Loveridge, Rob J. van ’t Hof, Gemma Charlesworth, Ayala King, Ee Hong Tan, Lorraine Rose, Anna Daroszewska, Amanda Prior, Imran Ahmad, Michelle Welsh, Ernest J. Mui, Catriona Ford, Mark Salji, Owen Sansom, Karen Blyth & Hing Y. Leung. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports 7:1.
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J. Y. Li, S. G. Liu, G. N. Xiao, M. Y. Mao, X. W. Zhang & H. Q. Sun. (2017) Fibroblast growth factor receptor 1 propagates estrogen and fluid shear stress driven proliferation and differentiation response in MC3T3-E1 cells. Molecular Biology 51:2, pages 300-312.
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Geng Bin, Zhang Bo, Wang Jing, Jiang Jin, Tan Xiaoyi, Chen Cong, An Liping, Ma Jinglin, Wang Cuifang, Chen Yonggang & Xia Yayi. (2016) Fluid shear stress suppresses TNF-α-induced apoptosis in MC3T3-E1 cells: Involvement of ERK5-AKT-FoxO3a-Bim/FasL signaling pathways. Experimental Cell Research 343:2, pages 208-217.
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Nhat-Tu Le, Nguyet Minh Hoang, Keigi Fujiwara & Jun-ichi Abe. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 23 .
Geng Bin, Wang Cuifang, Zhang Bo, Wang Jing, Jiang Jin, Tan Xiaoyi, Chen Cong, Chen Yonggang, An Liping, Ma Jinglin & Xia Yayi. (2015) Fluid shear stress inhibits TNF-α-induced osteoblast apoptosis via ERK5 signaling pathway. Biochemical and Biophysical Research Communications 466:1, pages 117-123.
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Jin Jiang, Liang-gong Zhao, Yuan-jun Teng, Shao-long Chen, Li-ping An, Jing-ling Ma, Jing Wang & Ya-yi Xia. (2015) ERK5 signalling pathway is essential for fluid shear stress-induced COX-2 gene expression in MC3T3-E1 osteoblast. Molecular and Cellular Biochemistry 406:1-2, pages 237-243.
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Shoichi Kaneshiro, Dai Otsuki, Kiyoshi Yoshida, Hideki Yoshikawa & Chikahisa Higuchi. (2015) MEK5 suppresses osteoblastic differentiation. Biochemical and Biophysical Research Communications 463:3, pages 241-247.
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Zhi Yang, Shuyi Tan, Yun Shen, Rui Chen, Changjing Wu, Yajuan Xu, Zijun Song & Qiang Fu. (2015) Inhibition of FSS-induced actin cytoskeleton reorganization by silencing LIMK2 gene increases the mechanosensitivity of primary osteoblasts. Bone 74, pages 182-190.
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