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Connective Tissue Research Volume 34, 1996 - Issue 1
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Original Article

Engineering, Expression and Renaturation of Targeted TGF-Beta Fusion Proteins

Tai-Lan Tuan Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
David T. Cheung Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
Ling-Tao Wu Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
Ann Yee Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
Steven Gabriel Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
Bo Han Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
Lisa Morton Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
,
Marcel E. Nimni Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
&
Frederick L. Hall Research Institute of Childrens Hospital Los Angeles, University of Southern California Schools of Medicine and Pharmacy, Los Angeles, CA, 90027
 show all
Pages 1-9 | Received 10 Feb 1995, Accepted 23 Aug 1995, Published online: 07 Jul 2009

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J. A. Andrades, L. T. Wu, F. L. Hall, M. E. Nimni & J. Becerra. (2001) Engineering, Expression, and Renaturation of a Collagen-Targeted Human bFGF Fusion Protein. Growth Factors 18:4, pages 261-275.
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Articles from other publishers (35)

Erlinda M. Gordon & Frederick L. Hall. (2023) The advent of a pan-collagenous CLOVIS POINT for pathotropic targeting and cancer gene therapy, a retrospective. Frontiers in Molecular Medicine 3.
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Khushbu Rauniyar, Soheila Akhondzadeh, Anna Gąciarz, Jaana Künnapuu & Michael Jeltsch. (2022) Bioactive VEGF-C from E. coli. Scientific Reports 12:1.
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Aditya Prakash Soni, Juhee Lee, Kunyoo Shin, Hisashi Koiwa & Inhwan Hwang. (2022) Production of Recombinant Active Human TGFβ1 in Nicotiana benthamiana. Frontiers in Plant Science 13.
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Siqi Liu, Junfu Guo, Xianda Cheng, Wenna Li, Shuangyu Lyu, Xuanyi Chen, Qingwei Li & Hao Wang. (2022) Molecular Evolution of Transforming Growth Factor-β (TGF-β) Gene Family and the Functional Characterization of Lamprey TGF-β2. Frontiers in Immunology 13.
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Erlinda M. Gordon & Frederick L. HallFrederick L. Hall & Erlinda M. Gordon. 2021. Our Journey Beyond Sunset Boulevard - Evidence-based Analysis of Tumor-Targeted Gene- and Immuno-Therapies Shine a Critical Spotlight on “True” Long-Term Cancer-Free Survival. Our Journey Beyond Sunset Boulevard - Evidence-based Analysis of Tumor-Targeted Gene- and Immuno-Therapies Shine a Critical Spotlight on “True” Long-Term Cancer-Free Survival.
Gustavo A. Rico-Llanos, Sara Borrego-González, Miguelangel Moncayo-Donoso, José Becerra & Rick Visser. (2021) Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering. Polymers 13:4, pages 599.
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Yoshihiro Ito. (2019) Growth Factor Engineering for Biomaterials. ACS Biomaterials Science & Engineering 5:11, pages 5597-5609.
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Cyril AddiFrederic MurschelGregory De Crescenzo. (2017) Design and Use of Chimeric Proteins Containing a Collagen-Binding Domain for Wound Healing and Bone Regeneration. Tissue Engineering Part B: Reviews 23:2, pages 163-182.
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H. Mao & Y. Ito. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 321 359 .
Harold L. Moses, Anita B. Roberts & Rik Derynck. (2016) The Discovery and Early Days of TGF-β: A Historical Perspective. Cold Spring Harbor Perspectives in Biology 8:7, pages a021865.
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Yana V. Kim, Marine E. Gasparian, Eduard V. Bocharov, Rita V. Chertkova, Elena N. Tkach, Dmitry A. Dolgikh & Mikhail P. Kirpichnikov. (2014) New Strategy for High-Level Expression and Purification of Biologically Active Monomeric TGF-β1/C77S in Escherichia coli. Molecular Biotechnology 57:2, pages 160-171.
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Rick VisserPilar M. ArrabalLeonor Santos-RuizRaul Fernandez-BarrancoJose BecerraManuel Cifuentes. (2014) A Collagen-Targeted Biomimetic RGD Peptide to Promote Osteogenesis. Tissue Engineering Part A 20:1-2, pages 34-44.
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Maniraj Bhagawati & Sanjay Kumar. 2014. Micro- and Nanoengineering of the Cell Surface. Micro- and Nanoengineering of the Cell Surface 315 348 .
Seiichi Tada, Takashi Kitajima & Yoshihiro Ito. (2012) Design and Synthesis of Binding Growth Factors. International Journal of Molecular Sciences 13:5, pages 6053-6072.
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Takashi Kitajima & Yoshihiro Ito. 2012. Handbook of Intelligent Scaffold for Tissue Engineering and Regenerative Medicine. Handbook of Intelligent Scaffold for Tissue Engineering and Regenerative Medicine 337 353 .
Sílvia Gomes, Isabel B. Leonor, João F. Mano, Rui L. Reis & David L. Kaplan. (2012) Natural and genetically engineered proteins for tissue engineering. Progress in Polymer Science 37:1, pages 1-17.
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Kenrick KuwaharaJosephine Y. FangZhi YangBo Han. (2011) Enzymatic Crosslinking and Degradation of Gelatin as a Switch for Bone Morphogenetic Protein-2 Activity. Tissue Engineering Part A 17:23-24, pages 2955-2964.
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Y. Ito. 2011. Comprehensive Biomaterials. Comprehensive Biomaterials 247 279 .
Rick Visser, Pilar M. Arrabal, Jose Becerra, Ursula Rinas & Manuel Cifuentes. (2009) The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo. Biomaterials 30:11, pages 2032-2037.
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Hiroko Miyazaki, Koichi Kato, Yuji Teramura & Hiroo Iwata. (2008) A Collagen-Binding Mimetic of Neural Cell Adhesion Molecule. Bioconjugate Chemistry 19:6, pages 1119-1123.
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Koichi Kato, Hideki Sato & Hiroo Iwata. (2007) Ultrastructural Study on the Specific Binding of Genetically Engineered Epidermal Growth Factor to Type I Collagen Fibrils. Bioconjugate Chemistry 18:6, pages 2137-2143.
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Dustin J. Maxwell, Brandon C. Hicks, Sarah Parsons & Shelly E. Sakiyama-Elbert. (2005) Development of rationally designed affinity-based drug delivery systems. Acta Biomaterialia 1:1, pages 101-113.
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. (2002) Tumor Site Specific Phase I Evaluation of Safety and Efficacy of Hepatic Arterial Infusion of a Matrix-Targeted Retroviral Vector Bearing a Dominant Negative Cyclin G1 Construct as Intervention for Colorectal Carcinoma Metastatic to Liver. Human Gene Therapy 13:12, pages 1515-1537.
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Lawrence A Wolfraim, Gonnie M Alkemade, Biju Alex, Shellyann Sharpe, W.Tony Parks & John J Letterio. (2002) Development and application of fully functional epitope-tagged forms of transforming growth factor-β. Journal of Immunological Methods 266:1-2, pages 7-18.
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Bo Han, Natalya Perelman, Baowei Tang, Fredrick Hall, Edwin C. Shors & Marcel E. Nimni. (2002) Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. Journal of Orthopaedic Research 20:4, pages 747-755.
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SE Sakiyama-ElbertJA Hubbell. (2001) Functional Biomaterials: Design of Novel Biomaterials. Annual Review of Materials Research 31:1, pages 183-201.
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Chun Fang GAO, Xian Tao KONG, Axel M GRESSNER & Ralf WEISKIRCHEN. (2001) The expression and antigenicity identification of recombinant rat TGF-β1 in bacteria. Cell Research 11:2, pages 95-100.
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Frederick L. Hall, Bo Han, Ramendra Krishna Kundu, Ann Yee, Marcel E. Nimni & Erlinda M. Gordon. (2001) Phenotypic Differentiation of TGF-β1-Responsive Pluripotent Premesenchymal Prehematopoietic Progenitor (P4 Stem) Cells from Murine Bone Marrow. Journal of Hematotherapy & Stem Cell Research 10:2, pages 261-271.
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J. A. Andrades, J. A. Santamar�a, L. T. Wu, F. L. Hall, M. E. Nimni & J. Becerra. (2001) Production of a recombinant human basic fibroblast growth factor with a collagen binding domain. Protoplasma 218:1-2, pages 95-103.
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Frederick L. Hall, Liqiong Liu, Nian Ling Zhu, Maria Stapfer, W. French Anderson, Robert W. Beart & Erlinda M. Gordon. (2000) Molecular Engineering of Matrix-Targeted Retroviral Vectors Incorporating a Surveillance Function Inherent in von Willebrand Factor. Human Gene Therapy 11:7, pages 983-993.
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José A. Andrades, Bo Han, José Becerra, Nino Sorgente, Frederick L. Hall & Marcel E. Nimni. (1999) A Recombinant Human TGF-β1 Fusion Protein with Collagen-Binding Domain Promotes Migration, Growth, and Differentiation of Bone Marrow Mesenchymal Cells. Experimental Cell Research 250:2, pages 485-498.
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Marcel E Nimni & Bo Han. (1999) Collagen and collagen-glycosaminoglycan matrices as carriers for growth factors. Proceedings / Indian Academy of Sciences 111:1, pages 283-289.
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Frederick L. Hall, Erlinda M. Gordon, Lingtao Wu, Nian Ling Zhu, Michael J. Skotzko, Vaughn A. Starnes & W. French Anderson. (1997) Targeting Retroviral Vectors to Vascular Lesions by Genetic Engineering of the MoMLV gp70 Envelope Protein. Human Gene Therapy 8:18, pages 2183-2192.
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Bo Han, Frederick L. Hall & Marcel E. Nimni. (1997) Refolding of a Recombinant Collagen-Targeted TGF-β2 Fusion Protein Expressed inEscherichia coli. Protein Expression and Purification 11:2, pages 169-178.
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M.E. Nimni. (1997) Polypeptide growth factors: targeted delivery systems. Biomaterials 18:18, pages 1201-1225.
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