Advanced search
Publication Cover
Upsala Journal of Medical Sciences Volume 116, 2011 - Issue 4
Journal homepage
1,156
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

Sinan Gursoy Anesthesiology and Reanimation, Cumhuriyet University School of Medicine, Sivas, Turkey
,
Ercan OzdemirDepartment of Physiology, Cumhuriyet University School of Medicine, Sivas, TurkeyCorrespondence[email protected]
,
Ihsan BagcivanDepartment of Pharmacology, Cumhuriyet University School of Medicine, Sivas, Turkey
,
Ahmet AltunDepartment of Pharmacology, Cumhuriyet University School of Medicine, Sivas, Turkey
&
Nedim DurmusDepartment of Pharmacology, Cumhuriyet University School of Medicine, Sivas, Turkey
Pages 238-246 | Received 11 Apr 2011, Accepted 14 Jun 2011, Published online: 16 Sep 2011

Citations (26)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Pinyi Zhang, Jianlong Bu, Xiaohong Wu, Lin Deng, Meng Chi, Chao Ma, Xiaoding Shi & Guonian Wang. (2020) Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain. Journal of Pain Research 13, pages 2617-2627.
Read now

Articles from other publishers (25)

Deniz Yildiz Pehlivan, Ali Yucel Kara, Ahmet Koyu & Fatma Simsek. (2024) Enhancing fentanyl antinociception and preventing tolerance with α-2 adrenoceptor agonists in rats. Behavioural Brain Research 457, pages 114726.
Crossref
Iwao Arai, Minoru Tsuji, Saburo Saito & Hiroshi Takeda. (2023) Experimental Study: Interleukin-31 Augments Morphine-Induced Antinociceptive Activity and Suppress Tolerance Development in Mice. International Journal of Molecular Sciences 24:22, pages 16548.
Crossref
O. Avci, A.S. Taskiran & O. Gundogdu. (2023) Dexmedetomidine, an α2 agonist, increases the morphine analgesic effect and decreases morphine tolerance development by suppressing oxidative stress and TNF/IL-1 signalling pathway in rats. Revista Española de Anestesiología y Reanimación (English Edition) 70:6, pages 327-340.
Crossref
O. Avci, A.S. Taskiran & O. Gundogdu. (2023) Dexmedetomidina, un agonista de α2, incrementa el efecto analgésico de la morfina y reduce el desarrollo de tolerancia a la morfina suprimiendo el estrés oxidativo y la vía de señalización de TNF/IL-1 en ratas. Revista Española de Anestesiología y Reanimación 70:6, pages 327-340.
Crossref
Bruno H. Pypendop. 2023. Small Animal Critical Care Medicine. Small Animal Critical Care Medicine 905 910 .
Ercan Ozdemir, Tayfun Baser & Ahmet Sevki Taskiran. (2022) Blockade of orexin receptor type-1 by SB-334867 and activation of orexin receptor type-2 attenuate morphine tolerance in rats. Physiology International.
Crossref
Safiye Özdemir-Çezik, Asiye Nurten, Berna Midilli, Başak Gürtekin & Nurhan Enginar. (2022) Effect of oxytocin pretreatment on the development of morphine tolerance and dependence in rats. Neuroscience Letters 784, pages 136764.
Crossref
Robert Root-Bernstein. (2022) Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction. Pharmaceuticals 15:2, pages 214.
Crossref
Xiaoqian Jia, Anqi Zhang, Zheng Li, Xiaoling Peng, Xuebi Tian & Feng Gao. (2021) Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine‐tolerant rats. Journal of Neurochemistry 158:2, pages 373-390.
Crossref
Tayfun BaserErcan OzdemirAhmet Kemal FilizAhmet Sevki TaskiranSinan Gursoy. (2021) Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats. Canadian Journal of Physiology and Pharmacology 99:5, pages 461-467.
Crossref
Ehsan Motaghi, Masumeh Ghasemi Pirbalooti, Hooman Bozorgi, Majid Eslami & Mohsen Rashidi. (2021) Safety and Efficacy of Dexmedetomidine in Breast Surgeries: A Systematic Review and Meta-Analysis. Journal of PeriAnesthesia Nursing 36:2, pages 179-186.
Crossref
Lyvia Maria Rodrigues de Sousa Gomes, Nicolau Gregori Czeczko, Rayanne Luiza Tajra Mualem Araújo, Maria do Socorro de Sousa Cartagenes, José Osvaldo Barbosa Neto & João Batista Santos Garcia. (2021) Effect of intra-articular dexmedetomidine on experimental osteoarthritis in rats. PLOS ONE 16:1, pages e0245194.
Crossref
Ge Huang, Guo Liu, Zhiguo Zhou, Jinfeng Yang & Chen Su. (2020) Successful Treatment of Refractory Cancer Pain and Depression with Continuous Intrathecal Administration of Dexmedetomidine and Morphine: A Case Report. Pain and Therapy 9:2, pages 797-804.
Crossref
Ercan Ozdemir. (2020) The Role of the Cannabinoid System in Opioid Analgesia and Tolerance. Mini-Reviews in Medicinal Chemistry 20:10, pages 875-885.
Crossref
Sandeep Raj Karna, Kavitha Kongara, Preet Mohinder Singh, Paul Chambers & Nicolas Lopez-Villalobos. (2019) Evaluation of analgesic interaction between morphine, dexmedetomidine and maropitant using hot-plate and tail-flick tests in rats. Veterinary Anaesthesia and Analgesia 46:4, pages 476-482.
Crossref
Ian A. Clark & Bryce Vissel. (2018) The Inflammatory Nature of Post-surgical Delirium Predicts Benefit of Agents With Anti-TNF Effects, Such as Dexmedetomidine. Frontiers in Neuroscience 12.
Crossref
Chan Noh, Young Kwon Ko, Yoon Hee Kim, Chae Seong Lim, Woo Suk Chung, Ji Yong Lee & Seung Hyun Song. (2017) Effect of dexmedetomidine on endotracheal intubating conditions during endotracheal intubation without neuromuscular blocker following propofol/remifentanil. Anesthesia and Pain Medicine 12:1, pages 56-61.
Crossref
Tuğçe Uskur, M. Aydın Barlas, A. Gökhan Akkan, Andleeb Shahzadi & Tayfun Uzbay. (2016) Dexmedetomidine induces conditioned place preference in rats: Involvement of opioid receptors. Behavioural Brain Research 296, pages 163-168.
Crossref
Ahmet Altun, Kemal Yildirim, Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy & Nedim Durmus. (2015) Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. The Journal of Physiological Sciences 65:5, pages 407-415.
Crossref
Bruno H. Pypendop. 2015. Small Animal Critical Care Medicine. Small Animal Critical Care Medicine 866 871 .
Hong-jun LiuXian-zhong GaoXiao-ming LiuMing XiaWei-yan LiYi Jin. (2014) Effect of Intrathecal Dexmedetomidine on Spinal Morphine Analgesia in Patients with Refractory Cancer Pain. Journal of Palliative Medicine 17:7, pages 837-840.
Crossref
Blas Catalani, Craig S. Hamilton, Edwin W. Herron, Richard D. Urman, Charles J. Fox & Alan David Kaye. (2014) Psychiatric agents and implications for perioperative analgesia. Best Practice & Research Clinical Anaesthesiology 28:2, pages 167-181.
Crossref
Xia Zhang & Xiaofeng Bai. (2014) New therapeutic uses for an alpha2 adrenergic receptor agonist – Dexmedetomidine in pain management. Neuroscience Letters 561, pages 7-12.
Crossref
Shinichi Harada, Kazuo Nakamoto & Shogo Tokuyama. (2013) The involvement of midbrain astrocyte in the development of morphine tolerance. Life Sciences 93:16, pages 573-578.
Crossref
Richard J. Bodnar. (2012) Endogenous opiates and behavior: 2011. Peptides 38:2, pages 463-522.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.