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Scandinavian Journal of Rheumatology Volume 16, 1987 - Issue sup64
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Original Article

The Pathogenesis and Consequence of Non Steroidal Anti-Inflammatory Drug Induced Small Intestinal Inflammation in Man

I. Bjarnason Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
,
G. Zanelli Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
,
T. Smith Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
,
P. Smethurst Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
,
A. B. Price Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
,
M. J. Gumpel Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
&
A. J. Levi Section of Gastroenterology and Division of Radioisolopes, MRC Clinical Research Centre, Harrow, Middlesex, England; Department of Rheumatology and Histopathology, Northwick Park Hospital, Watford Road, Harrow, Middlesex, England
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Pages 55-62 | Published online: 12 Jul 2009

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T. R. Meling, L. Aabakken, A. Røseth & M. Osnes. (1996) Faecal Calprotectin Shedding after Short-Term Treatment with Non-Steroidal Anti-Inflammatory Drugs. Scandinavian Journal of Gastroenterology 31:4, pages 339-344.
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L. Aabakken & M. Osnes. (1990) 51Cr-Ethylenediaminetetraacetic Acid Absorption Test: Effects of Naproxen, a Non-Steroidal, Antiinflammatory Drug. Scandinavian Journal of Gastroenterology 25:9, pages 917-924.
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Articles from other publishers (33)

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Uayporn Kaosombatwattana, Julajak Limsrivilai, Ananya Pongpaibul, Monthira Maneerattanaporn & Phunchai Charatcharoenwitthaya. (2017) Severe enteropathy with villous atrophy in prolonged mefenamic acid users – a currently under-recognized in previously well-recognized complication. Medicine 96:44, pages e8445.
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John L. Wallace, Gilberto de Nucci & Oksana Sulaieva. (2015) Toward More GI-Friendly Anti-Inflammatory Medications. Current Treatment Options in Gastroenterology 13:4, pages 377-385.
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Marc S. Levin. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 1346 1363 .
Kristina T. FlicekAmy K. HaraGiovanni De PetrisShabana F. PashaAnitha D. YadavC. Daniel Johnson. (2014) Diaphragm Disease of the Small Bowel: A Retrospective Review of CT Findings. American Journal of Roentgenology 202:2, pages W140-W145.
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A. D. Shearman, G. W. H. Stamp, P. Tekkis & E. Tan. (2012) Pan‐enteric diaphragm disease. Colorectal Disease 15:1.
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Ilja Tachecí, Marcela Kopáčová, Stanislav Rejchrt & Jan Bureš. (2010) Non-steroidal Anti-inflammatory Drug Induced Injury to the Small Intestine. Acta Medica (Hradec Kralove, Czech Republic) 53:1, pages 3-11.
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Angel Lanas. (2009) Nonsteroidal Antiinflammatory Drugs and Cyclooxygenase Inhibition in the Gastrointestinal Tract: A Trip From Peptic Ulcer to Colon Cancer. The American Journal of the Medical Sciences 338:2, pages 96-106.
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Angel Lanas & Federico Sopeña. (2009) Nonsteroidal Anti-Inflammatory Drugs and Lower Gastrointestinal Complications. Gastroenterology Clinics of North America 38:2, pages 333-352.
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MARIE E. ROBERT. 2009. Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas 321 354 .
M. Alice McGarvey, Fardod O'Kelly & Rajunor R. Ettarh. (2007) Nimesulide Inhibits Crypt Epithelial Cell Proliferation at 6 Hours in the Small Intestine in CD-1 Mice. Digestive Diseases and Sciences 52:9, pages 2087-2094.
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M. Alice McGarvey, Gary Bass & R. R. Ettarh. (2007) Nimesulide Alters Cell Recruitment into Mitosis in Murine Intestinal Crypts Without Influencing the Cell Production Rate. Digestive Diseases and Sciences 52:6, pages 1471-1478.
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S. Chandrashekara, Rajreddy Patil, H. S. Vadiraja & A. Shobha. (2005) The incidence of Proteus mirabilis infection increases in patients on treatment but does not trigger disease activity. Clinical Rheumatology 25:4, pages 520-523.
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Ángel Lanas & Carmelo Scarpignato. (2006) Microbial Flora in NSAID-Induced Intestinal Damage: A Role for Antibiotics?. Digestion 73:1, pages 136-150.
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Thomas Y. Ma & James M. Anderson. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 1559 1594 .
K Campbell & R J C Steele. (1991) Non-steroidal anti-inflammatory drugs and complicated diverticular disease: A case—control study. British Journal of Surgery 78:2, pages 190-191.
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O. A. Hatoum, D. G. Binion & D. D. Gutterman. (2005) Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. European Journal of Clinical Investigation 35:10, pages 599-609.
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David Y. Graham, Antone R. Opekun, Field F. Willingham & Waqar A. Qureshi. (2005) Visible small-intestinal mucosal injury in chronic NSAID users. Clinical Gastroenterology and Hepatology 3:1, pages 55-59.
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J A Hardin, L Donegan, R C Woodman, C Trevenen & D G Gall. (2002) Mucosal inflammation in a genetic model of spontaneous type I diabetes mellitus. Canadian Journal of Physiology and Pharmacology 80:11, pages 1064-1070.
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C. J. Hawkey, L. Jackson, S. E. Harper, T. J. Simon, E. Mortensen & C. R. Lines. (2008) The gastrointestinal safety profile of rofecoxib, a highly selective inhibitor of cyclooxygenase‐2, in humans. Alimentary Pharmacology & Therapeutics 15:1, pages 1-9.
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Richard H Hunt, Barry Bowen, Eric R Mortensen, Thomas J Simon, Cindy James, Angeline Cagliola, Hui Quan & James A Bolognese. (2000) A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects. The American Journal of Medicine 109:3, pages 201-206.
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Davies. (2001) Review article: non‐steroidal anti‐inflammatory drug‐induced gastrointestinal permeability. Alimentary Pharmacology & Therapeutics 12:4, pages 303-320.
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X. Wang. (1998) Aspirin-like drugs cause gastrointestinal injuries by metallic cation chelation. Medical Hypotheses 50:3, pages 227-238.
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R. MELARANGE, G. MOORE, P. R. BLOWER, M. E. COATES, F. W. WARD & V. RONAASEN. (2007) A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ‐free rats. Alimentary Pharmacology & Therapeutics 6:1, pages 67-77.
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G. R. DAVIES & D. S. RAMPTON. (2007) The pro‐drug sulindac may reduce the risk of intestinal damage associated with the use of conventional non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 5:6, pages 593-598.
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Melanie C. Bacon, Patience H. White, Daniel J. Raiten, Neal Craft, Sam Margolis, Orville A. Levander, Martha L. Taylor, Robert N. Lipnick & Seppideh Sami. (1990) Nutritional status and growth in juvenile rheumatoid arthritis. Seminars in Arthritis and Rheumatism 20:2, pages 97-106.
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Mary Ellen Mortensen & Robert M. Rennebohm. (1989) Clinical Pharmacology and Use of Nonsteroidal Anti-Inflammatory Drugs. Pediatric Clinics of North America 36:5, pages 1113-1139.
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R. Balfour Sartor. (1989) Importance of intestinal mucosal immunity and luminal bacterial cell wall polymers in the aetiology of inflammatory joint diseases. Baillière's Clinical Rheumatology 3:2, pages 223-245.
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Ingvar Bjarnason, Paul Smethurst, Christopher G. Fenn, Carole E. Lee, Ian S. Menzies & A. Jonathan Levi. (1989) Misoprostol reduces indomethacin-induced changes in human small intestinal permeability. Digestive Diseases and Sciences 34:3, pages 407-411.
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I. Bjarnason, A.B. Price, G. Zanelli, P. Smethurst, M. Burke, J.M. Gumpel & A.J. Levi. (1988) Clinicopathological features of nonsteroidal antiinflammatory drug-induced small intestinal strictures. Gastroenterology 94:4, pages 1070-1074.
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I Bjarnason & J Peters. (1987) Helping the mucosa make sense of macromolecules.. Gut 28:9, pages 1057-1061.
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