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Original Article

Excessive circadian amplitude of blood pressure increases risk of ischaemic stroke and nephropathy

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Pages 23-30 | Published online: 09 Jul 2009

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Read on this site (7)

Kuniaki Otsuka, Shougo Murakami, Kiyotaka Okajima, Koichi Shibata, Yutaka Kubo, Denis G Gubin, Larry A Beaty & Germaine Cornelissen. (2023) Appropriate Circadian-Circasemidian Coupling Protects Blood Pressure from Morning Surge and Promotes Human Resilience and Wellbeing. Clinical Interventions in Aging 18, pages 755-769.
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Cathy Lee Gierke & Germaine Cornelissen. (2016) Chronomics analysis toolkit (CATkit). Biological Rhythm Research 47:2, pages 163-181.
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Manuela S. Bartlang, Sergey A. Savelyev, Anne-Sofie Johansson, Stefan O. Reber, Charlotte Helfrich-Förster & Gabriella B. S. Lundkvist. (2014) Repeated psychosocial stress at night, but not day, affects the central molecular clock. Chronobiology International 31:9, pages 996-1007.
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Yoshihiko Watanabe, Franz Halberg, Kuniaki Otsuka & Germaine Cornelissen. (2013) Toward a Personalized Chronotherapy of High Blood Pressure and a Circadian Overswing. Clinical and Experimental Hypertension 35:4, pages 257-266.
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PAVEL PRIKRYL, GERMAINE CORNÉLISSEN, JIRI NEUBAUER, PAVEL PRIKRYL$suffix/text()$suffix/text(), ZDENEK KARPISEK, YOSHIHIKO WATANABE, KUNIAKI OTSUKA & FRANZ HALBERG. (2005) Chronobiologically Explored Effects of Telmisartan. Clinical and Experimental Hypertension 27:2-3, pages 119-128.
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K Otsuka, G Cornelissen, M Shinagawa & F Halberg. (1999) Blood Pressure Variability Assessed by Semiautomatic and Ambulatorily Functional Devices for Home Use. Clinical and Experimental Hypertension 21:5-6, pages 729-740.
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F. Halberg, G. Cornélissen, K. Otsuka, Y. Watanabe, M. A. Wood, C. R. Lambert, R. Zaslavskayall, D. Gubin, E. Yuryevna Petukhova, P. Delmore & E. Bakken. (1997) Rewards in practice from chrono-meta-analyses ‘recycling’ heart rate, ectopy, ischemia and blood pressure information. Journal of Medical Engineering & Technology 21:5, pages 174-184.
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Articles from other publishers (50)

Fatimatou Saka & Germaine Cornelissen. (2020) Chronobiologic assessment of the effect of the DASH diet on blood pressure. Journal of Human Hypertension 35:8, pages 678-684.
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Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang & Lihong Chen. (2021) Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease. Biomolecules 11:6, pages 868.
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Germaine Cornelissen. (2021) Applications of cosinor rhythmometry in pharmacology. Journal of Pharmacokinetics and Pharmacodynamics 48:3, pages 339-359.
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Glenn C. Rodrigo & Karl E. Herbert. (2018) Regulation of vascular function and blood pressure by circadian variation in redox signalling. Free Radical Biology and Medicine 119, pages 115-120.
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Kuniaki Otsuka, Germaine Cornelissen & Franz HalbergKuniaki Otsuka, Germaine Cornelissen & Franz Halberg. 2016. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Chronomics and Continuous Ambulatory Blood Pressure Monitoring 271 303 .
Kuniaki Otsuka, Germaine Cornelissen & Franz HalbergKuniaki Otsuka, Germaine Cornelissen & Franz Halberg. 2016. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Chronomics and Continuous Ambulatory Blood Pressure Monitoring 185 214 .
Kuniaki Otsuka, Germaine Cornelissen & Franz HalbergKuniaki Otsuka, Germaine Cornelissen & Franz Halberg. 2016. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Chronomics and Continuous Ambulatory Blood Pressure Monitoring 603 659 .
Kuniaki Otsuka, Germaine Cornelissen & Franz HalbergKuniaki Otsuka, Germaine Cornelissen & Franz Halberg. 2016. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Chronomics and Continuous Ambulatory Blood Pressure Monitoring 481 497 .
Kuniaki Otsuka, Germaine Cornelissen & Franz HalbergKuniaki Otsuka, Germaine Cornelissen & Franz Halberg. 2016. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Chronomics and Continuous Ambulatory Blood Pressure Monitoring 405 428 .
Kuniaki Otsuka, Germaine Cornelissen & Franz HalbergKuniaki Otsuka, Germaine Cornelissen & Franz Halberg. 2016. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Chronomics and Continuous Ambulatory Blood Pressure Monitoring 359 403 .
Germaine Cornelissen. (2014) Cosinor-based rhythmometry. Theoretical Biology and Medical Modelling 11:1.
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Kiyotaka Okajima, Kuniaki Otsuka, Sachiko Oinuma, Junko Sasaki, Takashi Yamanaka & Germaine Cornelissen. (2014) Aging and Within- and Between-Day Variability Assessed Using 7-Day/24-Hour Ambulatory Blood Pressure Monitoring. Journal of the American Geriatrics Society 62:12, pages 2440-2442.
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Elena Vasiljevna Syutkina, Olga Viktorovna Kozhevnikova, Leila Seimurovna Namazova-Baranova, Ivan Jevgenievitch Smirnov, Anatoly Viktorovich Masalov, Germaine Cornelissen, Othild Schwartzkopff, Maria Dmitrijevna Mitish, Lyazzat Gumarova & Franz Halberg. (2014) Vascular variability anomalies (VVAs) in children. Journal of Applied Biomedicine 12:3, pages 147-153.
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Franz HalbergDeborah PowellKuniaki OtsukaYoshihiko WatanabeLarry A. BeatyPaul Rosch, Jerzy Czaplicki, Dewayne HillmanOthild SchwartzkopffGermaine Cornelissen. (2013) Diagnosing vascular variability anomalies, not only MESOR-hypertension. American Journal of Physiology-Heart and Circulatory Physiology 305:3, pages H279-H294.
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Anthony J. VieraFeng-Chang LinAlan L. HinderliterDaichi ShimboSharina D. PersonMark J. PletcherDavid R. JacobsJrJr. (2012) Nighttime Blood Pressure Dipping in Young Adults and Coronary Artery Calcium 10–15 Years Later. Hypertension 59:6, pages 1157-1163.
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Z Jiang, W Li, Y Liu, Y Wang, Z Wang, J Xiao, H Guo, G Cornélissen & F Halberg. (2009) Circadian blood pressure and heart rate characteristics in haemorrhagic vs ischaemic stroke in Chinese people. Journal of Human Hypertension 24:3, pages 165-174.
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Germaine Cornélissen & Franz Halberg. 2009. Chronopharmaceutics. Chronopharmaceutics 257 323 .
Germaine Cornélissen, Franz Halberg, Kuniaki Otsuka, R.B. Singh & Chen-Huan Chen. (2007) Chronobiology Predicts Actual and Proxy Outcomes when Dipping Fails. Hypertension 49:1, pages 237-239.
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. (2006) Ambulatory Blood-Pressure Monitoring. New England Journal of Medicine 355:8, pages 850-851.
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. 2006. Introducing Biological Rhythms. Introducing Biological Rhythms 426 525 .
P. Prikryl, G. Corn?lissen, K. Otsuka & F. Halberg. (2005) Plasma catecholamines: follow-up on 10-year study in health and cardiovascular disease. Biomedicine & Pharmacotherapy 59, pages S180-S187.
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G. Corn?lissen, A. Delcourt, G. Toussaint, K. Otsuka, Y. Watanabe, J. Siegelova, B. Fiser, J. Dusek, P. Homolka, R.B. Singh, A. Kumar, R.K. Singh, S. Sanchez, C. Gonzalez, D. Holley, B. Sundaram, Z. Zhao, B. Tomlinson, B. Fok, M. Zeman, K. Dulkova & Franz Halberg. (2005) Opportunity of detecting pre-hypertension: worldwide data on blood pressure overswinging. Biomedicine & Pharmacotherapy 59, pages S152-S157.
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C. Maggioni, G. Corn?lissen, K. Otsuka, F. Halberg, D. Consonni & U. Nicolini. (2005) Circadian rhythm of maternal blood pressure and fetal growth. Biomedicine & Pharmacotherapy 59, pages S86-S91.
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B. Sundaram, D.C. Holley, G. Corn?lissen, D. Naik, R. Hanumansetty, R.B. Singh, K. Otsuka & F. Halberg. (2005) Circadian and circaseptan (about-weekly) aspects of immigrant Indians' blood pressure and heart rate in California, USA. Biomedicine & Pharmacotherapy 59, pages S76-S85.
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Frédéric Duflo, Romain Guyot & Dominique Chassard. (2005) Chronobiologie en anesthésie-réanimation. Le Praticien en Anesthésie Réanimation 9:1, pages 15-22.
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Germaine Cornélissen, Franz Halberg, Earl Bakken, Ram B. Singh, Kuniaki Otsuka, Brian Tomlinson, Alain Delcourt, Guy Toussaint, Srilakshmi Bathina, Othild Schwartzkopff, Zhengrong Wang, Roberto Tarquini, Federico Perfetto, Giancarlo Pantaleoni, Rita Jozsa, Patrick A. Delmore & Ellis Nolley. (2004) 100 or 30 years after Janeway or Bartter, Healthwatch helps avoid ‘flying blind’. Biomedicine & Pharmacotherapy 58, pages S69-S86.
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Ram B. Singh, Daniel Pella, Viola Mechirova & Kuniaki Otsuka. (2004) Can brain dysfunction be a predisposing factor for metabolic syndrome?. Biomedicine & Pharmacotherapy 58, pages S56-S68.
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. (2004) References. American Journal of Kidney Diseases 43, pages 268-290.
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David C. Warltier, Dominique Chassard & Bernard Bruguerolle. (2004) Chronobiology and Anesthesia. Anesthesiology 100:2, pages 413-427.
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Franz Halberg, Germaine Cornélissen, Barbara Schack, Hans W. Wendt, Hélène Minne, Robert B. Sothern, Yoshihiko Watanabe, George Katinas, Kuniaki Otsuka & Earl E. Bakken. (2003) Blood pressure self-surveillance for health also reflects 1.3-year Richardson solar wind variation: spin-off from chronomics. Biomedicine & Pharmacotherapy 57, pages 58-76.
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K Otsuka, S Murakami, Y Kubo, T Yamanaka, G Mitsutake, S Ohkawa, K Matsubayashi, S Yano, G Cornélissen & F Halberg. (2003) Chronomics for chronoastrobiology with immediate spin-offs for life quality and longevity. Biomedicine & Pharmacotherapy 57, pages 1-18.
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John S. Lee, Mary S. Lee, Jong Y. Lee, Germaine Cornélissen, Kuniaki Otsuka & Franz Halberg. (2003) Effects of diaphragmatic breathing on ambulatory blood pressure and heart rate. Biomedicine & Pharmacotherapy 57, pages 87-91.
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Mary S. Lee, John S. Lee, Jong Y. Lee, Germaine Corn?lissen, Kuniaki Otsuka & Franz Halberg. (2003) About 7?day (circaseptan) and circadian changes in cold pressor test (CPT). Biomedicine & Pharmacotherapy 57, pages 39-44.
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Kuniaki Otsuka, Germaine Cornélissen, Othild Schwartzkopff, Earl E. Bakken, Franz Halberg, Naoto Burioka, George S. Katinas, Robert Kane, Philip J. Regal, Erwin Schaffer, Robert Sonkowsky, Robert Patterson, Mark Engebretson, Brian Brockway, Zhengrong Wang, Patrick Delmore, Charlotte Halpin, Steven Sarkozy, Dan Wall & Julia Halberg. (2003) Clinical chronobiology and chronome-geriatrics At variance with recommendations of subsequent guidelines, yet focusing indeed on pre-hypertension in the physiological range. Biomedicine & Pharmacotherapy 57, pages 164-198.
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Ram B Singh, Germaine Cornélissen, Andi Weydahl, Othild Schwartzkopff, George Katinas, Kuniaki Otsuka, Yoshihiko Watanabe, Shoki Yano, Hideki Mori, Yuhei Ichimaru, Gen Mitsutake, Daniel Pella, Lu Fanghong, Ziyan Zhao, Reema S Rao, Anna Gvozdjakova & Franz Halberg. (2003) Circadian heart rate and blood pressure variability considered for research and patient care. International Journal of Cardiology 87:1, pages 9-28.
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Ram B. Singh, Kumar Kartikey, Mahmood Moshiri, Narankar S. Neki, Udai P. Singh, Adarsh Kumar, Daniel Pella & Shanti S. Rastogi. 2003. Frontiers in Cardiovascular Health. Frontiers in Cardiovascular Health 243 260 .
Makoto Shinagawa, Kuniaki Otsuka, Shogo Murakami, Yutaka Kubo, Germaine Cornelissen, Kozo Matsubayashi, Shohki Yano, Gen Mitsutake, Ken-ichiro Yasaka & Franz Halberg. (2002) Seven-day (24-h) ambulatory blood pressure monitoring, self-reported depression and quality of life scores. Blood Pressure Monitoring 7:1, pages 69-76.
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Y Hata, H Muratani, Y Kimura, K Fukiyama, Y Kawano, T Ashida, M Yokouchi, Y Imai, T Ozawa, J Fujii & T Omae. (2002) Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy. Journal of Human Hypertension 16:2, pages 141-146.
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Michael Daffertshofer. 2002. Pan Vascular Medicine. Pan Vascular Medicine 1075 1112 .
ERWIN M. SCHAFFER, GERMAINE CORNEéLISSEN, NELSON RHODUS, MAX HALHUBER, YOSHIHIKO WATANABE & FRANZ HALBERG. (2001) Blood pressure outcomes of dental patients screened chronobiologically. The Journal of the American Dental Association 132:7, pages 891-899.
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F. Halberg, G. Cornelissen, Y. Watanabe, K. Otsuka, B. Fiser, J. Siegelova, V. Mazankova, C. Maggioni, R. B. Sothern, G. S. Katinas, E. V. Syutkina, N. Burioka & O. Schwartzkopff. (2001) Near 10-Year and Longer Periods Modulate Circadians: Intersecting Anti-aging and Chronoastrobiological Research. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56:5, pages M304-M324.
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M. Shinagawa, Y. Kubo, K. Otsuka, S. Ohkawa, G. Cornélissen & F. Halberg. (2000) Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of stroke. Biomedicine & Pharmacotherapy 55, pages s125-s132.
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R.B. Singh, A. Weydahl, K. Otsuka, Y. Watanabe, S. Yano, H. Mori, Y. Ichimaru, G. Mitsutake, Y. Sato, L. Fanghong, Z.-Y. Zhao, C. Kartik & A. Gvozdjakova. (2000) Can nutrition influence circadian rhythm and heart rate variability?. Biomedicine & Pharmacotherapy 55, pages s115-s124.
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K. Otsuka, G. Cornélissen & F. Halberg. (2000) Circadian rhythms and clinical chronobiology. Biomedicine & Pharmacotherapy 55, pages s7-s18.
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Ann Caplea, Darcie Seachrist, Gail Dunphy & Daniel Ely. (2000) SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats. American Journal of Physiology-Heart and Circulatory Physiology 279:1, pages H58-H66.
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FRANZ HALBERG, GERMAINE CORNÉLISSEN, GEORGE KATINAS, YOSHIHIKO WATANABE, KUNIAKI OTSUKA, CRISTINA MAGGIONI, FEDERICO PERFETTO, ROBERTO TARQUINI, OTHILD SCHWARTZKOPFF & EARL E. BAKKEN. (2006) Feedsidewards: Intermodulation (Strictly) among Time Structures, Chronomes, in and around Us, and Cosmo-vasculo-neuroimmunity: About Ten-yearly Changes: What Galileo Missed and Schwabe Found. Annals of the New York Academy of Sciences 917:1, pages 348-375.
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