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Review Article

UGT3A: novel UDP-glycosyltransferases of the UGT superfamily

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Pages 45-54 | Published online: 14 Jan 2010

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Ricardo Blanco-Castañeda, Carlos Galaviz-Hernández, Paula C. S. Souto, Victor Vitorino Lima, Fernanda R. Giachini, Carlos Escudero, Alicia E Damiano, L. Jazel Barragán-Zúñiga, Gerardo Martínez-Aguilar & Martha Sosa-Macías. (2020) The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field. Expert Review of Clinical Pharmacology 13:3, pages 247-263.
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Molly Lin, Justin Ly, Ryan Takahashi, John Chen, Alan Deese, Sarah J. Robinson, Aleksandr Kolesnikov, Susan Wong, Xiaojing Wang & Jae H. Chang. (2018) Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole. Xenobiotica 48:10, pages 1021-1027.
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Gurinder Walia, Alexander D. Smith, Zoe Riches, Abby C. Collier & Michael W. H. Coughtrie. (2018) The effects of UDP-sugars, UDP and Mg2+on uridine diphosphate glucuronosyltransferase activity in human liver microsomes. Xenobiotica 48:9, pages 882-890.
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Dong Gui Hu, Peter I. Mackenzie, Ross A. McKinnon & Robyn Meech. (2016) Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk. Drug Metabolism Reviews 48:1, pages 47-69.
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Zoe Riches & Abby C Collier. (2015) Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases. Expert Opinion on Drug Metabolism & Toxicology 11:6, pages 949-965.
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Tuomas Rahikainen, Merja R. Häkkinen, Moshe Finel, Markku Pasanen & Risto O. Juvonen. (2013) A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes. Xenobiotica 43:10, pages 853-861.
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Articles from other publishers (33)

Wenyu Liu, Jing Li, Rui Zhao, Yao Lu & Panpan Huang. (2023) The Uridine diphosphate (UDP)-glycosyltransferases (UGTs) superfamily: the role in tumor cell metabolism. Frontiers in Oncology 12.
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Bao Guo, Xiaoyan Xu, Miaomiao Shao, Xu Yang, Gaofei He, Kangwei Qi, Jianxin Gu & Lan Wang. (2022) UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response. Biochemical and Biophysical Research Communications 613, pages 207-213.
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Cui-Lan Meng, Wei Zhao & Dan-Ni Zhong. (2021) Epigenetics and microRNAs in UGT1As. Human Genomics 15:1.
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Ana G. Vergara, Christy J. W. Watson, Jeffrey M. Watson, Gang Chen & Philip Lazarus. (2020) Altered Metabolism of Polycyclic Aromatic Hydrocarbons by UDP-Glycosyltransferase 3A2 Missense Variants. Chemical Research in Toxicology 33:11, pages 2854-2862.
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Yuejian Liu, Justine Badée, Ryan H. Takahashi, Stephan Schmidt, Neil Parrott, Stephen Fowler, Peter I. Mackenzie, Michael W. H. Coughtrie & Abby C. Collier. (2019) Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation. The Journal of Clinical Pharmacology 60:6, pages 722-733.
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Alexander D. Smith, Brent D. G. Page, Abby C. Collier & Michael W. H. Coughtrie. (2020) Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding. ACS Omega 5:12, pages 6872-6887.
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Ana G. Vergara, Christy J.W. Watson, Gang Chen & Philip Lazarus. (2020) UDP-Glycosyltransferase 3A Metabolism of Polycyclic Aromatic Hydrocarbons: Potential Importance in Aerodigestive Tract Tissues. Drug Metabolism and Disposition 48:3, pages 160-168.
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Dong Gui Hu, J.ulie-Ann Hulin, Pramod C. Nair, Alex Z. Haines, Ross A. McKinnon, Peter I. Mackenzie & Robyn Meech. (2019) The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism. Pharmacology & Therapeutics 204, pages 107414.
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Lei Feng, Jing Ning, Xiangge Tian, Chao Wang, Liyuan Zhang, Xiaochi Ma & Tony D. James. (2019) Fluorescent probes for bioactive detection and imaging of phase II metabolic enzymes. Coordination Chemistry Reviews 399, pages 213026.
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Robyn Meech, Dong Gui Hu, Ross A. McKinnon, Siti Nurul Mubarokah, Alex Z. Haines, Pramod C. Nair, Andrew Rowland & Peter I. Mackenzie. (2019) The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms. Physiological Reviews 99:2, pages 1153-1222.
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Xia Lv, Yangliu Xia, Moshe Finel, Jingjing Wu, Guangbo Ge & Ling Yang. (2019) Recent progress and challenges in screening and characterization of UGT1A1 inhibitors. Acta Pharmaceutica Sinica B 9:2, pages 258-278.
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Nurul Mubarokah, Julie-Ann Hulin, Peter I. Mackenzie, Ross A. McKinnon, Alex Z. Haines, Dong Gui Hu & Robyn Meech. (2018) Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4 α Is Mediated by a Novel Composite Regulatory Element . Molecular Pharmacology 93:5, pages 541-552.
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Cong Wang, Fang Chen, Yichen Liu, Qingqing Xu, Liang Guo, Xiaoqing Zhang, Yunfeng Ruan, Ye Shi, Lu Shen, Mo Li, Huihui Du, Xiaofang Sun, Jingsong Ma, Lin He & Shengying Qin. (2018) Genetic Association of Drug Response to Erlotinib in Chinese Advanced Non-small Cell Lung Cancer Patients. Frontiers in Pharmacology 9.
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K.K. Wolf & M.F. Paine. 2018. Comprehensive Toxicology. Comprehensive Toxicology 74 98 .
R. Meech, D.-G. Hu, J.O. Miners & P.I. Mackenzie. 2018. Comprehensive Toxicology. Comprehensive Toxicology 468 496 .
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Huma Mehboob, Imtiaz Mahmood Tahir, Tahir Iqbal, Naheed Akhter, Naveed Munir & Muhammad Riaz. 2017. Genetic Polymorphisms. Genetic Polymorphisms.
Abby C. Collier, Audrey D. Thévenon, William Goh, Mark Hiraoka & Claire E. Kendal-Wright. (2014) Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term. European Journal of Drug Metabolism and Pharmacokinetics 40:4, pages 471-480.
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Motoi Takagi, Masaya Sakamoto, Tomoo Itoh & Ryoichi Fujiwara. (2015) Underlying mechanism of drug–drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8. Drug Metabolism and Pharmacokinetics 30:4, pages 288-294.
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Ryoichi Fujiwara, Kyohei Sumida, Yuki Kutsuno, Masaya Sakamoto & Tomoo Itoh. (2015) UDP-glucuronosyltransferase (UGT) 1A1 mainly contributes to the glucuronidation of trovafloxacin. Drug Metabolism and Pharmacokinetics 30:1, pages 82-88.
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Rhiannon N. Hardwick, Daniel W. Ferreira, Vijay R. More, April D. Lake, Zhenqiang Lu, Jose E. Manautou, Angela L. Slitt & Nathan J. Cherrington. (2013) Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition 41:3, pages 554-561.
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Ryan T. Bushey, Douglas F. Dluzen & Philip Lazarus. (2013) Importance of UDP-Glucuronosyltransferases 2A2 and 2A3 in Tobacco Carcinogen Metabolism. Drug Metabolism and Disposition 41:1, pages 170-179.
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Alexander V. LyubimovRobert S. Foti, Dan A. Rock, Larry C. Wienkers & Jan L. Wahlstrom. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 68 .
Hongbo Zhang, Anne-Sisko Patana, Peter I. Mackenzie, Shinichi Ikushiro, Adrian Goldman & Moshe Finel. (2012) Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. Drug Metabolism and Disposition 40:10, pages 1935-1944.
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Robyn Meech, Anne Rogers, Lizhe Zhuang, Benjamin C. Lewis, John O. Miners & Peter I. Mackenzie. (2012) Identification of Residues That Confer Sugar Selectivity to UDP-Glycosyltransferase 3A (UGT3A) Enzymes. Journal of Biological Chemistry 287:29, pages 24122-24130.
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Alexander V. LyubimovRonald E. Savage. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 38 .
Robyn Meech, John O. Miners, Benjamin C. Lewis & Peter I. Mackenzie. (2012) The glycosidation of xenobiotics and endogenous compounds: Versatility and redundancy in the UDP glycosyltransferase superfamily. Pharmacology & Therapeutics 134:2, pages 200-218.
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Abu J. M. Sadeque, Khawja A. Usmani, Safet Palamar, Matthew A. Cerny & Weichao G. Chen. (2012) Identification of Human UDP-Glucuronosyltransferases Involved in N -Carbamoyl Glucuronidation of Lorcaserin . Drug Metabolism and Disposition 40:4, pages 772-778.
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Alexander V. LyubimovRobert S. Foti & Michael B. Fisher. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 71 .
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Daniela Buchheit, Ellen I. Schmitt, Daniel Bischoff, Thomas Ebner & Matthias Bureik. (2011) S -Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells . bchm 392:12, pages 1089-1095.
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Daniela Buchheit,Ellen I. Schmitt,Daniel Bischoff,Thomas Ebner,Matthias Bureik,. (2011) S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells. Biological Chemistry, pages ---.
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P. I. MacKenzie, A. Rogers, D. J. Elliot, N. Chau, J.-A. Hulin, J. O. Miners & R. Meech. (2010) The Novel UDP Glycosyltransferase 3A2: Cloning, Catalytic Properties, and Tissue Distribution. Molecular Pharmacology 79:3, pages 472-478.
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