Citations (165)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (16)
Sara Algeelani, Novera Alam, Md Amin Hossain, Gerd Mikus & David J. Greenblatt. (2018) In vitro inhibition of human UGT isoforms by ritonavir and cobicistat. Xenobiotica 48:8, pages 764-769.
Read now
Read now
Christina M. Street, Zhaohui Zhu, Moshe Finel & Michael H. Court. (2017) Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Xenobiotica 47:1, pages 1-10.
Read now
Read now
Antoinette Čolić, Marco Alessandrini & Michael S. Pepper. (2015) Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine. Drug Metabolism Reviews 47:2, pages 111-123.
Read now
Read now
Emily Reeve, Michael D Wiese & Arduino A Mangoni. (2015) Alterations in drug disposition in older adults. Expert Opinion on Drug Metabolism & Toxicology 11:4, pages 491-508.
Read now
Read now
Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2014) Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metabolism Reviews 46:4, pages 421-458.
Read now
Read now
Dongxue Sun, Liangliang Zhu, Ling Xiao, Yangliu Xia, Guangbo Ge, Yunfeng Cao, Yan Wu, Jun Yin & Ling Yang. (2014) In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica 44:11, pages 988-995.
Read now
Read now
Ted W. Simon, S. Stoney Simons$suffix/text()$suffix/text(), R. Julian Preston, Alan R. Boobis, Samuel M. Cohen, Nancy G. Doerrer, Penelope A. Fenner-Crisp, Tami S. McMullin, Charlene A. McQueen & J. Craig Rowlands. (2014) The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events. Critical Reviews in Toxicology 44:sup3, pages 17-43.
Read now
Read now
Limei Ai, Liangliang Zhu, Lu Yang, Guangbo Ge, Yunfeng Cao, Yong Liu, Zhongze Fang & Yanyan Zhang. (2014) Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases. Xenobiotica 44:4, pages 320-325.
Read now
Read now
Li Di. (2014) The role of drug metabolizing enzymes in clearance. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 379-393.
Read now
Read now
Wei Liu, Kaustubh Kulkarni & Ming Hu. (2013) Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1555-1569.
Read now
Read now
Rui-Hua Dong, Zhong-Ze Fang, Liang-Liang Zhu, Guang-Bo Ge, Ling Yang & Ze-Yuan Liu. (2012) Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol. Xenobiotica 42:10, pages 1009-1016.
Read now
Read now
J. Xing, F. Y. Du, T. Liu & F. P. Zhu. (2012) Autoinduction of phase I and phase II metabolism of artemisinin in rats. Xenobiotica 42:9, pages 929-938.
Read now
Read now
Shakil Ahmed Saghir, Sarosh Ahmed Khan & Alene Theresa McCoy. (2012) Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies. Critical Reviews in Toxicology 42:5, pages 323-357.
Read now
Read now
Michael H. Court, Xiuling Zhang, Xinxin Ding, Karen K. Yee, Leah M. Hesse & Moshe Finel. (2012) Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues. Xenobiotica 42:3, pages 266-277.
Read now
Read now
Sanna Kaivosaari, Moshe Finel & Mikko Koskinen. (2011) N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases. Xenobiotica 41:8, pages 652-669.
Read now
Read now
J. G. Hengstler, H. Foth, T. Gebel, P.-J. Kramer, W. Lilienblum, H. Schweinfurth, W. Völkel, K.-M. Wollin & U. Gundert-Remy. (2011) Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A. Critical Reviews in Toxicology 41:4, pages 263-291.
Read now
Read now
Articles from other publishers (149)
Qi Li, Fengzhen Zhang, Zhenzhen Wang, Yaoze Feng & Yahong Han. (2023) Advances in the Preparation, Stability, Metabolism, and Physiological Roles of Anthocyanins: A Review. Foods 12:21, pages 3969.
Crossref
Crossref
David Uihwan Lee, Dabin Choi, Mohammed Rifat Shaik, Kimmy Schuster, Sophie Schellhammer, Reid Ponder, Ki Jung Lee, Hannah Chou, Samuel Ding, Aneesh Bahadur, Gregory Fan & Zurabi Lominadze. (2023) The impact of race and gender on the outcomes of patients with acetaminophen-induced acute liver failure: propensity score-matched analysis of the NIS database. European Journal of Gastroenterology & Hepatology 35:9, pages 1049-1060.
Crossref
Crossref
John O. Miners, Thomas M. Polasek, Julie-Ann Hulin, Andrew Rowland & Robyn Meech. (2023) Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance. Pharmacology & Therapeutics 248, pages 108459.
Crossref
Crossref
Jun Matsumoto, Anzu Nishimoto, Shogo Watari, Hideo Ueki, Shoya Shiromizu, Naohiro Iwata, Tatsuaki Takeda, Soichiro Ushio, Makoto Kajizono, Masachika Fujiyoshi, Toshihiro Koyama, Motoo Araki, Koichiro Wada, Yoshito Zamami, Yasutomo Nasu & Noritaka Ariyoshi. (2022) Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. Molecular and Cellular Biochemistry 478:8, pages 1779-1790.
Crossref
Crossref
Rong-Jing He, Zhen-Hao Tian, Jian Huang, Meng-Ru Sun, Feng Wei, Chun-Yu Li, Hai-Rong Zeng, Feng Zhang, Xiao-Qing Guan, Yan Feng, Xiang-Ming Meng, Hui Yang & Guang-Bo Ge. (2023) Rationally Engineered CYP3A4 Fluorogenic Substrates for Functional Imaging Analysis and Drug–Drug Interaction Studies. Journal of Medicinal Chemistry 66:10, pages 6743-6755.
Crossref
Crossref
Milica Radosavljevic, Dubravka Svob Strac, Jasna Jancic & Janko Samardzic. (2023) The Role of Pharmacogenetics in Personalizing the Antidepressant and Anxiolytic Therapy. Genes 14:5, pages 1095.
Crossref
Crossref
Xinyi Wu, Jie En Valerie Sia, Min Hai, Xuan Lai, Haiyan Li, Cheng Cui & Dongyang Liu. (2023) Physiologically Based Pharmacokinetic Model for Older Adults and Its Application in
Geriatric Drug Research. Current Drug Metabolism 24:3, pages 211-222.
Crossref
Crossref
A. Floreani, D. Bizzaro, S. Shalaby, G. Taliani & P. Burra. (2023) Sex disparity and drug-induced liver injury. Digestive and Liver Disease 55:1, pages 21-28.
Crossref
Crossref
Arduino A. Mangoni & Elzbieta A. Jarmuzewska. 2023. Optimizing Pharmacotherapy in Older Patients. Optimizing Pharmacotherapy in Older Patients
3
14
.
Xianhuan Shen, Xinyi Chen, Jieluan Lu, Qing Chen, Wenzhou Li, Jiahao Zhu, Yaodong He, Huijuan Guo, Chenshu Xu & Xiaomei Fan. (2022) Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: Effect of ABCB1 gene polymorphism. Frontiers in Pharmacology 13.
Crossref
Crossref
Haiyan Li, Yang Sheng, Wei Li & Lin Yuan. (2022) Recent Advances in Molecular Fluorescent Probes for CYP450 Sensing and Imaging. Chemosensors 10:8, pages 304.
Crossref
Crossref
Qiang Jin, JingJing Wu, Yue Wu, Hongxin Li, Moshe Finel, Dandan Wang & Guangbo Ge. (2022) Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives. Acta Pharmaceutica Sinica B 12:3, pages 1068-1099.
Crossref
Crossref
Yan-Nan Zang, Wei Guo, Meng-Xi Niu, Shuang Bao, Qian Wang, Yan Wang, Fang Dong, An-Ning Li & Can-Jun Ruan. (2021) Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar disorder. European Journal of Clinical Pharmacology 78:3, pages 405-418.
Crossref
Crossref
Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I. Mackenzie & Yuji Ishii. (2022) Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in Pharmacology 13.
Crossref
Crossref
Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Joanna Łapczuk-Romańska, Maciej Wrzesiński, Stefan Oswald & Marek Droździk. (2021) The reference liver—CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype. Pharmacological Reports 74:1, pages 204-215.
Crossref
Crossref
Robert Løvsletten Smith, Birgit M. Wollmann, Lennart Kyllesø, Thu Thuy Anh Tran, Marit Tveito & Espen Molden. (2022) Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia. Journal of Clinical Psychopharmacology 42:1, pages 43-50.
Crossref
Crossref
Margaret O. James. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology
563
584
.
Cui-Lan Meng, Wei Zhao & Dan-Ni Zhong. (2021) Epigenetics and microRNAs in UGT1As. Human Genomics 15:1.
Crossref
Crossref
Yuu Miyauchi, Shinji Takechi & Yuji Ishii. (2021) Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological and Pharmaceutical Bulletin 44:11, pages 1635-1644.
Crossref
Crossref
Kefeng Sun & Devin Welty. (2021) Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi–Physiologically Based Modeling Approaches. Drug Metabolism and Disposition 49:11, pages 1025-1037.
Crossref
Crossref
Lei Feng, Yi Wang, Jiasheng Qin, Yu Fu, Zeyi Guo, Jianmin Zhang, Guolin He, Zesheng Jiang, Xiaoping Xu, Chenjie Zhou & Yi Gao. (2021) UGT1A Gene Family Members Serve as Potential Targets and Prognostic Biomarkers for Pancreatic Cancer. BioMed Research International 2021, pages 1-20.
Crossref
Crossref
Zhe Wang, Xiaoyu Wang, Zhen Wang, Yaqin Jia, Yuyi Feng, Lili Jiang, Yangliu Xia, Jun Cao & Yong Liu. (2021) In vitro inhibition of human UDP-glucuronosyltransferase (UGT) 1A1 by osimertinib, and prediction of in vivo drug-drug interactions. Toxicology Letters 348, pages 10-17.
Crossref
Crossref
Theresa Küting, Bianca Schneider, Anna Heidbreder, Michael Krämer, Pouria Jarsiah, Burkhard Madea & Cornelius Hess. (2021) Detection of γ‐hydroxybutyric acid‐related acids in blood plasma and urine: Extending the detection window of an exogenous γ‐hydroxybutyric acid intake?. Drug Testing and Analysis 13:9, pages 1635-1649.
Crossref
Crossref
Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity
79
137
.
Yazun Jarrar & Su-Jun Lee. (2021) The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases. Journal of Personalized Medicine 11:6, pages 554.
Crossref
Crossref
Arduino A. Mangoni & Elzbieta A. Jarmuzewska. (2021) Incorporating pharmacokinetic data into personalised prescribing for older people: challenges and opportunities. European Geriatric Medicine 12:3, pages 435-442.
Crossref
Crossref
Shanna C. Trenaman, Susan K. Bowles, Melissa K. Andrew & Kerry Goralski. (2021) The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs. Pharmacology Research & Perspectives 9:3.
Crossref
Crossref
John O. Miners, Andrew Rowland, Jonathan J. Novak, Kimberly Lapham & Theunis C. Goosen. (2021) Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping. Pharmacology & Therapeutics 218, pages 107689.
Crossref
Crossref
Jingjing Wu, Xiaoqing Guan, Ziru Dai, Rongjing He, Xinxin Ding, Ling Yang & Guangbo Ge. (2021) Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives. Coordination Chemistry Reviews 427, pages 213600.
Crossref
Crossref
Christopher R. Gibson, Ying-Hong Wang, Ninad Varkhede & Bennett Ma. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
443
479
.
Jin Zhou, Upendra A. Argikar & John O. Miners. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
301
338
.
Xiaoyan Li, Yiyan Lu, Xiaojun Ou, Sijing Zeng, Ying Wang, Xiaoxiao Qi, Lijun Zhu & Zhongqiu Liu. (2020) Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer. PeerJ 8, pages e10182.
Crossref
Crossref
Christoph Hassenberg, Florian Clausen, Grete Hoffmann, Armido Studer & Jennifer Schürenkamp. (2020) Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide. International Journal of Legal Medicine 134:6, pages 2105-2119.
Crossref
Crossref
E. E. J. Kasteel, K. Darney, N. I. Kramer, J. L. C. M. Dorne & L. S. Lautz. (2020) Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors. Archives of Toxicology 94:8, pages 2637-2661.
Crossref
Crossref
Anthony Kicic, Emma de Jong, Kak-Ming Ling, Kristy Nichol, Denise Anderson, Peter A.B. Wark, Darryl A. Knight, Anthony Bosco, Stephen M. Stick, Anthony Kicic, Stephen M. Stick, Darryl A. Knight, Elizabeth Kicic-Starcevich, Luke W. Garratt, Marc Padros-Goosen, Ee-Lyn Tan, Erika N. Sutanto, Kevin Looi, Jessica Hillas, Thomas Iosifidis, Nicole C. Shaw, Samuel T. Montgomery, Kak-Ming Ling, Kelly M. Martinovich, Francis J. Lannigan, Ricardo Bergesio, Bernard Lee, Shyan Vijaya-Sekeran, Paul Swan, Mairead Heaney, Ian Forsyth, Tobias Schoep, Alexander Larcombe, Monica Hunter, Kate McGee, Nyssa Millington, Anthony Kicic, Stephen M. Stick, Elizabeth Kicic-Starcevich, Luke W. Garratt, Erika N. Sutanto, Kevin Looi, Jessica Hillas, Thomas Iosifidis, Nicole C. Shaw, Samuel T. Montgomery, Kak-Ming Ling, Kelly M. Martinovich, Matthew W.-P. Poh, Daniel R. Laucirica, Craig Schofield, Samantha McLean, Katherine Landwehr, Emma de Jong, Nigel Farrow, Eugene Roscioli, David Parsons, Darryl A. Knight, Christopher Grainge, Andrew T. Reid, Su-Ling Loo & Punnam C. Veerati. (2020) Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium. Journal of Allergy and Clinical Immunology 145:6, pages 1562-1573.
Crossref
Crossref
Jacinta Walsh, Loreto Olavarria-Ramirez, Gilliard Lach, Marcus Boehme, Timothy G. Dinan, John F. Cryan, Brendan T. Griffin, Niall P. Hyland & Gerard Clarke. (2020) Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin. American Journal of Physiology-Gastrointestinal and Liver Physiology 318:4, pages G816-G826.
Crossref
Crossref
Olubadewa A. Fatunde & Sherry-Ann Brown. (2020) The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology. International Journal of Molecular Sciences 21:2, pages 604.
Crossref
Crossref
Merve Eda Eker, Kjersti Aaby, Irena Budic-Leto, Suzana Rimac Brnčić, Sedef Nehir El, Sibel Karakaya, Sebnem Simsek, Claudine Manach, Wieslaw Wiczkowski & Sonia de Pascual-Teresa. (2019) A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability. Foods 9:1, pages 2.
Crossref
Crossref
Dong Gui Hu, J.ulie-Ann Hulin, Pramod C. Nair, Alex Z. Haines, Ross A. McKinnon, Peter I. Mackenzie & Robyn Meech. (2019) The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism. Pharmacology & Therapeutics 204, pages 107414.
Crossref
Crossref
Mo'tasem M. Alsmadi, Mahdi Qasem Alfarah, Jawaher Albderat, Ghazi Alsalaita, Reham AlMardini, Salim Hamadi, Ahmad Al‐Ghazawi, Omar Abu‐Duhair & Nasir Idkaidek. (2019) The development of a population physiologically based pharmacokinetic model for mycophenolic mofetil and mycophenolic acid in humans using data from plasma, saliva, and kidney tissue. Biopharmaceutics & Drug Disposition 40:9, pages 325-340.
Crossref
Crossref
Robert L. SmithLennart KyllesøTore HaslemoOle Andreas Andreassen & Espen Molden. (2019) Reduction in N-Desmethylclozapine Level Is Determined by Daily Dose But Not Serum Concentration of Valproic Acid—Indications of a Presystemic Interaction Mechanism. Therapeutic Drug Monitoring 41:4, pages 503-508.
Crossref
Crossref
Philippe B. Pierrillas, Emilie Henin, Kathryn Ball, Julien Ogier, Magali Amiel, Laurence Kraus-Berthier, Marylore Chenel, François Bouzom & Michel Tod. (2019) Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy. Drug Metabolism and Disposition 47:6, pages 648-656.
Crossref
Crossref
Yasmin Schmid, Alexander Navarini, Zita-Rose Manjaly Thomas, Bettina Pfleiderer, Stephan Krähenbühl & Simon M Mueller. (2019) Sex differences in the pharmacology of itch therapies—a narrative review. Current Opinion in Pharmacology 46, pages 122-142.
Crossref
Crossref
Lydia Woelflingseder, Benedikt Warth, Immina Vierheilig, Heidi Schwartz-Zimmermann, Christian Hametner, Veronika Nagl, Barbara Novak, Bojan Šarkanj, Franz Berthiller, Gerhard Adam & Doris Marko. (2019) The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol. Archives of Toxicology 93:6, pages 1729-1743.
Crossref
Crossref
Yuu Miyauchi, Sora Kimura, Akane Kimura, Ken Kurohara, Yuko Hirota, Keiko Fujimoto, Peter I. Mackenzie, Yoshitaka Tanaka & Yuji Ishii. (2019) Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants. Molecular Pharmacology 95:5, pages 551-562.
Crossref
Crossref
Robyn Meech, Dong Gui Hu, Ross A. McKinnon, Siti Nurul Mubarokah, Alex Z. Haines, Pramod C. Nair, Andrew Rowland & Peter I. Mackenzie. (2019) The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms. Physiological Reviews 99:2, pages 1153-1222.
Crossref
Crossref
Felix Stader, Marco Siccardi, Manuel Battegay, Hannah Kinvig, Melissa A. Penny & Catia Marzolini. (2018) Repository Describing an Aging Population to Inform Physiologically Based Pharmacokinetic Models Considering Anatomical, Physiological, and Biological Age-Dependent Changes. Clinical Pharmacokinetics 58:4, pages 483-501.
Crossref
Crossref
Xia Lv, Yangliu Xia, Moshe Finel, Jingjing Wu, Guangbo Ge & Ling Yang. (2019) Recent progress and challenges in screening and characterization of UGT1A1 inhibitors. Acta Pharmaceutica Sinica B 9:2, pages 258-278.
Crossref
Crossref
Bahar Matin, Ahmad A Sherbini, Novera Alam, Jerold S Harmatz & David J Greenblatt. (2019)
Resveratrol glucuronidation
in vitro
: potential implications of inhibition by probenecid
. Journal of Pharmacy and Pharmacology 71:3, pages 371-378.
Crossref
Crossref
Yuu Miyauchi, Hideyuki Yamada & Yuji Ishii. (2019) Advantage of a Co-expression System for Estimating Physiological Effects of Functional Interaction Between Cytochrome P450 3A4 and Uridine 5’-Diphospho-Glucuronosyltransferase 2B7. BPB Reports 2:5, pages 61-66.
Crossref
Crossref
Xia Lv, Jian‐Bin Zhang, Jie Hou, Tong‐Yi Dou, Guang‐Bo Ge, Wen‐Zhong Hu & Ling Yang. (2018) Chemical Probes for Human UDP‐Glucuronosyltransferases: A Comprehensive Review. Biotechnology Journal 14:1.
Crossref
Crossref
Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C. Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O. Cameron & Amit S. Kalgutkar. (2018)
6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1
H
-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to
β
-Estradiol
. Drug Metabolism and Disposition 46:12, pages 1836-1846.
Crossref
Crossref
Niladri Chattopadhyay, Tobias Kanacher, Manuela Casjens, Sebastian Frechen, Sandra Ligges, Torsten Zimmermann, Antje Rottmann, Bart Ploeger, Joachim Höchel & Marcus‐Hillert Schultze‐Mosgau. (2018) CYP3A4‐mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1‐mediated effects on bilirubin glucuronidation in humans. British Journal of Clinical Pharmacology 84:12, pages 2857-2866.
Crossref
Crossref
Manoranjenni Chetty, Trevor N. Johnson, Sebastian Polak, Farzaneh Salem, Kosuke Doki & Amin Rostami-Hodjegan. (2018) Physiologically based pharmacokinetic modelling to guide drug delivery in older people. Advanced Drug Delivery Reviews 135, pages 85-96.
Crossref
Crossref
Dong Gui Hu, Julie-Ann Hulin, Dhilushi D. Wijayakumara, Ross A. McKinnon, Peter I. Mackenzie & Robyn Meech. (2018)
Intergenic Splicing between Four Adjacent
UGT
Genes (
2B15, 2B29P2, 2B17, 2B29P1
) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions
. Molecular Pharmacology 94:3, pages 938-952.
Crossref
Crossref
Haihui Zheng, Liping Wang, Sijing Zeng, Jiamei Chen, Haojia Wang, Jia Yu, Xia Gong, Huangyu Jiang, Xia Yang, Xiaoxiao Qi, Ying Wang, Linlin Lu, Ming Hu, Lijun Zhu & Zhongqiu Liu. (2018) Age-related changes in hepatic expression and activity of drug metabolizing enzymes in male wild-type and breast cancer resistance protein knockout mice. Biopharmaceutics & Drug Disposition 39:7, pages 344-353.
Crossref
Crossref
Jessica B. Rubin, Bilal Hameed, Michelle Gottfried, William M. Lee & Monika Sarkar. (2018) Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women. Clinical Gastroenterology and Hepatology 16:6, pages 936-946.
Crossref
Crossref
R. Meech, D.-G. Hu, J.O. Miners & P.I. Mackenzie. 2018. Comprehensive Toxicology. Comprehensive Toxicology
468
496
.
Xia Lv, Lei Feng, Chun-Zhi Ai, Jie Hou, Ping Wang, Li-Wei Zou, Jie Cheng, Guang-Bo Ge, Jing-Nan Cui & Ling Yang. (2017) A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin. Journal of Medicinal Chemistry 60:23, pages 9664-9675.
Crossref
Crossref
Ioannis Papageorgiou & Michael H. Court. (2017) Identification and validation of the microRNA response elements in the 3′-untranslated region of the UDP glucuronosyltransferase ( UGT ) 2B7 and 2B15 genes by a functional genomics approach. Biochemical Pharmacology 146, pages 199-213.
Crossref
Crossref
Novera Alam, Mia G Angeli & David J Greenblatt. (2017) Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir. Journal of Pharmacy and Pharmacology 69:12, pages 1794-1801.
Crossref
Crossref
Lei Cao, Awewura Kwara & David J Greenblatt. (2017)
Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through
in-vitro
inhibition studies
. Journal of Pharmacy and Pharmacology 69:12, pages 1762-1772.
Crossref
Crossref
Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge & Ruihua Dong. (2017) Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1. Acta Pharmaceutica Sinica B 7:6, pages 657-664.
Crossref
Crossref
Lei Cao, David J. Greenblatt & Awewura Kwara. (2017) Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes. Drug Metabolism and Disposition 45:9, pages 1035-1043.
Crossref
Crossref
Ioannis Papageorgiou & Michael H. Court. (2017) Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach. Biochemical Pharmacology 137, pages 93-106.
Crossref
Crossref
Dhilushi D. Wijayakumara, Peter I. Mackenzie, Ross A. McKinnon, Dong Gui Hu & Robyn Meech. (2017) Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells. Journal of Pharmacology and Experimental Therapeutics 361:3, pages 386-397.
Crossref
Crossref
Marije Strikwold, Bert Spenkelink, Ruud A. Woutersen, Ivonne M.C.M. Rietjens & Ans Punt. (2017) Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity. Toxicological Sciences 157:2, pages 365-376.
Crossref
Crossref
Elena Buzzetti, Pathik M. Parikh, Alessio Gerussi & Emmanuel Tsochatzis. (2017) Gender differences in liver disease and the drug-dose gender gap. Pharmacological Research 120, pages 97-108.
Crossref
Crossref
Jeannette Connerney, Dana Lau-Corona, Andy Rampersaud & David J. Waxman. (2017) Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses. Endocrinology 158:5, pages 1386-1405.
Crossref
Crossref
Huan Liu, Jie Yang, Shaowen Huang, Ruijing Liu, Yongjian He, Dongdong Zheng & Chunhong Liu. (2017) Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects. Journal of Functional Foods 32, pages 367-374.
Crossref
Crossref
J. E. Slovak, K. Mealey & M. H. Court. (2017) Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes. Journal of Veterinary Pharmacology and Therapeutics 40:2, pages 123-129.
Crossref
Crossref
Stefan J Schaller, Saad M Alam, Jianren Mao, Yanli Zhao, Manfred Blobner, David J Greenblatt & J A Jeevendra Martyn. (2017) Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination. Journal of Pharmacy and Pharmacology 69:1, pages 82-88.
Crossref
Crossref
Luigi Brunetti, Betty Sanchez-Catanese, Leonid Kagan, Xia Wen, Min Liu, Brian Buckley, James P. Luyendyk & Lauren M. Aleksunes. (2016) Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting. Thrombosis Journal 14:1.
Crossref
Crossref
Jamie N. Connarn, Ruijuan Luo, Jim Windak, Xinyuan Zhang, Andrew Babiskin, Marisa Kelly, Gloria Harrington, Vicki L. Ellingrod, Masoud Kamali, Melvin McInnis & Duxin Sun. (2016) Identification of non‐reported bupropion metabolites in human plasma. Biopharmaceutics & Drug Disposition 37:9, pages 550-560.
Crossref
Crossref
Ioannis Papageorgiou, Marina Freytsis & Michael H. Court. (2016) Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochemical Pharmacology 117, pages 78-87.
Crossref
Crossref
Sung-joon Cho, Miaoran Ning, Yanyan Zhang, Leah H. Rubin & Hyunyoung Jeong. (2016) 17 β -Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α. Acta Pharmaceutica Sinica B 6:5, pages 504-509.
Crossref
Crossref
Xia Lv, Xin-Xin Wang, Jie Hou, Zhong-Ze Fang, Jing-Jing Wu, Yun-Feng Cao, Shu-Wen Liu, Guang-Bo Ge & Ling Yang. (2016) Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases. Toxicology and Applied Pharmacology 301, pages 42-49.
Crossref
Crossref
Xin-Xin Wang, Xia Lv, Shi-Yang Li, Jie Hou, Jing Ning, Jia-Yue Wang, Yun-Feng Cao, Guang-Bo Ge, Bin Guo & Ling Yang. (2015) Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi). Toxicology and Applied Pharmacology 289:1, pages 70-78.
Crossref
Crossref
Yuli Qian, Ahmad Sherbini, Bahar Matin, Yanli Zhao, John Castellot & David J Greenblatt. (2015) Inhibition of 2-methoxyestradiol glucuronidation by probenecid. Journal of Pharmacy and Pharmacology 67:11, pages 1585-1592.
Crossref
Crossref
Xia Lv, Jie Hou, Yang-Liu Xia, Jing Ning, Gui-Yuan He, Ping Wang, Guang-Bo Ge, Zhi-Long Xiu & Ling Yang. (2015) Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: Identification of UGT1A1 and UGT1A8 as the major contributing enzymes. Drug Metabolism and Pharmacokinetics 30:5, pages 358-365.
Crossref
Crossref
Dhilushi D. Wijayakumara, Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2015) Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines. Journal of Pharmacology and Experimental Therapeutics 354:3, pages 417-425.
Crossref
Crossref
Li Jiang, Si-Cheng Liang, Chao Wang, Guang-Bo Ge, Xiao-Kui Huo, Xiao-Yi Qi, Sa Deng, Ke-Xin Liu & Xiao-Chi Ma. (2015) Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4. Scientific Reports 5:1.
Crossref
Crossref
Liangliang Zhu, Ling Xiao, Yangliu Xia, Kun Zhou, Huili Wang, Minyi Huang, Guangbo Ge, Yan Wu, Ganlin Wu & Ling Yang. (2015) Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation. Toxicology and Applied Pharmacology 283:2, pages 109-116.
Crossref
Crossref
Ala′ A.A. Al-Subeihi, Wasma Alhusainy, Reiko Kiwamoto, Bert Spenkelink, Peter J. van Bladeren, Ivonne M.C.M. Rietjens & Ans Punt. (2015) Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations. Toxicology and Applied Pharmacology 283:2, pages 117-126.
Crossref
Crossref
. (2015) From the Editor's Desk, Editorial Highlights, Letter to the Editor. Toxicological Sciences 143:2, pages 229-230.
Crossref
Crossref
Ken-ichi Fujita. (2015) Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer. World Journal of Gastroenterology 21:43, pages 12234.
Crossref
Crossref
Catherine A. Wassenaar, David V. Conti, Soma Das, Peixian Chen, Edwin H. Cook, Mark J. Ratain, Neal L. Benowitz & Rachel F. Tyndale. (2015)
UGT1A
and
UGT2B
Genetic Variation Alters Nicotine and Nitrosamine Glucuronidation in European and African American Smokers
. Cancer Epidemiology, Biomarkers & Prevention 24:1, pages 94-104.
Crossref
Crossref
Nenad Manevski, Piet Swart, Kamal Kumar Balavenkatraman, Barbara Bertschi, Gian Camenisch, Olivier Kretz, Hilmar Schiller, Markus Walles, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Peter Itin, Joanna Ashton-Chess, Francois Pognan, Armin Wolf & Karine Litherland. (2015)
Phase II Metabolism in Human Skin: Skin Explants Show Full Coverage for Glucuronidation, Sulfation,
N
-Acetylation, Catechol Methylation, and Glutathione Conjugation
. Drug Metabolism and Disposition 43:1, pages 126-139.
Crossref
Crossref
Yazun Bashir Jarrar, Eun-Young Cha, Kyung-Ah Seo, Jong-Lyul Ghim, Hyo-Ji Kim, Dong-Hyun Kim, Su-Jun Lee & Jae-Gook Shin. (2014) Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation. Journal of Lipid Research 55:11, pages 2334-2342.
Crossref
Crossref
David E Amacher. (2013) Female gender as a susceptibility factor for drug-induced liver injury. Human & Experimental Toxicology 33:9, pages 928-939.
Crossref
Crossref
Brahim Achour, Amin Rostami-Hodjegan & Jill Barber. (2014) Protein expression of various hepatic uridine 5′-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: a meta-analysis. Biopharmaceutics & Drug Disposition 35:6, pages 353-361.
Crossref
Crossref
Michael H. Court, Fawziah E. Almutairi, David J. Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Kathrin Klein, Ulrich M. Zanger, Joanne Bourgea, Christopher J. Patten & Awewura Kwara. (2014)
Isoniazid Mediates the
CYP2B6*6
Genotype-Dependent Interaction between Efavirenz and Antituberculosis Drug Therapy through Mechanism-Based Inactivation of CYP2A6
. Antimicrobial Agents and Chemotherapy 58:7, pages 4145-4152.
Crossref
Crossref
Jose de Leon. (2014) False-Negative Studies May Systematically Contaminate the Literature on the Effects of Inducers in Neuropsychopharmacology. Journal of Clinical Psychopharmacology 34:3, pages 291-296.
Crossref
Crossref
Hannah K. Batchelor, Nikoletta Fotaki & Sandra Klein. (2014) Paediatric oral biopharmaceutics: Key considerations and current challenges. Advanced Drug Delivery Reviews 73, pages 102-126.
Crossref
Crossref
Dong Gui Hu, Robyn Meech, Lu Lu, Ross A. McKinnon & Peter I. Mackenzie. (2014) Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene Promoter. Drug Metabolism and Disposition 42:5, pages 854-862.
Crossref
Crossref
Huijuan WangTing BianTianbo JinYong Chen, Aifen Lin & Chao Chen. (2014)
Association analysis of
UGT1A
genotype and haplotype with SN-38 glucuronidation in human livers
. Pharmacogenomics 15:6, pages 785-798.
Crossref
Crossref
Brahim Achour, Matthew R. Russell, Jill Barber & Amin Rostami-Hodjegan. (2014) Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics. Drug Metabolism and Disposition 42:4, pages 500-510.
Crossref
Crossref
Misaki Kojima & Masakuni Degawa. (2014) Sex Differences in the Constitutive Gene Expression of Sulfotransferases and UDP-glucuronosyltransferases in the Pig Liver: Androgen-mediated Regulation. Drug Metabolism and Pharmacokinetics 29:2, pages 192-197.
Crossref
Crossref
Michael H. Court, Inga Peter, Suwagmani Hazarika, Magdalini Vasiadi, David J. Greenblatt & William M. Lee. (2014) Candidate Gene Polymorphisms in Patients with Acetaminophen-Induced Acute Liver Failure. Drug Metabolism and Disposition 42:1, pages 28-32.
Crossref
Crossref
J.C. Stingl, H. Bartels, R. Viviani, M.L. Lehmann & J. Brockmöller. (2014) Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review. Pharmacology & Therapeutics 141:1, pages 92-116.
Crossref
Crossref
Ying-Hong Wang & Christopher R. Gibson. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
337
362
.
Michael H. Court. 2014. Optimization in Drug Discovery. Optimization in Drug Discovery
117
136
.
Lifang Zhang, Xiaoman Chu, Hong Wang, Hao Xie, Cen Guo, Lijuan Cao, Xueyan Zhou, Guangji Wang & Haiping Hao. (2013) Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver. European Journal of Pharmacology 721:1-3, pages 277-285.
Crossref
Crossref
Jana C. Precht, Werner Schroth, Kathrin Klein, Hiltrud Brauch, Evgeny Krynetskiy, Matthias Schwab & Thomas E. Mürdter. (2013) The Letrozole Phase 1 Metabolite Carbinol as a Novel Probe Drug for UGT2B7. Drug Metabolism and Disposition 41:11, pages 1906-1913.
Crossref
Crossref
María L. Ruiz, Aldo D. Mottino, Viviana A. Catania & Mary Vore. 2011. Comprehensive Physiology. Comprehensive Physiology
1721
1740
.
Gudrun H?iseth, Jannike M?rch Andersen & J?rg M?rland. (2013) Less glucuronidation of morphine in the presence of ethanol in vivo. European Journal of Clinical Pharmacology 69:9, pages 1683-1687.
Crossref
Crossref
Jiangbo Du, Tiangeng You, Xiaoyan Chen & Dafang Zhong. (2013) Stereoselective Glucuronidation of Ornidazole in Humans: Predominant Contribution of UDP-Glucuronosyltransferases 1A9 and 2B7. Drug Metabolism and Disposition 41:7, pages 1306-1318.
Crossref
Crossref
Verawan Uchaipichat, Chuthamanee Suthisisang & John O. Miners. (2013) The Glucuronidation of R- and S-Lorazepam: Human Liver Microsomal Kinetics, UDP-Glucuronosyltransferase Enzyme Selectivity, and Inhibition by Drugs. Drug Metabolism and Disposition 41:6, pages 1273-1284.
Crossref
Crossref
Andrew Rowland, John O. Miners & Peter I. Mackenzie. (2013) The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification. The International Journal of Biochemistry & Cell Biology 45:6, pages 1121-1132.
Crossref
Crossref
Umit Yasar, David J Greenblatt, Chantal Guillemette & Michael H Court. (2013) Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers. Journal of Pharmacy and Pharmacology 65:6, pages 874-883.
Crossref
Crossref
Michael H. Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X. Duan, David J. Greenblatt & William M. Lee. (2013) The UDP-Glucuronosyltransferase (UGT) 1A Polymorphism c.2042C>G (rs8330) Is Associated with Increased Human Liver Acetaminophen Glucuronidation, Increased UGT1A Exon 5a/5b Splice Variant mRNA Ratio, and Decreased Risk of Unintentional Acetaminophen-Induced Acute Liver Failure. Journal of Pharmacology and Experimental Therapeutics 345:2, pages 297-307.
Crossref
Crossref
Katherine L. Gill, Michael Gertz, J. Brian Houston & Aleksandra Galetin. (2013) Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data. Drug Metabolism and Disposition 41:4, pages 744-753.
Crossref
Crossref
Rhiannon N. Hardwick, Daniel W. Ferreira, Vijay R. More, April D. Lake, Zhenqiang Lu, Jose E. Manautou, Angela L. Slitt & Nathan J. Cherrington. (2013) Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition 41:3, pages 554-561.
Crossref
Crossref
Uta Fernekorn, Jörg Hampl, Caroline Augspurger, Christian Hildmann, Frank Weise, Maren Klett, Annette Läffert, Michael Gebinoga, Adam Williamson & Andreas Schober. (2013) In vitro cultivation of biopsy derived primary hepatocytes leads to a more metabolic genotype in perfused 3D scaffolds than static 3D cell culture. RSC Advances 3:37, pages 16558.
Crossref
Crossref
Liangliang Zhu, Guangbo Ge, Yong Liu, Zhimou Guo, Chengcheng Peng, Feng Zhang, Yunfeng Cao, Jingjing Wu, Zhongze Fang, Xinmiao Liang & Ling Yang. (2012) Characterization of UDP-Glucuronosyltransferases Involved in Glucuronidation of Diethylstilbestrol in Human Liver and Intestine. Chemical Research in Toxicology 25:12, pages 2663-2669.
Crossref
Crossref
Fanping Zhu, Fuying Du, Xinxiu Li & Jie Xing. (2012) An investigation of the auto-induction of and gender-related variability in the pharmacokinetics of dihydroartemisinin in the rat. Malaria Journal 11:1.
Crossref
Crossref
Hyewon Kim, Janel Long‐Boyle, Nancy Rydholm, Paul J. Orchard, Jakub Tolar, Angela R. Smith, Pamala Jacobson & Richard Brundage. (2013) Population Pharmacokinetics of Unbound Mycophenolic Acid in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplantation. The Journal of Clinical Pharmacology 52:11, pages 1665-1675.
Crossref
Crossref
Aida Serra, Nyssa Bryant, Maria José Motilva, Jeffrey B. Blumberg & C.-Y. Oliver Chen. (2012) Fetal programming of dietary fructose and saturated fat on hepatic quercetin glucuronidation in rats. Nutrition 28:11-12, pages 1165-1171.
Crossref
Crossref
Frans L. Opdam, Hans Gelderblom & Henk-Jan Guchelaar. (2012) Phenotyping drug disposition in oncology. Cancer Treatment Reviews 38:6, pages 715-725.
Crossref
Crossref
Karl Walter Bock. (2012) Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors. Biochemical Pharmacology 84:8, pages 1000-1006.
Crossref
Crossref
William P. Petros, Islam R. Younis, James N. Ford & Scott A. Weed. (2012) Effects of Tobacco Smoking and Nicotine on Cancer Treatment. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 32:10, pages 920-931.
Crossref
Crossref
Anne-Laure Gagez, Koukeb Rouguieg-Malki, Fran?ois-Ludovic Sauvage, Pierre Marquet & Nicolas Picard. (2012) Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography?tandem mass spectrometry. Analytical Biochemistry 427:1, pages 52-59.
Crossref
Crossref
Veronique Michaud, Tamara Bar-Magen, Jacques Turgeon, David Flockhart, Zeruesenay Desta & Mark A. Wainberg. (2012) The Dual Role of Pharmacogenetics in HIV Treatment: Mutations and Polymorphisms Regulating Antiretroviral Drug Resistance and Disposition. Pharmacological Reviews 64:3, pages 803-833.
Crossref
Crossref
Cecilie Johannessen Landmark, Svein I. Johannessen & Torbjörn Tomson. (2012) Host factors affecting antiepileptic drug delivery—Pharmacokinetic variability. Advanced Drug Delivery Reviews 64:10, pages 896-910.
Crossref
Crossref
Alexander V. LyubimovRonald E. Savage. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
38
.
Alexander V. LyubimovMichael D. Coleman & Louis L. Radulovic. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
50
.
Robert L. Walsky, Jonathan N. Bauman, Karine Bourcier, Georgina Giddens, Kimberly Lapham, Andre Negahban, Tim F. Ryder, R. Scott Obach, Ruth Hyland & Theunis C. Goosen. (2012) Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors. Drug Metabolism and Disposition 40:5, pages 1051-1065.
Crossref
Crossref
Chun Li & Nataraj Kalyanaraman. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development
189
212
.
Ulrich M. Zanger. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics
285
300
.
Katherine L. Gill, J. Brian Houston & Aleksandra Galetin. (2012) Characterization of In Vitro Glucuronidation Clearance of a Range of Drugs in Human Kidney Microsomes: Comparison with Liver and Intestinal Glucuronidation and Impact of Albumin. Drug Metabolism and Disposition 40:4, pages 825-835.
Crossref
Crossref
A. J. McLachlan & L. G. Pont. (2011) Drug Metabolism in Older People--A Key Consideration in Achieving Optimal Outcomes With Medicines. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 67A:2, pages 175-180.
Crossref
Crossref
Thomas Eissing, Jörg Lippert & Stefan Willmann. (2012) Pharmacogenomics of Codeine, Morphine, and Morphine-6-Glucuronide. Molecular Diagnosis & Therapy 16:1, pages 43-53.
Crossref
Crossref
Alexander V. LyubimovDeepak K. Dalvie & Cho‐Ming Loi. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
36
.
Yingjie Guo, Cheng Hu, Xiaojing He, Feng Qiu & Limei Zhao. (2012) Effects of UGT1A6, UGT2B7, and CYP2C9 Genotypes on Plasma Concentrations of Valproic Acid in Chinese Children with Epilepsy. Drug Metabolism and Pharmacokinetics 27:5, pages 536-542.
Crossref
Crossref
S. M. Bratton, C. M. Mosher, F. Khallouki, M. Finel, M. H. Court, J. H. Moran & A. Radominska-Pandya. (2011) Analysis of R- and S-Hydroxywarfarin Glucuronidation Catalyzed by Human Liver Microsomes and Recombinant UDP-Glucuronosyltransferases. Journal of Pharmacology and Experimental Therapeutics 340:1, pages 46-55.
Crossref
Crossref
Arjun Muralidharan & Maree T Smith. (2011) Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology 63:11, pages 1387-1400.
Crossref
Crossref
Bradley W. Bolling, Michael H. Court, Jeffrey B. Blumberg & C.-Y. Oliver Chen. (2011) Microsomal Quercetin Glucuronidation in Rat Small Intestine Depends on Age and Segment. Drug Metabolism and Disposition 39:8, pages 1406-1414.
Crossref
Crossref
Karl Walter Bock. (2011) From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochemical Pharmacology 82:1, pages 9-16.
Crossref
Crossref
Yongchuan Gu, Malcolm D. Tingle & William R. Wilson. (2011) Glucuronidation of Anticancer Prodrug PR-104A: Species Differences, Identification of Human UDP-Glucuronosyltransferases, and Implications for Therapy. Journal of Pharmacology and Experimental Therapeutics 337:3, pages 692-702.
Crossref
Crossref
Shinsuke Uchihashi, Hiroyuki Fukumoto, Makoto Onoda, Hiroyoshi Hayakawa, Shin-ichi Ikushiro & Toshiyuki Sakaki. (2011) Metabolism of the c-Fos/Activator Protein-1 Inhibitor T-5224 by Multiple Human UDP-Glucuronosyltransferase Isoforms. Drug Metabolism and Disposition 39:5, pages 803-813.
Crossref
Crossref
John O. Miners, Kushari Bowalgaha, David J. Elliot, Pawel Baranczewski & Kathleen M. Knights. (2011) Characterization of Niflumic Acid as a Selective Inhibitor of Human Liver Microsomal UDP-Glucuronosyltransferase 1A9: Application to the Reaction Phenotyping of Acetaminophen Glucuronidation. Drug Metabolism and Disposition 39:4, pages 644-652.
Crossref
Crossref
Marisol L?pez, Pedro Dorado, Nancy Monroy, Mar?a Elisa Alonso, Helgi Jung-Cook, Esther Mach?n, Eva Pe?as-Lled?Adri?n Llerena. (2011) Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine. Drug Metabolism and Drug Interactions 26:1.
Crossref
Crossref
Sandi L. Navarro, Misty R. Saracino, Karen W. Makar, Sushma S. Thomas, Lin Li, Yingye Zheng, Lisa Levy, Yvonne Schwarz, Jeannette Bigler, John D. Potter & Johanna W. Lampe. (2011) Determinants of Aspirin Metabolism in Healthy Men and Women: Effects of Dietary Inducers of UDP-Glucuronosyltransferases. Journal of Nutrigenetics and Nutrigenomics 4:2, pages 110-118.
Crossref
Crossref
Si-Cheng Liang, Guang-Bo Ge, Hui-Xin Liu, Hai-Tao Shang, Hong Wei, Zhong-Ze Fang, Liang-Liang Zhu, Yu-Xi Mao & Ling Yang. (2011) Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC–ESI-MS. Journal of Pharmaceutical and Biomedical Analysis 54:1, pages 236-241.
Crossref
Crossref
Sara Correia Marques & Ogechi N Ikediobi. (2010) The clinical application of UGT1A1pharmacogenetic testing: Gene-environment interactions. Human Genomics 4:4.
Crossref
Crossref
. (2010) Scientific Opinion on Bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of Bisphenol A. EFSA Journal 8:9, pages 1829.
Crossref
Crossref
Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay & Appavu Chandrasekaran. (2010) In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans. Drug Metabolism and Disposition 38:9, pages 1471-1479.
Crossref
Crossref
Karl Walter Bock. (2010) Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): Mechanisms responsible for interindividual variation of UGT levels. Biochemical Pharmacology 80:6, pages 771-777.
Crossref
Crossref
Si-Cheng Liang, Guang-Bo Ge, Hui-Xin Liu, Yan-Yan Zhang, Li-Ming Wang, Jiang-Wei Zhang, Lu Yin, Wei Li, Zhong-Ze Fang, Jing-Jing Wu, Guo-Hui Li & Ling Yang. (2010) Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the In Vitro Glucuronidation of Daphnetin. Drug Metabolism and Disposition 38:6, pages 973-980.
Crossref
Crossref