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Drug Metabolism Reviews Volume 42, 2010 - Issue 1
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Review Article

Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism

Drew R. JonesDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
,
Jeffery H. MoranArkansas Department of Health, Arkansas Public Health Laboratory, Little, Rock, Arkansas, USA
&
Grover P. MillerDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USACorrespondence[email protected]
Pages 55-61 | Accepted 27 Jul 2009, Published online: 14 Jan 2010

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Shenglei Yan, Yuying Liu, Jianfang Feng, Hua Zhao, Zhongshu Yu, Jing Zhao, Yao Li & Jingqing Zhang. (2018) Difference and alteration in pharmacokinetic and metabolic characteristics of low-solubility natural medicines. Drug Metabolism Reviews 50:2, pages 140-160.
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Christian Riebeling, Katrin Hayess, Annelieke K. Peters, Margino Steemans, Horst Spielmann, Andreas Luch & Andrea E. M. Seiler. (2012) Assaying embryotoxicity in the test tube: Current limitations of the embryonic stem cell test (EST) challenging its applicability domain. Critical Reviews in Toxicology 42:5, pages 443-464.
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Michal Šiller, Pavel Anzenbacher, Eva Anzenbacherová, Karel Doležal & Miroslav Strnad. (2011) In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism. Xenobiotica 41:11, pages 934-944.
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Petra Jančová, Michal Šiller, Eva Anzenbacherová, Vladimír Křen, Pavel Anzenbacher & Vilím Šimánek. (2011) Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica 41:9, pages 743-751.
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Articles from other publishers (17)

Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage & Timothy S. Tracy. (2022) Pharmacokinetic Modeling of Warfarin ІI – Model-Based Analysis of Warfarin Metabolites after Warfarin Administered Either Alone or Together with Fluconazole or Rifampin. Drug Metabolism and Disposition 50:9, pages 1302-1311.
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Dakota L. Pouncey, Dustyn A. Barnette, Riley W. Sinnott, Sarah J. Phillips, Noah R. Flynn, Howard P. Hendrickson, S. Joshua Swamidass & Grover P. Miller. (2022) Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin. Frontiers in Pharmacology 12.
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Kazuki Takeda, Yoshinori Ikenaka, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Tsutomu Tanikawa, Hazuki Mizukawa & Mayumi Ishizuka. (2018) Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion. Pesticide Biochemistry and Physiology 148, pages 42-49.
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Xia-Wen Liu, Yi Rong, Xing-Fei Zhang, Jun-Jun Huang, Yi Cai, Bi-Yun Huang, Liu Zhu, Bo Wu, Ning Hou & Cheng-Feng Luo. (2018) Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro. Frontiers in Pharmacology 8.
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Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa & Mayumi Ishizuka. (2016) Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis. Pesticide Biochemistry and Physiology 134, pages 1-7.
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Sook Hee An, Byung Chul Chang, Kyung Eun Lee & Hye Sun Gwak. (2015) Influence of UDP-Glucuronosyltransferase Polymorphisms on Stable Warfarin Doses in Patients with Mechanical Cardiac Valves. Cardiovascular Therapeutics 33:6, pages 324-328.
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Jacqueline A. Gibbons, Michiel de Vries, Walter Krauwinkel, Yoshiaki Ohtsu, Jan Noukens, Jan-Stefan van der Walt, Roelof Mol, Joyce Mordenti & Taoufik Ouatas. (2015) Pharmacokinetic Drug Interaction Studies with Enzalutamide. Clinical Pharmacokinetics 54:10, pages 1057-1069.
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Siji Joseph, Murali Subramanian & Smriti Khera. (2015) Simultaneous and stereospecific analysis of warfarin oxidative metabolism using 2D LC/Q-TOF. Bioanalysis 7:18, pages 2297-2309.
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Paweł Nowak, Paulina Olechowska, Mariusz Mitoraj, Michał Woźniakiewicz & Paweł Kościelniak. (2015) Determination of acid dissociation constants of warfarin and hydroxywarfarins by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 112, pages 89-97.
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C. Preston Pugh, Dakota L. Pouncey, Jessica H. Hartman, Robert Nshimiyimana, Linda P. Desrochers, Thomas E. Goodwin, Gunnar Boysen & Grover P. Miller. (2014) Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Archives of Biochemistry and Biophysics 564, pages 244-253.
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Osama Y. Alshogran, Andrew J. Ocque, Jielu Zhao, Billy W. Day, Fran?ois A. Leblond, Vincent Pichette & Thomas D. Nolin. (2014) Determination of warfarin alcohols by ultra-high performance liquid chromatography?tandem mass spectrometry: Application to in vitro enzyme kinetic studies. Journal of Chromatography B 944, pages 63-68.
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Alexander V. LyubimovRonald E. Savage. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 38 .
Baojian Wu, Kaustubh Kulkarni, Sumit Basu, Shuxing Zhang & Ming Hu. (2011) First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics. Journal of Pharmaceutical Sciences 100:9, pages 3655-3681.
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Pauline Peltier-Pain, Shannon C. Timmons, Agn?s Grandemange, Etienne Benoit & Jon S. Thorson. (2011) Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer Activity. ChemMedChem 6:8, pages 1347-1350.
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Drew R. Jones, Gunnar Boysen & Grover P. Miller. (2011) Novel multi-mode ultra performance liquid chromatography–tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma. Journal of Chromatography B 879:15-16, pages 1056-1062.
Crossref
Trinity Vera & David E. Stec. (2010) Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 299:4, pages R1044-R1049.
Crossref
Drew R. Jones, So-Young Kim, Michael Guderyon, Chul-Ho Yun, Jeffery H. Moran & Grover P. Miller. (2010) Hydroxywarfarin Metabolites Potently Inhibit CYP2C9 Metabolism of S -Warfarin . Chemical Research in Toxicology 23:5, pages 939-945.
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