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Review Article

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro–in vivo extrapolation of drug clearance and drug-drug interaction potential

, &
Pages 196-208 | Received 30 Jun 2009, Accepted 28 Jul 2009, Published online: 01 Oct 2009

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Tingting Cai, Lihua Yao & Robert J. Turesky. (2016) Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases. Chemical Research in Toxicology 29:5, pages 879-891.
Crossref
Natacha Lenuzza, Xavier Duval, Grégory Nicolas, Etienne Thévenot, Sylvie Job, Orianne Videau, Céline Narjoz, Marie-Anne Loriot, Philippe Beaune, Laurent Becquemont, France Mentré, Christian Funck-Brentano, Loubna Alavoine, Philippe Arnaud, Marcel Delaforge & Henri Bénech. (2014) Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers. European Journal of Drug Metabolism and Pharmacokinetics 41:2, pages 125-138.
Crossref
A. Pattanawongsa, P. C. Nair, A. Rowland & J. O. Miners. (2015) Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition. Drug Metabolism and Disposition 44:3, pages 378-388.
Crossref
Ryo Mitsugi, Kyohei Sumida, Yoshiko Fujie, Robert H. Tukey, Tomoo Itoh & Ryoichi Fujiwara. (2016) Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 39:10, pages 1604-1610.
Crossref
Tony K. L. Kiang & Mary H. H. Ensom. 2016. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents 497 534 .
Nan Zhang, Yong Liu & Hyunyoung Jeong. (2015) Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases. Scientific Reports 5:1.
Crossref
Kushari Burns, Pramod C. Nair, Andrew Rowland, Peter I. Mackenzie, Kathleen M. Knights & John O. Miners. (2015) The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes. Drug Metabolism and Disposition 43:12, pages 1934-1937.
Crossref
Karen Rowland-Yeo & Geoffrey T. Tucker. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 283 308 .
J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 79 130 .
Attarat Pattanawongsa, Nuy Chau, Andrew Rowland & John O. Miners. (2015) Inhibition of Human UDP-Glucuronosyltransferase Enzymes by Canagliflozin and Dapagliflozin: Implications for Drug-Drug Interactions. Drug Metabolism and Disposition 43:10, pages 1468-1476.
Crossref
Aki T. Heikkinen, Floriane Lignet, Paul Cutler & Neil Parrott. (2015) The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development. PROTEOMICS - Clinical Applications 9:7-8, pages 732-744.
Crossref
Mark Johnson, Shayne Gad & Christopher Kemper. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 153 283 .
Jose de Leon. (2015) The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part II: Pharmacological issues and further understanding. Revista de Psiquiatría y Salud Mental (English Edition) 8:3, pages 167-188.
Crossref
Jose de Leon. (2015) Efectos de los inductores antiepilépticos en la neuropsicofarmacología: una cuestión ignorada. Parte II: cuestiones farmacológicas y comprensión adicional. Revista de Psiquiatría y Salud Mental 8:3, pages 167-188.
Crossref
Hua Sun, Zhiguo Ma, Danyi Lu & Baojian Wu. (2015) Regio- and Isoform-Specific Glucuronidation of Psoralidin: Evaluation of 3-O-Glucuronidation as a Functional Marker for UGT1A9. Journal of Pharmaceutical Sciences 104:7, pages 2369-2377.
Crossref
Nan Wang, Feng Wang, Yu Meng, Guo-Hui Yang, Ju-Wu Chen & Jia-Xiang Wang. (2015) Albumin Supplement Affects the Metabolism and Metabolism-Related Drug-Drug Interaction of Fenoprofen Enantiomers. Chirality 27:7, pages 436-440.
Crossref
Li Jiang, Si-Cheng Liang, Chao Wang, Guang-Bo Ge, Xiao-Kui Huo, Xiao-Yi Qi, Sa Deng, Ke-Xin Liu & Xiao-Chi Ma. (2015) Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4. Scientific Reports 5:1.
Crossref
Julieta Gradinaru, Stéphanie Romand, Laurent Geiser, Pierre-Alain Carrupt, Dany Spaggiari & Serge Rudaz. (2015) Inhibition screening method of microsomal UGTs using the cocktail approach. European Journal of Pharmaceutical Sciences 71, pages 35-45.
Crossref
Yoichi Naritomi, Fumihiro Nakamori, Takako Furukawa & Kenji Tabata. (2015) Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation. Drug Metabolism and Pharmacokinetics 30:1, pages 21-29.
Crossref
Xin Liu, Li Sheng, Manman Zhao, Jiaqi Mi, Zhihao Liu & Yan Li. (2015) In?vitro glucuronidation of the primary metabolite of 10-chloromethyl-11-demethyl-12-oxo-calanolide A by human liver microsomes and its interactions with UDP-glucuronosyltransferase substrates. Drug Metabolism and Pharmacokinetics 30:1, pages 89-96.
Crossref
R. Meech, N. Mubarokah, A. Shivasami, A. Rogers, P. C. Nair, D. G. Hu, R. A. McKinnon & P. I. Mackenzie. (2014) A Novel Function for UDP Glycosyltransferase 8: Galactosidation of Bile Acids. Molecular Pharmacology 87:3, pages 442-450.
Crossref
Lei Wang, ChienWei Chiang, Hong Liang, Hengyi Wu, Weixing Feng, Sara K. Quinney, Jin Li & Lang Li. (2015) How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective. BioMed Research International 2015, pages 1-9.
Crossref
Lin-Zhi Chen, John P. Sabo, Elsy Philip, Lois Rowland, Yan Mao, Bachir Latli, Diane Ramsden, Debra A. Mandarino & Rucha S. Sane. (2015) Mass Balance, Metabolite Profile, and In Vitro-In Vivo Comparison of Clearance Pathways of Deleobuvir, a Hepatitis C Virus Polymerase Inhibitor . Antimicrobial Agents and Chemotherapy 59:1, pages 25-37.
Crossref
Andrew Rowland, Peter I. Mackenzie & John O. Miners. (2015) Transporter-Mediated Uptake of UDP–Glucuronic Acid by Human Liver Microsomes: Assay Conditions, Kinetics, and Inhibition. Drug Metabolism and Disposition 43:1, pages 147-153.
Crossref
Michael A. Zientek & Kuresh Youdim. (2015) Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 43:1, pages 163-181.
Crossref
Xiang-Ge Tian, Chao Wang, Guang-Bo Ge, Jing Ning, Chun-Zhi Ai, James Y. Hong, Yong-Xv Cai, Xiao-Kui Huo, Jie Hou, Ke-Xin Liu, Hong-Zhi Sun & Xiao-Chi Ma. (2015) A highly selective probe for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human microsomes: isoform specificity, kinetic characterization, and applications. RSC Advances 5:8, pages 5924-5927.
Crossref
Seung Jun Lee, Jung Bae Park, Doyun Kim, Soo Hyeon Bae, Young-Won Chin, Euichaul Oh & Soo Kyung Bae. (2015) In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug–drug interactions. Toxicology Letters 232:2, pages 458-465.
Crossref
N Marsousi, Y Daali, S Rudaz, L Almond, H Humphries, J Desmeules & C F Samer. (2014) Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic Model. CPT: Pharmacometrics & Systems Pharmacology 3:12, pages 1-8.
Crossref
Kyung-Ah Seo, Hyo-Ji Kim, Eun Sook Jeong, Nagi Abdalla, Chang-Soo Choi, Dong-Hyun Kim & Jae-Gook Shin. (2014) In Vitro Assay of Six UDP-Glucuronosyltransferase Isoforms in Human Liver Microsomes, Using Cocktails of Probe Substrates and Liquid Chromatography–Tandem Mass Spectrometry. Drug Metabolism and Disposition 42:11, pages 1803-1810.
Crossref
Kathleen Knights & Arduino Mangoni. 2014. Nutrition and Performance in Masters Athletes. Nutrition and Performance in Masters Athletes 243 262 .
Soo Hyeon Bae, Min Jo Kwon, Jung Bae Park, Doyun Kim, Dong-Hee Kim, Jae-Seon Kang, Chun-Gyu Kim, Euichaul Oh & Soo Kyung Bae. (2014) Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7- O -Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro . Antimicrobial Agents and Chemotherapy 58:9, pages 5036-5046.
Crossref
Kohei Yamamoto, Marina Mukai, Kenjiro Nagaoka, Keiko Hayashi, Hiroyuki Hichiya, Kenji Okada, Mikio Murata, Masato Shigeyama, Shizuo Narimatsu & Nobumitsu Hanioka. (2014) Functional characterization of cynomolgus monkey UDP-glucuronosyltransferase 1A9. European Journal of Drug Metabolism and Pharmacokinetics 39:3, pages 195-202.
Crossref
Kyra J. Barnes, Andrew Rowland, Thomas M. Polasek & John O. Miners. (2014) Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins. European Journal of Clinical Pharmacology 70:9, pages 1097-1106.
Crossref
Brahim Achour, Amin Rostami-Hodjegan & Jill Barber. (2014) Protein expression of various hepatic uridine 5′-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: a meta-analysis. Biopharmaceutics & Drug Disposition 35:6, pages 353-361.
Crossref
Su-Lin Liu, Shu-Yao Zhang, Miao-Jun Wang, Hong Jiang, Yu-Xian Yang & Lei Chen. (2013) Demethylzeylasteral exhibits dose-dependent inhibitory behaviour towards estradiol glucuronidation. European Journal of Drug Metabolism and Pharmacokinetics 39:2, pages 99-102.
Crossref
Nuy Chau, David J. Elliot, Benjamin C. Lewis, Kushari Burns, Martin R. Johnston, Peter I. Mackenzie & John O. Miners. (2014) Morphine Glucuronidation and Glucosidation Represent Complementary Metabolic Pathways That Are Both Catalyzed by UDP-Glucuronosyltransferase 2B7: Kinetic, Inhibition, and Molecular Modeling Studies. Journal of Pharmacology and Experimental Therapeutics 349:1, pages 126-137.
Crossref
Maciej J. Zamek-Gliszczynski, Xiaoyan Chu, Joseph W. Polli, Mary F. Paine & Aleksandra Galetin. (2014) Understanding the Transport Properties of Metabolites: Case Studies and Considerations for Drug Development. Drug Metabolism and Disposition 42:4, pages 650-664.
Crossref
Diane Ramsden, Donald J. Tweedie, Roger St. George, Lin-Zhi Chen & Yongmei Li. (2014) Generating an In Vitro–In Vivo Correlation for Metabolism and Liver Enrichment of a Hepatitis C Virus Drug, Faldaprevir, Using a Rat Hepatocyte Model (HepatoPac). Drug Metabolism and Disposition 42:3, pages 407-414.
Crossref
Meiyu Wang, Jia Lu, Jiajun Li, Huixin Qi, Yedong Wang & Hongjian Zhang. (2014) Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. Food and Chemical Toxicology 64, pages 135-143.
Crossref
Daniel R. Albaugh & Michael B. Fisher. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 35 .
Rong Shi, Yuanyuan Yang, Jie Zhong, Tianming Wang & Yueming Ma. (2014) Validated assay for the evaluation of multiple glucuronidation activities in human liver microsomes via liquid chromatography-tandem mass spectrometry. RSC Adv. 4:99, pages 56132-56138.
Crossref
J.C. Stingl, H. Bartels, R. Viviani, M.L. Lehmann & J. Brockmöller. (2014) Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review. Pharmacology & Therapeutics 141:1, pages 92-116.
Crossref
Jin Zhou & John O. Miners. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 203 228 .
Michael H. Court. 2014. Optimization in Drug Discovery. Optimization in Drug Discovery 117 136 .
Jana C. Precht, Werner Schroth, Kathrin Klein, Hiltrud Brauch, Evgeny Krynetskiy, Matthias Schwab & Thomas E. Mürdter. (2013) The Letrozole Phase 1 Metabolite Carbinol as a Novel Probe Drug for UGT2B7. Drug Metabolism and Disposition 41:11, pages 1906-1913.
Crossref
Kathleen M. Knights, Andrew Rowland & John O. Miners. (2013) Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 ( CYP ) and UDP ‐glucuronosyltransferase ( UGT ) . British Journal of Clinical Pharmacology 76:4, pages 587-602.
Crossref
Hua-Mao Jiang, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Xiao-Yu Sun, Mo Hong, Ling Yang, Guang-Bo Ge, Yong Liu, Yan-Yan Zhang, Qiang Dong & Ren-Jie Liu. (2013) New insights for the risk of bisphenol A: Inhibition of UDP-glucuronosyltransferases (UGTs). Chemosphere 93:6, pages 1189-1193.
Crossref
Martin Perreault, Louis Gauthier-Landry, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Moshe Finel & Olivier Barbier. (2013) The Human UDP-Glucuronosyltransferase UGT2A1 and UGT2A2 Enzymes Are Highly Active in Bile Acid Glucuronidation. Drug Metabolism and Disposition 41:9, pages 1616-1620.
Crossref
Takashi Izumi, Fujiko Tsuruta, Tomoko Ishizuka, Kouichi Nakamura, Masakatsu Kothuma & Takahashi Makoto. (2013) Stereoselectivity in Pharmacokinetics of Rivoglitazone, A Novel Peroxisome Proliferator-Activated Receptor ? Agonist, in Rats and Monkeys: Model-Based Pharmacokinetic Analysis and In Vitro-In Vivo Extrapolation Approach. Journal of Pharmaceutical Sciences 102:9, pages 3174-3188.
Crossref
Hyo-Ji Kim, Eun Sook Jeong, Kyung-Ah Seo, Kye Jung Shin, Yeon Jae Choi, Su-Jun Lee, Jong Lyul Ghim, Dong-Ryul Sohn, Jae-Gook Shin & Dong-Hyun Kim. (2013) Glucuronidation of a Sarpogrelate Active Metabolite Is Mediated by UDP-Glucuronosyltransferases 1A4, 1A9, and 2B4. Drug Metabolism and Disposition 41:8, pages 1529-1537.
Crossref
Laurent Grosse, Anne-Sophie Campeau, Sarah Caron, Frédéric-Alexandre Morin, Kim Meunier, Jocelyn Trottier, Patrick Caron, Mélanie Verreault & Olivier Barbier. (2013) Enantiomer Selective Glucuronidation of the Non-Steroidal Pure Anti-Androgen Bicalutamide by Human Liver and Kidney: Role of the Human UDP-Glucuronosyltransferase (UGT)1A9 Enzyme. Basic & Clinical Pharmacology & Toxicology 113:2, pages 92-102.
Crossref
Jiangbo Du, Tiangeng You, Xiaoyan Chen & Dafang Zhong. (2013) Stereoselective Glucuronidation of Ornidazole in Humans: Predominant Contribution of UDP-Glucuronosyltransferases 1A9 and 2B7. Drug Metabolism and Disposition 41:7, pages 1306-1318.
Crossref
Verawan Uchaipichat, Chuthamanee Suthisisang & John O. Miners. (2013) The Glucuronidation of R- and S-Lorazepam: Human Liver Microsomal Kinetics, UDP-Glucuronosyltransferase Enzyme Selectivity, and Inhibition by Drugs. Drug Metabolism and Disposition 41:6, pages 1273-1284.
Crossref
Andrew Rowland, John O. Miners & Peter I. Mackenzie. (2013) The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification. The International Journal of Biochemistry & Cell Biology 45:6, pages 1121-1132.
Crossref
Rhiannon N. Hardwick, Daniel W. Ferreira, Vijay R. More, April D. Lake, Zhenqiang Lu, Jose E. Manautou, Angela L. Slitt & Nathan J. Cherrington. (2013) Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition 41:3, pages 554-561.
Crossref
Nenad Manevski, Johanna Troberg, Paolo Svaluto-Moreolo, Klaudyna Dziedzic, Jari Yli-Kauhaluoma & Moshe Finel. (2013) Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects Are Enzyme and Substrate Dependent. PLoS ONE 8:1, pages e54767.
Crossref
Mitsuhiro Nishihara, Yuto Hiura, Naohiro Kawaguchi, Junzo Takahashi & Satoru Asahi. (2013) UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation. Drug Metabolism and Pharmacokinetics 28:6, pages 475-484.
Crossref
Porntipa Korprasertthaworn, Andrew Rowland, Benjamin C. Lewis, Peter I. Mackenzie, Krongtong Yoovathaworn & John O. Miners. (2012) Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity. Biochemical Pharmacology 84:11, pages 1511-1521.
Crossref
Nenad Manevski, Jari Yli-Kauhaluoma & Moshe Finel. (2012) UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin. Drug Metabolism and Disposition 40:11, pages 2192-2203.
Crossref
Alexander V. LyubimovPeter L. Bullock & Olga V. Trubetskoy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Alexander V. LyubimovKarthik Venkatakrishnan. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 62 .
Alexander V. LyubimovMurali Subramanian & Timothy S. Tracy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 24 .
Alexander V. LyubimovMurali Subramanian & Timothy S. Tracy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 27 .
Alexander V. LyubimovRobert S. Foti, Dan A. Rock, Larry C. Wienkers & Jan L. Wahlstrom. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 68 .
Paula S. Montenegro-Miranda, Nina Sneitz, D. Rudi de Waart, Lysbeth ten Bloemendaal, Suzanne Duijst, Robert J. de Knegt, Ulrich Beuers, Moshe Finel & Piter J. Bosma. (2012) Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:8, pages 1223-1229.
Crossref
Baojian Wu, Xiaoqiang Wang, Shuxing Zhang & Ming Hu. (2012) Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches. Pharmaceutical Research 29:6, pages 1544-1561.
Crossref
Alexander V. LyubimovRonald E. Savage. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 38 .
Alexander V. LyubimovMichael A. Sinz. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 31 .
Nitsupa Wattanachai, Wichittra Tassaneeyakul, Andrew Rowland, David J. Elliot, Kushari Bowalgaha, Kathleen M. Knights & John O. Miners. (2012) Effect of Albumin on Human Liver Microsomal and Recombinant CYP1A2 Activities: Impact on In Vitro-In Vivo Extrapolation of Drug Clearance. Drug Metabolism and Disposition 40:5, pages 982-989.
Crossref
Robert L. Walsky, Jonathan N. Bauman, Karine Bourcier, Georgina Giddens, Kimberly Lapham, Andre Negahban, Tim F. Ryder, R. Scott Obach, Ruth Hyland & Theunis C. Goosen. (2012) Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors. Drug Metabolism and Disposition 40:5, pages 1051-1065.
Crossref
Eloise A. Gelston, Janet K. Coller, Olga V. Lopatko, Heather M. James, Helmut Schmidt, Jason M. White & Andrew A. Somogyi. (2012) Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects. British Journal of Clinical Pharmacology 73:5, pages 786-794.
Crossref
Chun Li & Nataraj Kalyanaraman. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 189 212 .
Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel & Ling Yang. (2012) Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms. Drug Metabolism and Disposition 40:3, pages 529-538.
Crossref
Sheila Annie Peters. 2012. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations 183 207 .
Toshifumi Shiraga, Kanako Yajima, Kenta Suzuki, Katsuhiro Suzuki, Tadashi Hashimoto, Takafumi Iwatsubo, Aiji Miyashita & Takashi Usui. (2012) Identification of UDP-Glucuronosyltransferases Responsible for the Glucuronidation of Darexaban, an Oral Factor Xa Inhibitor, in Human Liver and Intestine. Drug Metabolism and Disposition 40:2, pages 276-282.
Crossref
V. A. Gruber, P. M. Rainey, D. E. Moody, G. D. Morse, Q. Ma, S. Prathikanti, P. A. Pade, A. A. H. Alvanzo & E. F. McCance-Katz. (2011) Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-Ritonavir and Fosamprenavir-Ritonavir. Clinical Infectious Diseases 54:3, pages 414-423.
Crossref
Alexander V. LyubimovDeepak K. Dalvie & Cho‐Ming Loi. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Alexander V. LyubimovRobert S. Foti & Michael B. Fisher. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 71 .
Toshifumi Shiraga, Kanako Yajima, Takuya Teragaki, Katsuhiro Suzuki, Tadashi Hashimoto, Takafumi Iwatsubo, Aiji Miyashita & Takashi Usui. (2012) Identification of Enzymes Responsible for the N-Oxidation of Darexaban Glucuronide, the Pharmacologically Active Metabolite of Darexaban, and the Glucuronidation of Darexaban N-Oxides in Human Liver Microsomes. Biological and Pharmaceutical Bulletin 35:3, pages 413-421.
Crossref
Yun-Feng Cao, Rong-Rong He, Jun Cao, Jian-Xing Chen, Ting Huang & Yong Liu. (2012) Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-8.
Crossref
Baojian Wu, Shuxing Zhang & Ming Hu. (2011) Evaluation of 3,3′,4′-Trihydroxyflavone and 3,6,4′-Trihydroxyflavone (4′- O -Glucuronidation) as the in Vitro Functional Markers for Hepatic UGT1A1 . Molecular Pharmaceutics 8:6, pages 2379-2389.
Crossref
Tina Trdan Lušin, Jurij Trontelj & Aleš Mrhar. (2011) Raloxifene Glucuronidation in Human Intestine, Kidney, and Liver Microsomes and in Human Liver Microsomes Genotyped for the UGT1A1 * 28 Polymorphism . Drug Metabolism and Disposition 39:12, pages 2347-2354.
Crossref
Benjamin C. Lewis, Peter I. Mackenzie & John O. Miners. (2011) Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling. Biochemical Pharmacology 82:12, pages 2016-2023.
Crossref
Nenad Manevski, Paolo Svaluto Moreolo, Jari Yli-Kauhaluoma & Moshe Finel. (2011) Bovine Serum Albumin Decreases K m Values of Human UDP-Glucuronosyltransferases 1A9 and 2B7 and Increases V max Values of UGT1A9 . Drug Metabolism and Disposition 39:11, pages 2117-2129.
Crossref
Anne SoikkeliMika KurkelaJouni HirvonenMarjo YliperttulaMoshe Finel. (2011) Fluorescence-Based High-Throughput Screening Assay for Drug Interactions with UGT1A6. ASSAY and Drug Development Technologies 9:5, pages 496-502.
Crossref
Keigo Kosaka, Norifumi Sakai, Yuya Endo, Yuga Fukuhara, Minoru Tsuda-Tsukimoto, Tatsuyuki Ohtsuka, Ichiro Kino, Tomohiko Tanimoto, Naomi Takeba, Masakatsu Takahashi & Toshiyuki Kume. (2011) Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene. Drug Metabolism and Disposition 39:9, pages 1495-1502.
Crossref
James A. McLure, Donald J. Birkett, David J. Elliot, J. Andrew Williams, Andrew Rowland & John O. Miners. (2011) Application of the Fluorescent Probe 1-Anilinonaphthalene-8-Sulfonate to the Measurement of the Nonspecific Binding of Drugs to Human Liver Microsomes. Drug Metabolism and Disposition 39:9, pages 1711-1717.
Crossref
Baojian Wu, Kaustubh Kulkarni, Sumit Basu, Shuxing Zhang & Ming Hu. (2011) First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics. Journal of Pharmaceutical Sciences 100:9, pages 3655-3681.
Crossref
Yuanchao (Derek) Zhang, Lei Zhang, John M. Strong & Shiew‐Mei Huang. 2011. Oral Bioavailability. Oral Bioavailability 413 429 .
Verawan Uchaipichat, Pritsana Raungrut, Nuy Chau, Benjamas Janchawee, Allan M. Evans & John O. Miners. (2011) Effects of Ketamine on Human UDP-Glucuronosyltransferases In Vitro Predict Potential Drug-Drug Interactions Arising from Ketamine Inhibition of Codeine and Morphine Glucuronidation. Drug Metabolism and Disposition 39:8, pages 1324-1328.
Crossref
Baojian Wu, Beibei Xu & Ming Hu. (2011) Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms. Pharmaceutical Research 28:8, pages 1905-1918.
Crossref
Nitsupa Wattanachai, Thomas M. Polasek, Tahlia M. Heath, Verawan Uchaipichat, Wongwiwat Tassaneeyakul, Wichittra Tassaneeyakul & John O. Miners. (2011) In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance. European Journal of Clinical Pharmacology 67:8, pages 815-824.
Crossref
W. Griffith Humphreys. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 229 253 .
John O. Miners, Kushari Bowalgaha, David J. Elliot, Pawel Baranczewski & Kathleen M. Knights. (2011) Characterization of Niflumic Acid as a Selective Inhibitor of Human Liver Microsomal UDP-Glucuronosyltransferase 1A9: Application to the Reaction Phenotyping of Acetaminophen Glucuronidation. Drug Metabolism and Disposition 39:4, pages 644-652.
Crossref
Ronald Maul, Diana Siegl & Sabine E. Kulling. (2011) Glucuronidation of the Red Clover Isoflavone Irilone by Liver Microsomes from Different Species and Human UDP-Glucuronosyltransferases. Drug Metabolism and Disposition 39:4, pages 610-616.
Crossref
Jiping Wang, Allan M Evans, Kathleen M Knights & John O Miners. (2011) Differential disposition of intra-renal generated and preformed glucuronides: studies with 4-methylumbelliferone and 4-methylumbelliferyl glucuronide in the filtering and nonfiltering isolated perfused rat kidney. Journal of Pharmacy and Pharmacology 63:4, pages 507-514.
Crossref
P. I. MacKenzie, A. Rogers, D. J. Elliot, N. Chau, J.-A. Hulin, J. O. Miners & R. Meech. (2010) The Novel UDP Glycosyltransferase 3A2: Cloning, Catalytic Properties, and Tissue Distribution. Molecular Pharmacology 79:3, pages 472-478.
Crossref
Jin Zhou, Timothy S. Tracy & Rory P. Remmel. (2011) Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UDP-Glucuronosyltransferase 1A1 Substrates/Inhibitors. Drug Metabolism and Disposition 39:2, pages 322-329.
Crossref
Won Young Song, Hye Young Ji, Nam-In Baek, Tae-Sook Jeong & Hye Suk Lee. (2010) In Vitro metabolism of Jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes. Archives of Pharmacal Research 33:12, pages 1985-1996.
Crossref
Karthik Venkatakrishnan, Michael D. Pickard & Lisa L. von Moltke. (2010) A Quantitative Framework and Strategies for Management and Evaluation of Metabolic Drug-Drug Interactions in Oncology Drug Development. Clinical Pharmacokinetics 49:11, pages 703-727.
Crossref
Pritsana Raungrut, Verawan Uchaipichat, David J. Elliot, Benjamas Janchawee, Andrew A. Somogyi & John O. Miners. (2010) In Vitro–In Vivo Extrapolation Predicts Drug–Drug Interactions Arising from Inhibition of Codeine Glucuronidation by Dextropropoxyphene, Fluconazole, Ketoconazole, and Methadone in Humans. Journal of Pharmacology and Experimental Therapeutics 334:2, pages 609-618.
Crossref
Kathleen M. Knights, Kushari Bowalgaha & John O. Miners. (2010) Spironolactone and Canrenone Inhibit UGT2B7-Catalyzed Human Liver and Kidney Microsomal Aldosterone 18β-Glucuronidation: A Potential Drug Interaction. Drug Metabolism and Disposition 38:7, pages 1011-1014.
Crossref
Xiaoxin Qi, Allan M. Evans, Jiping Wang, John O. Miners, Richard N. Upton & Robert W. Milne. (2010) Inhibition of Morphine Metabolism by Ketamine. Drug Metabolism and Disposition 38:5, pages 728-731.
Crossref
Hongliang Cai, Nghia Nguyen, Vincent Peterkin, Young-Sun Yang, Kathy Hotz, Deirdre Beaton La Placa, Shujuan Chen, Robert H. Tukey & Jeffrey C. Stevens. (2010) A Humanized UGT1 Mouse Model Expressing the UGT1A1 * 28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation . Drug Metabolism and Disposition 38:5, pages 879-886.
Crossref

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