1,017
Views
53
CrossRef citations to date
0
Altmetric
Review Article

Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

, &
Pages 540-557 | Received 11 May 2011, Accepted 27 Jul 2011, Published online: 26 Sep 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Fan Yang, Jiangkang Xu, Manfei Fu, Jianbo Ji, Liqun Chi & Guangxi Zhai. (2020) Development of stimuli-responsive intelligent polymer micelles for the delivery of doxorubicin. Journal of Drug Targeting 28:10, pages 993-1011.
Read now
Jianfen Shen, Youzhi Zhang, Hui Shen, Hua Pan, Longsheng Xu, Linna Yuan & Zhiying Ding. (2018) The synergistic effect of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside combined with Adriamycin on MCF-7 breast cancer cells. Drug Design, Development and Therapy 12, pages 4083-4094.
Read now
Rui Yang, YanLi An, FengQin Miao, MengFei Li, PeiDang Liu & QiuSha Tang. (2014) Preparation of folic acid-conjugated, doxorubicin-loaded, magnetic bovine serum albumin nanospheres and their antitumor effects in vitro and in vivo. International Journal of Nanomedicine 9, pages 4231-4243.
Read now
V. Hanušová, I. Boušová, A. Pakostová & L. Skálová. (2012) The influence of oracin on reduction and toxicity of doxorubicin in hepatocytes and mammary epithelial cells MCF-10A. Xenobiotica 42:6, pages 571-579.
Read now

Articles from other publishers (48)

Juan Tornín, Borja Gallego, Verónica Rey, Dzohara Murillo, Carmen Huergo, Aida Rodríguez, Cristina Canal & René Rodríguez. (2023) Cold plasma-treated medium preferentially eliminates doxorubicin-resistant osteosarcoma cells. Free Radical Biology and Medicine 209, pages 127-134.
Crossref
Reza Safavi, Hossein Soltanzadeh & Zahra Hojjati Bonab. (2023) Scrophularia amplexicaulis increases anti‐cancer potential of doxorubicin in gastric cancer cells . Environmental Toxicology 38:11, pages 2741-2750.
Crossref
Xinru Kong, Zhijing He, Yu Zhang, Yuelin Fang, Dongzhu Liu, Hang Wu, Jianbo Ji, Yanwei Xi, Lei Ye, Xiaoye Yang & Guangxi Zhai. (2023) Intelligent Self-amplifying Ferroptosis-inducible nanoplatform for enhanced tumor microenvironment reconstruction and combination therapy. Chemical Engineering Journal 468, pages 143729.
Crossref
Shengjun Peng, Yizhou Wang, Zhifang Sun, Laien Zhao, Yanmei Huang, Xiaoxuan Fu, Rongrui Luo, Jianyue Xue, Shubin Yang, Longbing Ling & Zhuhong Zhang. (2023) Nanoparticles loaded with pharmacologically active plant-derived natural products: Biomedical applications and toxicity. Colloids and Surfaces B: Biointerfaces 225, pages 113214.
Crossref
Yan Song, Xi Chen, Rui Huang & Juan Liu. (2023) Dysregulated YAP1/Hippo Pathway Contributes to Doxorubicin (ADM) Resistance in Acute Myeloid Leukemia (AML). Current Pharmaceutical Biotechnology 24:5, pages 676-685.
Crossref
Linh Doan, Loc T. Nguyen & Ngan T. N. Nguyen. (2023) Modifying superparamagnetic iron oxides nanoparticles for doxorubicin delivery carriers: a review. Journal of Nanoparticle Research 25:4.
Crossref
Haohao Guo, Ziyang Wang, Runsheng Ma, Xin Chen, Hongqiang Li, Yifeng Tang, Gongbo Du, Yifei Zhang & Detao Yin. (2023) A novel pharmacological mechanism of anti-cancer drugs that induce pyroptosis. Inflammopharmacology 31:2, pages 745-754.
Crossref
Xuanping Zhao, Chuan Liu, Zichao Wang, Yingyuan Zhao, Xuyang Chen, Haizhen Tao, Hong Chen, Xueqin Wang & Shaofeng Duan. (2023) Synergistic Pro-Apoptotic Effect of a Cyclic RGD Peptide-Conjugated Magnetic Mesoporous Therapeutic Nanosystem on Hepatocellular Carcinoma HepG2 Cells. Pharmaceutics 15:1, pages 276.
Crossref
Peng Lu, Yingchun Jiang & Zongyu Xia. (2022) Long noncoding RNA TUG1 decreases bladder cancer chemo-sensitivity toward doxorubicin through elevating KPNA2 expression and activating the PI3K/AKT pathway via adsorbing miR-582-5p. Anti-Cancer Drugs 34:1, pages 144-154.
Crossref
Fatemeh Mohajer, Ghodsi Mohammadi Ziarani, Alireza Badiei, Siavash Iravani & Rajender S. Varma. (2022) Advanced MXene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy. Micromachines 13:10, pages 1773.
Crossref
Sijongesonke Peter, Sibusiso Alven, Rejoice Bethusile Maseko & Blessing Atim Aderibigbe. (2022) Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents: A Review. Molecules 27:14, pages 4478.
Crossref
Cheng Wu, Jiayi Luo, Yuanxin Liu, Jiannan Fan, Xianwen Shang, Riguang Liu, Chuan Ye, Jihong Yang & Hong Cao. (2021) Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production. European Journal of Pharmaceutical Sciences 167, pages 106013.
Crossref
Bharat Pateliya, Vinod Burade & Sunita Goswami. (2021) Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study. Naunyn-Schmiedeberg's Archives of Pharmacology 394:9, pages 1949-1961.
Crossref
Kuldeep Kumar Bansal, Ezgi Özliseli, Ari Rosling & Jessica Marianne Rosenholm. (2021) Synthesis and Evaluation of Novel Functional Polymers Derived from Renewable Jasmine Lactone for Stimuli‐Responsive Drug Delivery. Advanced Functional Materials 31:33, pages 2101998.
Crossref
Wei-Hao Liao, Ming-Yen Hsiao, Yi Kung, Abel Po-Hao Huang & Wen-Shiang Chen. (2021) Investigation of the Therapeutic Effect of Doxorubicin Combined With Focused Shockwave on Glioblastoma. Frontiers in Oncology 11.
Crossref
Afnan H. El-Gowily, Samah A. Loutfy, Ehab M. M. Ali, Tarek M. Mohamed & Mohammed A. Mansour. (2021) Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. Pharmaceuticals 14:3, pages 254.
Crossref
Lin-Song Li, Bin Ren, Xiaojing Yang, Zhong-Chao Cai, Xue-Jie Zhao & Mei-Xia Zhao. (2021) Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity. Pharmaceuticals 14:2, pages 101.
Crossref
Bharat Pateliya, Vinod Burade & Sunita Goswami. (2021) Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo. European Journal of Pharmacology 891, pages 173725.
Crossref
Amir Sadra Zangouei, Hamid Reza Rahimi, Majid Mojarrad & Meysam Moghbeli. (2020) Non coding RNAs as the critical factors in chemo resistance of bladder tumor cells. Diagnostic Pathology 15:1.
Crossref
Maristela B. Martins‐Teixeira & Ivone Carvalho. (2020) Antitumour Anthracyclines: Progress and Perspectives. ChemMedChem 15:11, pages 933-948.
Crossref
Wei Guo, Yuanyuan Song, Wantong Song, Yingmin Liu, Zhihe Liu, Dawei Zhang, Zhaohui Tang & Ou Bai. (2020) Co-delivery of Doxorubicin and Curcumin with Polypeptide Nanocarrier for Synergistic Lymphoma Therapy. Scientific Reports 10:1.
Crossref
Antonella Di Sotto, Silvia Di Giacomo, Elisabetta Rubini, Alberto Macone, Marco Gulli, Caterina Loredana Mammola, Margherita Eufemi, Romina Mancinelli & Gabriela Mazzanti. (2020) Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. Cells 9:4, pages 858.
Crossref
Di Sotto, Irannejad, Eufemi, Mancinelli, Abete, Mammola, Altieri, Mazzanti & Di Giacomo. (2020) Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study. International Journal of Molecular Sciences 21:2, pages 633.
Crossref
Bibifatemeh Mahdavi, Parvaneh Shokrani, Seyed Hossein Hejazi, Ardeshir Talebi & Azade Taheri. (2019) Doxorubicin-loaded PVP coated Gd2O3 NPs for effective chemoradiotherapy in melanoma. Journal of Drug Delivery Science and Technology 53, pages 101189.
Crossref
Andrew C. D'Lugos, Christopher S. Fry, Jordan C. Ormsby, Kaylin R. Sweeney, Camille R. Brightwell, Taben M. Hale, Rayna J. Gonzales, Siddhartha S. Angadi, Chad C. Carroll & Jared M. Dickinson. (2019) Chronic doxorubicin administration impacts satellite cell and capillary abundance in a muscle‐specific manner. Physiological Reports 7:7, pages e14052.
Crossref
Yuzhu Hu, Cong Wu, Changhui Zhu, Qingyu Fu, Jiajun Guo, Lihong Deng, Yihong He, Daoke Yang, Yongzhong Cheng & Xiang Gao. (2018) Enhanced uptake and improved anti-tumor efficacy of doxorubicin loaded fibrin gel with liposomal apatinib in colorectal cancer. International Journal of Pharmaceutics 552:1-2, pages 319-327.
Crossref
Yuanfang Huang, Ping Xie, Sheng-Tao Yang, Xuemei Zhang, Guangfu Zeng, Qian Xin & Xiao-Hai Tang. (2018) Carbon nanoparticles suspension injection for the delivery of doxorubicin: Comparable efficacy and reduced toxicity. Materials Science and Engineering: C 92, pages 416-423.
Crossref
Shizheng Li, Song Yuan, Qian Zhao, Bo Wang, Xiuyan Wang & Kun Li. (2018) Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. Biomedicine & Pharmacotherapy 100, pages 441-447.
Crossref
Martijn Kerkhofs, Mart Bittremieux, Giampaolo Morciano, Carlotta Giorgi, Paolo Pinton, Jan B. Parys & Geert Bultynck. (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death & Disease 9:3.
Crossref
Jiahui Hou, Xiwei Yu, Yaping Shen, Yijie Shi, Chang Su & Liang Zhao. (2017) Triphenyl Phosphine-Functionalized Chitosan Nanoparticles Enhanced Antitumor Efficiency Through Targeted Delivery of Doxorubicin to Mitochondria. Nanoscale Research Letters 12:1.
Crossref
Veronika Hanušová, Kateřina Caltová, Hana Svobodová, Martin Ambrož, Adam Skarka, Natálie Murínová, Věra Králová, Pavel Tomšík & Lenka Skálová. (2017) The effects of β-caryophyllene oxide and trans-nerolidol on the efficacy of doxorubicin in breast cancer cells and breast tumor-bearing mice. Biomedicine & Pharmacotherapy 95, pages 828-836.
Crossref
Dalong Xie, Hui Zhang, Xuanhao Hu & Chao Shang. (2017) Knockdown of long non-coding RNA Taurine Up-Regulated 1 inhibited doxorubicin resistance of bladder urothelial carcinoma via Wnt/β-catenin pathway. Oncotarget 8:51, pages 88689-88696.
Crossref
Jun Xie, Jia-Hui Liu, Heng Liu, Xiao-Zhong Liao, Yuling Chen, Mei-Gui Lin, Yue-Yu Gu, Tao-Li Liu, Dong-Mei Wang, Hui Ge & Sui-Lin Mo. (2016) Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way. BMC Cancer 16:1.
Crossref
Roya Biabanikhankahdani, Noorjahan Banu Mohamed Alitheen, Kok Lian Ho & Wen Siang Tan. (2016) pH-responsive Virus-like Nanoparticles with Enhanced Tumour-targeting Ligands for Cancer Drug Delivery. Scientific Reports 6:1.
Crossref
Jie Wang, Hua Wu, Chao Zhou & Hao Wang. (2016) Sulfated polysaccharide‑protein complex sensitizes doxorubicin‑induced apoptosis of breast cancer cells in?vitro and in?vivo. Experimental and Therapeutic Medicine.
Crossref
Jun Xie, Jiahui Liu, Heng Liu, Shihui Liang, Meigui Lin, Yueyu Gu, Taoli Liu, Dongmei Wang, Hui Ge & Sui-lin Mo. (2015) The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharmaceutica Sinica B 5:6, pages 554-563.
Crossref
David E. Durrant, Anindita Das, Samya Dyer, Seyedmehrad Tavallai, Paul Dent & Rakesh C. Kukreja. (2015) Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity. Molecular Pharmacology 88:3, pages 512-523.
Crossref
Martin Ambrož, Iva Boušová, Adam Skarka, Veronika Hanušová, Věra Králová, Petra Matoušková, Barbora Szotáková & Lenka Skálová. (2015) The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells. Molecules 20:8, pages 15343-15358.
Crossref
Juliette Gautier, Emilie Munnier, Martin Souc?Igor Chourpa & Laurence Douziech Eyrolles. (2015) Analysis of doxorubicin distribution in MCF-7 cells treated with drug-loaded nanoparticles by combination of two fluorescence-based techniques, confocal spectral imaging and capillary electrophoresis. Analytical and Bioanalytical Chemistry 407:12, pages 3425-3435.
Crossref
Ummugul Uyeturk, Ugur Uyeturk, Tulin Firat, Ayhan Cetinkaya, Buket Kin Tekce & Serkan Cakir. (2014) Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage. Chemotherapy 60:1, pages 7-12.
Crossref
Helei Hou, Hefen Sun, Ping Lu, Chao Ge, Lixing Zhang, Hong Li, Fangyu Zhao, Hua Tian, Lin Zhang, Taoyang Chen, Ming Yao & Jinjun Li. (2013) Tunicamycin Potentiates Cisplatin Anticancer Efficacy through the DPAGT1/Akt/ABCG2 Pathway in Mouse Xenograft Models of Human Hepatocellular Carcinoma. Molecular Cancer Therapeutics 12:12, pages 2874-2884.
Crossref
Rania Soudy, Christopher Chen & Kamaljit Kaur. (2013) Novel Peptide–Doxorubucin Conjugates for Targeting Breast Cancer Cells Including the Multidrug Resistant Cells. Journal of Medicinal Chemistry 56:19, pages 7564-7573.
Crossref
Seung-Young Lee, Jacqueline Y. Tyler, Sungwon Kim, Kinam Park & Ji-Xin Cheng. (2013) FRET Imaging Reveals Different Cellular Entry Routes of Self-Assembled and Disulfide Bonded Polymeric Micelles. Molecular Pharmaceutics 10:9, pages 3497-3506.
Crossref
Juan-Juan Yin, Sonali Sharma, Stepan P. Shumyak, Zhi-Xin Wang, Zhi-Wei Zhou, Yangde Zhang, Peixuan Guo, Chen-Zhong Li, Jagat R. Kanwar, Tianxin Yang, Shyam S. Mohapatra, Wanqing Liu, Wei Duan, Jian-Cheng Wang, Qi Li, Xueji Zhang, Jun Tan, Lee Jia, Jun Liang, Ming Q. Wei, Xiaotian Li & Shu-Feng Zhou. (2013) Synthesis and Biological Evaluation of Novel Folic Acid Receptor-Targeted, β-Cyclodextrin-Based Drug Complexes for Cancer Treatment. PLoS ONE 8:5, pages e62289.
Crossref
Changli Du, Dawei Deng, Lingling Shan, Shunan Wan, Jie Cao, Junmei Tian, Samuel Achilefu & Yueqing Gu. (2013) A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery. Biomaterials 34:12, pages 3087-3097.
Crossref
Veronika Hanušová, Pavel Tomšík, Lenka Kriesfalusyová, Alena Pakostová, Iva Boušová & Lenka Skálová. (2013) In vivo effect of oracin on doxorubicin reduction, biodistribution and efficacy in Ehrlich tumor bearing mice. Pharmacological Reports 65:2, pages 445-452.
Crossref
Zoey Tay, Ru Jun Eng, Kenichi Sajiki, Kim Kiat Lim, Ming Yi Tang, Mitsuhiro Yanagida & Ee Sin Chen. (2013) Cellular Robustness Conferred by Genetic Crosstalk Underlies Resistance against Chemotherapeutic Drug Doxorubicin in Fission Yeast. PLoS ONE 8:1, pages e55041.
Crossref
Thadée Grocholski, Terhi Oja, Laurence Humphrey, Pekka Mäntsälä, Jarmo Niemi & Mikko Metsä-Ketelä. (2012) Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis. Journal of Bacteriology 194:11, pages 2829-2836.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.