Advanced search
Publication Cover
Drug Metabolism Reviews Volume 43, 2011 - Issue 4
Submit an article Journal homepage
304
Views
27
CrossRef citations to date
0
Altmetric
Review Article

Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order

Yasushi YamazoeDivision of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, JapanCorrespondence[email protected]
,
Kazumi ItoDivision of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
&
Kouichi YoshinariDivision of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Pages 409-439 | Received 01 Dec 2010, Accepted 12 Sep 2011, Published online: 21 Oct 2011

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Jingxuan Chen, Sibo Jiang, Jin Wang, Jwala Renukuntla, Suman Sirimulla & Jianjun Chen. (2019) A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism. Drug Metabolism Reviews 51:2, pages 178-195.
Read now

Articles from other publishers (26)

Yasushi Yamazoe & Kouichi Yoshinari. (2024) Construction of a fused grid-based CYP2C18-Template system and its application to drug metabolism. Drug Metabolism and Pharmacokinetics 54, pages 100534.
Crossref
Yasushi Yamazoe, Norie Murayama, Tomoko Kawamura & Takashi Yamada. (2023) Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms. Genes and Environment 45:1.
Crossref
Cristian Sandoval, Yolanda Calle, Karina Godoy & Jorge Farías. (2023) An Updated Overview of the Role of CYP450 during Xenobiotic Metabolization in Regulating the Acute Myeloid Leukemia Microenvironment. International Journal of Molecular Sciences 24:7, pages 6031.
Crossref
Yoshiya Yamamura, Kouichi Yoshinari & Yasushi Yamazoe. (2023) Construction of a fused grid-based CYP2C19-Template system and the application. Drug Metabolism and Pharmacokinetics 48, pages 100481.
Crossref
Yasushi Yamazoe, Yoshiya Yamamura & Kouichi Yoshinari. (2023) Construction of a fused grid-based CYP2C8-Template system and the application. Drug Metabolism and Pharmacokinetics, pages 100492.
Crossref
Yasushi Yamazoe, Yoshiya Yamamura & Kouichi Yoshinari. (2022) Construction of a fused grid-based template system of CYP2C9 and its application. Drug Metabolism and Pharmacokinetics 45, pages 100451.
Crossref
Yasushi Yamazoe, Norie Murayama & Kouichi Yoshinari. (2021) Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions. Drug Metabolism and Pharmacokinetics 41, pages 100413.
Crossref
Yasushi Yamazoe & Masahiro Tohkin. (2021) Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template. Drug Metabolism and Pharmacokinetics 38, pages 100357.
Crossref
Yasushi Yamazoe, Takashi Yamada, Akihiko Hirose & Norie Murayama. (2021) Deciphering Key Interactions of Ligands with CYP3A4-Template* system. Food Safety 9:1, pages 10-21.
Crossref
Takahiro Goto, Yasushi Yamazoe & Masahiro Tohkin. (2020) Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study. Drug Metabolism and Pharmacokinetics 35:6, pages 485-496.
Crossref
Yasushi Yamazoe, Takahiro Goto & Masahiro Tohkin. (2020) Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study. Drug Metabolism and Pharmacokinetics 35:3, pages 253-265.
Crossref
Yasushi Yamazoe & Kouichi Yoshinari. (2020) Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system. Drug Metabolism and Pharmacokinetics 35:1, pages 165-185.
Crossref
Yasushi Yamazoe, Takashi Yamada & Kiyoshi Nagata. (2020) Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system. Food Safety 8:2, pages 34-51.
Crossref
Takahiro Goto, Masahiro Tohkin & Yasushi Yamazoe. (2019) Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system. Drug Metabolism and Pharmacokinetics 34:6, pages 351-364.
Crossref
Yasushi Yamazoe & Kouichi Yoshinari. (2019) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions part 3: Difference in substrate specificity of human and rodent CYP1A2 and the refinement of predicting system. Drug Metabolism and Pharmacokinetics 34:4, pages 217-232.
Crossref
Yasushi Yamazoe, Takahiro Goto & Masahiro Tohkin. (2019) Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition. Drug Metabolism and Pharmacokinetics 34:2, pages 113-125.
Crossref
Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
Crossref
Matthew L. Danielson, Bingjie Hu, Jie Shen & Prashant V. Desai. 2017. Translating Molecules into Medicines. Translating Molecules into Medicines 81 117 .
Yasushi Yamazoe, Kazumi Ito, Yoshiya Yamamura, Ryutaro Iwama & Kouichi Yoshinari. (2016) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals. Drug Metabolism and Pharmacokinetics 31:5, pages 363-384.
Crossref
Hannu Raunio, Mira Kuusisto, Risto O. Juvonen & Olli T. Pentikäinen. (2015) Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes. Frontiers in Pharmacology 6.
Crossref
Yasushi Yamazoe, Takashi Yamada & Kunitoshi Mitsumori. (2015) Embryo- and Testicular-toxicities of Methoxyacetate and the Related: a Review on Possible Roles of One-carbon Transfer and Histone Modification. Food Safety 3:3, pages 92-107.
Crossref
F. Peter Guengerich. 2015. Cytochrome P450. Cytochrome P450 523 785 .
Takashi Yamada, Yushiro Tanaka, Ryuichi Hasegawa, Yuki Sakuratani, Yasushi Yamazoe, Atsushi Ono, Akihiko Hirose & Makoto Hayashi. (2014) Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether. Regulatory Toxicology and Pharmacology 70:3, pages 711-719.
Crossref
Laura E. Martikainen, Minna Rahnasto-Rilla, Silvie Neshybova, Maija Lahtela-Kakkonen, Hannu Raunio & Risto O. Juvonen. (2012) Interactions of inhibitor molecules with the human CYP2E1 enzyme active site. European Journal of Pharmaceutical Sciences 47:5, pages 996-1005.
Crossref
Kimihiko Sato & Yasushi Yamazoe. (2012) Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism. Drug Metabolism and Disposition 40:3, pages 486-496.
Crossref
Ernest Hodgson. 2012. Toxicology and Human Environments. Toxicology and Human Environments 349 372 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.