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Drug Metabolism Reviews Volume 44, 2012 - Issue 1
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Review Article

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling

Dong DongDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USA
&
Baojian WuDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USACorrespondence[email protected]
Pages 1-17 | Received 14 Nov 2011, Accepted 14 Nov 2011, Published online: 30 Jan 2012

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Vijayalakshmi Ravindranath & Henry W Strobel. (2013) Cytochrome P450-mediated metabolism in brain: functional roles and their implications. Expert Opinion on Drug Metabolism & Toxicology 9:5, pages 551-558.
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Dong Dong, Roland Ako, Ming Hu & Baojian Wu. (2012) Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes. Xenobiotica 42:8, pages 808-820.
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Articles from other publishers (7)

Xiuxuan Zhang, Yan Zhou, Xiaofei Gu, Yu Cheng, Manxin Hong, Liqiang Yan, Fulong Ma & Zhengjian Qi. (2018) Synthesis of a selective ratiometric fluorescent probe based on Naphthalimide and its application in human cytochrome P450 1A. Talanta 186, pages 413-420.
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Siddharth S. Kesharwani, Prajwal P. Nandekar, Preeti Pragyan, Vijay Rathod & Abhay T. Sangamwar. (2016) Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular dynamics simulations. Journal of Molecular Recognition 29:8, pages 370-390.
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Claudio A. Erratico, Anand K. Deo & Stelvio M. Bandiera. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 131 149 .
Siddharth S. Kesharwani, Prajwal P. Nandekar, Preeti Pragyan & Abhay T. Sangamwar. (2014) Comparative Proteomics Among Cytochrome P450 Family 1 for Differential Substrate Specificity. The Protein Journal 33:6, pages 536-548.
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Bernard Testa. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction 1 26 .
H van de Waterbeemd & B Testa. 2013. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Brooke M. VandenBrink, John A. Davis, Josh T. Pearson, Robert S. Foti, Larry C. Wienkers & Dan A. Rock. (2012) Cytochrome P450 Architecture and Cysteine Nucleophile Placement Impact Raloxifene-Mediated Mechanism-Based Inactivation. Molecular Pharmacology 82:5, pages 835-842.
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