Advanced search
Publication Cover
Drug Metabolism Reviews Volume 45, 2013 - Issue 1: Thematic Issue: Nuclear Receptor
Submit an article Journal homepage
404
Views
17
CrossRef citations to date
0
Altmetric
Review Article

Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor

Mengxi JiangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences
&
Wen XieCorrespondence[email protected]
Pages 156-163 | Received 19 Sep 2012, Accepted 22 Oct 2012, Published online: 21 Jan 2013

Citations (17)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Jenni Küblbeck, Vanessa Zancanella, Viktoria Prantner, Ferdinand Molnár, E. James Squires, Mauro Dacasto, Paavo Honkakoski & Mery Giantin. (2016) Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons. Xenobiotica 46:3, pages 200-210.
Read now

Articles from other publishers (16)

Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek & Radim Nencka. (2023) Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure . Journal of Medicinal Chemistry 66:4, pages 2422-2456.
Crossref
Sarah Da Won Bae, Romario Nguyen, Liang Qiao & Jacob George. (2021) Role of the constitutive androstane receptor (CAR) in human liver cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:2, pages 188516.
Crossref
Yuhua Li, Qiang Meng, Mengbi Yang, Dongyang Liu, Xiangyu Hou, Lan Tang, Xin Wang, Yuanfeng Lyu, Xiaoyan Chen, Kexin Liu, Ai-Ming Yu, Zhong Zuo & Huichang Bi. (2019) Current trends in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B 9:6, pages 1113-1144.
Crossref
Oliver Keminer, Björn Windshügel, Frank Essmann, Serene M. L. Lee, Tobias S. Schiergens, Matthias Schwab & Oliver Burk. (2019) Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Archives of Toxicology.
Crossref
Pengfei Xu, Yonggong Zhai & Jing Wang. (2018) The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis. International Journal of Molecular Sciences 19:4, pages 1260.
Crossref
Viktoria Prantner, Yuval Cinnamon, Jenni Küblbeck, Ferdinand Molnár & Paavo Honkakoski. (2018) Functional Characterization of a Novel Variant of the Constitutive Androstane Receptor (CAR, NR1I3). Nuclear Receptor Research 5.
Crossref
X. Ding, L. Li, L.S. Van Winkle & Q.-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 171 193 .
X. Ding & Q-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 8 44 .
Garima Verma, Mohemmed Faraz Khan, Mohammad Shaquiquzzaman, Wasim Akhtar, Mymoona Akhter, Syed Misbahul Hasan & Mohammad Mumtaz Alam. (2017) Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach . Journal of Molecular Recognition 30:12, pages e2651.
Crossref
Lushan Yu, Zhangting Wang, Minmin Huang, Yingying Li, Kui Zeng, Jinxiu Lei, Haihong Hu, Baian Chen, Jing Lu, Wen Xie & Su Zeng. (2016) Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1100-1111.
Crossref
T. Yasujima, K. Saito, R. Moore & M. Negishi. (2016) Phenobarbital and Insulin Reciprocate Activation of the Nuclear Receptor Constitutive Androstane Receptor through the Insulin Receptor. Journal of Pharmacology and Experimental Therapeutics 357:2, pages 367-374.
Crossref
Keiyu Oshida, David J. Waxman & J. Christopher Corton. (2016) Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome. PLOS ONE 11:3, pages e0150284.
Crossref
Devinder Sharma, Aik Jiang Lau, Matthew A Sherman & Thomas K H Chang. (2015) Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine. British Journal of Pharmacology 172:5, pages 1263-1276.
Crossref
Alejandro Carazo Fernández, Tomas Smutny, Lucie Hyrsová, Karel Berka & Petr Pavek. (2015) Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Toxicology Letters 233:2, pages 68-77.
Crossref
Keiyu Oshida, Naresh Vasani, Carlton Jones, Tanya Moore, Susan Hester, Stephen Nesnow, Scott Auerbach, David R. Geter, Lauren M. Aleksunes, Russell S. Thomas, Dawn Applegate, Curtis D. Klaassen & J. Christopher Corton. (2015) Identification of Chemical Modulators of the Constitutive Activated Receptor (CAR) in a Gene Expression Compendium. Nuclear Receptor Signaling 13:1, pages nrs.13002.
Crossref
Chunyan Yang, Qianrong Li & Yong Li. (2014) Targeting Nuclear Receptors with Marine Natural Products. Marine Drugs 12:2, pages 601-635.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.