Citations (73)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Jie Zhang, Petr Pavek, Rajamanikkam Kamaraj, Li Ren & Tiehua Zhang. (2023) Dietary phytochemicals as modulators of human pregnane X receptor. Critical Reviews in Food Science and Nutrition 63:19, pages 3279-3301.
Read now
Read now
Skyler H. Hoang, Kevin M. Tveter, Esther Mezhibovsky & Diana E. Roopchand. (2023) Proanthocyanidin B2 derived metabolites may be ligands for bile acid receptors S1PR2, PXR and CAR: an in silico approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
Read now
Read now
Megha Rachmale, Niraj Rajput, Tarang Jadav, Amit Kumar Sahu, Rakesh K. Tekade & Pinaki Sengupta. (2022) Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer drug discovery. Drug Metabolism Reviews 54:2, pages 101-119.
Read now
Read now
Yue-Ming Wang, Sergio C Chai, Christopher T Brewer & Taosheng Chen. (2014) Pregnane X receptor and drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 10:11, pages 1521-1532.
Read now
Read now
Anatoly A. Soshilov & Michael S. Denison. (2014) Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis. Molecular and Cellular Biology 34:9, pages 1707-1719.
Read now
Read now
Articles from other publishers (68)
Lucia Sládeková, Eliška Zgarbová, Radim Vrzal, David Vanda, Miroslav Soural, Klára Jakubcová, Gerardo Vázquez-Gómez, Jan Vondráček & Zdeněk Dvořák. (2023) Switching on/off aryl hydrocarbon receptor and pregnane X receptor activities by chemically modified tryptamines. Toxicology Letters 387, pages 63-75.
Crossref
Crossref
Yingjian Chen, Tianqi Cui, Shaorong Xiao, Tianyao Li, Yadi Zhong, Kaijia Tang, Jingyi Guo, Shangyi Huang, Jiabing Chen, Jiayu Li, Qi Wang, Jiawen Huang, Huafeng Pan & Yong Gao. (2023) Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling. iScience 26:4, pages 106318.
Crossref
Crossref
Shyaron Poudel, Andrew D. Huber & Taosheng Chen. (2023) Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond. Drug Metabolism and Disposition 51:2, pages 228-236.
Crossref
Crossref
Kaiyang Liu, Xi Chen, Yue Ren, Chaoqun Liu, Tianyi Lv, Ya'nan Liu & Yanling Zhang. (2022) Multi-target-based polypharmacology prediction (mTPP): An approach using virtual screening and machine learning for multi-target drug discovery. Chemico-Biological Interactions 368, pages 110239.
Crossref
Crossref
Jianhong Wang, Junyan Fu, Wanbing Sun, Xuyang Yin, Kun Lv & Jun Zhang. (2022) Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy. Epilepsy Research 186, pages 107000.
Crossref
Crossref
Kodye L. Abbott, Julia M. Salamat, Patrick C. Flannery, Chloe S. Chaudhury, Aneesh Chandran, Saraswathi Vishveshwara, Sridhar Mani, Jianfeng Huang, Amit K. Tiwari & Satyanarayana R. Pondugula. (2022) Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes. ACS Omega 7:38, pages 34034-34044.
Crossref
Crossref
Pengfei Zhao, Shicheng Fan, Yue Gao, Min Huang & Huichang Bi. (2022) Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update. Drug Metabolism and Disposition 50:5, pages 636-645.
Crossref
Crossref
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng & Taosheng Chen. (2022) Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. Nucleic Acids Research 50:6, pages 3254-3275.
Crossref
Crossref
Moumita Dutta, Joe Jongpyo Lim & Julia Yue Cui. (2022) Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. Drug Metabolism and Disposition 50:4, pages 478-491.
Crossref
Crossref
Ge Zhao, Yue Tong, Fei Luan, Wenjing Zhu, Chenglin Zhan, Tiantian Qin, Weixiao An & Nan Zeng. (2022) Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Frontiers in Pharmacology 13.
Crossref
Crossref
Yujiao Lai, Hori Masatoshi, Yanbo Ma, Yuming Guo & Bingkun Zhang. (2022) Role of Vitamin K in Intestinal Health. Frontiers in Immunology 12.
Crossref
Crossref
Surabhi Talele, Afroz S. Mohammad, Julia A. Schulz, Bjoern Bauer, Anika M. S. Hartz, Jann N. Sarkaria & William F. Elmquist. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain
723
762
.
Aikaterini Skandalaki, Panagiotis Sarantis & Stamatios Theocharis. (2021) Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment. Biomolecules 11:8, pages 1142.
Crossref
Crossref
Adrian Hall, Hugues Chanteux, Karelle MénochetMarie Ledecq & Monika-Sarah E. D. Schulze. (2021) Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches. Journal of Medicinal Chemistry 64:10, pages 6413-6522.
Crossref
Crossref
Yongtao Li, Wenwei Lin, William C. Wright, Sergio C. Chai, Jing Wu & Taosheng Chen. (2021) Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. Journal of Medicinal Chemistry 64:3, pages 1733-1761.
Crossref
Crossref
Andrew D. Huber, William C. Wright, Wenwei Lin, Kinjal Majumder, Jonathan A. Low, Jing Wu, Cameron D. Buchman, David J. Pintel & Taosheng Chen. (2020) Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning. Cellular and Molecular Life Sciences 78:1, pages 317-335.
Crossref
Crossref
Sergio C. Chai & Taosheng Chen. 2021. Nuclear Receptors. Nuclear Receptors
179
198
.
Thanh T. Lai, Yiğitcan Eken & Angela K. Wilson. (2020) Binding of Per- and Polyfluoroalkyl Substances to the Human Pregnane X Receptor. Environmental Science & Technology 54:24, pages 15986-15995.
Crossref
Crossref
Yuanjun Shen, Zhanquan Shi, Jun Ting Fan & Bingfang Yan. (2020) Dechlorination and demethylation of ochratoxin A enhance blocking activity of PXR activation, suppress PXR expression and reduce cytotoxicity. Toxicology Letters 332, pages 171-180.
Crossref
Crossref
Miguel Ortiz-Flores, Andrés Portilla-Martínez, Francisco Cabrera-Pérez, Nayelli Nájera, Eduardo Meaney, Francisco Villarreal, Javier Pérez-Durán & Guillermo Ceballos. (2020) PXR is a target of (-)-epicatechin in skeletal muscle. Heliyon 6:10, pages e05357.
Crossref
Crossref
Sergio C. Chai, William C. Wright & Taosheng Chen. (2019) Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer. Medicinal Research Reviews 40:3, pages 1061-1083.
Crossref
Crossref
Zhilun Yu, Bei Yue, Lili Ding, Xiaoping Luo, Yijing Ren, Jingjing Zhang, Sridhar Mani, Zhengtao Wang & Wei Dou. (2020) Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease. Frontiers in Pharmacology 11.
Crossref
Crossref
Desirée Bartolini, Francesca De Franco, Pierangelo Torquato, Rita Marinelli, Bruno Cerra, Riccardo Ronchetti, Arne Schon, Francesca Fallarino, Antonella De Luca, Guido Bellezza, Ivana Ferri, Angelo Sidoni, William G. Walton, Samuel J. Pellock, Matthew R. Redinbo, Sridhar Mani, Roberto Pellicciari, Antimo Gioiello & Francesco Galli. (2020) Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. Journal of Medicinal Chemistry 63:7, pages 3701-3712.
Crossref
Crossref
Michael D. Coleman. 2020. Human Drug Metabolism. Human Drug Metabolism
183
261
.
Michael D. Coleman. 2020. Human Drug Metabolism. Human Drug Metabolism
109
181
.
Guohui Zhang, Meijing Liu, Meng Song, Jueyu Wang, Jiazhong Cai, Chuanquan Lin, Yanwu Li, Xin Jin, Chuangpeng Shen, Zhao Chen, Dake Cai, Yong Gao, Chenchen Zhu, Chaozhan Lin & Changhui Liu. (2020) Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory. Journal of Ethnopharmacology 248, pages 112302.
Crossref
Crossref
Yijing Ren, Bei Yue, Gaiyan Ren, Zhilun Yu, Xiaoping Luo, Aning Sun, Jingjing Zhang, Mengqing Han, Zhengtao Wang & Wei Dou. (2019) Activation of PXR by alantolactone ameliorates DSS-induced experimental colitis via suppressing NF-κB signaling pathway. Scientific Reports 9:1.
Crossref
Crossref
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Shoko Hattori, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta & Shigeyuki Kitamura. (2019) Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation. Food and Chemical Toxicology 133, pages 110792.
Crossref
Crossref
Alejandro Carazo, Přemysl Mladěnka & Petr Pávek. (2019) Marine Ligands of the Pregnane X Receptor (PXR): An Overview. Marine Drugs 17:10, pages 554.
Crossref
Crossref
Jeff L. Staudinger. (2019) Clinical applications of small molecule inhibitors of Pregnane X receptor. Molecular and Cellular Endocrinology 485, pages 61-71.
Crossref
Crossref
Kodye L. Abbott, Chloe S. Chaudhury, Aneesh Chandran, Saraswathi Vishveshwara, Zdenek Dvorak, Eva Jiskrova, Karolina Poulikova, Barbora Vyhlidalova, Sridhar Mani & Satyanarayana R. Pondugula. (2019) Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin-Induced CYP3A4 and MDR1 Gene Expression. Molecular Pharmacology 95:3, pages 324-334.
Crossref
Crossref
Roger Lille-Langøy, Odd André Karlsen, Line Merethe Myklebust, Jared V Goldstone, Astrid Mork-Jansson, Rune Male, Bruce Blumberg, John J Stegeman & Anders Goksøyr. (2019)
Sequence Variations in
pxr (nr1i2)
From Zebrafish (
Danio rerio
) Strains Affect Nuclear Receptor Function
. Toxicological Sciences 168:1, pages 28-39.
Crossref
Crossref
Manon Garcia, Laura Thirouard, Lauriane Sedès, Mélusine Monrose, Hélène Holota, Françoise Caira, David Volle & Claude Beaudoin. (2018) Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases. International Journal of Molecular Sciences 19:11, pages 3630.
Crossref
Crossref
Seema Negi, Shashi Kala Singh, Sanjay Kumar, Subodh Kumar & Rakesh K. Tyagi. (2018) Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. Toxicology in Vitro 52, pages 222-234.
Crossref
Crossref
Litaty Céphanoée Mbatchi, Jean-Paul Brouillet & Alexandre Evrard. (2018) Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability. Pharmacogenomics 19:1, pages 61-77.
Crossref
Crossref
X. Ding, L. Li, L.S. Van Winkle & Q.-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology
171
193
.
X. Ding & Q-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology
8
44
.
Sana-Kay Whyte-Allman, Md Tozammel Hoque, Mohammad-Ali Jenabian, Jean-Pierre Routy & Reina Bendayan. (2017) Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier. Journal of Pharmacology and Experimental Therapeutics 363:3, pages 324-335.
Crossref
Crossref
Wenwei LinAsli N. GoktugJing WuDuane G. CurrierTaosheng Chen. (2017) High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor. ASSAY and Drug Development Technologies 15:8, pages 383-394.
Crossref
Crossref
Wenwei Lin, Yue-Ming Wang, Sergio C. Chai, Lili Lv, Jie Zheng, Jing Wu, Qijun Zhang, Yong-Dong Wang, Patrick R. Griffin & Taosheng Chen. (2017) SPA70 is a potent antagonist of human pregnane X receptor. Nature Communications 8:1.
Crossref
Crossref
Aneesh Chandran & Saraswathi Vishveshwara. (2016) Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket. Protein Science 25:11, pages 1989-2005.
Crossref
Crossref
Darja Gramec Skledar, Tihomir Tomašič, Adriana Carino, Eleonora Distrutti, Stefano Fiorucci & Lucija Peterlin Mašič. (2016) New brominated flame retardants and their metabolites as activators of the pregnane X receptor. Toxicology Letters 259, pages 116-123.
Crossref
Crossref
Manjul Rana, Suneeta Devi, Samudrala Gourinath, Ravinder Goswami & Rakesh K. Tyagi. (2016) A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1183-1197.
Crossref
Crossref
Sergio C. Chai, Milu T. Cherian, Yue-Ming Wang & Taosheng Chen. (2016) Small-molecule modulators of PXR and CAR. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1141-1154.
Crossref
Crossref
Danielle Pasquel, Aneta Doricakova, Hao Li, Sandhya Kortagere, Matthew D. Krasowski, Arunima Biswas, William G. Walton, Matthew R. Redinbo, Zdenek Dvorak & Sridhar Mani. (2016) Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1155-1169.
Crossref
Crossref
Giuseppe Esposito, Nicola Nobile, Stefano Gigli, Luisa Seguella, Marcella Pesce, Alessandra d’Alessandro, Eugenia Bruzzese, Elena Capoccia, Luca Steardo, Rosario Cuomo & Giovanni Sarnelli. (2016) Rifaximin Improves Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-κB Pathway. Frontiers in Pharmacology 7.
Crossref
Crossref
Monimoy Banerjee, Sergio C. Chai, Jing Wu, Delira Robbins & Taosheng Chen. (2016) Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding. Biochemical Pharmacology 104, pages 131-138.
Crossref
Crossref
Tao Zhou, Wen-ting You, Zeng-chun Ma, Qian-de Liang, Hong-ling Tan, Cheng-rong Xiao, Xiang-lin Tang, Bo-li Zhang, Yu-guang Wang & Yue Gao. (2016) Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. Acta Pharmacologica Sinica 37:2, pages 177-186.
Crossref
Crossref
Satyanarayana R. Pondugula, Petr Pavek & Sridhar Mani. (2016) Pregnane X Receptor and Cancer: Context-Specificity is Key. Nuclear Receptor Research 3.
Crossref
Crossref
Žiga Hodnik, Tihomir Tomašič, Domen Smodiš, Claudio D'Amore, Lucija Peterlin Mašič, Stefano Fiorucci & Danijel Kikelj. (2015) Diethylstilbestrol-scaffold-based pregnane X receptor modulators. European Journal of Medicinal Chemistry 103, pages 551-562.
Crossref
Crossref
Frederick M. Stanley, Kathryn M. Linder & Timothy J. Cardozo. (2015) Statins Increase Plasminogen Activator Inhibitor Type 1 Gene Transcription through a Pregnane X Receptor Regulated Element. PLOS ONE 10:9, pages e0138097.
Crossref
Crossref
Yue-Ming Wang, Sergio C. Chai, Wenwei Lin, Xiaojuan Chai, Ayesha Elias, Jing Wu, Su Sien Ong, Satyanarayana R. Pondugula, Jordan A. Beard, Erin G. Schuetz, Su Zeng, Wen Xie & Taosheng Chen. (2015) Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo. Biochemical Pharmacology 96:4, pages 357-368.
Crossref
Crossref
Jingjing Zhang, Lili Ding, Baocan Wang, Gaiyan Ren, Aning Sun, Chao Deng, Xiaohui Wei, Sridhar Mani, Zhengtao Wang & Wei Dou. (2015) Notoginsenoside R1 Attenuates Experimental Inflammatory Bowel Disease via Pregnane X Receptor Activation. Journal of Pharmacology and Experimental Therapeutics 352:2, pages 315-324.
Crossref
Crossref
Satyanarayana R. Pondugula, Patrick C. Flannery, Kodye L. Abbott, Elaine S. Coleman, Sridhar Mani, Temesgen Samuel & Wen Xie. (2015) Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicology Letters 232:3, pages 580-589.
Crossref
Crossref
A. D. Bastiaan Vliegenthart, Carl S. Tucker, Jorge Del Pozo & James W. Dear. (2014) Zebrafish as model organisms for studying drug-induced liver injury. British Journal of Clinical Pharmacology 78:6, pages 1217-1227.
Crossref
Crossref
Qiang Meng, Xinli Chen, Changyuan Wang, Qi Liu, Huijun Sun, Pengyuan Sun, Jinyong Peng & Kexin Liu. (2014) Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor. Biochemical Pharmacology 92:2, pages 289-298.
Crossref
Crossref
Georges de Sousa, Ahmad Nawaz, Jean-Pierre Cravedi & Roger Rahmani. (2014) A Concentration Addition Model to Assess Activation of the Pregnane X Receptor (PXR) by Pesticide Mixtures Found in the French Diet. Toxicological Sciences 141:1, pages 234-243.
Crossref
Crossref
Wei Dou, Jingjing Zhang, Hao Li, Sandhya Kortagere, Katherine Sun, Lili Ding, Gaiyan Ren, Zhengtao Wang & Sridhar Mani. (2014) Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway. The Journal of Nutritional Biochemistry 25:9, pages 923-933.
Crossref
Crossref
Stephen S. Ferguson & Jessica A. Bonzo. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction
441
484
.
Žiga Hodnik, Lucija Peterlin Mašič, Tihomir Tomašić, Domen Smodiš, Claudio D’Amore, Stefano Fiorucci & Danijel Kikelj. (2014) Bazedoxifene-Scaffold-Based Mimetics of Solomonsterols A and B as Novel Pregnane X Receptor Antagonists. Journal of Medicinal Chemistry 57:11, pages 4819-4833.
Crossref
Crossref
Aneta Novotna, Alzbeta Kamenickova, Michaela Pecova, Martina Korhonova, Iveta Bartonkova & Zdenek Dvorak. (2014) Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chemico-Biological Interactions 208, pages 64-76.
Crossref
Crossref
Tomas Smutny & Petr Pavek. (2014) Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism. Journal of Pharmacological Sciences 126:2, pages 177-178.
Crossref
Crossref
Lei Xiao, Zihui Zhang & Xiaoqin Luo. (2014) Roles of Xenobiotic Receptors in Vascular Pathophysiology. Circulation Journal 78:7, pages 1520-1530.
Crossref
Crossref
Aaron M. Gusdon, Ke-xiu Song & Shen Qu. (2014) Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective. Oxidative Medicine and Cellular Longevity 2014, pages 1-20.
Crossref
Crossref
Vijay Rathod, Sumit Jain, Prajwal Nandekar & Abhay T. Sangamwar. (2014) Human pregnane X receptor: a novel target for anticancer drug development. Drug Discovery Today 19:1, pages 63-70.
Crossref
Crossref
Monimoy Banerjee & Taosheng Chen. (2013) Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor. Biochemical Pharmacology 86:6, pages 824-835.
Crossref
Crossref
Ayesha Elias, Jing Wu & Taosheng Chen. (2013) Tumor Suppressor Protein p53 Negatively Regulates Human Pregnane X Receptor Activity. Molecular Pharmacology 83:6, pages 1229-1236.
Crossref
Crossref
Hao Li, Matthew R. Redinbo, Madhukumar Venkatesh, Sean Ekins, Anik Chaudhry, Nicolin Bloch, Abdissa Negassa, Paromita Mukherjee, Ganjam Kalpana & Sridhar Mani. (2013) Novel Yeast-based Strategy Unveils Antagonist Binding Regions on the Nuclear Xenobiotic Receptor PXR. Journal of Biological Chemistry 288:19, pages 13655-13668.
Crossref
Crossref