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Review Article

Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters

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Pages 196-217 | Received 10 Jun 2012, Accepted 30 Nov 2012, Published online: 01 Feb 2013

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Bo Feng, Manthena V Varma, Chester Costales, Hui Zhang & Larry Tremaine. (2014) In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery. Expert Opinion on Drug Discovery 9:8, pages 873-890.
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Sumit Kr Anand, Ankita Sharma, Neha Singh & Poonam Kakkar. (2020) Activation of autophagic flux via LKB1/AMPK/mTOR axis against xenoestrogen Bisphenol-A exposure in primary rat hepatocytes. Food and Chemical Toxicology 141, pages 111314.
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Eva Gijbels, Vânia Vilas-Boas, Neel Deferm, Lindsey Devisscher, Hartmut Jaeschke, Pieter Annaert & Mathieu Vinken. (2019) Mechanisms and in vitro models of drug-induced cholestasis. Archives of Toxicology 93:5, pages 1169-1186.
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Eva Gijbels & Mathieu Vinken. 2019. Experimental Cholestasis Research. Experimental Cholestasis Research 1 14 .
Mathieu Vinken & Jan G. Hengstler. (2018) Characterization of hepatocyte-based in vitro systems for reliable toxicity testing. Archives of Toxicology 92:10, pages 2981-2986.
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Dan-Dan Hu, Xing-Long Chen, Xue-Rong Xiao, Yi-Kun Wang, Fang Liu, Qi Zhao, Xian Li, Xiu-Wei Yang & Fei Li. (2018) Comparative metabolism of tripolide and triptonide using metabolomics. Food and Chemical Toxicology 115, pages 98-108.
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Young-Jun Choi, Hyemin Kim, Ji-Woo Kim, Seokjoo Yoon & Han-Jin Park. (2018) Hepatic esterase activity is increased in hepatocyte-like cells derived from human embryonic stem cells using a 3D culture system. Biotechnology Letters 40:5, pages 755-763.
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Deanna J. Brackman & Kathleen M. Giacomini. (2018) Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response . Clinical Pharmacology & Therapeutics 103:2, pages 233-242.
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Elodie Jouan, Marc Le Vée, Claire Denizot, Yannick Parmentier & Olivier Fardel. (2016) Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells. Pharmaceutics 9:4, pages 3.
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Katrin Zeilinger, Nora Freyer, Georg Damm, Daniel Seehofer & Fanny Knöspel. (2016) Cell sources for in vitro human liver cell culture models . Experimental Biology and Medicine 241:15, pages 1684-1698.
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Tom De Bruyn, Patrick F. Augustijns & Pieter P. Annaert. (2016) Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat. Journal of Pharmaceutical Sciences 105:2, pages 846-853.
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Abdullah Mayati, Marc Le Vee, Amélie Moreau, Elodie Jouan, Simon Bucher, Bruno Stieger, Claire Denizot, Yannick Parmentier & Olivier Fardel. (2015) Protein kinase C-dependent regulation of human hepatic drug transporter expression. Biochemical Pharmacology 98:4, pages 703-717.
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Jennifer Bolleyn, Joery De Kock, Robim Marcelino Rodrigues, Mathieu Vinken, Vera Rogiers & Tamara Vanhaecke. (2014) MicroRNAs as key regulators of xenobiotic biotransformation and drug response. Archives of Toxicology 89:9, pages 1523-1541.
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Marc Le Vee, Elodie Jouan, Gregory Noel, Bruno Stieger & Olivier Fardel. (2015) Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes. Toxicology in Vitro 29:5, pages 938-946.
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O. B. Usta, W. J. McCarty, S. Bale, M. Hegde, R. Jindal, A. Bhushan, I. Golberg & M. L. Yarmush. (2015) Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies . TECHNOLOGY 03:01, pages 1-26.
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Adriana Prado, Georg A. Petroianu, Dietrich E. Lorke & Jeremy W. Chambers. (2015) A trivalent approach for determining in vitro toxicology: Examination of oxime K027 . Journal of Applied Toxicology 35:2, pages 219-227.
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Marc Le Vée, Elodie Jouan, Claire Denizot, Yannick Parmentier & Olivier Fardel. 2015. Protocols in In Vitro Hepatocyte Research. Protocols in In Vitro Hepatocyte Research 287 302 .
Moritz Kleine, Marc Riemer, Till Krech, Daphne DeTemple, Mark D. Jäger, Frank Lehner, Michael P. Manns, Jürgen Klempnauer, Jürgen Borlak, Hueseyin Bektas & Florian W. R. Vondran. (2014) Explanted Diseased Livers – A Possible Source of Metabolic Competent Primary Human Hepatocytes. PLoS ONE 9:7, pages e101386.
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Tom De Bruyn, Wouter Sempels, Jan Snoeys, Nico Holmstock, Sagnik Chatterjee, Bruno Stieger, Patrick Augustijns, Johan Hofkens, Hideaki Mizuno & Pieter Annaert. (2014) Confocal Imaging with a Fluorescent Bile Acid Analogue Closely Mimicking Hepatic Taurocholate Disposition. Journal of Pharmaceutical Sciences 103:6, pages 1872-1881.
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Jeong-Kwon Noh, In Keun Jang, Hyo Eun Kim, Jong Eun Lee, Mal Sook Yang, Eun Mi Jang, Ji-Hyun Lee, Hey-Jung Park, Young-A Kim, Suk-Koo Lee, Ho-Sang Jeong, Joon-Ik Ahn & Doo-Hoon Lee. (2014) Quality and Availability Evaluation of Human Hepatocytes Isolated from Resected Partial Livers for Toxicology and Drug Metabolism Studies in Korea. KSBB Journal 29:1, pages 58-66.
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Xiao-Mei Zhuang, Guo-Lin Shen, Wei-Bin Xiao, Yan Tan, Chuang Lu & Hua Li. (2013) Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model. Drug Metabolism and Disposition 41:12, pages 2158-2165.
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Marc Le Vee, Gregory Noel, Elodie Jouan, Bruno Stieger & Olivier Fardel. (2013) Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Toxicology in Vitro 27:6, pages 1979-1986.
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