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Review Article

Epigenetic regulation of pregnane X receptor activity

Pages 166-172 | Received 04 Oct 2012, Accepted 03 Dec 2012, Published online: 22 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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David E. Amacher. (2016) The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors. Expert Opinion on Drug Metabolism & Toxicology 12:12, pages 1463-1477.
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Yue-Ming Wang, Sergio C Chai, Christopher T Brewer & Taosheng Chen. (2014) Pregnane X receptor and drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 10:11, pages 1521-1532.
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Articles from other publishers (14)

Xiaxia Niu, Ting Wu, Qishuang Yin, Xinsheng Gu, Gege Li, Changlong Zhou, Mei Ma, Li Su, Shu Tang, Yanan Tian, Ming Yang & Hongmei Cui. (2022) Combination of Paclitaxel and PXR Antagonist SPA70 Reverses Paclitaxel-Resistant Non-Small Cell Lung Cancer. Cells 11:19, pages 3094.
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Xiaomin Su, Minying Zhang, Houbao Qi, Yunhuan Gao, Yazheng Yang, Huan Yun, Qianjing Zhang, Xiaorong Yang, Yuan Zhang, Jiangshan He, Yaqi Fan, Yuxue Wang, Pei Guo, Chunze Zhang & Rongcun Yang. (2022) Gut microbiota–derived metabolite 3-idoleacetic acid together with LPS induces IL-35+ B cell generation. Microbiome 10:1.
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Martine Daujat-Chavanieu & Sabine Gerbal-Chaloin. (2020) Regulation of CAR and PXR Expression in Health and Disease. Cells 9:11, pages 2395.
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P. Kellie Turner, Stephen D. Hall, Sonya C. Chapman, Jessica L. Rehmel, Jane E. Royalty, Yingying Guo & Palaniappan Kulanthaivel. (2020) Abemaciclib Does Not Have a Clinically Meaningful Effect on Pharmacokinetics of CYP1A2, CYP2C9, CYP2D6, and CYP3A4 Substrates in Patients with Cancer. Drug Metabolism and Disposition 48:9, pages 796-803.
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Pei Wang, Guangming Liu, Yali Nie, Shengna Han, Jiangfeng Li, Xiao-Bo Zhong & Lirong Zhang. (2019) Epigenetic Memory Is Involved in the Persistent Alterations of Drug-Processing Genes in Adult Mice Due to PCN-Activated PXR During Early Life. Toxicological Sciences 172:1, pages 98-108.
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X. Ding, L. Li, L.S. Van Winkle & Q.-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 171 193 .
X. Ding & Q-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 8 44 .
Julia Yue Cui & Curtis D. Klaassen. (2016) RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1198-1217.
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Danielle Pasquel, Aneta Doricakova, Hao Li, Sandhya Kortagere, Matthew D. Krasowski, Arunima Biswas, William G. Walton, Matthew R. Redinbo, Zdenek Dvorak & Sridhar Mani. (2016) Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1155-1169.
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Tingting Li, Ah-Ng Tony Kong, Zhiqiang Ma, Haiyan Liu, Pinghua Liu, Yu Xiao, Xuehua Jiang & Ling Wang. (2016) Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant. Oncotarget 7:15, pages 20236-20248.
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Hye-Min Kim, Ji-Woo Kim, Youngjun Choi, Hang-Suk Chun, Ilkyun Im, Yong-Mahn Han, Chang-Woo Song, Seokjoo Yoon & Han-Jin Park. (2016) Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells. Scientific Reports 6:1.
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Satyanarayana R. Pondugula, Petr Pavek & Sridhar Mani. (2016) Pregnane X Receptor and Cancer: Context-Specificity is Key. Nuclear Receptor Research 3.
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Thomas J. Velenosi, David A. Feere, Gurjeev Sohi, Daniel B. Hardy & Bradley L. Urquhart. (2014) Decreased nuclear receptor activity and epigenetic modulation associates with down‐regulation of hepatic drug‐metabolizing enzymes in chronic kidney disease. The FASEB Journal 28:12, pages 5388-5397.
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Martin Šíma, I. Netíková & O. Slanař. (2013) Pregnane Xenobiotic Receptors and Their Effect on Drug Elimination from the Organism. Prague Medical Report 114:4, pages 205-213.
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