625
Views
39
CrossRef citations to date
0
Altmetric
Review Article

Cytochrome P450 pharmacogenetics in African populations

, , , &
Pages 253-275 | Received 13 Oct 2012, Accepted 21 Feb 2013, Published online: 16 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Karol J Marwa, Anthony Kapesa, Erasmus Kamugisha & Göte Swedberg. (2023) The Influence of Cytochrome P450 Polymorphisms on Pharmacokinetic Profiles and Treatment Outcomes Among Malaria Patients in Sub-Saharan Africa: A Systematic Review. Pharmacogenomics and Personalized Medicine 16, pages 449-461.
Read now
Keneuoe Cecilia Nthontho, Andrew Khulekani Ndlovu, Kirthana Sharma, Ishmael Kasvosve, Daniel Louis Hertz & Giacomo Maria Paganotti. (2022) Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective. Pharmacogenomics and Personalized Medicine 15, pages 613-652.
Read now
Apolonia Novillo, María Gaibar, Alicia Romero-Lorca, Hassen Chaabani, Nadir Amir, Pedro Moral, M. Esther Esteban & Ana Fernández-Santander. (2018) UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European data. Annals of Human Biology 45:6-8, pages 516-523.
Read now
Johannes P. Mouton, Karen Cohen & Gary Maartens. (2016) Key toxicity issues with the WHO-recommended first-line antiretroviral therapy regimen. Expert Review of Clinical Pharmacology 9:11, pages 1493-1503.
Read now
Rashmi R. Shah. (2015) Inter-ethnic differences in drug response: Implications for drug development and complying with drug regulation. Clinical Research and Regulatory Affairs 32:3, pages 88-98.
Read now
Antoinette Čolić, Marco Alessandrini & Michael S. Pepper. (2015) Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine. Drug Metabolism Reviews 47:2, pages 111-123.
Read now
Collet Dandara, Marelize Swart, Bafokeng Mpeta, Ambroise Wonkam & Collen Masimirembwa. (2014) Cytochrome P450 pharmacogenetics in African populations: implications for public health. Expert Opinion on Drug Metabolism & Toxicology 10:6, pages 769-785.
Read now

Articles from other publishers (32)

Jonathan G. Leung. (2023) Ethnopsychopharmacology: Clinical and scientific writing pearls. Mental Health Clinician 13:6, pages 276-288.
Crossref
Chiratidzo R. Chamboko, Wayde Veldman, Rolland Bantar Tata, Birgit Schoeberl & Özlem Tastan Bishop. (2023) Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles. International Journal of Molecular Sciences 24:4, pages 3383.
Crossref
Aymen Shatnawi, Zourayz Kamran & Qusai Al-Share. (2023) Pharmacogenomics of lipid-lowering agents: the impact on efficacy and safety. Personalized Medicine 20:1, pages 65-86.
Crossref
Karol J Marwa, Anthony C Liwa, Eveline T Konje, Stanley Mwita, Erasmus Kamugisha & Göte Swedberg. (2022) Lumefantrine plasma concentrations in uncontrolled conditions among patients treated with artemether-lumefantrine for uncomplicated plasmodium falciparum malaria in Mwanza, Tanzania. International Journal of Infectious Diseases 123, pages 192-199.
Crossref
Carolina Dagli-Hernandez, Yitian Zhou, Volker Martin Lauschke, Fabiana Dalla Vecchia Genvigir, Thiago Dominguez Crespo Hirata, Mario Hiroyuki Hirata & Rosario Dominguez Crespo Hirata. (2021) Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts. Pharmacological Reports 74:1, pages 47-66.
Crossref
Nadia Quignot, Witold Więcek, Leonie Lautz, Jean-Lou Dorne & Billy Amzal. (2021) Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment. Toxicology Letters 337, pages 111-120.
Crossref
Yasna Rostam‐Abadi, Jaleh Gholami, Masoumeh Amin‐Esmaeili, Anousheh Safarcherati, Ramin Mojtabai, Mohammad Reza Ghadirzadeh, Hosein Rahimi & Afarin Rahimi‐Movaghar. (2020) Tramadol use and public health consequences in Iran: a systematic review and meta‐analysis. Addiction 115:12, pages 2213-2242.
Crossref
Zana Elmaasarani, Caitlin Mardis, Logan Gylten, David J. Taber, James Fleming, Neha Patel, Prabhakar Baliga, Vinaya Rao, Vinayak Rohan, Derek DuBay & Nicole A. Pilch. (2019) Protocol‐based nurse coordinator management of ambulatory tacrolimus dosing in de novo renal transplant recipients—A single‐center experience with a large African American population. Clinical Transplantation 33:10.
Crossref
Sibongile Tshabalala, Ananyo Choudhury, Natasha Beeton-Kempen, Neil Martinson, Michèle Ramsay & Dalu Mancama. (2019) Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes. Pharmacogenetics and Genomics 29:7, pages 167-178.
Crossref
Arinao NdadzaNicholas Ekow ThomfordStanley MukanganyamaAmbroise WonkamMpiko NtsekheCollet Dandara. (2019) The Genetics of Warfarin Dose–Response Variability in Africans: An Expert Perspective on Past, Present, and Future. OMICS: A Journal of Integrative Biology 23:3, pages 152-166.
Crossref
Jake A. Kleinmahon, Jane Gralla, Richard Kirk, Scott R. Auerbach, Heather T. Henderson, Gonzalo A. Wallis, Karthik Ramakrishnan, Rakesh K. Singh, Randall L. Caldwell, Andrew J. Savage & Melanie D. Everitt. (2019) Cardiac allograft vasculopathy and graft failure in pediatric heart transplant recipients after rejection with severe hemodynamic compromise. The Journal of Heart and Lung Transplantation 38:3, pages 277-284.
Crossref
M. Gaibar, A. Novillo, A. Romero-Lorca, M. E. Esteban & A. Fernández-Santander. (2018) Pharmacogenetics of ugt genes in North African populations. The Pharmacogenomics Journal 18:5, pages 609-612.
Crossref
Rashmi R. Shah & Andrea Gaedigk. (2017) Precision medicine: does ethnicity information complement genotype-based prescribing decisions?. Therapeutic Advances in Drug Safety 9:1, pages 45-62.
Crossref
David J. Taber, Zemin Su, James N. Fleming, John W. McGillicuddy, Maria A. Posadas-Salas, Frank A. Treiber, Derek Dubay, Titte R. Srinivas, Patrick D. Mauldin, William P. Moran & Prabhakar K. Baliga. (2017) Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation. Transplantation 101:12, pages 2931-2938.
Crossref
Merve Arici & Gül Özhan. (2017) CYP2C9, CYPC19 and CYP2D6 gene profiles and gene susceptibility to drug response and toxicity in Turkish population. Saudi Pharmaceutical Journal 25:3, pages 376-380.
Crossref
Merve Arici & Gül Özhan. (2017) The genetic profiles of CYP1A1, CYP1A2 and CYP2E1 enzymes as susceptibility factor in xenobiotic toxicity in Turkish population. Saudi Pharmaceutical Journal 25:2, pages 294-297.
Crossref
K. L. Mpye, A. Matimba, K. Dzobo, S. Chirikure, A. Wonkam & C. Dandara. (2017) Disease burden and the role of pharmacogenomics in African populations. Global Health, Epidemiology and Genomics 2.
Crossref
T M Dodgen, C De J Labuschagne, A van Schalkwyk, F E Steffens, A Gaedigk, A D Cromarty, M Alessandrini & M S Pepper. (2015) Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort. The Pharmacogenomics Journal 16:6, pages 566-572.
Crossref
Marco AlessandriniMamoonah ChaudhryTyren M. DodgenMichael S. Pepper. (2016) Pharmacogenomics and Global Precision Medicine in the Context of Adverse Drug Reactions: Top 10 Opportunities and Challenges for the Next Decade. OMICS: A Journal of Integrative Biology 20:10, pages 593-603.
Crossref
Cheedy JajaNadine BarrettNiren PatelMatt LyonHongyan XuAbdullah Kutlar. (2016) Progressing Preemptive Genotyping of CYP2C19 Allelic Variants for Sickle Cell Disease Patients. Genetic Testing and Molecular Biomarkers 20:10, pages 609-615.
Crossref
Thato Motshoge, Leabaneng Tawe, Charles Waithaka Muthoga, Joel Allotey, Rita Romano, Isaac Quaye & Giacomo Maria Paganotti. (2016) Cytochrome P450 2C8*2 allele in Botswana: Human genetic diversity and public health implications. Acta Tropica 157, pages 54-58.
Crossref
Rashmi R Shah, Andrea Gaedigk, Adrián LLerena, Michel Eichelbaum, Julia Stingl & Robert L Smith. (2016) CYP450 genotype and pharmacogenetic association studies: a critical appraisal. Pharmacogenomics 17:3, pages 259-275.
Crossref
Zhengchao Xia, Hongyan Wei, Jingjing Duan, Ting Zhou, Zhen Yang & Feng Xu. (2016) Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats. PeerJ 4, pages e1611.
Crossref
Tyren M Dodgen, Britt I Drögemöller, Galen EB Wright, Louise Warnich, Francois E Steffens, A Duncan Cromarty, Marco Alessandrini & Michael S Pepper. (2015) Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort . Pharmacogenomics 16:12, pages 1343-1354.
Crossref
Tyren M. Dodgen, Arinda Eloff, Connie Mataboge, Louw (.J.L.). Roos, Werdie (.C.W.). van Staden & Michael S. Pepper. (2015) Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort. Applied & Translational Genomics 5, pages 40-46.
Crossref
Mqondisi Tshabalala, Juanita Mellet & Michael S. Pepper. (2015) Human Leukocyte Antigen Diversity: A Southern African Perspective. Journal of Immunology Research 2015, pages 1-11.
Crossref
Edoardo Spina & Jose de Leon. (2014) Clinical applications of CYP genotyping in psychiatry. Journal of Neural Transmission 122:1, pages 5-28.
Crossref
Karol J Marwa, Theresa Schmidt, Maria Sjögren, Omary MS Minzi, Erasmus Kamugisha & Göte Swedberg. (2014) Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations. Malaria Journal 13:1.
Crossref
Giacomo Maria Paganotti, Valentina Cosentino, Gianluca Russo, Francesca Tabacchi, Silvia Gramolelli, Mario Coluzzi & Rita Romano. (2014) Absence of the human CYP2C8*3 allele in Ugandan children exposed to Plasmodium falciparum malaria. Infection, Genetics and Evolution 27, pages 432-435.
Crossref
Panjasaram Naidoo, Vasudevan V. Chetty & Manoranjenni Chetty. (2014) Impact of CYP polymorphisms, ethnicity and sex differences in metabolism on dosing strategies: the case of efavirenz. European Journal of Clinical Pharmacology 70:4, pages 379-389.
Crossref
Marco Alessandrini & Michael S Pepper. (2014) Priority pharmacogenetics for the African continent: focus on CYP450. Pharmacogenomics 15:3, pages 385-400.
Crossref
Collen Masimirembwa, Collet Dandara & Julia Hasler. 2014. Handbook of Pharmacogenomics and Stratified Medicine. Handbook of Pharmacogenomics and Stratified Medicine 971 998 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.