Advanced search
Publication Cover
Drug Metabolism Reviews Volume 46, 2014 - Issue 4
Submit an article Journal homepage
415
Views
59
CrossRef citations to date
0
Altmetric
Review Article

Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target

Evan Q. ComeauxDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham Birmingham, ALUSA
&
Robert C. A. M. van WaardenburgDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham Birmingham, ALUSACorrespondence[email protected]
Pages 494-507 | Received 04 Aug 2014, Accepted 19 Sep 2014, Published online: 20 Oct 2014

Citations (59)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Olga A. Luzina & Nariman F. Salakhutdinov. (2018) Usnic acid and its derivatives for pharmaceutical use: a patent review (2000–2017). Expert Opinion on Therapeutic Patents 28:6, pages 477-491.
Read now
Anastasia O. Komarova, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Irina V. Kulikova, Vladimir E. Oslovsky, Olga D. Zakharova, Alexandra L. Zakharenko, Sergey N. Mikhailov & Olga I. Lavrik. (2018) Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1415-1429.
Read now

Articles from other publishers (57)

N. S. Dyrkheeva, I. V. Ilyina, K. P. Volcho, N. F. Salakhutdinov & O. I. Lavrik. (2023) 3-Oxabicyclo[3.3.1]nonenes: synthesis and investigation as tyrosyl-DNA phosphodiesterase 1 inhibitors. Russian Chemical Bulletin 72:10, pages 2525-2535.
Crossref
Alina A. Okhina, Tatyana E. Kornienko, Artem D. Rogachev, Olga A. Luzina, Nelly A. Popova, Valery P. Nikolin, Alexandra L. Zakharenko, Nadezhda S. Dyrkheeva, Andrey G. Pokrovsky, Nariman F. Salakhutdinov & Olga I. Lavrik. (2023) Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan. Journal of Pharmaceutical and Biomedical Analysis, pages 115731.
Crossref
Alina A. Okhina, Artem D. Rogachev, Kseniya S. Kovaleva, Olga I. Yarovaya, Anna S. Khotskina, Evgeniy L. Zavyalov, Sergey Z. Vatsadze, Andrey G. Pokrovsky & Nariman F. Salakhutdinov. (2023) Development of an LC-MS/MS-based method for quantification and pharmacokinetics study on SCID mice of a dehydroabietylamine-adamantylamine conjugate, a promising inhibitor of the DNA repair enzyme. Journal of Pharmaceutical and Biomedical Analysis, pages 115507.
Crossref
Tatyana M. Khomenko, Alexandra L. Zakharenko, Tatyana E. Kornienko, Arina A. Chepanova, Nadezhda S. Dyrkheeva, Anastasia O. Artemova, Dina V. Korchagina, Chigozie Achara, Anthony Curtis, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2023) New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan. International Journal of Molecular Sciences 24:11, pages 9155.
Crossref
Hao Yang, Chao Qin, Min Wu, Fang‐Ting Wang, Wenjie Wang, Keli Agama, Yves Pommier, De‐Xuan Hu & Lin‐Kun An. (2023) Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors. ChemMedChem 18:10.
Crossref
T. E. Kornienko, A. L. Zakharenko, E. S. Ilina, A. A. Chepanova, O. D. Zakharova, N. S. Dyrkheeva, N. A. Popova, V. P. Nikolin, A. S. Filimonov, O. A. Luzina, N. F. Salakhutdinov & O. I. Lavrik. (2023) Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo. Molecular Biology 57:2, pages 214-224.
Crossref
Alexandra L. Zakharenko, Olga A. Luzina, Arina A. Chepanova, Nadezhda S. Dyrkheeva, Nariman F. Salakhutdinov & Olga I. Lavrik. (2023) Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1. International Journal of Molecular Sciences 24:6, pages 5781.
Crossref
Nadezhda S. Dyrkheeva, Anastasia A. Malakhova, Aleksandra L. Zakharenko, Larisa S. Okorokova, Dmitriy N. Shtokalo, Sophia V. Pavlova, Sergey P. Medvedev, Suren M. Zakian, Anna A. Nushtaeva, Alexey E. Tupikin, Marsel R. Kabilov, Svetlana N. Khodyreva, Olga A. Luzina, Nariman F. Salakhutdinov & Olga I. Lavrik. (2023) Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor. International Journal of Molecular Sciences 24:6, pages 5148.
Crossref
A. A. Chepanova, A. L. Zakharenko, N. S. Dyrkheeva, I. A. Chernyshova, O. D. Zakharova, E. S. Ilina, O. A. Luzina, N. F. Salakhutdinov & O. I. Lavrik. (2023) Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan. Doklady Biochemistry and Biophysics 508:1, pages 25-30.
Crossref
Evan J. Brettrager, Selma M. Cuya, Zachary E. Tibbs, Jun Zhang, Charles N. Falany, Stephen G. Aller & Robert C. A. M. van Waardenburg. (2023) N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells. Scientific Reports 13:1.
Crossref
Xue Zhi Zhao, Wenjie Wang, George T. Lountos, Evgeny Kiselev, Joseph E. Tropea, Danielle Needle, Yves Pommier & Terrence R. Burke. (2023) Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. RSC Chemical Biology.
Crossref
Dmitry I. Ivankin, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Ekaterina S. Ilina, Timofey O. Zarkov, Jóhannes Reynisson, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2022) Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. Bioorganic & Medicinal Chemistry Letters 73, pages 128909.
Crossref
Xue Zhi Zhao, Wenjie Wang, George T. Lountos, Joseph E. Tropea, Danielle Needle, Yves Pommier & Terrence R. BurkeJrJr. (2022) Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Frontiers in Chemistry 10.
Crossref
Yves Pommier, André Nussenzweig, Shunichi Takeda & Caroline Austin. (2022) Human topoisomerases and their roles in genome stability and organization. Nature Reviews Molecular Cell Biology 23:6, pages 407-427.
Crossref
Hao Yang, Fang-Ting Wang, Min Wu, Wenjie Wang, Keli Agama, Yves Pommier & Lin-Kun An. (2022) Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity. Bioorganic Chemistry 123, pages 105789.
Crossref
Aldar A. Munkuev, Nadezhda S. Dyrkheeva, Tatyana E. Kornienko, Ekaterina S. Ilina, Dmitry I. Ivankin, Evgeniy V. Suslov, Dina V. Korchagina, Yuriy V. Gatilov, Alexandra L. Zakharenko, Anastasia A. Malakhova, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2022) Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan. Molecules 27:11, pages 3374.
Crossref
Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Georgy A. Ivanov, Yuri B. Porozov, Anastasia A. Zenchenko, Vladimir E. Oslovsky, Alexandra L. Zakharenko, Darina I. Nasyrova, Galina N. Likhatskaya, Sergey N. Mikhailov, Olga I. Lavrik & Mikhail S. Drenichev. (2022) In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions. Molecules 27:8, pages 2433.
Crossref
Xia Wei, Fang-Ting Wang, Mei-Xia Si-Tu, Hao Fan, Jin-Shan Hu, Hao Yang, Shan-Yue Guan, Lin-Kun An & Cui-Xian Zhang. (2022) Pyranodipyran Derivatives with Tyrosyl DNA Phosphodiesterase 1 Inhibitory Activities and Fluorescent Properties from Aspergillus sp. EGF 15-0-3. Marine Drugs 20:3, pages 211.
Crossref
Morgan Crewe & Ram Madabhushi. (2021) Topoisomerase-Mediated DNA Damage in Neurological Disorders. Frontiers in Aging Neuroscience 13.
Crossref
Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov & Olga I. Lavrik. (2021) New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules 11:7, pages 973.
Crossref
De-Xuan Hu, Wen-Lin Tang, Yu Zhang, Hao Yang, Wenjie Wang, Keli Agama, Yves Pommier & Lin-Kun An. (2021) Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer. Journal of Medicinal Chemistry 64:11, pages 7617-7629.
Crossref
Kseniya Kovaleva, Olga Yarovaya, Konstantin Ponomarev, Sergey Cheresiz, Amirhossein Azimirad, Irina Chernyshova, Alexandra Zakharenko, Vasily Konev, Tatiana Khlebnikova, Evgenii Mozhaytsev, Evgenii Suslov, Dmitry Nilov, Vytas Švedas, Andrey Pokrovsky, Olga Lavrik & Nariman Salakhutdinov. (2021) Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties. Pharmaceuticals 14:5, pages 422.
Crossref
Xue Zhi Zhao, Evgeny Kiselev, George T. Lountos, Wenjie Wang, Joseph E. Tropea, Danielle Needle, Thomas A. Hilimire, John S. Schneekloth, David S. Waugh, Yves Pommier & Terrence R. Burke. (2021) Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites. Chemical Science 12:11, pages 3876-3884.
Crossref
N. S. Dyrkheeva, A. L. Zakharenko, E. S. Novoselova, A. A. Chepanova, N. A. Popova, V. P. Nikolin, O. A. Luzina, N. F. Salakhutdinov, E. I. Ryabchikova & O. I. Lavrik. (2021) Antitumor Activity of the Combination of Topotecan and Tyrosyl-DNA-Phosphodiesterase 1 Inhibitor on Model Krebs-2 Mouse Ascite Carcinoma. Molecular Biology 55:2, pages 273-277.
Crossref
Elizaveta D. Gladkova, Ivan V. Nechepurenko, Roman A. Bredikhin, Arina A. Chepanova, Alexandra L. Zakharenko, Olga A. Luzina, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Evgeniya M. Mamontova, Rashid O. Anarbaev, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2020) The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme. International Journal of Molecular Sciences 21:19, pages 7162.
Crossref
Olga Luzina, Alexander Filimonov, Alexandra Zakharenko, Arina Chepanova, Olga Zakharova, Ekaterina Ilina, Nadezhda Dyrkheeva, Galina Likhatskaya, Nariman Salakhutdinov & Olga Lavrik. (2020) Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Journal of Natural Products 83:8, pages 2320-2329.
Crossref
Alexandra L. Zakharenko, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Georgy A. Ivanov, Vladimir E. Oslovsky, Ekaterina S. Ilina, Irina A. Chernyshova, Olga I. Lavrik & Sergey N. Mikhailov. (2020) Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides. Molecules 25:16, pages 3694.
Crossref
Chao Mei, Lin Lei, Li-Ming Tan, Xiao-Jing Xu, Bai-Mei He, Chao Luo, Ji-Ye Yin, Xi Li, Wei Zhang, Hong-Hao Zhou & Zhao-Qian Liu. (2020) The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage. Biomedicine & Pharmacotherapy 125, pages 109875.
Crossref
Trinh A. D. Holth, Michael A. Walters, Oliver E. Hutt & Gunda I. Georg. (2020) Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds. ACS Combinatorial Science 22:3, pages 150-155.
Crossref
Brettrager, Segura & van Waardenburg. (2019) Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function. Genes 10:11, pages 897.
Crossref
George T Lountos, Xue Zhi Zhao, Evgeny Kiselev, Joseph E Tropea, Danielle Needle, Yves Pommier, Terrence R BurkeJrJr & David S Waugh. (2019) Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Research 47:19, pages 10134-10150.
Crossref
A. A. Chepanova, N. S. Li-Zhulanov, A. S. Sukhikh, A. Zafar, J. Reynisson, A. L. Zakharenko, O. D. Zakharova, D. V. Korchagina, K. P. Volcho, N. F. Salakhutdinov & O. I. Lavrik. (2020) Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy. Russian Journal of Bioorganic Chemistry 45:6, pages 647-655.
Crossref
Kseniya Kovaleva, Olga Oleshko, Evgeniya Mamontova, Olga Yarovaya, Olga Zakharova, Alexandra Zakharenko, Alena Kononova, Nadezhda Dyrkheeva, Sergey Cheresiz, Andrey Pokrovsky, Olga Lavrik & Nariman Salakhutdinov. (2019) Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells. Journal of Natural Products 82:9, pages 2443-2450.
Crossref
Wenjie Wang, Monica Rodriguez-Silva, Arlet M. Acanda de la Rocha, Aizik L. Wolf, Yanhao Lai, Yuan Liu, William C. Reinhold, Yves Pommier, Jeremy W. Chambers & Yuk-Ching Tse-Dinh. (2019) Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents. Cancers 11:10, pages 1416.
Crossref
Alexandra Zakharenko, Nadezhda Dyrkheeva & Olga Lavrik. (2019) Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity. Medicinal Research Reviews 39:4, pages 1427-1441.
Crossref
Evgenii S. Mozhaitsev, Alexandra L. Zakharenko, Evgeniy V. Suslov, Dina V. Korchagina, Olga D. Zakharova, Inna A. Vasil'eva, Arina A. Chepanova, Ellena Black, Jinal Patel, Raina Chand, Jóhannes Reynisson, Ivanhoe K.H. Leung, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2019) Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments. Anti-Cancer Agents in Medicinal Chemistry 19:4, pages 463-472.
Crossref
Evgenii Mozhaitsev, Evgenii Suslov, Yuliya Demidova, Dina Korchagina, Konstantin Volcho, Alexandra Zakharenko, Inna Vasil'eva, Maksim Kupryushkin, Arina Chepanova, Daniel Moscoh Ayine-Tora, Jóhannes Reynisson, Nariman Salakhutdinov & Olga Lavrik. (2019) The Development of Tyrosyl-DNA Phosphodyesterase 1 (TDP1) Inhibitors Based on the Amines Combining Aromatic/Heteroaromatic and Monoterpenoid Moieties. Letters in Drug Design & Discovery 16:5, pages 597-605.
Crossref
E. V. Suslov, K. Yu. Ponomarev, D. V. Korchagina, K. P. Volcho & N. F. Salakhutdinov. (2019) Synthesis of diazaadamantanes from 1,5-dimethylbispidinone and some natural ketones. Russian Chemical Bulletin 68:3, pages 601-605.
Crossref
Xiao-Ru Zhang, Hao-Wen Wang, Wen-Lin Tang, Yu Zhang, Hui Yang, De-Xuan Hu, Azhar Ravji, Christophe Marchand, Evgeny Kiselev, Kwabena Ofori-Atta, Keli Agama, Yves Pommier & Lin-Kun An. (2018) Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents. Journal of Medicinal Chemistry 61:22, pages 9908-9930.
Crossref
Olga Zakharova, Olga Luzina, Alexandra Zakharenko, Dmitry Sokolov, Alexandr Filimonov, Nadezhda Dyrkheeva, Arina Chepanova, Ekaterina Ilina, Anna Ilyina, Kristina Klabenkova, Boris Chelobanov, Dmitry Stetsenko, Ayesha Zafar, Chatchakorn Eurtivong, Jóhannes Reynisson, Konstantin Volcho, Nariman Salakhutdinov & Olga Lavrik. (2018) Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors. Bioorganic & Medicinal Chemistry 26:15, pages 4470-4480.
Crossref
A. L. Zakharenko, E. S. Mozhaitsev, E. V. Suslov, D. V. Korchagina, K. P. Volcho, N. F. Salakhutdinov & O. I. Lavrik. (2018) Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). Chemistry of Natural Compounds 54:4, pages 672-676.
Crossref
Oksana Salomatina, Irina Popadyuk, Alexandra Zakharenko, Olga Zakharova, Dmitriy Fadeev, Nina Komarova, Jóhannes Reynisson, H. Arabshahi, Raina Chand, Konstantin Volcho, Nariman Salakhutdinov & Olga Lavrik. (2018) Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Molecules 23:3, pages 679.
Crossref
Konstantin Yu. Ponomarev, Evgeniy V. Suslov, Alexandra L. Zakharenko, Olga D. Zakharova, Artem D. Rogachev, Dina V. Korchagina, Ayesha Zafar, Jóhannes Reynisson, Andrey A. Nefedov, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2018) Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors. Bioorganic Chemistry 76, pages 392-399.
Crossref
Ajinkya S Kawale & Lawrence F Povirk. (2018) Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation. Nucleic Acids Research 46:2, pages 520-537.
Crossref
Selma M. Cuya & Robert C. A. M. van Waardenburg. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 5334 5343 .
А.Л. Захаренко, О.А. Лузина, Д.Н. Соколов, О. Д. Захарова, М. Е. Рахманова, А. А. Чепанова, Н.С. Дырхеева, О.И. Лаврик & Н.Ф. Салахутдинов. (2017) ПРОИЗВОДНЫЕ УСНИНОВОЙ КИСЛОТЫ КАК ЭФФЕКТИВНЫЕ ИНГИБИТОРЫ ТИРОЗИЛ-ДНК-ФОСФОДИЭСТЕРАЗЫ I, "Биоорганическая химия". Биоорганическая химия:1, pages 97-104.
Crossref
A. L. Zakharenko, O. A. Luzina, D. N. Sokolov, O. D. Zakharova, M. E. Rakhmanova, A. A. Chepanova, N. S. Dyrkheeva, O. I. Lavrik & N. F. Salakhutdinov. (2017) Usnic acid derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1. Russian Journal of Bioorganic Chemistry 43:1, pages 84-90.
Crossref
Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly & Sherif El-Khamisy. 2017. Personalised Medicine. Personalised Medicine 41 58 .
Selma M. Cuya, Evan Q. Comeaux, Keith Wanzeck, Karina J. Yoon & Robert C.A.M. van Waardenburg. (2016) Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin. Oncotarget 7:52, pages 86660-86674.
Crossref
Alexandra Zakharenko, Olga Luzina, Olga Koval, Dmitry Nilov, Irina Gushchina, Nadezhda Dyrkheeva, Vytas Švedas, Nariman Salakhutdinov & Olga Lavrik. (2016) Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin. Journal of Natural Products 79:11, pages 2961-2967.
Crossref
Sergey S. Laev, Nariman F. Salakhutdinov & Olga I. Lavrik. (2016) Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorganic & Medicinal Chemistry 24:21, pages 5017-5027.
Crossref
Tatyana Khomenko, Alexandra Zakharenko, Tatyana Odarchenko, Homayon John Arabshahi, Victoriya Sannikova, Olga Zakharova, Dina Korchagina, Jóhannes Reynisson, Konstantin Volcho, Nariman Salakhutdinov & Olga Lavrik. (2016) New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties. Bioorganic & Medicinal Chemistry 24:21, pages 5573-5581.
Crossref
Anand G. Patel, Karen S. Flatten, Kevin L. Peterson, Thomas G. Beito, Paula A. Schneider, Angela L. Perkins, Daniel A. Harki & Scott H. Kaufmann. (2016) Immunodetection of human topoisomerase I-DNA covalent complexes. Nucleic Acids Research 44:6, pages 2816-2826.
Crossref
Selma M. Cuya & Robert C. A. M. van Waardenburg. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 10 .
A. L. Zakharenko, K. U. Ponomarev, E. V. Suslov, D. V. Korchagina, K. P. Volcho, I. A. Vasil’eva, N. F. Salakhutdinov & O. I. Lavrik. (2015) Inhibitory properties of nitrogen-containing adamantane derivatives with monoterpenoid fragments against tyrosyl-DNA phosphodiesterase 1. Russian Journal of Bioorganic Chemistry 41:6, pages 657-662.
Crossref
Alexandra Zakharenko, Tatyana Khomenko, Svetlana Zhukova, Olga Koval, Olga Zakharova, Rashid Anarbaev, Natalya Lebedeva, Dina Korchagina, Nina Komarova, Vladimir Vasiliev, Jóhannes Reynisson, Konstantin Volcho, Nariman Salakhutdinov & Olga Lavrik. (2015) Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety. Bioorganic & Medicinal Chemistry 23:9, pages 2044-2052.
Crossref
Homayon J. Arabshahi, Michelle van Rensburg, Lisa I. Pilkington, Chae Yeon Jeon, Mirae Song, Ling-Mey Gridel, Euphemia Leung, David Barker, Milena Vuica-Ross, Konstantin P. Volcho, Alexandra L. Zakharenko, Olga I. Lavrik & Jóhannes Reynisson. (2015) A synthesis, in silico, in vitro and in vivo study of thieno[2,3-b]pyridine anticancer analogues. MedChemComm 6:11, pages 1987-1997.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.