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Research Article

Sex-Related Differences in Drug Metabolism

R. Kato Research Laboratories Fujisawa Pharmaceutical Co., Ltd., Osaka, 532, Japan
Pages 1-32 | Published online: 22 Sep 2008

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Kazuo Oda, Naoyuki Nakada & Yasuhisa Nagasaka. (2015) In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats. Xenobiotica 45:6, pages 488-494.
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Fu-Chuo Peng, Shiuan-Woei Lin Wu & Jui-Lin Lin. (2001) METABOLISM OF TERRITREM A IN LIVER MICROSOMES FROM WISTAR RATS: 2. SEX DIFFERENCES AND REGULATION WITH GONADAL HORMONES AND PHENOBARBITAL. Journal of Toxicology and Environmental Health, Part A 64:8, pages 661-671.
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RYUICHI KATO & YASUSHI YAMAZOE. (2000) HISTORY OF DRUG METABOLISM RESEARCH IN JAPAN*. Drug Metabolism Reviews 32:1, pages 45-79.
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Cheryl A. Mugford & Gregory L. Kedderis. (1998) Sex-Dependent Metabolism of Xenobiotics. Drug Metabolism Reviews 30:3, pages 441-498.
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Meir Steiner, Patricia Lepage & Edward J Dunn. (1997) Serotonin and gender-specific psychiatric disorders. International Journal of Psychiatry in Clinical Practice 1:1, pages 3-13.
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Y. Tanaka, Y. Kadoh & H. Ishikawa. (1992) Effects of hypophysectomy and testosterone treatment on the urinary excretion of zenarestat in rats. Xenobiotica 22:1, pages 51-55.
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Y. Tanaka, Y. Deguchi, I. Ishii & T. Terai. (1991) Sex differences in excretion of zenarestat in rat. Xenobiotica 21:9, pages 1119-1125.
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S. Knott, A. Warrander, P. J. Phillips & J. R. Harding. (1990) The disposition of tert-butyl-D-serine in the rat. Xenobiotica 20:1, pages 1-5.
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G. Bellucci, C. Chiappe, F. Marioni & C. Simonelli. (1989) The low reactivity of 5H-dibenzo[a, cflcycloheptene 10,ll-oxide in microsomal epoxide hydrolase catalysed hydration. Xenobiotica 19:3, pages 279-285.
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M. Van Der Graaff, N. P. E. Vermeulen & D. D. Breimer. (1988) Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metabolism Reviews 19:2, pages 109-164.
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James N. Macleod, M. Peter Sorensen & Bernard H. Shapiro. (1987) Strain independent elevation of hepatic mono-oxygenase enzymes in female mice. Xenobiotica 17:9, pages 1095-1102.
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Takemi Yoshida, Takiko Oguro & Yukio Kuroiwa. (1987) Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences. Xenobiotica 17:8, pages 957-963.
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Frank J. Gonzalez, Byung-Joon Song & James P. Hardwick. (1986) Pregnenolone 16 Alpha-Carbonitrile-Inducible P-450 Gene Family: Gene Conversion and Differential Regulation. Molecular and Cellular Biology 6:8, pages 2969-2976.
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Milton Adesnik, Michael Atchison & Daniel W. Nebert. (1986) Genes for Cytochrome P-450 and Their Regulatio. Critical Reviews in Biochemistry 19:3, pages 247-305.
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Ryuichi Kato & Snorri S. Thorgeirsson. (1986) Metabolic activation of mutagenic heterocylic aromatic amines from protein pyrolysates. CRC Critical Reviews in Toxicology 16:4, pages 307-348.
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K. Iwasaki, T. Shiraga, K. Tada, K. Noda & H. Noguchi. (1986) Age- and sex-related changes in amine sulphoconjugations in Sprague-Dawley strain rats. Comparison with phenol and alcohol sulphoconjugations. Xenobiotica 16:8, pages 717-723.
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T. Kobari, Y. Iguro, T. Ito, H. Namekawa, Y. Kato & S. Yamada. (1985) Absorption, distribution and excretion of sultopride in man and several animal species. Xenobiotica 15:7, pages 605-613.
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Julian Heicklen, Terry Wilson, Gregory D. Miller & Edward J. Massaro. (1984) Tye Effect of Diethylhydroxylamine on the Incidence of Tumors Induced by Benzo(A)Pyrene in the Mouse. Drug and Chemical Toxicology 7:4, pages 315-327.
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E. F. Johnson & G. E. Schwab. (1984) Constitutive forms of rabbit-liver microsomal cytochrome P-450: Enzymatic diversity, polymorphism and allosteric regulation. Xenobiotica 14:1-2, pages 3-18.
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B. A. Merrick, K. L. Johnson, K. A. Kester, M. H. Davies & R. C. Schnell. (1983) Species and Sex Differences in Selenium Inhibition of Hepatic Drug Metabolism in Rodents. Drug and Chemical Toxicology 6:4, pages 329-340.
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R. Kato & T. Kamataki. (1982) Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat. Xenobiotica 12:11, pages 787-800.
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H. M. Norbury & R. H. Waring. (1981) The metabolism and disposition of 3,5-dibromosalicylanilide in male and female rats. Xenobiotica 11:8, pages 511-518.
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Maureen J. Crawford & D. H. Hutson. (1980) S-Oxygenation of an alkylmercaptotriazine herbicide by rat, rabbit and human liver enzymes. Xenobiotica 10:3, pages 187-192.
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J. F. Wheldrake, D. Hawke & R. V. Baudinette. (1979) Mixed-Function Oxidase Activity in a Desert Rodent, Notomys Alexis. Xenobiotica 9:9, pages 565-569.
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C. H. Walker. (1978) Species Differences in Microsomal Monooxygenase Activity and Their Relationship to Biological Half-Lives. Drug Metabolism Reviews 7:2, pages 295-323.
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L. A. Reinke, S. J. Stohs & H. Rosenberg. (1978) Increased Aryl Hydrocarbon Hydroxylase Activity in Hepatic Microsomes from Streptozotocin-Diabetic Female Rats. Xenobiotica 8:12, pages 769-778.
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Lester A. Reinke, Sidney J. Stohs & Harry Rosenberg. (1978) Altered Activity of Hepatic Mixed-Function Monooxygenase Enzymes in Streptozotocin-induced Diabetic Rats. Xenobiotica 8:10, pages 611-619.
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J. Noordhoek, A. P. Van Den Berg, E. M. Savenije-chapel & E. Koopman-kool. (1978) Sex Differences in the Kinetic Constants of Ethylmorphine Demethylation and Type I Binding to Hepatic Microsomal Cytochrome P-450 in Mice. The Influence of Castration and Testosterone. Xenobiotica 8:8, pages 515-522.
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M. Metzler & H. G. Neumann. (1977) Epoxidation of the Stilbene Double Bond, a Major Pathway in Aminostilbene Metabolism. Xenobiotica 7:3, pages 117-132.
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Ryuichi Kato. (1977) Drug Metabolism under Pathological and Abnormal Physiological States in Animals and Man. Xenobiotica 7:1-2, pages 25-92.
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