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Drug Metabolism Reviews Volume 5, 1976 - Issue 2
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Research Article

Formation of Stable Epoxides in the Metabolism of Tricyclic Drugs

A. Frigerio Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
,
M. Cavo-briones Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
&
G. Belvedere Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
Pages 197-218 | Published online: 22 Sep 2008

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C. S. Lee, L. H. Wang, T. C. Marbury, J. Bruni & R. J. Perchalski. (1980) Hemodialysis Clearance and Total Body Elimination of Carbamazepine during Chronic Hemodialysis. Clinical Toxicology 17:3, pages 429-438.
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K.-J. Hoffmann, A. Arfwidsson, K. O. Borg & I. Skånberg. (1979) Identification of Urinary and Biliary Metabolites of Alprenolol in the Rat. Xenobiotica 9:2, pages 93-106.
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Bernard Testa & Peter Jenner. (1978) Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology. Drug Metabolism Reviews 7:2, pages 325-369.
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Articles from other publishers (18)

René Fournier, Alexa R. Green, Arthur Greenberg, Edward Lee-Ruff, Joel F. Liebman & Anita Rágyanszki. (2020) Predicted Reversal in N-Methylazepine/N-Methyl-7-azanorcaradiene Equilibrium upon Formation of Their N-Oxides. Molecules 25:20, pages 4767.
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Shumel Zbaida & Rami Kariv. (2006) Simulation of the hepatic metabolism of stilbene and its tricyclic derivatives by fenton and ruff reagents: Models for cytochrome P‐450 activation of chemical carcinogens. Biopharmaceutics & Drug Disposition 11:1, pages 39-51.
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Shmuel Zbaida & Rami Kariv. (2006) Biomimetic models for monooxygenases. Biopharmaceutics & Drug Disposition 10:5, pages 431-442.
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Sunao Kaneko, Koichi Otani, Yutaka Fukushima, Yoshihiro Ogawa, Yukimitsu Nomura, Tsuneo Ono, Yoshibumi Nakane, Takashi Teranishi & Masashi Goto. (2007) Teratogenicity of Antiepileptic Drugs: Analysis of Possible Risk Factors. Epilepsia 29:4, pages 459-467.
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GM Pacifici, M Franchi, C Bencini & A Rane. (1986) Valpromide inhibits human epoxide hydrolase.. British Journal of Clinical Pharmacology 22:3, pages 269-274.
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G.M. Pacifici, T. Tomson, L. Bertilsson & A. Rane. (1985) VALPROMIDE/CARBAMAZEPINE AND RISK OF TERATOGENICITY. The Lancet 325:8425, pages 397-398.
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Michael Höller, Karin Dengler, Karin Dietrich & Heinz Penin. (1985) Studies on the intracerebral metabolism of anticonvulsant drugs—II. Disposition of carbamazepine in the isolated perfused rat brain. Biochemical Pharmacology 34:2, pages 171-174.
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E. F. Hvidberg. 1985. Antiepileptic Drugs. Antiepileptic Drugs 725 764 .
. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
L.A. Damani & D.E. Case. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 223 246 .
G. M. Pacifici, C. Colizzi, L. Giuliani & A. Rane. (1983) Cytosolic epoxide hydrolase in fetal and adult human liver. Archives of Toxicology 54:4, pages 331-341.
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Hansruedi Glatt, Reinhard Jung & Franz Oesch. (1983) Bacterial mutagenicity investigation of epoxides: drugs, drug metabolites, steroids and pesticides. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 111:2, pages 99-118.
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Neville Finch. (2006) Toxicological considerations for the medicinal chemist. Medicinal Research Reviews 1:4, pages 337-372.
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M M Manson. (1980) Epoxides--is there a human health problem?. Occupational and Environmental Medicine 37:4, pages 317-336.
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M. H. Bickel. 1980. Psychotropic Agents. Psychotropic Agents 551 572 .
A. Frigerio, P. Negrini, L. Cappellini, D. Rotilio, A. De Pascale & E. Rossi. (1979) In vivo studies on the metabolism of dibenzo [c,f]-[1,2] diazepine. European Journal of Drug Metabolism and Pharmacokinetics 4:2, pages 67-74.
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A. Frigerio, P. Negrini, L. Cappellini, D. Rotilio, A. De Pascale & E. Rossi. (1979) In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine. European Journal of Drug Metabolism and Pharmacokinetics 4:1, pages 35-41.
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A. Frigerio, P. Negrini, D. Rotilio, A. De Pascale & E. Rossi. 1979. Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Recent Developments in Mass Spectrometry in Biochemistry and Medicine 9 25 .

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