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Drug Metabolism Reviews Volume 6, 1977 - Issue 2
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Research Article

Metabolism of Hydralazine

Z. H. Israili Departments of Medicine and Chemistry, Emory University Atlanta, Georgia, 30322
&
P. G. Dayton Departments of Medicine and Chemistry, Emory University Atlanta, Georgia, 30322
Pages 283-305 | Published online: 22 Sep 2008

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Angela H. Hofstra. (1994) Metabolism of Hydralazine: Relevance to Drug-Induced Lupus. Drug Metabolism Reviews 26:3, pages 485-505.
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John P. O'Donnell. (1982) The Reaction of Amines with Carbonyls: Its Significance in the Nonenzymatic Metabolism of Xenobiotics. Drug Metabolism Reviews 13:1, pages 123-159.
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Björn Lindeke. (1982) The Non-and Postenzymatic Chemistry of N-Oxygenated Molecules. Drug Metabolism Reviews 13:1, pages 71-121.
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C Johnson, J G P Stell & C Stubley. (1982) The Inhibition of Rabbit Liver Aldehyde Oxidase by Hydralazine. Journal of Pharmacy and Pharmacology 34:Supplement_12, pages 63P-63P.
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Shan Wei, Yoshitoshi Kasuya, Masashi Yanagisawa, Sadao Kimura, Tomoh Masaki & Katsutoshi Goto. (1997) Studies on endothelium-dependent vasorelaxation by hydralazine in porcine coronary artery. European Journal of Pharmacology 321:3, pages 307-314.
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S.M. Khedun, J. Moodley, T. Naicker & B. Maharaj. (1997) Drug management of hypertensive disorders of pregnancy. Pharmacology & Therapeutics 74:2, pages 221-258.
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Günter SeyffartGünter Seyffart. 1991. Drug Dosage in Renal Insufficiency. Drug Dosage in Renal Insufficiency 279 295 .
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Huang Cheng-Yi, J.Steven Cridland & Kathryn M. Ivanetich. (1987) Prizidilol. Biochemical Pharmacology 36:5, pages 689-697.
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Lynn B. Lacagnin, Howard D. Colby & John P. O'donnell. (1986) Separation and quantitation of hydralazine metabolites by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 377, pages 319-327.
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Christine Johnson, Christine Stubley-Beedham, J. Godfrey & P. Stell. (1985) Hydralazine: A potent inhibitor of aldehyde oxidase activity in vitro and in vivo. Biochemical Pharmacology 34:24, pages 4251-4256.
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P.A. Reece, I. Stafford, R.H. Prager, G.J. Walker & R. Zacest. (1985) Synthesis, Formulation, and Clinical Pharmacological Evaluation of Hydralazine Pyruvic Acid Hydrazone in two Healthy Volunteers. Journal of Pharmaceutical Sciences 74:2, pages 193-196.
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E G Spokas, G Folco, J Quilley, P Chander & J C McGiff. (1983) Endothelial mechanism in the vascular action of hydralazine.. Hypertension 5:2_pt_2.
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MATS DANIELSON, JAN KJELLBERG, PETER ÖHMAN & BÖRJE WERNERSSON. (2009) Evaluation of Once Daily Hydralazine in Inadequately Controlled Hypertension. Acta Medica Scandinavica 214:5, pages 373-380.
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Shuichi Hara, Tetsuo Satoh & Haruo Kitagawa. (1983) Dose-dependence of the effect of hydralazine on the central nervous system in rats. Journal of Pharmacy and Pharmacology 35:1, pages 50-52.
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A. Hanson, B. W. Johansson, B. Wernersson & L. �. W�hlander. (1983) Pharmacokinetics of oral hydralazine in chronic heart failure. European Journal of Clinical Pharmacology 25:4, pages 467-473.
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Nels C. Henningsen, Arne Hanson & Börje Wernersson. (2009) Single Versus Multiple Daily Administration of Hydralazine in the Maintenance Treatment of Hypertension. Acta Medica Scandinavica 211:3, pages 179-185.
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Judith Lueck & Silvio Aladjem. (1982) Effect of therapeutic levels of magnesium sulphate, methyldopa, hydralazine and phenobarbitone on normal term human trophoblast in vitro. Placenta 3:1, pages 39-43.
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David B. Jack, Martin J. Kendall, Sandra Dean, Steven J. Laugher, Razia Zaman & Michael E. Tenneson. (2006) The effect of hydralazine on the pharmacokinetics of three different beta adrenoceptor antagonists: Metoprolol, nadolol, and acebutolol. Biopharmaceutics & Drug Disposition 3:1, pages 47-54.
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Peter G. Dayton & Zafar H. Israili. (1981) Hydralazine Eeactions. Science 214:4516, pages 94-95.
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Lewis M. Dubroff, Robert J. ReidJr.Jr., Michael M. Papalian & Scott W. Alexander. (1981) Response : Hydralazine Reactions . Science 214:4516, pages 95-95.
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Lewis Dubroff, Robert ReidJR.JR. & Michael Papalian. (2005) Molecular models for hydralazine‐related systemic lupus erythematosus. Arthritis & Rheumatism 24:8, pages 1082-1085.
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T. M. Ludden, J. L. McnayJR.JR., A. M. M. Shepherd & M. S. Lin. (2005) Variability of plasma hydralazine concentrations in male hypertensive patients. Arthritis & Rheumatism 24:8, pages 987-992.
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R. J. Walden, R. Hernandez, D. Witts, B. R. Graham & B. N. C. Prichard. (1981) Effect of food on the absorption of hydralazine in man. European Journal of Clinical Pharmacology 20:1, pages 53-58.
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L H Michael & C L Seidel. (1981) Hydralazine: effect on contraction mechanics of WKY and SHR rat heart muscle.. Hypertension 3:3, pages 356-361.
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V Facchini & JA Timbrell. (2012) Further evidence for an acetylator phenotype difference in the metabolism of hydralazine in man.. British Journal of Clinical Pharmacology 11:4, pages 345-351.
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Paolo Ventura, Francesco Parravicini, Luca Simonotti, Riccardo Colombo & Giorgio Pifferix. (1981) Degradation of Propildazine in Water. Journal of Pharmaceutical Sciences 70:3, pages 334-336.
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Vincenzo Facchini, Anthony J. Streeter & John A. Timbrell. (1980) Determination of hydralazine and its acetylated metabolites in urine by gas chromatography and high-pressure liquid chromatography. Journal of Chromatography A 187:1, pages 218-223.
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L. Tardoa, E. Kósa, L. Jaszlits, I. Berzétei & A. Rónai. 1980. Pharmacological Control of Heart and Circulation. Pharmacological Control of Heart and Circulation 239 243 .
T.M. Ludden, L.K. Goggin, J.L. McNayJr.Jr., K.D. Haegele & A.M.M. Shepherd. (1979) High-pressure Liquid Chromatographic Assay for Hydralazine in Human Plasma. Journal of Pharmaceutical Sciences 68:11, pages 1423-1425.
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L. Simonotti, R. Colombo & G. Pifferi. 1979. Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Recent Developments in Mass Spectrometry in Biochemistry and Medicine 27 41 .

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