45
Views
73
CrossRef citations to date
0
Altmetric
Research Article

The Current Status of Attempts to Predict Species Differences in Drug Metabolism

Pages 221-237 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Katsutoshi Yoshizato & Chise Tateno. (2009) In vivo modeling of human liver for pharmacological study using humanized mouse. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1435-1446.
Read now
Matthias Kapischke & Alexandra Pries. (2008) Animal models of pancreatic cancer for drug research. Expert Opinion on Drug Discovery 3:10, pages 1177-1188.
Read now
M. Almar, L. Otero, C. Santos & J. Gonzalez Gallego. (1998) Liver glutathione content and glutathione‐dependent enzymes of two species of freshwater fish as bioindicators of chemical pollution. Journal of Environmental Science and Health, Part B 33:6, pages 769-783.
Read now
Peter Dogterom, Gerhard Zbinden & Gerd K. Reznik. (1992) Cardiotoxicity of Vasodilators and Positive Inotropic/Vasodilating Drugs in Dogs: An Overview. Critical Reviews in Toxicology 22:3-4, pages 203-241.
Read now
Hans W. Ruelius. (1987) Extrapolation from animals to man: predictions, pitfalls and perspectives. Xenobiotica 17:3, pages 255-265.
Read now
M. E. Veronese, S. McLean, C. A. D'souza & N. W. Davies. (1985) Formation of reactive metabolites of phenacetin in humans and rats. Xenobiotica 15:11, pages 929-940.
Read now

Articles from other publishers (64)

Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation 293 330 .
Koki Hasegawa, Kazuaki Nakano, Masaki Nagaya, Masahito Watanabe, Ayuko Uchikura, Hitomi Matsunari, Kazuhiro Umeyama, Eiji Kobayashi & Hiroshi Nagashima. (2022) Transplantation of human cells into Interleukin-2 receptor gamma gene knockout pigs under several conditions. Regenerative Therapy 21, pages 62-72.
Crossref
Adeel Sattar, Mian Abdul Hafeez, Qin Wu, Adnan Hassan Tahir, Muhammad Abu Bakr Shabbir, Dongmei Chen, Lingli Huang, Shuyu Xie & Zonghui Yuan. (2020) Disposition of cyadox in domesticated cats following oral, intramuscular, and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics 43:2, pages 97-107.
Crossref
Yun-Jung Choi, EunSu Kim, Abu Musa Md Talimur Reza, Kwonho Hong, Hyuk Song, Chankyu Park, Seong-Keun Cho, Kiho Lee, Randall S. Prather & Jin-Hoi Kim. (2017) Recombination activating gene-2null severe combined immunodeficient pigs and mice engraft human induced pluripotent stem cells differently. Oncotarget 8:41, pages 69398-69407.
Crossref
Clare Salamon & Shayne Gad. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 431 497 .
Shayne Gad & John Peckham. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 341 430 .
Shayne Gad. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 1 20 .
Mark Walker, Michael Templin, John Bernal, Stewart Jacobson, Shayne Gad & Christopher Kemper. 2015. Animal Models in Toxicology, Third Edition. Animal Models in Toxicology, Third Edition 671 762 .
Aksorn Saengtienchai, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayu Kakehi, Nesta Bortey-Sam, Wageh Sobhy Darwish, Toshio Tsubota, Masanori Terasaki, Amnart Poapolathep & Mayumi Ishizuka. (2014) Identification of interspecific differences in phase II reactions: Determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene. Environmental Toxicology and Chemistry 33:9, pages 2062-2069.
Crossref
Catherine Belzung. (2013) Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?. Neuropsychopharmacology 39:5, pages 1041-1051.
Crossref
Alberto Corsini, Patricia Ganey, Cynthia Ju, Neil Kaplowitz, Dominique Pessayre, Robert Roth, Paul B. Watkins, Mudher Albassam, Baolian Liu, Saray Stancic, Laura Suter & Michele Bortolini. (2012) Current Challenges and Controversies in Drug-Induced Liver Injury. Drug Safety 35:12, pages 1099-1117.
Crossref
Alexander V. LyubimovRonald E. Savage. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 38 .
Binu Shrestha, J. Michael Reed, Philip T. Starks, Gretchen E. Kaufman, Jared V. Goldstone, Melody E. Roelke, Stephen J. O'Brien, Klaus-Peter Koepfli, Laurence G. Frank & Michael H. Court. (2011) Evolution of a Major Drug Metabolizing Enzyme Defect in the Domestic Cat and Other Felidae: Phylogenetic Timing and the Role of Hypercarnivory. PLoS ONE 6:3, pages e18046.
Crossref
Martin E. Dowty, Dean M. Messing, Yurong Lai & Leonid (Leo) Kirkovsky. 2011. ADMET for Medicinal Chemists. ADMET for Medicinal Chemists 145 200 .
Bo Jiang, Alok R. Khandelwal, Lynette K. Rogers, Valeria Y. Hebert, James J. Kleinedler, James H. Zavecz, Weibin Shi, A. Wayne Orr & Tammy R. Dugas. (2010) Antiretrovirals Induce Endothelial Dysfunction via an Oxidant-Dependent Pathway and Promote Neointimal Hyperplasia. Toxicological Sciences 117:2, pages 524-536.
Crossref
Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
Crossref
Karl K. Rozman, John Doull & Wayland J. HayesJr.Jr.. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 3 101 .
K. England, C. am Ende, H. Lu, T. J. Sullivan, N. L. Marlenee, R. A. Bowen, S. E. Knudson, D. L. Knudson, P. J. Tonge & R. A. Slayden. (2009) Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia. Journal of Antimicrobial Chemotherapy 64:5, pages 1052-1061.
Crossref
Dennis A. Smith & R. Scott Obach. (2009) Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment. Chemical Research in Toxicology 22:2, pages 267-279.
Crossref
Katsutoshi Yoshizato & Chise Tateno. (2009) A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans. PPAR Research 2009, pages 1-11.
Crossref
John Timbrell. 2008. Principles of Biochemical Toxicology, Fourth Edition. Principles of Biochemical Toxicology, Fourth Edition 129 191 .
Connie Cheung & Frank J. Gonzalez. (2008) Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment. Journal of Pharmacology and Experimental Therapeutics 327:2, pages 288-299.
Crossref
Marina Prigol, Ethel A. Wilhelm, Eluza C. Stangherlin, Daniela A. Barancelli, Cristina W. Nogueira & Gilson Zeni. (2007) Diphenyl Diselenide-Induced Seizures in Rat Pups: Possible Interaction with Glutamatergic System. Neurochemical Research 33:6, pages 996-1004.
Crossref
Ru Yan, Tatiana N. Nanovskaya, Olga L. Zharikova, Donald R. Mattison, Gary D.V. Hankins & Mahmoud S. Ahmed. (2008) Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons. Biochemical Pharmacology 75:9, pages 1848-1857.
Crossref
William Bains. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Andreza Fabro de Bem, Rafael de Lima Portella, Juliano Perottoni, Emilene Becker, Denise Bohrer, Márcio Weber Paixão, Cristina Wayne Nogueira, Gilson Zeni & João Batista Teixeira Rocha. (2006) Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods. Chemico-Biological Interactions 162:1, pages 1-10.
Crossref
Frank J. GonzalezAi-Ming Yu. (2006) CYTOCHROME P450 AND XENOBIOTIC RECEPTOR HUMANIZED MICE. Annual Review of Pharmacology and Toxicology 46:1, pages 41-64.
Crossref
Tsutomu Sakuma, Tsukasa Shimojima, Kiyoshi Miwa & Tetsuya Kamataki. (2004) CLONING CYP2D21 AND CYP3A22 CDNAS FROM LIVER OF MINIATURE PIGS. Drug Metabolism and Disposition 32:4, pages 376-378.
Crossref
Margit Spatzenegger, Stephanie Born & James Halpert. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 179 209 .
C.W Nogueira, F.C Meotti, E Curte, C Pilissão, G Zeni & J.B.T Rocha. (2003) Investigations into the potential neurotoxicity induced by diselenides in mice and rats. Toxicology 183:1-3, pages 29-37.
Crossref
Pawinee Piyachaturawat, Chatsuda Tubtim, Aporn Chuncharunee, Prayad Komaratat & Apichart Suksamrarn. (2002) Evaluation of the acute and subacute toxicity of a choleretic phloracetophenone in experimental animals. Toxicology Letters 129:1-2, pages 123-132.
Crossref
E Dybing, J Doe, J Groten, J Kleiner, J O'Brien, A.G Renwick, J Schlatter, P Steinberg, A Tritscher, R Walker & M Younes. (2002) Hazard characterisation of chemicals in food and diet. Food and Chemical Toxicology 40:2-3, pages 237-282.
Crossref
Karl K. Rozman, John Doull & Wayland J. HayesJr.Jr.. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 1 93 .
A.G. Rauws, E.J. De Waal & J.W. Van Der Laan. 1997. Advances in Drug Research Volume 30. Advances in Drug Research Volume 30 15 72 .
PW van Vliet & J. de Jongh. (2016) Biokinetics and biokinetic models in risk assessment. Human & Experimental Toxicology 15:10, pages 799-809.
Crossref
Harold Boxenbaum & Clifford DiLea. (2013) First‐Time‐in‐Human Dose Selection: Allometric Thoughts and Perspectives. The Journal of Clinical Pharmacology 35:10, pages 957-966.
Crossref
D. Bruce Campbell. (1995) Are interspecies comparisons in the toxicity of centrally acting drugs valid without brain concentrations? A commentary. Neurochemistry International 26:2, pages 103-110.
Crossref
D. Bruce Campbell. (2016) Can Allometric Interspecies Scaling be Used to Predict Human Kinetics?. Drug Information Journal 28:1, pages 235-245.
Crossref
James G. Morris, Quinton R. Rogers, Seungwook W. Kim & Robert C. Backus. 1994. Taurine in Health and Disease. Taurine in Health and Disease 59 70 .
Haiyung Cheng & William J. Jusko. (2006) Pharmacokinetics of reversible metabolic systems. Biopharmaceutics & Drug Disposition 14:9, pages 721-766.
Crossref
Zoheir A. Damanhouri & Osama S. Tayeb. (1993) A comparative study of liver mixed function oxidases in camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus). Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 105:3, pages 487-491.
Crossref
John Caldwell. (1992) Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism. Toxicology Letters 64-65, pages 651-659.
Crossref
B.H. Ali & H.A. El Sheikh. (1992) Mini-review. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 101:2, pages 189-195.
Crossref
H.A. El Sheikh, B.H. Ali, A.M. Homeida & H.J. Hapke. (1991) Activities of glutathione-S-transferase and ethoxycoumarin-O-deethylase in tissues of camels, sheep, goats and rats. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 98:2-3, pages 293-297.
Crossref
Christopher P. Chengelis. (2016) Examples of Alternative Use in Toxicology for Common Species. Journal of the American College of Toxicology 9:3, pages 319-342.
Crossref
A.G. Hendrickx & P.E. Binkerd. (1990) Nonhuman Primates and Teratological Research. Journal of Medical Primatology 19:2, pages 81-108.
Crossref
Kerstin Lindahl-Kiessling, Inger Karlberg & Anne-Mari Olofsson. (1989) Induction of sister-chromatid exchanges by direct and indirect mutagens in human lymphocytes, co-cultured with intact rat liver cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 211:1, pages 77-87.
Crossref
D.B. Campbell & R.M.J. Ings. (2016) New Approaches to the Use of Pharmacokinetics in Toxicology and Drug Development. Human Toxicology 7:5, pages 469-479.
Crossref
Karl Rozman. (2016) Disposition of Xenobiotics: Species Differences. Toxicologic Pathology 16:2, pages 123-129.
Crossref
C.R. Short, W. Flory, L.C. Hsieh, T. Aranas, S.-P. Ou & J. Weissinger. (1988) Comparison of hepatic drug metabolizing enzyme activities in several agricultural species. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 91:2, pages 419-424.
Crossref
H.A. El Sheikh, B.H. Ali, A.M. Homeida, T. Hassan & H-J. Hapke. (1988) The activities of aminopyrine N-demethylase, aniline 4-hydroxylase and UDP-glucuronyltransferase in tissues of camels, desert sheep and Nubian goats. General Pharmacology: The Vascular System 19:5, pages 713-717.
Crossref
R. R. DALVI, V. A. NUNN & JUDITH JUSKEVICH. (2008) Hepatic cytochrome P‐450 dependent drug metabolizing activity in rats, rabbits and several food‐producing species. Journal of Veterinary Pharmacology and Therapeutics 10:2, pages 164-168.
Crossref
W.G. Helferich, M.H. Silva, W.T. Flueck, B.D. Hammock & L.R. Shull. (1987) Xenobiotic biotransformation in livers and lungs of adult black-tailed deer: Comparison with domestic goat and sheep. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 88:1, pages 145-149.
Crossref
R.R. Dalvi, Vic A. Nunn & Judith Juskevich. (1987) Studies on comparative drug metabolism by hepatic cytochrome P-450-containing microsomal enzymes in quail, ducks, geese, chickens, turkeys and rats. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 87:2, pages 421-424.
Crossref
C.S. Smith, S.L. Morgan, S.V. Greene & R.K. Abramson. (1987) Solid-phase extraction and high-performance liquid chromatographic method for chlorpromazine and thirteen metabolites. Journal of Chromatography B: Biomedical Sciences and Applications 423, pages 207-216.
Crossref
Jean A. Boutin, Benedicte Antoine, Sylvie Fournel & Gerard Siest. (1987) Heterogeneity of hepatic microsomal UDP-glucuronosyltransferases activities: use and comparison of differential inductions in some mamalian species. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 87:3, pages 513-522.
Crossref
H Nau. (1986) Species differences in pharmacokinetics and drug teratogenesis.. Environmental Health Perspectives 70, pages 113-129.
Crossref
G. Gordon Gibson & Paul SkettG. Gordon Gibson & Paul Skett. 1986. Introduction to Drug Metabolism. Introduction to Drug Metabolism 147 174 .
I.D. Wilson, C.M. Macdonald, J.M. Fromson, J.A. Troke & D. Hillbeck. (1985) Species differences in the metabolism of 14C-p-trifluoromethylaniline: Production of an oxanilic acid as the major metabolite by the rat. Biochemical Pharmacology 34:11, pages 2025-2028.
Crossref
Zoltan Gregus, John B. Watkins, Thomas N. Thompson, Michael J. Harvey, Karl Rozman & Curtis D. Klaassen. (1983) Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing. Toxicology and Applied Pharmacology 67:3, pages 430-441.
Crossref
Lawrence Fishbein. (2016) An Overview of Some Metabolic and Modulating Factors in Toxicity and Chemical Carcinogenesis. Journal of the American College of Toxicology 2:1, pages 63-89.
Crossref
JOHN CALDWELL. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 291 306 .
JOHN CALDWELL. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 271 290 .
J. Caldwell, J. O’Gorman & R. H. Adamson. 1982. Theophylline and other Methylxanthines / Theophyllin und andere Methylxanthine. Theophylline and other Methylxanthines / Theophyllin und andere Methylxanthine 181 185 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.